2003 : University of Maryland Medical System Center for Advanced FetalCare, A.B.D., Misafir Doktor

2013 - 2015 : Şifa Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum, Anabilim Dalı Başkanlığı 

2016 : Kent Hastanesi Kadın Hastalıkları ve Doğum Bölümü 

Uzmanlık Alanı:

Kadın Hastalıkları ve Doğum 

Perinatoloji (Yüksek Riskli Gebelikler)

Mesleki İlgi ve Aktiviteler:

Normal Gebelik Takibi ve Doğum

Tekrarlayan Gebelik Kayıpları 

Erken Doğum

Yüksek Riskli Gebelikler

Jinekolojik hastalıkların (Kadın Hastalıkları) tanı ve tedavisi

Yayınlar:

·         PaternalDepressionRates in Prenatal and Postpartum Periods and Affecting Factors. Arch Psychiatr Nurs. 2016 Dec;30(6):747-752
·         Effect of Ramadanfasting on metabolic markers, dietary intake and abdominal fat distribution in pregnancy.Hippokratia. 2015 Oct-Dec;19(4):298-303.
·         Vitamin D deficiency in pregnancy may affect fetal thymus development.GinekolPol. 2016;87(5):378-83.
·         Investigation of the Roles of Cyclooxygenase-2 and Galectin-3 Expression in the Pathogenesis of Premenopausal Endometrial Polyps. J Pathol Transl Med. 2016 May;50(3):225-30
·         The role of cytokines in first trimester pregnancy losses with fetal chromosomal anomaly.Ginekol Pol. 2015 Nov;86(11):827-32
·         Investigation of the relationship between salivary cortisol, dehydroepiandrosteronesulfate, anxiety, and depression in patients with hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2016 Nov;29(22) 
·         Thyroid antibodies in euthyroid and subclinical hypothyroidic pregnant women with autoimmune hypothyroidism: effects on hematological parameters and postpartum hemorrhage.GinekolPol. 2015 Sep;86(9):666-71.
·         Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus Arch Endocrinol Metab. 2015 Oct;59(5):448-54.  
·         Does uterine prolapse alter endometrial cyclooxygenase 2 expression and promote the development of premalignant lesions? Gynecol Obstet Invest. 2015;80(2):119-23 
·         The effect of vitamin D level in pregnancy on postpartum depression . Arch Womens Ment Health. 2015 Apr;18(2):263-4 
·         Does bupivacaine and fentanyl combination for epidural analgesia shorten the duration of labour?J Obstet Gynaecol. 2015;35(7):672-5 
·         The effect of place of residence and lifestyle on vitamin D deficiency in pregnancy: Comparison of eastern and western parts of Turkey.J Turk Ger Gynecol Assoc. 2014 Aug 8;15(3):149-55 
·         Endometrial pathology in postmenopausal women with no bleeding. Climacteric. 2015 Apr;18(2):241-5 
·         Mid-pregnancy vitamin D levels and postpartum depression. Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:110-6
·         Ultrasonographic visceral fat thickness measurement may be a goodscan test for prediction of gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2015 May;28(8):893-4
·         Uterine closure with unlocked suture in cesarean section: Safety and Quality. Pak J MedSci. 2014 May;30(3):530-4
·         Ultrasonographic visceral fat thickness in the first trimester can predict metabolic syndrome and gestational diabetes mellitus.Endocrine. 2014 Nov;47(2):478-84
·         Cord blood ischemia-modified albumin: is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatalasphyxia? J Obstet Gynaecol Res. 2013 Mar;39(3):663-71
·         Do amniotic fluid leptin levels decrease in pregnancies with fetal trisomy 21? J Obstet Gynaecol. 2012 Aug;32(6):540-2
·         Comparison of uterine exteriorization and in situ repair during cesarean sections. Arch Gynecol Obstet. 2012 Jun;285(6):1541-5
·         Amniotic fluid angiogenin levels are decreased in pregnancies with fetal trisomy, (2011)
·         Late-onset maternal mortality after amniocentesis, (2011)
·         Effect of leptin treatment on neonatal hypoxic-ischemic brain injury. J  Matern Fetal Neonatal Med. 2012 Feb;25(2):141-6
·         Kordosentezin Fetal Orta Serebral Arter ve Umblikal Arter Dalga Formlarına Etkisi (2010)
·         The Influence of epidura lvolume extension on spinal block with hyperbaric or plain bupivacaine (2008)
·         Tuboovarianabseli olguların değerlendirilmesi (2008)
·         Congenital cystic adenomatoid malformation and intrauterine cysto amniotic shunt (2008)
·         The Effects of Different Maternal Positions On Non-stress Test: An ExperimentalStudy (2007)
·         Fetal gender affects maternal serum total and placental alkaline phosphatase levels during pregnancy(2006)
·         Cystectomy in a patient with immature teratoma of the ovary: Restaging, chemotherapyorfollow-up? (2006)
·         Nifedipine therapy for preterm labor: effects on placental, fetal cerebral and atrioventricular Dopp (2006)
