Tumor deposits in thyroid carcinomas
By
Durak, MG (Durak, Merih Guray) [1] ; Gokcay, D (Gokcay, Deniz) [1] ; Emecen, SB (Emecen, Serra Begum) [1] ; Ozdogan, O (Ozdogan, Ozhan) [2] ; Sevinc, AI (Sevinc, Ali Ibrahim) [3] ; Ikiz, AO (Ikiz, Ahmet Omer) [4] ; Dogan, E (Dogan, Ersoy) [4] ; Karabay, N (Karabay, Nuri) [5] ; Ellidokuz, H (Ellidokuz, Hulya) [6] ; Sarioglu, S (Sarioglu, Sulen) [1]
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Source
Volume
103
Issue
29
DOI
10.1097/MD.0000000000038952
Article Number
e38952
Published
JUL 19 2024
Indexed
2024-07-31
Document Type
Article
Jump to
Abstract
Tumor deposits (TDs) are defined as discontinuous neoplastic masses within the lymphatic drainage pathway of the primary tumor. The poor prognostic implication of these masses have been demonstrated in various cancers. The aim of this study is to investigate the incidence of TDs in our thyroid carcinoma cases, which has not been studied so far to the best of our knowledge, and to determine the prognostic value of their existence. In this retrospective cohort study, 194 thyroid carcinoma cases with cervical lymph node sampling and/or dissection were reevaluated for TDs. The case series consisted of 176 thyroid papillary carcinoma (TPC) and 18 thyroid medullary carcinoma (TMC) patients. TDs were detected in 54 (27.8%) patients. TMC cases (55.6%) had significantly more TDs compared to TPCs (25.0%; P = .006). TDs were more common in women (P = .045), and in multifocal tumors (P = .017). In addition, cases with TDs had larger tumor size (P = .002), more lymphatic invasion (P = .009), extrathyroidal extension (P < .001), and distant metastasis (P < .001). The mean follow-up period of the patients was 120.1 months (range, 4-341 months). Locoregional recurrence detected in 17 patients (8.8%) was more common in TMC (33.3%) than TPC cases (6.3%; P = .002). Distant metastasis was identified in 27 patients (13.9%). Ten-year recurrence free survival (RFS) and overall survival (OS) for all patients were 89.0% and 92.4%, respectively. Mean estimated OS time for TD negative and TD positive cases were: 281.9 (+/- 17.2), 325.6 (+/- 6.2) and 217.6 (+/- 27.4) months, respectively (P = .002). Sex (P = .001), tumor type (P = .002), pT classification of the tumor (P < .001), perineural invasion (P = .002) and TDs (P = .002) were significantly associated with OS. In TPC cases individually, extrathyroidal extension (P = .001) and TDs (P = .002) were significantly correlated with distant metastasis. In multivariate analysis, only tumor size was detected as an independent prognostic marker in TPC cases (P = .005). Our results demonstrate the existence of TDs in thyroid carcinoma cases, and indicate a more aggressive behavior pattern of TDs in these tumors.
Keywords
Author Keywords
medullary carcinoma papillary carcinoma thyroid tumor deposits
Dinutuximab beta plus conventional chemotherapy for relapsed/refractory high-risk neuroblastoma: A single-center experience
By
Olgun, N (Olgun, Nur) [1] ; Cecen, E (Cecen, Emre) [1] ; Ince, D (Ince, Dilek) [1] ; Kizmazoglu, D (Kizmazoglu, Deniz) [1] ; Baysal, B (Baysal, Birsen) [1] ; Onal, A (Onal, Ayse) [1] ; Ozdogan, O (Ozdogan, Ozhan) [2] ; Guleryuz, H (Guleryuz, Handan) [3] ; Cetingoz, R (Cetingoz, Riza) [4] ; Demiral, A (Demiral, Ayse) [4] ;
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Source
Volume
12
DOI
10.3389/fonc.2022.1041443
Article Number
1041443
Published
DEC 23 2022
Indexed
2023-01-20
Document Type
Article
Jump to
Abstract
BackgroundRelapsed/refractory high-risk neuroblastoma has a dismal prognosis. Anti-GD2-mediated chemo-immunotherapy has a notable anti-tumor activity in patients with relapsed/refractory high-risk neuroblastoma. The purpose of this study was to analyze the efficacy and safety of the combination of immunotherapy with dinutuximab beta (DB) and chemotherapy in patients with relapsed/refractory high-risk neuroblastoma. MethodsAll patients received the Turkish Pediatric Oncology Group NB 2009 national protocol for HR-NB treatment at the time of diagnosis. Salvage treatments were administered after progression or relapse. The patients who could not achieve remission in primary or metastatic sites were included in the study. The most common chemotherapy scheme was irinotecan and temozolomide. DB was administered intravenously for 10 days through continuous infusion with 10 mg/m(2) per day. The patients received 2 to 14 successive cycles with duration of 28 days each. Disease assessment was performed after cycles 2, 4, and 6 and every 2 to 3 cycles thereafter. ResultsBetween January 2020 and March 2022, nineteen patients received a total of 125 cycles of DB and chemotherapy. Objective responses were achieved in 12/19 (63%) patients, including complete remission in 6/19 and partial response in 6/19. Stable disease was observed in two patients. The remaining five patients developed bone/bone marrow and soft tissue progression after 2-4 cycles of treatment. The most common Grade >= 3 toxicities were leukopenia, thrombocytopenia, hypertransaminasemia, fever, rash/itching and capillary leak syndrome, respectively. ConclusionOur study results suggest that DB-based chemo-immunotherapy seems to be suitable with encouraging response rates in patients with relapsed/refractory high-risk neuroblastoma.
Keywords
Author Keywords
neuroblastoma relapsed refractory dinutuximab betaanti-GD2
Applying postoperative radioiodine therapy before 3 months seems to decrease ablation success in patients with differentiated thyroid carcinoma
By
Özdogan, Ö (Ozdogan, Ozhan) [1] ; Aksu, A (Aksu, Aysegul) [1] ; Dogan, E (Dogan, Ersoy) [2] ; Bülbül, O (Bulbul, Ogun) [1] ; Durak, MG (Durak, Merih Guray) [3] ; Sevinc, AI (Sevinc, Ali Ibrahim) [4] ; Bayraktar, F (Bayraktar, Firat) [5] ; Ikiz, AÖ (Ikiz, Ahmet Omer) [2]
(provided by Clarivate)
Source
Volume
35
Issue
2
Page
223-231
DOI
10.1007/s12149-020-01555-7
Published
FEB 2021
Early Access
JAN 2021
Indexed
2021-01-19
Document Type
Article
Abstract
Objectives Radioiodine can be applied for remnant ablation in low and low to intermediate-risk patients with differentiated thyroid cancer (DTC). A controversy still exists about the application time interval of radioiodine following total thyroidectomy. In this study, we investigated the effect of radioiodine (RAI) therapy timing on the success rates of the ablation. Methods We retrospectively reviewed the data of DTC patients who underwent total thyroidectomy and were treated with radioiodine remnant ablation during 2013-2017. Because the objective of this study was to determine the success of ablation according to the postoperative RAI therapy timing, any patients with a pathologic uptake outside the thyroid bed as well as high-risk patients determined before and at RAI therapy were excluded from the study. Finally, 503 patients with low and low to intermediate-risk groups were included in the study. Successful ablation was defined as no visible focal uptake on the neck on I-131 whole body scan with stimulated thyroglobulin (Tg) level of < 1 ng/mL and a normal or undetectable antithyroglobulin antibody (ATG). The time interval from total thyroidectomy to RAI therapy (titRAI) was calculated as months for each patient. Results A total of 115 (22.9%) patients were in the low to intermediate-risk group whereas most of the patients were at the low-risk group according to the American Thyroid Association (ATA) 2015. Successful ablation was observed in 388 (77.1%) patients. The titRAI was <= 3 months in 151 (30.0%) patients and > 3 months in 352 (70.0%) patients. The ratio of successful ablation was statistically higher in patients with a titRAI > 3 months (81.2% of patients) than in patients with <= 3 months (67.5% of patients) (chi(2) 11.247, p 0.001). The rate of successful ablation was 20.3% higher in patients treated after 3 months. There was no statistical difference when titRAI cut off was reduced to 2 months (p > 0.5). Conclusion Investigated the effect of radioiodine therapy initiated before 3 months after total thyroidectomy and it seems to decrease ablation success.
