2007 – 2013 Ege Üniversitesi Tıp Fakültesi
2014 – 2019 Dokuz Eylül Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Araştırma Görevlisi
2019 – 2020 İzmir Buca Seyfi Demirsoy Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Uzman Hekim
2020 – 2021 SBÜ Van Bölge Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Uzman Hekim
2021 – 2024 İzmir Buca Seyfi Demirsoy Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Uzman Hekim
2024 Mart – 2024 Temmuz Torbalı Devlet Hastanesi, Kadın Hastalıkları ve Doğum, Uzman Hekim
Tez: Endometrioziste menstrüel siklusun 2. ve 14. günü ölçülen CA-125 değerlerinin diagnostik kullanımı (Danışman Prof. Dr. Murat Celiloğlu, 2018, İzmir)
Yayınlar
1. Avsar HA, Kurt S, Celiloglu M., Timur T. Diagnostic use of CA 125 values measured on the 2nd and 14th days of the menstrual cycle in endometriosis. Journal of Surgery and Medicine, 6(5), 586-590. https://doi.org/10.28982/josam.988164
2. Kurt S, Avşar HA, Doğan ÖE, Saatli HB, Saygılı U. Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases. J Turk Ger Gynecol Assoc. 2019 May 28;20(2):84-88. doi: 10.4274/jtgga.galenos.2018.2018.0003.
3. Kurt S, Saygılı U, Doğan ÖE, Avşar HA, Okyay RE. Genital liken sklerozisin komplikasyonu olarak gelişen vulvar fimozisin tıbbi tedavisi: olgu sunumu, DEÜ Tıp Fakültesi Dergisi 2017;31(3):177-180 doi: 10.5505/deutip.2017.96720
4. Avsar HA, Atlıhan U, Ata C, Erkılınc S. Intrahepatic cholestasis of pregnancy and its association with preeclampsia and gestational diabetes: a retrospective analysis. Arch Gynecol Obstet. 2024 Jul;310(1):221-227. doi: 10.1007/s00404-024-07507-0. Epub 2024 Apr 16. PMID: 38625544.
5. Atlıhan, U., Yavuz, O., Avşar, H. A., Ata, C., Erkılınç, S., Bildacı, T. B. (2024). Vitamin D evaluation in adenomyosis: A retrospective cross-sectional study. Turk J Obstet Gynecol, 21(2), 98-103.
6. Atlıhan, U., Derundere, U., Avşar, H. A., Ata, C., Yavuz, O. (2024). Single Dose Methotrexate Treatment and Efficacy in the Treatment of Ectopic Pregnancy. Medical Journal of İzmir Hospital, 28(2), 108-115.
Ulusal Kongre Sözel Sunumlar
1. Atlıhan U, Avsar HA, Ata C. Bakırlı RİA Kullanımı ve Genital Enfeksiyon İlişkisi, X. Üreme Tıbbı ve Cerrahisi Derneği Kongresi, 1 – 5 Kasım 2023, Antalya
2. Atlıhan U, Avsar HA, Ata C. Postmenapozal Kanamada Endometrium Kalınlığının Histopatolojik Sonuçlarla İlişkisi, X. Üreme Tıbbı ve Cerrahisi Derneği Kongresi, 1 – 5 Kasım 2023, Antalya
3. Atlıhan U, Avsar HA, Ata C. Stres Üriner İnkontinansın Cerrahi Tedavisinde Mini Sling uygulamasına ait Sonuçlar, X. Üreme Tıbbı ve Cerrahisi Derneği Kongresi, 1 – 5 Kasım 2023, Antalya
4. Ata C, Avsar HA, Atlıhan U, Yavuz O, Erkılınç S, Bildacı TB. Anormal uterin kanama şikayeti olan kadınlarda endometrial patolojilerle metabolik sendrom arasındaki ilişkinin değerlendirilmesi, 21. Ulusal Jinekoloji ve Obstetrik Kongresi, 19-24 Mayıs 2024, K.K.T.C.
5. Ata C, Avsar HA, Atlıhan U, Yavuz O, Erkılınç S, Bildacı TB. İkinci trimesterde renal pelvis dilatasyonu saptanan fetusların retrospektif değerlendirilmesi, 21. Ulusal Jinekoloji ve Obstetrik Kongresi, 19-24 Mayıs 2024, K.K.T.C.