·         The effects of raloxifene on serum lipid profiles, C-reactive protein and homocysteine levels in posmenopausal women (2006)
·         Effect of fetal gender on maternal serum human chorionic gonadotropin levels throughout pregnancy (2005)
·         Travay sürecinde hasta kontrollü epidural analjezi uygulanan gebelerde epidural ve combinespinal-epidural anestezi (2005)
·         Raloxifene increases serum leptin levels in postmenopausal women: a prospectivestudy (2005)
·         Mirtazapin use in resistant hyperemesis gravidarum: report of three cases and review of the literature. (2005)
·         Sağlıklı postmenopozal kadınlarda konjuge equine östrojen ve nomegestrol asetat kullanımı,2005
·         The short-term effect of nifedipine tocolysis on placental, fetal cerebral and atrioventricular Doppler waveforms (2004).
·         Different maternal serum hCG levels in pregnant women with female and male fetuses: does fetal hypop (2004)
·         Venous Doppler in the prediction of acid-base status of growth-restricted fetuses with elevated placental (2004)
·         Gerçek Stress İnkontinansın tedavisinde genel anestezi altında uygulanan gerilimsiz vaginal bant operasyonu (2004)
·         Expressionof IGF-IR and VEGF and Trophoblastic Proliferative Activity in Placentas from Pregnancies (2003).
·         Vaginal Histerektomi sırasında sakrosipinöz fiksasyon (2003)
·         Importance of the intraoperative frozen section diagnosis in patientwithtamoxifeninducedmalignan (2003)
·         Gebelikte Vitamin Desteği (2003)
·         Servikal olgunlaşmada intravaginalmisoprostolünintakt tablet ve ezilmiş tablet olarak uygulanması (2003)
·         Mosaic form (45X/46XX) of Turner'ssyndrome. A casereport (2002)
·         Postmenopozal kadınlarda üç aylık transdermalöstrojen+progesteron tedavisi ile tibolon tedavisi (2002)
·         EndometrialAdenokarsinomlardacatepsin D ninprognostik önemi (2002)
·         EpitelyalOver Tümörlerinde P53 ve C-ErbB-2 İmmünoreaktivitesinin Klinik ve Patolojik Faktörler (2002)
·         Asemptomatikbakteriürili gebeliklerin sonuçları (2002)
·         Doessystematiclymphadenectomyhave a benefit on survival of suboptimallydebulkedpatients (2002)
·         Theeffect of ascites, massvolumeandperitonealcarsinomatosis on serum ca 125 levels in patients, (2002)
·         Erken evre epitelyaloverkarsinomundaintraoperatif kist rüptürününprognostik önemi 2002
·         Fetal Doku Örneklemeleri (2002)
·         Gebelik ve trombosit hastalıkları (2002)
·         Dermatomyozitis ve endometrium kanseri (2002)
·         Can serum ca 125 levelspredictthe optimal primarycytoreduction in patients (2002)
·         Epitelyalover Tümörlerinde p53 ve c-erbB-2 immünoreaktivitesi (2002)
·         Premenapozal Dönemde Tamoxifen Kullanımı ile Uyarılmış Endometriyozis Olgusu (2002)
·         Abdominalincisionalendometrioma (2002)
·         Risk FactorsforPelvicSurgery (2002)
·         Primaryendometrioidadenocarcinomawithcoexistingendometrialtuberculosis (2002)
·         Sıçan endometriumundaki östrojen ve progesteron reseptörleri (2002)
·         Postmenopozal kadınlarda HRT nin serum lipoprotein a ve HDL düzeylerine etkisi (2001)
·         Human KoryonikGonadotropinintriod fonksiyonları üzerine etkisinin araştırılması (2001)
·         May cathepsin D1 immunoreactivity be used as a prognosticfactor in endometrialcarcinomas? (2001)
·         Vulvanın Granüler Hücreli Tümörü-Olgu Sunumu (2001)
·         Erken doğum tehdidi yönetiminde maternalhidrasyon, Ritodrin ve Nifedipin (2000)
·         Combineduse of serum ca 125 andca 15-3 in thefollowup of patientswithepithelialovariancancer (2000)
·         Gebelikte Beyin Tümörleri (2000)
·         HELLP Sendromu'nda akut akciğer ödemi ilk bulgu olabilir mi? (2000)
·         Endometriozis ve myomauterili olgularda Tümör NekrozisFaktor düzeylerinin tanıda önemi (2000)
·         Postmenopozal osteoporozda 3 aylık dehidroepiandrosteron uygulamasının sonuçları (2000)
·         Serviks kanserli olgularda SouthernBlotHybridization metodu ile Human PapillomaVirusDNAsının saptanması (2000)
·         OoferektomizeratlardaDehidroepiandrosteron'un serum Interleukin-6 düzeylerine etkisi (2000)
·         Ekstragonadalgerm hücreli tümör saptanan bir inkompletandrojeninsensitivitesi olgusu (2000)
·         Servikal kanserli Türk kadınlarında Human PapillomaVirusinsidansınınpolimeraz zincir reaksiyonu (2000)
·         Postmenopozal osteoporozda serum insülin benzeri büyüme faktör bağlayıcı proteinlerin rolü (1999)
·         Jinekoloji ve obstetride antibiyotik proflaksisi (1999)
·         İntraabdominaladhezyon oluşumunun önlenmesinde kullanılan ilaçların etkinliklerinin kıyaslanması (1999)