Keywords
Author Keywords
Radioiodine Successful ablation Thyroid carcinoma Timing Remnant ablation
The use of molecular volumetric parameters for the evaluation of Lu-177 PSMA I&T therapy response and survival
By
Acar, E (Acar, Emine) [1] , [2] ; Özdogan, Ö (Ozdogan, Ozhan) [3] ; Aksu, A (Aksu, Aysegul) [3] ; Derebek, E (Derebek, Erkan) [3] ; Bekis, R (Bekis, Recep) [3] ; Kaya, GÇ (Kaya, Gamze Capa) [3]
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Source
Volume
33
Issue
9
Page
681-688
DOI
10.1007/s12149-019-01376-3
Published
SEP 2019
Indexed
2019-09-16
Document Type
Article
Abstract
Purpose The primary aim of this study was to evaluate the volumetric therapy response via Ga-68 PSMA I&T PET/CT in patients treated with Lu-177 PSMA I&T therapy. The secondary purpose was to determine the impact of volumetric parameter responses to overall survival. Methods PSMA tumor volumes (PSMA-TV) and tumor lesion PSMA expressions (TL-PSMA) were calculated with a semi-automatic program on Ga-68 PSMA I&T PET/CT images that were obtained before and after Lu-177 PSMA I&T therapies with 19 patients. The median overall survival was compared with PSMA-TV, TL-PSMA, SUVmax, PSA, and alteration in PERCIST criteria. Results PSMA-TV values were decreased in 12 patients (63%), and TL-PSMA values were decreased in 15 patients (79%) following the therapy. The SUVmax and the PSA values were also decreased in 14 (74%) and 10 (53%) patients, respectively. The complete remission (CR) was observed in two patients (10%). The partial response (PR) and progressive disease were observed in 6 (32%) and 11 (58%) patients, respectively, according to PRECIST criteria. The survival rates were statistically significant in patients with a decrease in PSMA-TV and TL-PSMA values than patients without any decrease (p 0.001, p < 0.001, respectively). However, the survival rates did not differ in responders (PR or CR) and non-responders according to the PERCIST criteria (p 0.232). The survival rates did not also differ in responders and non-responders according to the SUVmax and PSA values (p 0.140, p 0.206, respectively). Conclusions Molecular and volumetric parameters are beneficial in the assessment of Lu-177 PSMA I&T therapy response. Although the number of patients is small, TL-PSMA response, which includes both the tumor volume and PSMA expression in tumor, may be considered as the most valuable parameter for the evaluation of the therapy response and the prediction of survival rate.
Keywords
Author Keywords
PSMAMTVTLG Tumor volume Precision medicine Theranostic
F-18 FDG PET/CT findings of intrathoracic lymphadenopathy in EBUS-TBNA-proven anthracosis
By
Tertemiz, KC (Tertemiz, Kemal Can) [1] ; Güler, N (Guler, Nurcan) [1] ; Alpaydin, AÖ (Alpaydin, Aylin Ozgen) [1] ; Karaçam, V (Karacam, Volkan) [2] ; Özdögan, Ö (Ozdogan, Ozhan) [3] ; Ulukus, Ç (Ulukus, Cagnur) [4]
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Source
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
Volume
70
Issue
4
Page
305-312
DOI
10.5578/tt.20229601
Published
2022
Indexed
2023-01-23
Document Type
Article; Proceedings Paper
Conference
Meeting
Congress of Turkish-Thoracic-Society
Location
Antalya, TURKEY
Date
2021
Sponsor
Tukish Thorac Soc
Abstract
Introduction: Anthracosis is a kind of pneumoconiosis that may cause parenchymal and bronchiolar injury and mediastinal lymphadenopathy. In this study, we aimed to investigate F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) findings of pati-ents who had anthracosis diagnosis with endobronchial ultrasonography (EBUS).Materials and Methods: The patients who underwent EBUS-transbronchial needle aspiration (TBNA) and were diagnosed with anthracosis in a five year period were included in the study. The diagnosis was confirmed by surgery/ radiological stability. Demographic characteristics such as age, sex, smoking status, and occupational and environmental exposures were recorded. The characteristics: diameter (short axis), shape, central hilar structure, necrosis sign, echogenicity, and margins measured by EBUS, and maximum standardi-zed uptake value (SUV max value) by PET/CT of the lymph node stations were evaluated.Results: One hundred thirty-three patients with 239 lymph node stations were investigated. Biomass exposure was detected in nearly half of the patients (n= 55, 41.4%) and occupational exposure was detected in 32 (24.1%) patients. Eighty-six (64.7%) patients had more than 20 packs/years of smo-king history. Most of the lymph nodes (80.8%) have a higher PET/CT SUV max value than 2.5. The mean diameter of the lymph nodes measured by thorax CT (16.2 +/- 6.5 mm) and EBUS (12.7 +/- 5.6 mm) did not show any difference according to PET/CT SUV max value of >= 2.5 or not (p> 0.05). Subcarinal lymph nodes were significantly larger than the other lymph node stations. The lymph nodes with necrosis sign (p= 0.028), absence of central hilar structure (p= 0.013), and hete-rogeneous echogenicity (p= 0.008) were statistically significantly related to higher SUV max value.Conclusion: Anthracosis should be considered as a cause of false-positive PET/CT results for mediastinal lymph nodes, especially in patients with a history of occupational and environmental exposure including biomass and smoking.
Keywords
Author Keywords
Anthracosis pneumoconiosis ebus PET CT
The role of volumetric and textural analysis of pretreatment 18F-fluorodeoxyglucose PET/computerized tomography images in predicting complete response to transarterial radioembolization in hepatocellular cancer
By
Sen, NPK (Karahan Sen, Nazli Pinar) [1] ; Alatas, Ö (Alatas, Ozkan) [2] ; Gülcü, A (Gulcu, Aytac) [2] ; Özdogan, Ö (Ozdogan, Ozhan) [1] ; Derebek, E (Derebek, Erkan) [1] ; Kaya, GÇ (Capa Kaya, Gamze) [1]
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Source
NUCLEAR MEDICINE COMMUNICATIONS
Volume
43
Issue
7
Page
807-814
DOI
10.1097/MNM.0000000000001572
Published
JUL 2022
Indexed
2022-06-18
Document Type
Article
Jump to
Abstract
Objective This study evaluates the role of pretreatment F-18-FDG PET/CT in predicting the response to treatment in patients with hepatocellular cancer (HCC) who applied transarterial radioembolization (TARE) via the volumetric and texture features extracted from F-18-FDG PET/CT images. Methods Thirty-three patients with HCC who had applied TARE [lobar (LT) or superselective (ST)] after F-18-FDG PET/CT were included in the study. Response to the treatment was evaluated from posttherapy magnetic resonance (MR). Patients were divided into two groups: the responder group (RG) (complete responders) and non-RG (NRG) (including partial response, stabile, and progressive). Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) and texture features were extracted from PET/CT images. The differences among MTV, TLG, and texture features between response groups were analyzed with the Mann-Whitney U test. ROC analysis was performed for features with P < 0.05. Spearman correlation analysis was used, and features with correlation coefficient < 0.8 were evaluated with the logistic regression analysis. Results Significant differences were detected in TLG, MTV, SHAPE_compacity, GLCM_correlation, GLRLM_GLNU, GLRLM_RLNU, NGLDM_coarseness, NGLDM_busyness, GLZLM_LZHGE, GLZLM_GLNU, and GLZLM_ZLNU between RG and NRG. Multivariate analysis demonstrated that MTV was the only meaningful parameter with an AUC of 0.827 (P = 0.002; 95% CI, 0.688-0.966). The best cutoff value was determined as 74.11 ml with 78.9% sensitivity and 78.6% specificity in discriminating nonresponders. Conclusion In predicting the curative effect of TARE, multivariate analysis results demonstrated that MTV was the only independent predictor, and MTV higher than 74.11 ml were determined the best predictor of nonresponders.