Uluslararası Kongre Sözel Sunumlar
1. Avsar HA, Ata C, Erkılınç S. HPV testing before the age of 30; Review of cytology and colposcopy results, XIV. Türk Alman Jinekoloji Kongresi, 28 Mayıs – 1 Haziran 2022, Antalya
2. Avsar HA, Atlıhan U. The Relationship Between Serum 25-Hydroxyvitamin D Level And Herpes Simplex Virus Type-2 Prevalence, 3. Uluslararası Jinekoloji ve Obstetri Kongresi, 5 – 8 Ekim 2023, Çeşme, İzmir
3. Atlıhan U, Avsar HA. Evaluation Of Pregnancy Outcomes In Women With A History Of Hysterescopic Myomectomy, 3. Uluslararası Jinekoloji ve Obstetri Kongresi, 5 – 8 Ekim 2023, Çeşme, İzmir
4. Atlıhan U, Avsar HA, Ata C. Retrospective Analysis of Caesarean Hysterectomy Patients, 7. International Congress on Medical Sciences and Multidisciplinary Approaches, 11 – 12 Kasım 2023, İstanbul
5. Atlıhan U, Avsar HA, Ata C. Diabetes Mellitus Tanılı Hastalarda Obstetrik ve Perinatal Sonuçlar, 13. International Hipocrates Congress on Medical and Health Sciences, 15-16 Aralık 2023
6. Atlıhan U, Avsar HA, Ata C. Human Papillomavirus Virüs (Hpv) Pozitif Kadınlarda Mikoplazma Türlerinin Araştırılması, 14. International Medicine and Health Sciences Researches Congress, 23-24 Aralık 2023, Ankara
7. Atlıhan U, Avsar HA, Ata C. Epizyotomi Skarında Gelişen Endometriozis: Olgu Sunumu, 15. International Medicine and Health Sciences Researches Congress, 23-24 Mart 2024, Ankara
8. Atlıhan U, Avsar HA, Ata C. Gebelikte Memenin Metastatik İnvaziv Duktal Karsinomu: Olgu Sunumu, 15. International Medicine and Health Sciences Researches Congress, 23-24 Mart 2024, Ankara
9. Atlıhan U, Avsar HA, Ata C. Rüptüre Endometrioma: Olgu Sunumu, 14. International Hipocrates Congress on Medical and Health Sciences, 15-16 Mart 2024
10. Atlıhan U, Avsar HA, Ata C. Vajinal Leiomyom: Olgu Sunumu, 14. International Hipocrates Congress on Medical and Health Sciences, 15-16 Mart 2024
11. Atlıhan U, Avsar HA, Ata C, Yavuz O. Comparison of postmenopausal osteoporosis in women with a history of surgical and natural menopause, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
12. Atlıhan U, Avsar HA, Ata C, Yavuz O. Effect of first trimester vitamin D levels on gestational diabetes, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
13. Avsar HA, Atlıhan U, Ata C, Yavuz O. Comparison of serum magnesium and HBA1c values in the presence of gestational diabetes mellitus, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
14. Ata C, Atlıhan U, Avsar HA, Yavuz O. Evaluation of Erythrocyte and Hemoglobin Concentrations in Adolescents with Polycystic Ovary Syndrome, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
15. Ata C, Atlıhan U, Avsar HA, Yavuz O. Evaluation of the relationship between nausea and vomiting complaints and vitamin D levels in pregnant women, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
16. Avsar HA, Atlıhan U, Ata C, Yavuz O. Investigation of the effect of body mass index and physical activity level on the formation of preeclampsia, 1. Kadın Sağlığı Dernekleri Federasyonu Kongresi, 17-21 Nisan 2024, Antalya
17. Ata C, Atlıhan U, Avsar HA, Yavuz O, Erkılınç S, Bildacı TB. Birinci Trimester Maternal Tiroid Otoimmün Antikorları İle Gestasyonel Diyabet İlişkisi, 1. Uluslararası Jinekolojik ve Obstetrik Cerrahi Kongresi, 19-21 Nisan 2024, İstanbul
18. Ata C, Atlıhan U, Avsar HA, Yavuz O, Erkılınç S, Bildacı TB. Desensus Uteri Saptanan Gebede Bilateral Hidronefroz: Olgu Sunumu, 1. Uluslararası Jinekolojik ve Obstetrik Cerrahi Kongresi, 19-21 Nisan 2024, İstanbul
19. Atlıhan U, Avsar HA, Ata C. Medical Treatment in Ruptured Ectopic Pregnancy: Case Report, 8. International Congress on Medical Sciences and Multidisciplinary Approaches, 4 Mayıs 2024, İstanbul
20. Atlıhan U, Avsar HA, Ata C. Retrospective Analysis of Advanced Maternal Age Pregnancy, 8. International Congress on Medical Sciences and Multidisciplinary Approaches, 4 Mayıs 2024, İstanbul
OP. DR. HÜSEYİN AYTUĞ AVŞAR
GÖREV ALDIĞI BÖLÜMLER
KADIN HASTALIKLARI VE DOĞUM
Intrahepatic cholestasis of pregnancy and its association with preeclampsia and gestational diabetes: a retrospective analysis
By
Avsar, HA (Avsar, Huseyin Aytug) [1] ; Atlihan, U (Atlihan, Ufuk) [2] ; Ata, C (Ata, Can) [1] ; Erkilinc, S (Erkilinc, Selcuk) [1]
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Source
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Volume
310
Issue
1
Page
221-227
DOI
10.1007/s00404-024-07507-0
Published
JUL 2024
Indexed
2024-06-23
Document Type
Article
Jump to
Abstract
Purpose To evaluate maternal and neonatal outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods Patients who gave birth in our hospital between January 2018 and March 2022 were retrospectively reviewed from the hospital database and patient file records. The study comprised 1686 patients, 54 in the ICP group and 1632 controls. Patients who had ICP after 20 weeks of gestation and were monitored and delivered at our facility were enrolled. Maternal demographic and obstetric characteristics data were examined. Perinatal outcomes were also assessed. Logistic regression analysis was used to determine adverse maternal outcomes. Results The mean age was 29 years. ART, GDM, and preeclampsia were significantly higher in the ICP group. The mean serum bile acid level was 19.3 +/- 3 mu mol/L in the ICP group. There was a higher risk of GDM and pre-eclampsia in women with ICP compared with those without and a significant association between ICP and adverse perinatal outcomes. There was a statistically significant relation between the presence of ICP and spontaneous preterm delivery, iatrogenic preterm delivery, 5th-minute Apgar scores < 7, and NICU requirement. No significant relationship was found between the presence of ICP and SGA and meconium. There was a significant relationship between the presence of ICP, mode of delivery, and PPH (p < 0.05). Those with ICP had a lower gestational week and birth weight, and higher rates of cesarean delivery and PPH. Conclusion ICP should prompt close monitoring and management to mitigate the potential exacerbation of adverse outcomes, including preeclampsia, GDM, and preterm birth.