Emotions and Experiences of Pregnant Women with a History of Pregnancy Loss: A Qualitative Study Based on Watson's Theory of Human Caring

By

Tektas, P (Tektas, Pinar) [1] ; Yenal, K (Yenal, Kerziban) [2] ; Ozan, YD (Ozan, Yeter Durgun) [3] ; Güçlü, S (Guclu, Serkan) [4] ; Barbaros, A (Barbaros, Aylin) [5]

 (provided by Clarivate) 

Source

MEDITERRANEAN NURSING AND MIDWIFERY

Volume

5

Issue

1

Page

62-71

DOI

10.4274/MNM.2024.24237

Published

APR 2025

Indexed

2025-05-05

Document Type

Article

Abstract

Objective: This study aimed to determine the feelings and experiences of pregnant women with a history of pregnancy loss. Method: A semi-structured interview form based on Watson's caritas process was used to collect data from 13 pregnant women with a history of pregnancy loss between April and June 2020. Thematic analysis was performed according to Watson's caritas processes and reported in accordance with the Consolidated Criteria for Reporting Qualitative Research guidelines. Results: Pregnant women were found to expect respect, empathy, understanding, and smiling faces from healthcare professionals. In pregnancy after loss, the participants stated that they expected healthcare workers to be more sensitive to them and needed to talk to healthcare workers, share their feelings with them, and obtain more information. Conclusion: The use of interview methods based on Watson's theory of human caring can help guide health professionals and increase the quality of care.

Keywords

Author Keywords

Pregnancy pregnancy loss nursing qualitative study Watson's theory of human caring

A comparison of 2 cesarean section methods, modified Misgav-Ladach and Pfannenstiel-Kerr: A randomized controlled study

By

Sahin, N (Sahin, Nur) [1] ; Genc, M (Genc, Mine) [1] ; Turan, GA (Turan, Guluzar Arzu) [1] ; Kasap, E (Kasap, Esin) [2] ; Güçlü, S (Guclu, Serkan) [3]

 (provided by Clarivate) 

Source

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE

Volume

27

Issue

3

Page

357-361

DOI

10.17219/acem/66215

Published

MAR 2018

Indexed

2018-04-19

Document Type

Article

Abstract

Background. The modified Misgav-Ladach method (MML) is a minimally invasive cesarean section procedure compared with the classic Pfannenstiel-Kerr (PK) method.