Keywords
Author Keywords
F-18-fluorodeoxyglucose PET computerized tomography hepatocellular carcinoma metabolic
Relationships Between DCE-MRI, DWI, and 18F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma
By
Bülbül, HM (Bulbul, Hande Melike) [1] ; Bülbül, O (Bulbul, Ogun) [2] ; Sarioglu, S (Sarioglu, Sulen) [3] ; Özdogan, Ö (Ozdogan, Ozhan) [4] ; Dogan, E (Dogan, Ersoy) [5] ; Karabay, N (Karabay, Nuri) [6]
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Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
30
Issue
3
Page
177-186
DOI
10.4274/mirt.galenos.2021.25633
Published
OCT 2021
Indexed
2021-11-02
Document Type
Article
Jump to
Abstract
Objectives: Properties of head and neck squamous cell carcinoma (HNSCC) such as cellularity, vascularity, and glucose metabolism interact with each other. This study aimed to investigate the associations between diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and positron emission tomography/computed tomography (PET/CT) in patients with HNSCC.
Methods: Fourteen patients who were diagnosed with HNSCC were investigated using DCE-MRI, DCE, and (18)fluoride-fluorodeoxyglucose PET/CT and evaluated retrospectively. Ktrans, Kep, Ve, and initial area under the curve (iAUC) parameters from DCE-MRI, ADC(max), ADC(mean), and ADC(min) parameters from DWI, and maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) parameters from PET were obtained. Spearman's correlation coefficient was used to analyze associations between these parameters. In addition, these parameters were grouped according to tumor grade and T and N stages, and the difference between the groups was evaluated using the Mann-Whitney U test.
Results: Correlations at varying degrees were observed in the parameters investigated. ADC(mean) moderately correlated with Ve (p=0.035; r=0.566). Ktrans inversely correlated with SUVmax (p=0.017; r=-0.626). iAUC inversely correlated with SUVmax, SUVmean, TLG, and MTV (p<0.05, r <=-0.700). MTV (40% threshold) was significantly higher in T4 tumors than in T1-3 tumors (p=0.020). No significant difference was found in the grouping made according to tumor grade and N stage in terms of these parameters.
Conclusion: Tumor cellularity, vascular permeability, and glucose metabolism had significant correlations at different degrees. Furthermore, MTV may be useful in predicting T4 tumors.
Keywords
Author Keywords
Cancer of the head and neck squamous cell carcinoma diffusion permeability positron emission
The incidence of 18F-FDG PET/CT thyroid incidentalomas and the prevalence of malignancy: a prospective study
By
Sencan Eren, M (Sencan Eren, Mine) [1] ; Özdogan, Ö (Ozdogan, Ozhan) [1] ; Gedik, A (Gedik, Arzu) [2] ; Ceylan, M (Ceylan, Mehmet) [3] ; Güray Durak, M (Guray Durak, Merih) [4] ; Seçil, M (Secil, Mustafa) [3] ; Koçdor, MA (Kocdor, Mehmet Ali) [5] ; Çömlekçi, A (Comlekci, Abdurrahman) [2] ; Durak, H (Durak, Hatice) [1]
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Source
TURKISH JOURNAL OF MEDICAL SCIENCES
Volume
46
Issue
3
Page
840-847
DOI
10.3906/sag-1503-26
Published
2016
Indexed
2016-06-01
Document Type
Article
Abstract
Background/aim: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT).
Materials and methods: F-18-FDG PET/CT images were evaluated prospectively for the presence of thyroid uptake. The patients with a TI were evaluated by an endocrinologist according to the predefined diagnostic algorithm. The final diagnosis was obtained clinically and/or by pathology.
Results: TI was detected in 4.2% of 4204 patients. A malignant thyroid nodule was diagnosed in 29% and 33% of the focal and diffuse-focal uptake groups, respectively. However, no malignancy was detected in the diffuse uptake group. The standardized maximum uptake values (SUVmax) of the nodules were significantly higher in patients with thyroid malignancy than in patients with benign nodules (P = 0.006). The calculated cut-off value of SUVmax for malignancy was 3.5. In 2 patients in whom the cytopathological diagnosis was benign, malignancy was diagnosed after total thyroidectomy.
Conclusion: A malignant nodule was present in one-third of the patients with focal or diffuse-focal uptake. A SUVmax value of 3.5 was considered as a cut-off value for the differentiation of a malignant lesion. Benign cytology in fine-needle aspiration biopsy for 2 patients underestimated a thyroid malignancy.
Keywords
Author Keywords
F-18-FDGPET scan thyroid cancer second primary prevalence
Response to Cabazitaxel Beyond 20 Cycles in A Patient with Penile Metastasis of Prostate Cancer: A Case Report
By
Atag, E (Atag, Elif) [1] ; Semiz, HS (Semiz, Huseyin Salih) ; Kazaz, SN (Kazaz, Seher Nazli) ; Tuna, EB (Tuna, Emine Burcin) ; Ozdogan, O (Ozdogan, Ozhan) ; Bozkurt, O (Bozkurt, Ozan) ; Demir, O (Demir, Omer) ; Karaoglu, A (Karaoglu, Aziz)
(provided by Clarivate)
Source
Volume
14
Issue
1
Page
2985-2988
Published
JAN-FEB 2017
Indexed
2017-03-31
Document Type
Article
Abstract
Penile metastases are extremely rare events and generally occurs at a late stage of primary disease. They mostly originate from prostate and bladder in the genitourinary tract. Penile metastases have a dismal prognosis and very low survival rates. We report a case of penile metastasis in 70-year-old geriatric male patient with prostatic adenocarcinoma who was treated with cabazitaxel chemotherapy beyond 20 cycles with a good response and acceptable minimal toxicity.
Keywords
Author Keywords
cabazitaxel penile metastasis prostate cancer
Lu-177 PSMA I&T Therapy for Prostate Cancer; Treatment Response, Treatment Toxicity, and Survival Results
By
Acar, E (Acar, Emine) [1] , [2] ; Sönmezer, B (Sonmezer, Burak) [3] ; Derebek, E (Derebek, Erkan) [3] ; Bekis, R (Bekis, Recep) [3] ; Özdogan, Ö (Ozdogan, Ozhan) [3] ; Kaya, GÇ (Kaya, Gamze Capa) [3]
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Source
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
Volume
3
Issue
3
Page
158-164
DOI
10.30621/jbachs.2019.708
Published
2019
Indexed
2019-10-16
Document Type
Article
Abstract
Purpose: This study aims to evaluate the serum PSA response, Ga-68 PSMA PET/CT response, hematological/nephrological toxicity and survival results of patients with castration-resistant metastatic prostate cancer who are receiving Lu-177 PSMA therapy.
Methods: The data of 57 patients with a mean age of 68 years who were treated with Lu-177 PSMA I&T were retrospectively reviewed. Secondary toxicity to treatment was determined using the criteria of the Common Toxicity Criteria for Adverse Events v5.0. The Kaplan Meier method was used for survival and progression-free survival analysis.