Keywords
Bile acid Gestational diabetes mellitus Intrahepatic cholestasis of pregnancy Preeclampsia
Exploring irisin levels in patients with endometrial atypical hyperplasia and carcinoma: a comparative analysis
By
Bildaci, TB (Bildaci, Tevfik Berk) [1] ; Ata, C (Ata, Can) [1] ; Atlihan, U (Atlihan, Ufuk) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [1] ; Erkilinc, S (Erkilinc, Selcuk) [1]
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Source
Volume
25
Issue
1
DOI
10.1186/s12885-025-14843-0
Article Number
1440
Published
SEP 30 2025
Indexed
2025-10-15
Document Type
Article
Jump to
Abstract
BackgroundEndometrial atypical hyperplasia (EAH) is recognized as the precursor to type I endometrial cancer. Endometrial cancer (EC), strongly associated with disorders in glucose metabolism such as obesity and insulin resistance, is believed to be influenced by hormones secreted from adipose tissue known as adipokines.MethodsIn a cross-sectional case-control study, 88 patients diagnosed with either EAH or EC were enrolled. Their irisin levels in serum were compared to those of a control group.ResultsIrisin levels were significantly higher in patients with both EAH and EC compared to the control group (p = 0.022). In multivariable analysis, the association between irisin and EAH remained statistically significant and independent after adjustment for covariates (p = 0.018), whereas the association with EC was weakened and did not remain statistically significant (p = 0.071).ConclusionWe demonstrated that Irisin levels in patients with EAH or EC differ from those in a control group, suggesting that irisin levels are correlated with the risks of EH and EC. Larger studies are required to clarify the potential use of irisin in the diagnosis of EC.
Keywords
Author Keywords
AdipokineIrisin Endometrial atypical hyperplasia Endometrial carcinoma
Effects of dienogest treatment on endometrioma-related clinical symptoms and endometrioma size: retrospective cohort study
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ata, C (Ata, Can) [3] ; Avsar, HA (Avsar, Huseyin Aytug) [4] ; Erkilinc, S (Erkilinc, Selcuk) [3]
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Source
Volume
12
DOI
10.3389/fmed.2025.1581661
Article Number
1581661
Published
MAY 1 2025
Indexed
2025-05-19
Document Type
Article
Jump to
Abstract
Background To evaluate the efficacy and long-term safety of treatment with dienogest in patients with endometrioma. Methods Patients with endometrioma-related chronic pelvic pain were included in this retrospective study from March 2018 to March 2023. Enrolled patients received 2 mg of dienogest once daily. Data from 180 patients were analyzed. Group 2 (n = 104, 57.8%), comprising patients undergoing long-term therapy (>12 months), was compared with group 1 (n = 76, 42.2%), consisting of patients undergoing short-term therapy (<2 months), regarding their response to changes in endometrioma size and visual analog scale (VAS) scores. Statistical analysis was performed using the SPSS version 26.0 software. Non-normally distributed parameters were analyzed using the Mann-Whitney U test. In the evaluation of the data, apart from identifying statistical methods, the t-test was used in comparison of paired groups, and the matched t-test was used in the determination of changes before and after treatment. The Chi-square test and Fisher's precision test were used in the analysis of categorical data. Categorical variables are presents as percentages, and quantitative variables are summarized as mean (95% confidence intervals) and median (minimum-maximum). p-values of <0.05 were considered statistically significant. Results Findings at T0 (baseline) and T1 (sixth month) visits, in which the entire study cohort could be included, were compared. Then, patients who continued treatment at visits every 6 months after T1 (>12 months) were compared one by one with the findings at T0. The reduced libido was 4.3 times higher in the long-term group, but the weight gain was higher in the short-term group. Analysis within all patients and individual groups (short term vs. long term) showed a significant decrease in endometrioma size and VAS scores between T0 and T1 visit findings. Similarly, the findings of T2 and each subsequent visit of the patients in the long-term group were compared with the initial findings and a significant reduction in endometrioma size and VAS scores was observed. Conclusion Although the effectiveness of dienogest treatment for endometrioma seems to begin in the sixth month, its effectiveness maximizes in patients whose treatment duration is over 1 year.