Objectives. The aim of the study was to compare the MML method and the PK method in terms of intra-operative and short-term postoperative outcomes.

Material and methods. This prospective, randomized controlled trial involved 252 pregnant women scheduled for primary emergency or elective cesarean section between October, 2014 and July, 2015. The primary outcome measures were the duration of surgery, extraction time, Apgar score, blood loss, wound complications, and number of sutures used. Secondary outcome measures were the wound infection, time of bowel restitution, visual analogue scale (VAS) scores at 6 h and 24 h after the operation, limitations in movement, and analgesic requirements. At 6 weeks after surgery, the patients were evaluated regarding late complications.

Results. There was a significant reduction in total operating and extraction time in the MML group (p < 0.001). Limitations in movement were lower at 24 h after the MML operation, and less analgesic was required in the MML group. There was no difference between the 2 groups in terms of febrile morbidity or the duration of hospitalization. At 6 weeks after the operation, no complaints and no additional complications from the surgery were noted.

Conclusions. The MML method is a minimally invasive cesarean section. In the future, as surgeons' experience increases, MML will likely be chosen more often than the classic PK method.

Keywords

Author Keywords

cesarean section postoperative pain Pfannenstiel incision modified Misgav-Ladach technique

Color Doppler Sonographic Analysis of Pelvic Venous Blood Flow in Infertile Women with Polycystic Ovary Syndrome, Poor Ovarian Reserve, and Unexplained Infertility

By

Gur, EB (Gur, Esra Bahar) ; Ince, O (Ince, Ozlem) ; Gur, MS (Gur, Mehmet Serkan) ; Turan, GA (Turan, Guluzar Arzu) ; Tatar, S (Tatar, Sumeyra) ; Kasap, E (Kasap, Esin) ; Genç, M (Genc, Mine) ; Adakan, S (Adakan, Saban) ; Guclu, S (Guclu, Serkan)

 (provided by Clarivate) 

Source

JOURNAL OF REPRODUCTIVE MEDICINE

Volume

62

Issue

9-10

Page

552-558

Published

SEP-OCT 2017

Indexed

2017-11-19

Document Type

Article

Abstract

OBJECTIVE: To examine pelvic venous congestion (PVC) in infertile women with polycystic ovary syndrome (PCOS), poor ovarian reserve (POR), and unexplained infertility (UI) and compare it to that in a healthy fertile control group.

STUDY DESIGN: This prospective study was conducted at Sifa University Hospital in 47 patients with PCOS, 30 patients with POR, 34 patients with UI, and 42 healthy fertile control subjects. The patients were examined with transvaginal Doppler ultrasound for the presence of PVC. They were also questioned and physically examined for signs and symptoms of pelvic congestion syndrome. Serum estradiol (E2), total testosterone, and luteinizing hormone/follicle-stimulating hormone levels were measured in patients with PCOS as well as in PVC (+) and (-) patients.

RESULTS: PVC was observed in 31 (20.3%) patients. We observed that PVC was significantly more common in the PCOS group but not in the POR and UI groups (p=0.04). Considering all participants, uterine and ovarian volumes and spontaneous abortion number were significantly higher in the PVC (+) group, and E2 level was significantly higher in PVC (+) patients (p=0.03).

CONCLUSION: Impaired pelvic venous circulation may be a contributing factor to infertility in patients with PCOS.

Keywords

Author Keywords

hyperemia infertility ovarian reserve pelvic venous congestion

Paternal Depression Rates in Prenatal and Postpartum Periods and Affecting Factors

By

Top, ED (Top, Ekin Dila) [1] ; Cetisli, NE (Cetisli, Nuray Egelioglu) [1] ; Guclu, S (Guclu, Serkan) [2] ; Zengin, EB (Zengin, Esma Burcak) [3]

 (provided by Clarivate) 