Results: Forty percent of patients' serum PSA values' showed >25% regression after the first cycle of treatment. Serum PSA values were stable/regressed in 75% of the patients. While 2/57 patients showed grade 3 anemia, none showed grade 3 leukopenia or thrombocytopenia. One of 57 patient showed transient nephrotoxicity. Hematological and nephrological toxicity were not observed after treatment of eight cycles, and the serum PSA values of the patients were decreased by 97%. The mean survival time was 11.6 months in all patients, and 17.2 months in patients with serum PSA response. Progression-free survival was an average of 9.9 months.
Conclusion: Providing a stable or regressed disease via single cycle treatment in 75% of patients with progression despite the treatments improving survival is an indicator of the success of the therapy. The low rate of hematological and nephrological toxicity in patients (none of the patients that received eight cycles) suggests that the treatment is reliable. Survival was longer in patients with serum PSA response after treatment.
Keywords
Author Keywords
PSMA prostate cancer radioligand therapy mCRPC theranostic precision medicine
Paget's Disease Mimicking Bone Metastasis in a Patient with Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT
By
Gezer, NS (Gezer, Naciye Sinem) [1] ; Balci, A (Balci, Ali) [1] ; Özdogan, Ö (Ozdogan, Ozhan) [2] ; Özaksoy, D (Ozaksoy, Dinc) [1]
(provided by Clarivate)
Source
JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
Volume
100
Issue
1
DOI
10.5334/jbr-btr.903
Article Number
66
Published
2016
Indexed
2016-01-01
Document Type
Editorial Material
Abstract
Somatostatin (SST) is a neuropeptide present in neurons, endocrine cells, and a wide range of neuroendocrine tumors (NETs). Ga-68-DOTATOC, Ga-68-DOTANOC, and Ga-68-DOTATATE are current SST analogues used for PET/CT which bind to SST receptors expressed in NETs. These SST analogues have been used successfully for diagnosis of SST-expressing tumors with a more sensitive detection technique than conventional scintigraphy. However, there is a lack of clinical data on the differentiation between NETs and other malignant tumors or benign pathological conditions. Here, we report a case of Paget's disease mimicking bone metastasis of NET on PET/CT due to increased Ga-68-DOTANOC uptake and review examples of similar cases in the literature.
Keywords
Author Keywords
Metastasis Neuroendocrine tumors Paget's disease PET/CTSomatostatin Ga-68-DOTANOC
The diagnostic role of dual-phase 18F-FDG PET/CT in the characterization of solitary pulmonary nodules
By
Demir, Y (Demir, Yusuf) [1] ; Polack, BD (Polack, Berna D.) [2] ; Karaman, C (Karaman, Canan) [3] ; Özdogan, Ö (Ozdogan, Ozhan) [2] ; Sürücü, E (Surucu, Erdem) [1] ; Ayhan, S (Ayhan, Sadet) [2] ; Akkoçlu, A (Akkoclu, Atila) [3] ; Özdemir, N (Ozdemir, Nezih) [4]
(provided by Clarivate)
Source
NUCLEAR MEDICINE COMMUNICATIONS
Volume
35
Issue
3
Page
260-267
DOI
10.1097/MNM.0000000000000049
Published
MAR 2014
Indexed
2014-03-19
Document Type
Article
Abstract
ObjectiveOur objective was to evaluate the diagnostic role of dual-phase F-18-fluorodeoxyglucose (F-18-FDG) PET/computed tomography (CT) in the characterization of solitary pulmonary nodules (SPNs).Patients and methodsA total of 48 SPNs in 48 patients were included in this retrospective study. The final diagnosis was confirmed histopathologically or by follow-up CT. Two PET/CT scans were performed: the first (early scan) was performed 1 h after injection and the second (delayed scan) was performed 2 h later. Standardized uptake values (SUVs) [early and delayed SUVmax and SUVmean adjusted to body weight, body surface area (BSA), lean body mass (LBM) and blood glucose level (Glc)], retention index and nodule-to-mediastinum (nodule activity/subcarinal region of interest activity) ratios were calculated, along with the receiver operating characteristic curve. Intraobserver and interobserver variabilities among nuclear medicine physicians were analysed for the two phases.ResultsEighteen patients had malignant tumour, whereas 30 had benign lesions. The median (min-max) SUVmax was 1.5 (0.5-4.1) in the benign group and 3.6 (1.3-38) in the malignant group. With the threshold value of early SUVmax as 2.5 and 2.75 using the receiver operating characteristic curve, a sensitivity of 94-75%, specificity of 75-80% and an accuracy of 83-78% were calculated. With the same threshold values for delayed images, 94-100% sensitivity, 77-80% specificity and 83-88% accuracy were obtained. BSA-SUVmax, LBM-SUVmax and Glc-SUVmax did not show any advantage over other quantitative parameters in the SPN characterization. There was no variability in the results obtained between the two nuclear medicine physicians.ConclusionDual-phase PET/CT may increase the diagnostic potential of PET/CT in the characterization of SPNs. In this particular study group, a threshold value could not be determined for the retention index, but higher retention indices may show higher malignant potential in SPNs. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Keywords
Author Keywords
dual-phase PET/CTF-18-FDG PET/C T solitary pulmonary nodule standardized uptake value
Diagnostic value of combining heart rate recovery and P-wave changes with exercise-induced changes in the ST segments for prediction of myocardial ischaemia
By
Koyuncu, I (Koyuncu, Ilhan) [1] ; Tuluce, K (Tuluce, Kamil) [1] ; Tuluce, SY (Tuluce, Selcen Yakar) [2] ; Koyuncu, B (Koyuncu, Betul) [3] ; Eyupoglu, M (Eyupoglu, Mehmet) [4] ; Gursul, E (Gursul, Erdal) [2] ; Akcay, FA (Akcay, Filiz Akyildiz) [2] ; Safak, O (Safak, Ozgen) [2] ; Ekinci, MA (Ekinci, Mehmet Akif) [4] ; Ozdogan, O (Ozdogan, Ozhan) [5] ;
(provided by Clarivate)
Source
Volume
70
Issue
4
Page
422-429
DOI
10.1080/AC.70.4.3094651
Published
AUG 2015
Indexed
2015-09-16
Document Type
Article
Abstract
Background In patients admitted to outpatient clinics with chest pain, changes in the ST-segments of electrocardiogram (ECG) readings are the most widely used criteria during treadmill ECG tests to determine myocardial ischaemia, despite its poor accuracy. In this study, we evaluated the benefit of combining elongation of P-wave duration (Pdur) and abnormal heart rate recovery (HRR) parameters in addition to changes in the ST-segments for the detection of myocardial ischaemia with treadmill ECG testing.
Methods Patients (n =369) with chest pain who underwent both a treadmill ECG test and myocardial perfusion scintigraphy (MPS) were enrolled. P-wave duration was measured at rest and at the end of the first minute of the recovery phase and elongation of the P-wave was calculated. Abnormal HRR was defined as the failure of a decreasing HR at the end of the first minute of the recovery phase > 10% of the maximum HR reached during treadmill ECG testing. The sensitivity, specificity, positive and negative predictive values, diagnostic accuracy values, and likelihood ratios (LRs) of changes in the ST-segments, P-wave elongation, abnormal HRR, and the combination of these three variables for predicting myocardial ischaemia detected by MPS, were calculated separately in patients without previous coronary artery disease (CAD) and in those with CAD.