Keywords
Author Keywords
cyclic pelvic pain Effects of dienogest treatment on endometrioma-related clinical symptoms and endometrioma size: retrospective cohort study
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ata, C (Ata, Can) [3] ; Avsar, HA (Avsar, Huseyin Aytug) [4] ; Erkilinc, S (Erkilinc, Selcuk) [3]
(provided by Clarivate)
Source
Volume
12
DOI
10.3389/fmed.2025.1581661
Article Number
1581661
Published
MAY 1 2025
Indexed
2025-05-19
Document Type
Article
Jump to
Abstract
Translate Background To evaluate the efficacy and long-term safety of treatment with dienogest in patients with endometrioma. Methods Patients with endometrioma-related chronic pelvic pain were included in this retrospective study from March 2018 to March 2023. Enrolled patients received 2 mg of dienogest once daily. Data from 180 patients were analyzed. Group 2 (n = 104, 57.8%), comprising patients undergoing long-term therapy (>12 months), was compared with group 1 (n = 76, 42.2%), consisting of patients undergoing short-term therapy (<2 months), regarding their response to changes in endometrioma size and visual analog scale (VAS) scores. Statistical analysis was performed using the SPSS version 26.0 software. Non-normally distributed parameters were analyzed using the Mann-Whitney U test. In the evaluation of the data, apart from identifying statistical methods, the t-test was used in comparison of paired groups, and the matched t-test was used in the determination of changes before and after treatment. The Chi-square test and Fisher's precision test were used in the analysis of categorical data. Categorical variables are presents as percentages, and quantitative variables are summarized as mean (95% confidence intervals) and median (minimum-maximum). p-values of <0.05 were considered statistically significant. Results Findings at T0 (baseline) and T1 (sixth month) visits, in which the entire study cohort could be included, were compared. Then, patients who continued treatment at visits every 6 months after T1 (>12 months) were compared one by one with the findings at T0. The reduced libido was 4.3 times higher in the long-term group, but the weight gain was higher in the short-term group. Analysis within all patients and individual groups (short term vs. long term) showed a significant decrease in endometrioma size and VAS scores between T0 and T1 visit findings. Similarly, the findings of T2 and each subsequent visit of the patients in the long-term group were compared with the initial findings and a significant reduction in endometrioma size and VAS scores was observed. Conclusion Although the effectiveness of dienogest treatment for endometrioma seems to begin in the sixth month, its effectiveness maximizes in patients whose treatment duration is over 1 year.
Keywords
Author Keywords
cyclic pelvic pain dysmenorrhea dyspareunia endometrioma dienogest
dysmenorrhea dyspareunia endometrioma dienogest
Evaluation of pregnancy outcomes in patients with a history of bariatric surgery
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ata, C (Ata, Can) [3] ; Avsar, HA (Avsar, Huseyin Aytug) [4] ; Erkilinc, S (Erkilinc, Selcuk) [3]
(provided by Clarivate)
Source
Volume
12
DOI
10.3389/fmed.2025.1609344
Article Number
1609344
Published
JUN 11 2025
Indexed
2025-06-29
Document Type
Article
Jump to
Abstract
Translate Introduction: Obesity and overweight are significant risk factors for perinatal morbidity and mortality, and an increasing number of women of reproductive age are being offered bariatric surgery. The present study investigated the outcomes of pregnancies and births after bariatric surgery (BS).
Materials and methods: All patients who gave birth at our clinic between 2018 and 2023 were included in the study. Individuals who had undergone BS previously were identified using the hospital database, and their medical birth records were obtained for data on pregnancy, delivery, and perinatal results. The results of women who had undergone BS previously were analyzed by comparing them with other pregnancies.