Source

ARCHIVES OF PSYCHIATRIC NURSING

Volume

30

Issue

6

Page

747-752

DOI

10.1016/j.apnu.2016.07.005

Published

DEC 2016

Indexed

2017-01-04

Document Type

Article

Abstract

The objective of this study was to determine the paternal depression rates and affecting factors in prenatal and postpartum periods. The study, which was descriptive and cross-sectional, was conducted with 92 volunteer couples that suited the criteria for the sample. These participants were selected from couples that applied to the gynecology clinic of a private hospital between September 2014 and April 2015 and who were in their 37th-40th weeks of pregnancy. Data collection was planned in two interviews; the first one was done between the 37th and 40th weeks of the pregnancy, and the second was conducted between the 4th and 6th weeks after the birth. Interviews were completed with 84 couples. In this study, it was determined that there was no relationship between average paternal and maternal scores on the Edinburgh Postnatal Depression Scale (EPDS) in prenatal and postpartum periods. It was found that the average score of the Family-Work Conflict Scale increased and couples' marriage harmony decreased as the EPDS average score for fathers increased. In addition, it was found that the EPDS average score for fathers that wanted the pregnancy was less compared to fathers that did not want the pregnancy, and the difference between the two groups was statistically meaningful. (C) 2016 Elsevier Inc. All rights reserved.

Keywords

Keywords Plus

POSTNATAL DEPRESSION FATHERS ASSOCIATION

Investigation of the relationship between salivary cortisol, dehydroepiandrosterone sulfate, anxiety, and depression in patients with hyperemesis gravidarum

By

Kasap, E (Kasap, Esin) [1] ; Aksu, EE (Aksu, Ebru Emine) [2] ; Gur, EB (Gur, Esra Bahar) [1] ; Genc, M (Genc, Mine) [1] ; Eskicioglu, F (Eskicioglu, Fatma) [3] ; Gökduman, A (Gokduman, Ayse) [4] ; Güçlü, S (Guclu, Serkan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

29

Issue

22

Page

3686-3689

DOI

10.3109/14767058.2016.1140741

Published

NOV 2016

Indexed

2016-10-12

Document Type

Article

Abstract

Background: The aim of this study was to determine the relationship of the salivary levels of dehydroepiandrosterone sulfate (DHEA-S) and cortisol with factors related to depression and anxiety in patients with hyperemesis gravidarum (HG).Methods: Forty patients with a diagnosis of HG were selected for the study and matched with 40 control patients according to body mass index, parity, and age. Symptoms of depression and anxiety were investigated using the Beck Depression Inventory and Beck Anxiety Inventory for Adults, respectively. Saliva samples were collected in the morning and at night and subjected to enzyme-linked immunosorbent assay for the determination of DHEA-S and cortisol levels.Results: We observed a positive correlation between increased levels of depression and anxiety and increased salivary levels of cortisol and DHEA-S in patients with HG.Conclusions: Salivary cortisol and DHEA-S levels, as well as mood disorders, should be monitored in patients with HG, although further large, prospective studies are needed to confirm our results.

Keywords

Author Keywords

Anxiety cortisol dehydroepiandrosterone sulfate depression

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Investigation of the Roles of Cyclooxygenase-2 and Galectin-3 Expression in the Pathogenesis of Premenopausal Endometrial Polyps

By

Kasap, E (Kasap, Esin) [1] ; Karaarslan, S (Karaarslan, Serap) [2] ; Gur, EB (Gur, Esra Bahar) [1] ; Genc, M (Genc, Mine) [1] ; Sahin, N (Sahin, Nur) [1] ; Güclü, S (Guclu, Serkan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE

Volume

50

Issue

3

Page

225-230

DOI

10.4132/jptm.2016.03.08

Published

MAY 2016

Indexed

2017-03-08

Document Type

Article

Abstract

Background: The pathogenesis and etiology of endometrial polyps has not been elucidated. In this study, we aimed to examine the pathogenic mechanisms of endometrial polyp development using immunohistochemistry. We evaluated the expression of galectin-3 and cyclooxgenase-2 COX-2) during the menstrual cycle in premenopausal women with endometrial polyps or normal endometrium. Methods: Thirty-one patients with endometrial polyps and 50 healthy control patients were included in this study. The levels of expression of COX-2 and galectin-3 were studied by immunohistochemistry. Results: The percentage of COX-2-positive cells and the intensity of COX-2 staining in the endometrium did not vary during the menstrual cycle either in the control group or in patients with endometrial polyps. However, expression of galectin-3 was significantly lower in endometrial polyps and during the proliferative phase of the endometrium compared with the secretory phase. Conclusions: Our data suggests that the pathogenesis of endometrial polyps does not involve expression of COX-2 or galectin-3.