Results Elongation of Pdur by 20 ms or longer and abnormal HRR during treadmill ECG test were more common in patients with reversible perfusion defects in MPS than in those without perfusion defects (both P < 0.001).When patients were divided into two groups according to the presence or absence of a history of CAD, the addition of elongation of Pdur >= 20 ms and abnormal HRR to the development of significant changes in the ST-segments detected myocardial ischaemia with 46.7% sensitivity, 97.8% specificity, 67.2% negative predictive value, 88.9% positive predictive value, and 70% diagnostic accuracy in 77 patients with previous CAD. The LR + of the combination of the three variables was 12.27. The addition of elongation of Pdur >= 20 ms and abnormal HRR to the development of significant changes in the ST-segments detected myocardial ischaemia with 52.7% sensitivity, 98.7% specificity, 89.9% negative predictive value, 90.6% positive predictive value, and 90% diagnostic accuracy in 292 patients without previous CAD. The LR + of the combination of the three variables to detect myocardial ischaemia was calculated to be 41.48 in patients without a history of CAD.
Conclusions The addition of elongation of Pdur and abnormal HRR to the conventionally used criterion of changes in the ST-segments in patients with suspected myocardial ischaemia increased the specificity and positive and negative predictive values of treadmill ECG testing for detecting myocardial ischaemia, which might reduce the need for other expensive non-invasive techniques. The diagnostic utility of adding these two parameters was more obvious in patients with no history of CAD.
Keywords
Author Keywords
Treadmill ECG test P-wave duration heart rate recovery myocardial perfusion scintigraphy
A New 99mTc Labeled Peptide: 99mTc β-Casomorphin 6, Biodistribution and Imaging Studies on Rats
By
Ertay, T (Ertay, Turkan) [1] ; Unak, P (Unak, Perihan) [2] ; Eren, MS (Eren, Mine Sencan) [3] ; Biber Muftuler, FZ (Biber Muftuler, Fazilet Zumrut) [2] ; Ozdogan, O (Ozdogan, Ozhan) [1] ; Ülker, O (Ulker, Ozden) [1] ; Yesilagaç, R (Yesilagac, Reyhan) [1] ; Durak, H (Durak, Hatice) [1]
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Source
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
Volume
23
Issue
1
Page
15-22
DOI
10.9775/kvfd.2016.15691
Published
JAN-FEB 2017
Indexed
2016-12-14
Document Type
Article
Abstract
Peptide radiopharmaceuticals have an increasing significance in nuclear medicine practice. beta-casomorphin is a digestive peptide with 6 amino acids (Tyr-Pro-Phe-Pro-Gly-Pro). N terminal amino acid chain mainly tyr-pro-phe-pro structured exogen opioid peptid type beta cosomorphin are beta-receptor agonistic activity with priority. Animal studies show that beta-casomorphins can act as opioid receptor agonists. The aim of this study was to label beta-casomorphin with (99m) Tc and to examine its usefulness as an opioid receptor binding radiopharmaceutical in Albino Wistar rats and cancer cells. beta-casomorphin was labeled with (99m) Tc radionuclide using bifunctional chelating agent. Quality control studies were done by Instant Thin layer chromatography (ITLC) and High performance liquid chromatography (HPLC) methods. Binding efficiency of the compound was more than 99%. It was observed as stable for at least 3 h at room temperature. Lipophilicity was also performed for labeled molecule. Imaging studies for (99m) Tc labeled molecule was done in rats by using gamma camera. For biodistribution studies; (99m) Tc labeled molecule was injected to the rats from tail vein and radioactivity per gr weight of each organ was measured as count per second (cps). Receptor specificity was evaluated in imaging and biodistribution studies in experimental animals. Cell labeling studies were also performed on breast and ovarien cancer cells. In terms of evaluating the biodistribution of (99m) Tc-beta-casomorphin molecule in rats, uterus and ovary displayed high involvement. It was also confirmed by cell labeling studies. If the radiopharmaceutical is radiolabeled with therapeutic radionuclides it would be useful for therapy for uterus, ovary and breast tumors.
Keywords
Author Keywords
beta-casomorphin Cancer cellPeptideTc-99m receptor
The Effect of Radioiodine on the Intima Media Thickness of the Carotid Artery
By
Sürücü, E (Surucu, Erdem) [1] ; Bekis, R (Bekis, Recep) [2] ; Sengöz, T (Sengoz, Tarik) [2] ; Demir, Y (Demir, Yusuf) [1] ; Çelik, AO (Celik, Ahmet Orhan) [3] ; Aslan, Ö (Aslan, Ozge) [3] ; Birlik, B (Birlik, Bilge) [3] ; Ozdogan, Ö (Ozdogan, Ozhan) [2] ; Igci, E (Igci, Enis) [3] ; Durak, H (Durak, Hatice) [2]
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Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
22
Issue
3
Page
85-89
DOI
10.4274/Mirt.24119
Published
DEC 2013
Indexed
2013-12-01
Document Type
Article
Abstract
Aim: The radiation can induce vessel injury. The result of this injury can be severe and life-threatening. There are a few studies demonstrating an increase in intima-media thickness (IMT) of the common carotid artery (CCA) after radiotherapy, especially in head and neck cancers. We evaluated the effect of I-131 to the IMT of the CCA in the patients who were treated for hyperthyroidism.
Methods: 38 patients (25M, 13W) referred to our department for radioiodine treatment with the diagnosis of nodular goitre (25 patients) and diffuse hyperplasia (Graves disease (GD), 13 patients) were included to the prospective study. An USG was performed for all the patients before therapy, 3, 6 and 12 months after radioiodine therapy in order to measure IMT of CCA and the femoral artery (FA). The IMT was measured at the level of proximal part of bulbus anteriorly on the left and right side. The IMT of FA was measured just before the bifurcation.
Results: There was a statistically significant increase in IMT of both CCA and FA bilaterally in nodular hyperthyroid patients. However, in the patients with Graves disease, there was only statistically significant increase in the left IMT of CCA at 0-3rd, 0-6th month measurements and in the right IMT of FA at 0-3rd month measurements.
Conclusion: Though the limitation of the study is the interobserver and intraobserver variability, it was seen that I-131 therapy might affect the IMT of CCA in the patients with NG. I-131 effect on the IMT of CCA in patients with nodular goitre was higher than the IMT of CCA in patients with GD. I-131 effect on the IMT of CCA might be due to administered dose and adjacency. The interesting point of our study was the increased thickness of IMT in FA. We think that the increase in IMT is due to the systemic effect of radioactivity circulating in the blood vessel. I-131 effect on the IMT of FA in patients with nodular goitre was higher than the IMT of FA in the patients with GD due to I-131 uptake of thyroid gland. Because I-131 uptake was lower in patients with nodular goitre, I-131 in systemic circulation was higher.
Keywords
Author Keywords
Hyperthyroidism Carotid Intima-Media Thickness iIodine radioisotopesy
Acute Kidney Injury Secondary to NSAID Diagnosed on 99mTc MDP Bone Scan
By
Özdogan, Ö (Ozdogan, Ozhan) [1] ; Karahan, NP (Karahan, Nazli Pinar) [1] ; Sarioglu, S (Sarioglu, Sulen) [2] ; Durak, H (Durak, Hatice) [1]
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Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
22
Issue
2
Page
66-69
DOI
10.4274/Mirt.95
Published
AUG 2013
Indexed
2013-08-01
Document Type
Article
Abstract
A bone scan with Tc-99m MDP was obtained to rule out the presence of micro fractures in a patient with the diagnosis of idiopathic osteoporosis. There was not any sign of micro fractures, but interestingly, both kidneys were diffusely very active. A differential diagnosis of acute kidney injury secondary to the use of nonsteroidal anti-inflammatory drug was made and reported after elimination of other clinical situations. The renal functions obtained following bone scan were impaired. The anti-inflammatory drug was discontinued. The renal functions were recovered starting with the following day.