Results: A total of 298 women who had undergone BS previously and 4,374 women who had not undergone surgeries were included in the study. The BS group had higher rates of abortion (p = 0.009) and IVF history (p < 0.001). Additionally, the incidence of pregnancy-induced hypertension (p < 0.001), preeclampsia (p = 0.04), gestational diabetes (GDM) (p < 0.001), premature birth (p < 0.001), cesarean delivery (p < 0.001), and small for gestational age (p < 0.001) was significantly higher in the BS group.
Conclusion: Given the potential hazards associated with obesity in women of reproductive age, BS may be seen as a prudent course of therapy. Our study concluded that pregnancy prognosis is closely correlated with BMI at the time of pregnancy. Previous research revealed similar findings between groups in terms of pregnancy prognosis and pregnancy complications in obese and extremely obese patient groups.
Keywords
Author Keywords
bariatric surgery high-risk pregnancy neonatal outcomes pregnancy outcomes
Diagnostic role of galanin in distinguishing endometrial atypical hyperplasia and carcinoma from benign endometrial conditions
By
Ata, C (Ata, Can) [1] ; Bildaci, TB (Bildaci, Tevfik Berk) [1] ; Atlihan, U (Atlihan, Ufuk) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [3] ; Erkilinc, S (Erkilinc, Selcuk) [1]
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Source
Volume
15
Issue
1
DOI
10.1038/s41598-025-21347-1
Article Number
37438
Published
OCT 27 2025
Indexed
2025-11-07
Document Type
Article
Jump to
Abstract
Translate Endometrial atypical hyperplasia is recognized as a precursor to endometrial cancer, which ranks as the fourth most common cancer in women and is the leading type of gynecological malignancy in high-income countries. The development and progression of endometrial cancer are strongly linked to increased body fat and insulin resistance. Peptides involved in glucose metabolism, such as leptin, chemerin, and galanin, may contribute to carcinogenesis through shared pathways. This study aims to investigate the role of galanin levels in diagnosing endometrial neoplastic disorders. This prospective case-control study included 85 patients, divided into three groups: endometrial cancer, atypical hyperplasia, and a control group. Serum galanin levels were measured using ELISA across all groups. The mean galanin levels were 472.76 +/- 44.86 pg/ml in Control Group, 516.81 +/- 51.15 pg/ml in EAH, and 543.15 +/- 73.22 pg/ml in Cancer Group. Galanin levels were found to be significantly different among groups. (p < .001) . Galanin levels have the potential to differentiate between normal endometrium and patients with endometrial hyperplasia.
Keywords
Author Keywords
Endometrial cancer Galanin Endometrial hyperplasia Glucose metabolism Adipokine
Effect of deep infiltrative endometriosis surgery and surgical method on sexual function in females
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [3] ; Ata, C (Ata, Can) [4] ; Erkilinç, S (Erkilinc, Selcuk) [5] ; Bildaci, TB (Bildaci, Tevfik Berk) [6] ; Acet, F (Acet, Ferruh) [7] ; Ersak, B (Ersak, Burak) [8] ; Özay, AC (Ozay, Ali Cenk) [9]
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Source
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume
22
Issue
2
Page
147-153
DOI
10.4274/tjod.galenos.2025.46066
Published
JUN 2025
Indexed
2025-06-20
Document Type
Article
Jump to
Abstract
Translate Objective: Sexual function and quality of life are significantly reduced in endometriosis patients, particularly those with deep infiltrative endometriosis (DIE). The purpose of this study was to compare the effects of endometriosis excision and excision techniques on sexual function among individuals with DIE to those of healthy females in an objective manner. Materials and methods: Our study included 140 individuals who were diagnosed as having DIE and reported dyspareunia in our clinic between January 2018 and 2024, and 70 patients who presented to our family planning clinic. The preoperative and 6-month post-surgery scores of the female sexual function index (FSFI), quality of sexual experience scale (QSES), and visual analog scale (VAS) values of all patients who described preoperative dyspareunia were examined retrospectively from the patient files. Results: In our study, the FSFI score of healthy groups was seen to be significantly greater than the pre-surgery and post-surgery groups (p<0.001 and p<0.001, respectively). The QSES scores of the healthy group were found to be significantly higher than the pre-surgery and post-surgery groups (p<0.001 and p<0.001, respectively). The VAS dyspareunia values of the healthy group were discovered to be significantly lower than the pre-surgery and post-surgery groups (p<0.001 and p<0.001, respectively). The FSFI and QSES scores of the post-surgery group were significantly higher than those of the pre-surgery group (p<0.001 and p<0.001, respectively). The VAS dyspareunia score of the post-surgery group was seen to be significantly lower than that of the pre-surgery group (p<0.001). The FSFI and QSES scores of patients who underwent laparotomy were discovered to be significantly greater than that of individuals who underwent laparoscopic surgery (p<0.001 and p=0.01, respectively). Conclusion: The surgical approach may have a positive effect on both organ dysfunction and sexual function in women with DIE; this issue should be considered carefully.