Keywords

Author Keywords

Endometrial polyps Cyclooxgenase-2 Galectin-3

The relationship between uterine prolapse and premalignant endometrial pathology

By

Genc, M (Genc, M.) [1] ; Celik, E (Celik, E.) [1] ; Eskicioglu, F (Eskicioglu, F.) [2] ; Gur, EB (Gur, E. Bahar) [1] ; Kurtulmus, S (Kurtulmus, S.) [3] ; Gulec, E (Gulec, E.) [3] ; Guclu, S (Guclu, S.) [1]

 (provided by Clarivate) 

Source

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

Volume

43

Issue

4

Page

500-503

DOI

10.12891/ceog2095.2016

Published

2016

Indexed

2016-11-09

Document Type

Article

Abstract

Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ sparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The post-hysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or patho-logic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.

Keywords

Author Keywords

Uterine prolapse Hysterectomy Endometrial hyperplasia

The association of impaired gestational glucose tolerance with maternal and fetal outcomes

By

Kasap, E (Kasap, E.) [1] ; Genc, M (Genc, M.) [1] ; Turan, GA (Turan, G. A.) [1] ; Eskicioglu, F (Eskicioglu, F.) [2] ; Saklamaz, A (Saklamaz, A.) [3] ; Sahin, N (Sahin, N.) [1] ; Güclü, S (Guclu, S.) [1]

 (provided by Clarivate) 

Source

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

Volume

43

Issue

5

Page

755-758

DOI

10.12891/ceog3141.2016

Published

2016

Indexed

2016-11-02

Document Type

Article

Abstract

The aim of the present study was to examine the associations of gestational diabetes mellitus (GDM) and impaired glucose tolerance (IGT) with maternal and fetal outcomes. A total of 200 pregnant women were included in this cross-sectional study. A 50-gram oral glucose challenge test (GCT) was performed between 24 and 28 weeks of gestation, followed by glucose tolerance test (OGTT) with 100 grams of oral glucose in those with an abnormal one-hour test result. The following were not significantly different between groups. Preterm labour (PL), pregnancy induced hypertension(PIH), pre-eclampsia, polyhydramnios, and macrosomia. However, a significant increase was noted in the fetal birth weight as well as in number of cesarean deliveries among GDM subjects. Neonatal outcomes were also similar between the two groups. In conclusion, the present results suggest that single high glucose readings in OGTT may be as important as a diagnosis of GDM in terms of fetomaternal complication risk.

Keywords

Author Keywords

Gestational diabetes Impaired glucose tolerance Pregnancy

 Vitamin D deficiency in pregnancy may affect fetal thymus development

By

Gur, EB (Gur, Esra Bahar) [1] ; Gur, MS (Gur, Mehmet Serkan) [2] ; Ince, O (Ince, Ozlem) [3] ; Kasap, E (Kasap, Esin) [4] ; Genc, M (Genc, Mine) [4] ; Tatar, S (Tatar, Sumeyra) [4] ; Bugday, S (Bugday, Sultan) [4] ; Turan, GA (Turan, Guluzar Arzu) [4] ; Guclu, S (Guclu, Serkan) [4]

 (provided by Clarivate) 

Source

GINEKOLOGIA POLSKA

Volume

87

Issue

5

Page

378-383

DOI

10.5603/GP.2016.0008

Published

2016

Indexed

2016-07-13

Document Type

Article

Abstract

Objectives: The aim of our study was to evaluate the association of vitamin D deficiency (VDD) during pregnancy with thymus size in full-term fetuses.

Material and methods: In this prospective study, we evaluated mid-pregnancy serum 25-hydroxyvitamin D-3 (25(OH)D-3) concentrations. The fetal thymus size was measured by ultrasound in the third trimester. Neonatal 25(OH)D-3 levels were evaluated by umbilical cord blood sampling. Correlation of maternal and neonatal vitamin D levels and association between thymus size and both, maternal and neonatal vitamin D concentrations were investigated.

Results: Serum 25(OH)D-3 concentrations were within the normal range in 48 (29.8%) mothers and 10 (13.1%) newborns. A strong correlation between mid-pregnancy maternal and neonatal 25(OH)D-3 concentration (r = 0.8, p < 0.001) was found. A significant linear correlation was observed between both, maternal and neonatal 25(OH)D-3 concentrations and thymus perimeter length (r = 0.45, p = 0.04 and r = 0.43, p < 0.01, respectively). Both, maternal and fetal VDDs were associated with decreased thymus perimeter (p = 0.04, p = 0.03).