Keywords
Author Keywords
Acute kidney injuryTc-99m-MDP anti-inflammatory agentsnon-steroidal
Growth of a solitary pulmonary nodule after 6years diagnosed as oncocytic carcinoid tumour with a high 18-fluorodeoxyglucose (18F-FDG) uptake in positron emission tomography-computed tomography (PET-CT)
By
Turan, O (Turan, Onur) [1] ; Ozdogan, O (Ozdogan, Ozhan) [2] ; Gurel, D (Gurel, Duygu) [3] ; Onen, A (Onen, Ahmet) [4] ; Kargi, A (Kargi, Aydanur) [3] ; Sevinc, C (Sevinc, Can) [1]
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Source
Volume
7
Issue
1
Page
E1-E5
DOI
10.1111/j.1752-699X.2011.00274.x
Published
JAN 2013
Indexed
2013-05-07
Document Type
Article
Abstract
Introduction: Pulmonary carcinoid tumour is low-grade neuroendocrine malignancy that is seen 1%2% of all lung neoplasms. Oncocytic carcinoid type is a rarely seen variant of pulmonary carcinoids. As carcinoid tumours have hypometabolic activity, they usually have lower 18-fluorodeoxyglucose (18F-FDG) uptake than expected for lung carcinoma on positron emission tomography (PET). Case Report: A 45-year-old non-smoking man had a stable solitary pulmonary nodule followed for 6years; the tumour remained the same size (1.5x2.4cm) during this period. The patient was admitted to the hospital with complaints of repetitive sneezing and rhinorrhoea. He also experienced flushing and bronchospasm. His chest X-ray revealed a minimal increase in the size of the solitary pulmonary nodule (2.0x2.8cm). In PET-computed tomography (CT), the parenchymal nodule in the anterior segment of the right lung had a standard uptake value of 38.0mg/mL, which was interpreted as a malignant nodule. He underwent fibre-optic bronchoscopy, but cytology showed no evidence of malignancy. Right upper and middle bilobectomy was performed, and a pulmonary carcinoid tumour with an oncocytic subgroup was diagnosed. The diagnosis of carcinoid syndrome was further confirmed by an elevated 24-h urinary excretion of 5-hydroxyindoleacetic acid. Conclusion: We present a rare case of an oncocytic carcinoid tumour with an increase in the size of a solitary pulmonary nodule after 6years' follow-up. In addition, PET-CT showed a very high 18F-FDG uptake in this patient, which is an unexpected finding with a pulmonary carcinoid tumour. Please cite this paper as: Turan O, Ozdogan O, Gurel D, Onen A, Kargi A and Sevinc C. Growth of a solitary pulmonary nodule after 6years diagnosed as oncocytic carcinoid tumour with a high 18F-FDG uptake in positron emission tomography-computed tomography (PET-CT). Clin Respir J 2013; 7: e1e5.
Keywords
Author Keywords
18-fluorodeoxyglucose positron emission tomography scan carcinoid carcinoid syndrome
The Diagnosis of Yo-Yo Reflux with Dynamic Renal Scintigraphy in a Patient with Incomplete Ureteral Duplication
By
Özdogan, Ö (Ozdogan, Ozhan) [1] ; Ates, O (Ates, Oguz) [2] ; Kart, Y (Kart, Yeliz) [2] ; Aras, F (Aras, Feray) [3] ; Olguner, M (Olguner, Mustafa) [2] ; Akgür, F (Akgur, Feza) [2] ; Durak, H (Durak, Hatice) [1]
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Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
21
Issue
3
Page
114-116
DOI
10.4274/Mirt.71
Published
DEC 2012
Indexed
2012-12-01
Document Type
Article
Abstract
The diagnosis of yo-yo reflux in patients with incomplete upper collecting system duplications is difficult. We report a case with recurrent urinary tract infections and ultrasonographically detected duplication in the left collecting system in which the presence of yo-yo reflux is demonstrated with dynamic renal scintigraphy.
Keywords
Author Keywords
99mTc-MAG3 genitourinary abnormalities vesico-ureteral reflux
Tc-99m HIG Scintigraphy in Detection of Active Inflammation in Ankylosing Spondylitis
By
Özdogan, O (Ozdogan, Ozhan) [1] ; Degirmenci, B (Degirmenci, Bema) [1] ; Senocak, O (Senocak, Ozlem) [2] ; Gülbahar, S (Gulbahar, Selmin) [2] ; Arslan, G (Arslan, Gulhan) [1] ; Tasa, C (Tasa, Cengiz) [1] ; Akalin, E (Akalin, Elif) [2] ; Durak, H (Durak, Hatice) [1]
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Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
20
Issue
2
Page
52-58
DOI
10.4274/MIRT.21
Published
AUG 2011
Indexed
2011-08-01
Document Type
Article
Abstract
Objective: The diagnosis of active inflammation in ankylosing spondylitis (AS) is crucial for treatment to delay possible persistent deformities. There are no specific laboratory tests and imaging methods to clarify the active disease. We evaluated the value of Tc-99m human immunoglobulin (HIG) scintigraphy in detection of active inflammation.
Material and Methods: Twenty-nine patients were included. Tc-99m methylenediphosphonate bone (MDP) and HIG scintigraphies were performed within 2-5 day intervals. Two control groups were constituted both for MDP and HIG scintigraphies. Active inflammation was determined clinically and by serologic tests. Both scintigraphies were evaluated visually. Sacroiliac joint index values (SII) were calculated.
Results: Active inflammation was considered in five (sacroiliitis in 2, sacroiliitis-spinal inflammation in 1, achilles tendinitis in 1, arthritis of coxafemoral joints in 1) patients. HIG scintigraphy demonstrated active disease in all 3 patients with active sacroiliitis. But, it was negative in the rest. The other 2 active cases were HIG negative. Right and left SII obtained from HIG scintigraphy was higher (p<0.05) in clinically active patients than inactive patients. There was not any significant difference between patients with inactive sacroiliitis and normal controls. Right and left SII obtained from bone scintigraphy was higher (p<0.05) in patient group than in control group.
Conclusion: Clinically inactive AS patients, behave no differently than normal controls with quantitative sacroiliac joint evaluation on HIG scintigraphy. HIG scintigraphy may be valuable for evaluation of sacroiliac joints in patients with uncertain laboratory and clinical findings.
Keywords
Author Keywords
Tc-99m-HIGankylosing spondylitis inflammation
BENEFICIAL EFFECT OF ENDOCRINOLOGIST-PERFORMED ULTRASONOGRAPHY ON PREOPERATIVE PARATHYROID ADENOMA LOCALIZATION
By
Akinci, B (Akinci, Baris) [1] ; Demir, T (Demir, Tevfik) [1] ; Yener, S (Yener, Serkan) [1] ; Comlekci, A (Comlekci, Abdurrahman) [1] ; Binicier, O (Binicier, Omer) ; Ozdogan, O (Ozdogan, Ozhan) [2] ; Secil, M (Secil, Mustafa) [3] ; Sevinc, A (Sevinc, Ali) [4] ; Kocdor, MA (Kocdor, Mehmet Ali) [4] ; Bayraktar, F (Bayraktar, Firat) [1] ;
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Source
Volume
15
Issue
1
Page
17-23
DOI
10.4158/EP.15.1.17
Published
JAN-FEB 2009
Indexed
2009-01-01
Document Type
Article
Abstract
Objective: To evaluate whether endocrinologistperformed ultrasonography improves the localization of parathyroid adenomas in patients with primary hyperparathyroidism.
Methods: We performed a retrospective analysis of consecutive patients with primary hyperparathyroidism due to a single adenoma who underwent surgery at the Dokuz Eylul University Hospital in Izmir, Turkey, between January 2000 and January 2008. Data regarding the localization of adenomas were obtained from surgical reports. Neck ultrasonography was performed in all patients as first-line imaging. Parathyroid ultrasonography was performed by a staff radiologist between January 2000 and December 2004. Beginning January 2005, parathyroid ultrasonography was performed blindly by an endocrinologist in addition to the staff radiologist. In the case of discordant preoperative localization between the endocrinologist- and radiologist-performed ultrasonography, surgery was per-formed according to the technetium Tc 99m sestamibi (MIBI) scan and endocrinologist-performed Ultrasonography localization results.