Keywords
Author Keywords
Deep infiltrative endometriosis endometriosis sexual function
Vitamin D evaluation in adenomyosis: A retrospective cross-sectional study
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [3] ; Ata, C (Ata, Can) [3] ; Erkilinç, S (Erkilinc, Selcuk) [4] ; Bildaci, TB (Bildaci, Tevfik Berk) [5]
(provided by Clarivate)
Source
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume
21
Issue
2
Page
98-103
DOI
10.4274/tjod.galenos.2024.41662
Published
JUN 2024
Indexed
2024-11-11
Document Type
Article
Jump to
Abstract
Translate Objective: Adenomyosis is a chronic inflammatory illness that depends on estrogen. In addition to its immune regulatory effects in chronic diseases, vitamin D also plays roles in regulating normal cell growth. In the present study, the purpose was to evaluate the possible relationships between serum 25 OH vitamin D levels and clinical and laboratory parameters in patients who were histopathologically diagnosed with adenomyosis.
Materials and Methods: A total of 168 females with a history of hysterectomy between January 2019 and November 2022 who were histopathologically diagnosed with adenomyosis and 168 women who were not diagnosed with adenomyosis were retrospectively evaluated in the present study. Demographic, clinical, and laboratory data were recorded at the time of admission. Visual analogue scale (VAS) scores were calculated for each patient to evaluate the severity of dysmenorrhea.
Results: There was a significant difference between the groups in terms of VAS: the adenomyosis group scored an average of 6, whereas the control group scored an average of 3 (p<0.001). The average platelet volume value of the patients was 8.6 fL in the adenomyosis group, and that of the control group was 7.2 fL, and it was detected to be significantly elevated in the adenomyosis group (p<0.001). The CA-125 value of the patients was 63.5 U/mL in the adenomyosis group, and that of the control group was 15.6 U/mL and it was detected to be significantly rised in the adenomyosis group (p<0.001). The 25-OH vitamin D level of the patients was 12.6 ng/mL in the adenomyosis group and that of the control group was 19.1 ng/mL and it was detected to be significantly elevated in the control group.
Conclusion: The current investigation provides compelling evidence for the association between low vitamin D levels and adenomyosis, which agrees with other research in the field. The current study's findings agree with other research that suggests vitamin D regulates cellular and signaling networks, including those that control cytokines and gene expression during adenomyosis. However, further studies are needed because data assassing the therapeutic efficacy of vitamin D in adenomyosis are questionable.
Keywords
Author Keywords
Adenomyosis dysmenorrhea hysterectomy25-OH vitamin D
The role of serum inflammatory markers in determining the severity of cervical lesions
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ersak, B (Ersak, Burak) [3] ; Ata, C (Ata, Can) [4] ; Bildaci, TB (Bildaci, Tevfik Berk) [5] ; Erkilinc, S (Erkilinc, Selcuk) [5] ; Avsar, HA (Avsar, Huseyin Aytug) [6] ; Özay, AC (Ozay, Ali Cenk) [7] ; Solmaz, U (Solmaz, Ulas)
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Source
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Volume
51
Issue
3
DOI
10.1111/jog.16278
Article Number
e16278
Published
MAR 2025
Indexed
2025-03-29
Document Type
Article
Jump to
Abstract
Translate Objective: To evaluate the role of serum inflammatory markers in determining colposcopy indications more accurately, reducing unnecessary colposcopy requests, and preventing overtreatment. Materials and Methods: In our study, the data of 218 patients who were followed up in our hospital's oncology outpatient clinic between April 2017 and November 2023 and who underwent colposcopy and biopsy for suspected cervical lesions due to Papanicolaou smear test abnormalities or the presence of human papillomavirus were evaluated retrospectively. The parameters of patients with and without cervical lesions were compared. Patients with cervical lesions were compared according to lesion type. Results: Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio levels were significantly higher in the cervical lesions (+) group compared with the cervical lesions (-) (p < 0.001 and p < 0.001, respectively). Systemic immuno-inflammation index and systemic inflammatory response index levels were significantly higher in the cervical lesions (+) group compared with the cervical lesions (-) group (p < 0.001 and p < 0.001, respectively). Mean platelet volume level was significantly lower in the cervical lesions (+) group compared with the cervical lesions (-) group (p < 0.001). In the group with cervical lesions, no significant relationship was found between the severity of the cervical lesions and serum inflammatory marker levels. Conclusion: According to the results of our study, although there were significant differences between the serum inflammatory marker levels of patients with and without cervical lesions, their importance in predicting cervical lesions could not be clearly demonstrated. The importance of serum inflammatory markers should be evaluated in prospective studies with larger patient numbers and longer follow-up periods.