Conclusions: Vitamin D deficiency during pregnancy may be associated with smaller fetal thymus. Our data suggest that VDD in pregnancy may lead to systemic inflammatory response in the fetus.

Keywords

Author Keywords

pregnancy vitamin D deficiency fetal thymus size

Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus

By

Gur, EB (Gur, Esra Bahar) [1] ; Karadeniz, M (Karadeniz, Muammer) [2] ; Genc, M (Genc, Mine) [1] ; Eskicioglu, F (Eskicioglu, Fatma) [3] ; Yalcin, M (Yalcin, Murat) [4] ; Hepyilmaz, I (Hepyilmaz, Irem) [1] ; Guclu, S (Guclu, Serkan) [1]

 (provided by Clarivate) 

Source

ARCHIVES OF ENDOCRINOLOGY METABOLISM

Volume

59

Issue

5

Page

448-454

DOI

10.1590/2359-3997000000063

Published

OCT 2015

Indexed

2015-10-01

Document Type

Article

Abstract

Objective: To investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies. Subjects and methods: This study included 200 pregnant women. 25-hydroxyvitamin D-3 (25(OH)D-3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D-3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D-3 level in different MPV percentile (<= 50, 50-75, 75-90, >= 90 percentile) and MPV value in different 25(OH)D-3 level (<= 10, 10-20, >= 20 ng/mL) were calculated. Results: Low 25(OH)D-3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D-3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D-3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D-3 level in GMD group (p = 0.04). The optimal 25(OH)D-3 cut off point for predicting future cardiovascular risk was 10.4 ng/mL (area under curve (AUC) = 0.58). Conclusions: Vitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.

Keywords

Author Keywords

Gestational diabetes mellitus vitamin D deficiency mean platelet volume

Mature Cystic Teratoma of the Ovary Clinical, Radiological and, Histopathologic Aspects

By

Genç, M (Genc, Mine) [1] ; Sahin, N (Sahin, Neslin) [2] ; Karaarslan, S (Karaarslan, Serap) [3] ; Güclü, S (Guclu, Serkan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE

Volume

6

Page

370-374

Supplement

3

DOI

10.4328/JCAM.3136

Published

JUN 2015

Indexed

2015-06-01

Document Type

Article

Abstract

Aim: This study aims to analyze the clinical, radiological and, histopathological features of mature cystic teratomas (MCT) of the ovary. Material and Method: We reviewed the records of 33 patients who underwent laparotomic surgeries and whose final histopathological diagnoses were MCT from 2005 to 2013. The clinical, ultrasonographic (USG), magnetic resonance imaging, tumor markers, therapeutic, and histopathological data were analysed. Results: The mean age of the patients was 41,1 years. Nine patients were menopausal. The preoperative USG examination correctly diagnosed 21 patients as MCT. The CA-125 levels were measured preoperatively in 9 cases, with only 1 being abnormal. Thirty-three patients underwent a laparotomy. Thirteen patients underwent a total hysterectomy with bilateral salpingo-oophorectomy (TH+BSO), and 19 underwent a cystectomy. Only one patient underwent a TH+BSO and pelvic-para-aortic lymphadenectomy as histology of the frozen sections indicated the presence of a malignancy. The histological diagnosis was pure MCT in 29 cases, struma ovari in 2 cases, papillary microcarsinoma of the thyroid in struma ovari in 1 case, and malignant melanoma in a MCT in 1 case. Histopathologic examination of the endometrium of 4 of the 14 patients who underwent hysterectomy revealed simple endometrial hyperplasia without atypia. Primary endometrial carcinoma was detected on histopathological examination in 1 patient with a malignant melanoma developing from MCT. Discussion: MCT are usually observed in women of reproductive age. Malignant transformation is a rare complication of MCT as well as papillary carcinoma of the thyroid in struma ovari or malignant melanoma. Preoperative diagnosis of malignant transformation arising in MCT is difficult. Surgical resection is recommended for complication seen in MCT. Malignant transformation arising in MCT can associated with premalignant or malignant changes in the endometrium.