Results: A total of 156 patients with primary hyperparathyroidism due to a single adenoma were included. Of the 156 patients, 139 also underwent MIBI scan. Ultrasonography localized 102 parathyroid adenomas (65%). The accuracy of the ultrasonography was improved in patients who underwent endocrinologist-performed ultrasonography. Endocrinologist-performed ultrasonography localized the adenoma correctly in 19 patients for whom the staff radiologist had reported a negative or unsuccessful localization. When ultrasonography results were combined with the MIBI scan findings, parathyroid adenomas were again more likely to be localized in patients who underwent operation after January 2005 and thus, had endocrinologist-performed ultrasonography.
Conclusion: Our results suggest that endocrinologist-performed ultrasonography improves the preoperative localization of parathyroid adenoma. (Endocr Pract. 2009;15: 17-23)
Keywords
Keywords Plus
SPORADIC PRIMARY HYPERPARATHYROIDISM HIGH-RESOLUTION ULTRASONOGRAPHY DOPPLER
Three synchronous primary tumors with different histology detected by 18F-FDG PET/CT
By
Eren, MS (Eren, Mine Sencan) [1] ; Ozdogan, O (Ozdogan, Ozhan) [1] ; Koyuncuoglu, M (Koyuncuoglu, Meral) [2] ; Degirmenci, B (Degirmenci, Berna) [1]
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Source
HELLENIC JOURNAL OF NUCLEAR MEDICINE
Volume
15
Issue
1
Page
56-58
Published
JAN-APR 2012
Indexed
2012-04-11
Document Type
Article
Abstract
The aim of this study is to present a patient with 3 primaries diagnosed with the F-18-FDG PET/CT study performed for the staging of endometrial cancer. Pathologic accumulations of the tracer were detected in both lobes of the thyroid gland, in the left lung and in the known primary of the uterus. A bilateral multifocal differentiated thyroid carcinoma and a peripheral carcinoid tumor in left lung were the final diagnosis as shown by histology. In conclusion, in this patient the PET/CT study performed for staging endometrial cancer demonstrated two new synchronous primary tumors. This is the second similar case but the first where all three primaries had entirely different histology.
Keywords
Author Keywords
Positron emission tomography Endometrial neoplasms Thyroid neoplasms Lung neoplasms
INTEROBSERVER AND INTRAOBSERVER AGREEMENT IN PARATHYROID SCINTIGRAPHY: HOW CAN PARATHYROID SCINTIGRAPHY BE MADE MORE RELIABLE?
By
Dalar, C (Dalar, Cafer) [1] ; Ozdogan, O (Ozdogan, Ozhan) [1] ; Durak, MG (Durak, Merih Guray) [2] ; Koçdor, MA (Kocdor, Mehmet Ali) [3] ; Bekis, R (Bekis, Recep) [1] ; Cayvarli, H (Cayvarli, Hakan) [1] ; Kaya, GC (Kaya, Gamze Capa) [1] ; Comlekci, A (Comlekci, Abdurrahman) [4] ; Degirmenci, B (Degirmenci, Berna) [1]
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Source
Volume
18
Issue
4
Page
538-548
DOI
10.4158/EP11330.OR
Published
JUL-AUG 2012
Indexed
2012-09-05
Document Type
Article
Abstract
Objective: To determine the intraobserver and interobserver agreement levels in the evaluation of technetium Tc 99m sestamibi parathyroid scintigraphic images.
Methods: Ninety-eight patients with hyperparathyroidism were included in the study, and their parathyroid images were evaluated by 4 experienced nuclear medicine observers. The 98 cases were evaluated twice by each observer within an interval of 2 weeks. The evaluations were performed directly on workstations with use of digital images. A questionnaire was completed by each observer. The presence of a lesion, the number and the localizations of the lesions, and whether the lesion was clear or doubtful were all evaluated. Cohen kappa statistics and total agreement percentages were calculated by using SPSS version 11.0 software.
Results: The 4 observers performed 8 different evaluations and identified a minimum of 38 and a maximum of 43 cases with a parathyroid lesion (or lesions). Both the intraobserver and the interobserver agreements were "very good" for the presence of a parathyroid lesion. The intraobserver agreement was also "very good" and the interobserver agreement was "good" (for only 1 pair of observers) or "very good" for the evaluation of the number of parathyroid lesions. The intraobserver agreement was "very good" or "good" and the interobserver agreement was "good" for the lesion localization and for the presence of a doubtful lesion.
Conclusion: Parathyroid scintigraphy seems to be an observer independent method in the detection of a parathyroid lesion, in the determination of the number of lesions, and in the localizations of the lesions. The measured high agreement between observers increases the reliability of parathyroid scintigraphy. (Endocr Pract. 2012;18: 538-548)
Keywords
Keywords Plus
PRIMARY HYPERPARATHYROIDISM TC-99M SESTAMIBI LOCALIZATION REPRODUCIBILITY TC-99M-
New Quantitative Parameters for Evaluating Radionuclide Cystography and Their Value in Understanding the Physiology of Reflux
By
Ozdogan, O (Ozdogan, Ozhan) [1] ; Turkmen, M (Turkmen, Mehmet) [2] ; Atasever, S (Atasever, Seckin) [2] ; Arslan, G (Arslan, Gulhan) [1] ; Soylu, A (Soylu, Alper) [2] ; Kasap, B (Kasap, Belde) [2] ; Kavukcu, S (Kavukcu, Salih) [2] ; Degirmenci, B (Degirmenci, Berna) [1]
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Source
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY
Volume
37
Issue
2
Page
101-106
DOI
10.2967/jnmt.108.058115
Published
JUN 1 2009
Indexed
2009-06-01
Document Type
Article
Abstract
In this descriptive study of radionuclide cystography, time-activity curves were generated from renal pelves with reflux and evaluated to reveal the physiology of the reflux. The generated new parameters were also evaluated for any correlation with the frequency of urinary tract infections and renal scarring. Methods: Thirty-two children with reflux to the renal pelvis (36 refluxing units) were included. Regions of interest were drawn on the pelves and bladder, and time-activity curves were generated. The first reflux phase, the bladder volume at first reflux, and the bladder volume at maximal reflux were defined, and reflux percentages were calculated. Dimercaptosuccinic acid (DMSA) scintigraphy findings and urinary tract infections were used for correlation. Results: New curves from the renal pelvis during bladder filling and bladder emptying were generated and their patterns classified. Episodic reflux to the pelvis was observed on time-activity curves, which demonstrated 4 different emptying patterns during voiding. These patterns were described in detail. Visually, residual activity was present in the renal pelves in 58.8% of patients. The mean number of urinary tract infections per year was 1.07 (range, 0-4; SD, 0.88). The DMSA findings were normal in 57.1% of the patients. Conclusion: We obtained and categorized some new time-activity curve patterns from renal pelves with reflux on radionuclide cystography. Discussing these patterns may help physicians understand the physiology of the reflux and the relationship between infections and reflux.
Keywords
Author Keywords
radionuclide cystography prognosis vesicoureteral reflux time-activity curves curve patterns
Does cisplatin chemotherapy decrease the MDP uptake of normal bone?: An experimental study
By
Ozdogan, O (Ozdogan, Ozhan) [1] ; Ertay, T (Ertay, Turkan) [1] ; Arslan, G (Arslan, Gulhan) [1] ; Sisman, AR (Sisman, Ali R.) [2] ; Kaya, GC (Kaya, Gamze Capa) [1] ; Yilmaz, O (Yilmaz, Osman) [3] ; Çoker, C (Coker, Canan) [2] ; Gure, A (Gure, Ataman) [3] ; Durak, H (Durak, Hatice) [1]
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Source
Volume
22
Issue
5
Page
357-362
DOI
10.1007/s12149-007-0129-5
Published
JUN 2008
Indexed
2008-06-01
Document Type
Article
Abstract
Objective Bone scan is the accepted initial imaging modality for skeletal metastases. Cisplatin is a cell-cycle nonspecific antineoplastic agent used in some chemotherapy regimens. Knowing that platinum reacts with phosphate compounds such as methylenediphosphonic acid (MDP), decreases bone resorption and new bone formation, it can be proposed that cisplatin chemotherapy may decrease Tc-99m MDP bone uptake. We aimed to demonstrate, if present, the decrease in bone uptake and to determine the duration of this effect.