Keywords
Author Keywords
cervical intraepithelial neoplasia cervical lesions serum inflammatory markers
Comparison of Postpartum Sexual Function in Patients who had Undergone Episiotomy and had Perineal Tears
By
Atlihan, U (Atlihan, Ufuk) [1] ; Ata, C (Ata, Can) [2] ; Yavuz, O (Yavuz, Onur) [3] ; Acet, F (Acet, Ferruh) [4] ; Ersak, B (Ersak, Burak) [5] ; Avsar, HA (Avsar, Huseyin Aytug) [6] ; Bildaci, TB (Bildaci, Tevfik Berk) [7] ; Erkilinç, S (Erkilinc, Selcuk) [8]
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Source
CYPRUS JOURNAL OF MEDICAL SCIENCES
Volume
10
Issue
3
Page
206-211
DOI
10.4274/cjms.2025.2025-18
Published
JUN 2025
Indexed
2025-07-22
Document Type
Article
Abstract
Translate BACKGROUND/AIMS: To make a comparison regarding postpartum sexual function according to the presence of episiotomy and the degree of perineal tears. MATERIALS AND METHODS: Two hundred ninety-four primiparous patients in total between the ages of 18 and 45 who arrived at the obstetrics outpatient clinic between 2017 and 2024, underwent pregnancy follow-up and delivery, and fulfilled the inclusion criteria were analyzed in our research. The study included 131 women with perineal tears and 163 women who underwent episiotomy. Retrospectively, at 6 months postpartum, the Female Sexual Function Index (FSFI), Quality of Sexual Experience Scale (QSES), and visual analog scale (VAS) for dyspareunia values of all individuals were reviewed from participant files. RESULTS: The VAS, QSES, and FSFI values were significantly greater in the episiotomy (+) group than the episiotomy (-) group (p<0.01). The VAS value was significantly greater in the episiotomy (+) group in comparison with the other groups (p<0.01). The QSES and FSFI values were significantly smaller in the tear degree 4 group than those in the other groups (p<0.01). The values of arousal and lubrication were significantly smaller in the tear degree 4 group than those of the other groups (p<0.01). The orgasm and satisfaction values were significantly smaller in the tear degree 4 group compared with the other groups (p<0.01). CONCLUSION: Sexual dysfunction in the postpartum period can be affected by social, physical, psychogenic, and demographic factors. Our study showed that preventing advanced-stage tears through episiotomy might contribute positively to sexual function aspects. Prospective studies with larger samples are also needed to evaluate the effects of other maternal, demographic, and cultural factors that might influence females' sexual functions in the postpartum period.
Keywords Episiotomy perineal tear postpartum sexual function
The relationship of antimullerian hormone with severity of clinical symptoms in polycystic ovary syndrome
By
Ata, C (Ata, Can) [1] ; Atlihan, U (Atlihan, Ufuk) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [1] ; Yavuz, O (Yavuz, Onur) [3] ; Erkilinc, S (Erkilinc, Selcuk) [1] ; Bildaci, TB (Bildaci, Tevfik Berk) [1]
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Source
Volume
25
Issue
1
DOI
10.1186/s12905-025-03983-x
Article Number
432
Published
SEP 24 2025
Indexed
2025-10-01
Document Type
Article
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Abstract
Translate BackgroundPolycystic ovary syndrome (PCOS) is an endocrine disorder prevalent in around 6-8% of women in their reproductive years. The measurement of Anti-M & uuml;llerian Hormone (AMH) holds particular promise in discerning both the diagnosis and the extent of severity in PCOS cases. This study aims to evaluate the effectiveness of using AMH as a potential tool for identifying and diagnosing the severity of clinical aspects associated with the syndrome.Materials and methodsA retrospective analysis was performed on 309 female patients who presented for consultation at our hospital's gynecology outpatient clinic and were diagnosed with PCOS based on the Rotterdam criteria, between January 2018 and March 2022. Data were extracted from the hospital database and systematically assessed. Patients were divided into two groups based on the mean AMH level of 7.5 ng/mL, allowing comparison between higher and lower AMH subgroups. Clinical symptoms and findings were assessed based on AMH values.ResultsA statistically significant difference was observed between groups for the mean levels of total testosterone, androstenedione, free androgen index, luteinizing hormone, and follicle-stimulating hormone (p < 0.05). Additionally, a statistically significant difference was noted between AMH groups and the presence of oligomenorrhea (p < 0.05).ConclusionEven at the higher end of the spectrum, AMH retains significant value in determining the clinical aspects of PCOS.