Keywords

Author Keywords

Mature Cystic Teratoma Malignant Transformation Melanoma

Endometrial pathology in postmenopausal women with no bleeding

By

Genc, M (Genc, M.) [1] ; Genc, B (Genc, B.) [2] ; Sahin, N (Sahin, N.) [1] ; Celik, E (Celik, E.) [1] ; Turan, GA (Turan, G. A.) [1] ; Gur, EB (Gur, E. B.) [1] ; Guclu, S (Guclu, S.) [1]

 (provided by Clarivate) 

Source

CLIMACTERIC

Volume

18

Issue

2

Page

241-245

DOI

10.3109/13697137.2014.944152

Published

APR 2015

Indexed

2015-04-15

Document Type

Article

Abstract

Objective The aim of this study was to determine the rate of unexpected uterine pathology in postmenopausal women admitted to a gynecology clinic with symptoms other than vaginal bleeding and who were scheduled to undergo hysterectomy.

Materials and methods We reviewed retrospectively the medical records of 283 postmenopausal patients who had gynecological surgery between September 2007 and January 2014. We reviewed their presenting symptoms on admission, the indications for surgery, and their transvaginal ultrasonographic findings. Postoperative histopathological results based on uterine specimens were also recorded. The results were analyzed statistically.

Results Of 283 patients who had surgery, 209 had no vaginal bleeding at the time of admission. From this group, 75.6% were found to have unsuspected pathology, including endometrial hyperplasia, endometrial polyps, uterine fibroids, adenomyosis, and one case of endometrial carcinoma (0.5%). The remaining 74 patients had experienced postmenopausal bleeding and in 87.8% there were pathological findings including 13 cases (17.6%) of endometrial cancer (p = 0.0001).

Conclusion Vaginal bleeding in postmenopausal women is indicative of a wide array of gynecological pathologies, including endometrial carcinoma. However, uterine fibroids, pelvic masses, or even endometrial cancer may develop without co-morbid vaginal bleeding. Therefore we advocate that postmenopausal women should undergo yearly screening and consultation, without waiting for an episode of vaginal bleeding.

Keywords

Author Keywords

ENDOMETRIUM POSTMENOPAUSAL NO VAGINAL BLEEDING  SCREENING

Effect of Ramadan fasting on metabolic markers, dietary intake and abdominal fat distribution in pregnancy

By

Gur, EB (Gur, E. B.) [1] ; Turan, GA (Turan, G. A.) [2] ; Ince, O (Ince, O.) [3] ; Karadeniz, M (Karadeniz, M.) [4] ; Tatar, S (Tatar, S.) [2] ; Kasap, E (Kasap, E.) [2] ; Sahin, N (Sahin, N.) [2] ; Guclu, S (Guclu, S.) [2]

 (provided by Clarivate) 

Source

HIPPOKRATIA

Volume

19

Issue

4

Page

298-303

Published

2015

Indexed

2016-07-20

Document Type

Article

Abstract

Background: The aim of this study is to evaluate the effect of Ramadan intermittent fasting on metabolic markers, dietary intake, anthropometric measurements, and abdominal visceral fat thickness (VFT) in pregnancy.

Methods: Seventy-eight healthy pregnant subjects who had fasted for at least 15 days during the month of Ramadan in 2012 and 2013 and 78 controls were included in this study. Metabolic markers, dietary intake, anthropometric measurements, and ultrasonographic VFT were calculated for each subject before and after Ramadan fasting.

Results: When before and after Ramadan values in the fasting group were compared, we found that daily protein intake was increased (p <0.001), but fat and carbohydrate intake remained unchanged. A significant reduction was observed in liquid consumption while the frequency of asymptomatic bacteriuria was increased. High-density lipoprotein significantly increased, and glycated hemoglobin, insulin, and homeostasis model index significantly decreased (p =0.005, p =0.01, p <0.001, and p =0.03, respectively). A significant increase in ferritin was found (p =0.02). No change was observed in subcutaneous fat thickness, while VFT significantly decreased (p =0.08, p =0.005). However, in the control group, only ferritin level increased.

Conclusion: A combined change in the number and timing of meals and the portioning of the entire daily intake into only two meals per day may have beneficial metabolic effects and reduction in VFT during pregnancy.

Keywords

Author Keywords

Ramadan fasting pregnancy metabolic markers abdominal visceral fat thickness