Methods Thirty male Wistar rats were randomized into five groups, namely, placebo group (G1) and cisplatin groups (G2, G3, G4, G5). Pre-therapy bone scintigraphies were obtained in all the groups. Cisplatin chemotherapy was given as infusion. Post-therapy bone scintigraphies were obtained 10 min, 1 h, 24 h, and 72 h after chemotherapy in groups G2-G5, respectively. A placebo bone scintigraphy was obtained 10 min after infusion of serum physiologic in G1. Plasma samples for cisplatin plasma values were obtained. The graphite furnace atomic absorption spectrophotometry technique was used for cisplatin analysis. Quantitative analysis (bone uptake ratios) was performed by drawing regions of interest on the right femur, vertebral column, and adjacent soft tissues. The injection/examination time delay and the net injected MDP doses were also noted.
Results There was no statistically significant difference in bone uptake values, injected MDP doses or injection/examination time delay in any group. Cisplatin plasma values were significantly different in G2, G3, G4, and G5 (P < 0.05) but not in G1.
Conclusions Cisplatin chemotherapy seems to have no effect on the Tc-99m MDP uptake of normal bone.
Keywords
Author Keywords
cisplatinTc-99m MDP bone scintigraphy chemotherapy bone uptake
Adrenalectomy for Isolated Metastasis in Five Patients with Lung Cancer: Single Centre Experience and Review of the Literature
By
Unek, IT (Unek, Ilkay T.) [1] ; Kocdor, MA (Kocdor, Mehmet Ali) [2] ; Sevinc, AI (Sevinc, A. Ibrahim) [2] ; Onen, A (Onen, Ahmet) [3] ; Ozdogan, O (Ozdogan, Ozhan) [4] ; Oztop, I (Oztop, Ilhan) [1] ; Canda, T (Canda, Tulay) [5] ; Cetingoz, R (Cetingoz, Riza) [6] ; Degirmenci, B (Degirmenci, Berna) [4] ; Durak, MG (Durak, Merih G.) [5] ;
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Source
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
Volume
21
Issue
4
Page
230-240
DOI
10.4999/uhod.10092
Published
2011
Indexed
2011-01-01
Document Type
Review
Abstract
Isolated adrenal metastasis from non-small cell lung cancer (NSCLC) is a rare event. Nonsurgical treatment of a solitary adrenal metastasis is associated with poor survival. However, in the aspect of long-term survival, the role of adrenalectomy for isolated metastasis is unclear. Here, we reported our experience with surgical treatment of solitary adrenal metastasis in patients with NSCLC whose primary tumor control were achieved and reviewed current literature. Between the 2001 and 2009, five patients underwent curative adrenalectomy (in 1 patient it was bilateral) for suspected solitary adrenal metastasis after surgical treatment of NSCLC. The pathologic examination confirmed in 3 cases a NSCLC metastasis while in 2 cases it was a benign lesion. In the follow-up period, all of the 3 patients with adrenal metastasis had recurrence of NSCLC. Recurrence was local (in the operated adrenal bed) in 2 patients. Palliative radiotherapy focalized to adrenal bed was given to one of the patient with local recurrence. This patient is currently alive 51 months after the adrenalectomy. The other patient with local recurrence died 24 months after the adrenalectomy. Recurrence was systemic (brain and contralateral adrenal gland) in 1 patient who was treated with contralateral adrenalectomy and surgical resection of the cranial metastasis followed by cranial radiotherapy. The patient who underwent bilateral adrenalectomy for metastatic lung cancer died of wide-spread metastatic disease, 79 months after the adrenalectomy. In conclusion, survival benefit can be obtained after complete resection of isolated adrenal metastasis in patients with NSCLC. Therefore, resection of isolated adrenal metastasis should be considered if the primary NSCLC is resectable.
Keywords
Author Keywords
Adrenalectomy Lung cancer Solitary adrenal metastasis
Thymic Hyperplasia Presenting as a Neck Mass in Graves Disease
By
Yener, S (Yener, Serkan) [1] ; Seçil, M (Secil, Mustafa) [2] ; Koçdor, M (Kocdor, Mehmetali) [3] ; Özdogan, Ö (Ozdogan, Ozhan) [4] ; Çömlekçi, A (Comlekci, Abdurrahman) [1] ; Yesil, S (Yesil, Sena) [1]
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Source
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Volume
13
Issue
1
Page
11-12
Published
2009
Indexed
2009-01-01
Document Type
Article
Abstract
We describe a female patient who presented with Graves disease and a neck mass. Radiological characteristics of the mass suggested thymic hyperplasia. She was treated with methimazole, and because the mass did not regress after six months of therapy, the patient had total thyroidectomy and thymectomy. Pathological examination was consistent with chronic lymphocytic thyroiditis and thymic hyperplasia. Microscopic changes in the thymus can be detected in one third of patients with Graves disease, but massive enlargement is rare. It has been reported that regression occurs in most patients after a euthyroid state has been achieved; however, in some patients, thymectomy may be indicated.
Keywords
Author Keywords
Graves disease thymus hyperplasia
Advanced Age and Mild Thyrotoxicosis are Associated with Nodular Goiter in Graves Disease
By
Yener, S (Yener, Serkan) [1] ; Bayrakçi, N (Bayrakci, Nergiz) [1] ; Akinci, B (Akinci, Baris) [1] ; Demir, T (Demir, Tevfik) [1] ; Sevinç, A (Sevinc, Ali) [2] ; Özdogan, Ö (Ozdogan, Ozhan) [3] ; Canda, T (Canda, Tulay) [4] ; Çömlekçi, A (Comlekci, Abdurrahman) [1] ; Yesil, S (Yesil, Sena) [1]
(provided by Clarivate)
Source
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Volume
13
Issue
1
Page
1-4
Published
2009
Indexed
2009-01-01
Document Type
Article
Abstract
Objective: The primary goal of this study is to evaluate predictors of nodular goiter in Graves Disease (GD).
Materials and Methods: A total of 202 consecutive patients (mean age: 45; 145 female, 57 male) were enrolled. All patients were treated with antithyroid drugs as initial therapy. TSH, FT3, FT4, TRAb, ATPO, and ATG were measured. Radioactive iodine uptake and thyroid ultrasonography were performed, and thyroid volume and nodule diameter were assessed. Ultrasound-guided fine needle aspiration was performed on thyroid nodules =8mm.
Results: Diffuse goiter was detected in 51% of patients. Solitary nodules were detected in 16%, and multi-nodular disease in 33%. Mean nodule diameter was 8.82 mm. Nodular disease was slightly more common in women (p=0.063). Patients with nodular GD were older (p=0.004), had lower levels of FT3 (p=0.016) and TRAB (p=0.002) when compared with subjects with diffuse GD. Age (OR: 6.867) was the independent variable predicting nodular GD.
Conclusions: Increased prevalence of nodules was associated with advanced age and milder thyrotoxicosis. Apoptosis of thyroid follicular cells due to excess iodine might interfere with nodule formation, and lead to diffuse goiter in severe thyrotoxicosis. Because of increased rate if malignancy in GD, comprehensive evaluation of thyroid nodules of any size is mandatory.
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Author Keywords