Keywords
Author Keywords
Anti mullerian hormone Polycystic ovary syndrome Hyperandrogenism
The effect of pathogens in the vaginal flora on preterm birth in pregnant women with short cervical length
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ata, C (Ata, Can) [3] ; Avsar, HA (Avsar, Huseyin Aytug) [4] ; Bildaci, TB (Bildaci, Tevfik Berk) [5] ; Erkilinc, S (Erkilinc, Selcuk) [5]
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Source
DOI
10.5603/gpl.104886
Early Access
AUG 2025
Indexed
2025-12-06
Document Type
Article; Early Access
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Abstract
Translate Objectives: The aim of our study is to evaluate the effect of pathogens in the vaginal flora on preterm birth in pregnant women with short cervical length. Material and methods: In our study, 418 patients with asymptomatic cervical shortening in the second and third trimesters of pregnancy were evaluated retrospectively. Clinical data such as age, cervical length measurement, gestational age at hospital admission and delivery, and vaginal microbiological findings were evaluated for all patients. Results: The bacterial spectrum in the vagina revealed seven different bacterial taxa. The most common bacteria were Ureaplasma spp. and Mycoplasma spp. However, cases of Ureaplasma spp., Mycoplasma spp. and E.Coli taxa were also detected together. In 418 patients included, bacterial colonization was seen in 283 and not in 135. In women who delivered preterm before and after 34 weeks, the most common bacteria was Ureaplasma spp. However, the prevalence of these bacterial taxa was not significantly different between those who delivered preterm and those who did not. Conclusions: Our study provides a general idea about vaginal bacterial colonization and its possible effects in pregnant women with short cervical length. The clinical significance of vaginal bacterial colonization on preterm labor remains unclear and up-to-date.
Keywords
Author Keywords
Mycoplasma pregnancy preterm delivery short cervical length urea plasma
Maternal and Fetal Factors Affecting the Effectiveness of Vaginal Dinoprostone in Labor Induction
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Avsar, HA (Avsar, Huseyin Aytug) [3] ; Ata, C (Ata, Can) [4] ; Erkilinç, S (Erkilinc, Selcuk) [5] ; Bildaci, TB (Bildaci, Tevfik Berk) [6] ; Ersak, B (Ersak, Burak) [7] ; Acet, F (Acet, Ferruh) [8]
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Source
CYPRUS JOURNAL OF MEDICAL SCIENCES
Volume
10
Issue
2
Page
123-128
DOI
10.4274/cjms.2025.2024-148
Published
APR 2025
Indexed
2025-05-09
Document Type
Article
Abstract
Translate BACKGROUND/AIMS: Induction of labor is a common obstetric intervention used to encourage the onset of labor. The aim of the study was to evaluate the maternal and fetal factors that play a role in the efficacy of vaginal dinoprostone in labor induction. MATERIALS AND METHODS: Our study included 780 patients who underwent pregnancy follow-up and delivery in our hospital between March 2018 and 2024. All data, including body mass index (BMI), age, parity, induction criteria, obstetric history, bishop score, time of delivery, newborn weight, and Apgar score, were entered by the delivery room physician. Data from 620 patients who had a successful delivery with vaginal dinoprostone application, and 160 patients who did not have a vaginal delivery were evaluated retrospectively. RESULTS: The BMI value of women in group 2 at admission to the hospital was found to be significantly higher than that of women in group 1 (p<0.001). The Bishop score of women in group 1 at admission to the hospital was found to be significantly higher than that of women in group 2 (p<0.001). The nulliparity rate of women in group 2 was found to be significantly higher than that in group 1 (p<0.001). The uterocervical angle measurement of women in group 2 was found to be significantly lower than that in group 1 (p<0.001). The rate of newborns with 1st and 5th minute Apgar scores >= 8 in group 1 was found to be significantly higher than the rate in group 2 (p=0.006, p=0.04, respectively). CONCLUSION: It was determined that parity was one of the important determinants in achieving vaginal delivery in pregnancies where dinoprostone vaginal insert was applied. It was determined that multiparous women benefited more from induction with dinoprostone. However, according to the results of our study, more research is needed to evaluate nulliparous pregnancies requiring induction.
Keywords
Author Keywords
Dinoprostone induction of labor nulliparity multiparity
Laparoscopy without uterine manipulator vs. laparotomy in endometrial cancer: a retrospective study
By
Erkilinc, S (Erkilinc, Selcuk) [1] ; Özcan, S (Ozcan, Sena) [2] ; Öztürk, AB (Ozturk, Ayse Betul) [3] ; Iscan, SC (Iscan, Serhan Can) [4] ; Atlihan, U (Atlihan, Ufuk) [5] ; Ata, C (Ata, Can) [1] ; Avsar, HA (Avsar, Huseyin Aytug) [6] ; Bildaci, TB (Bildaci, Tevfik Berk) [1] ; Çakir, I (Cakir, Ilker) [1]
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Source
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
Volume
71
Issue
8
DOI
10.1590/1806-9282.20250434
Article Number
e20250434
Published
2025
Indexed
2025-10-07
Document Type
Article
Abstract
Translate OBJECTIVE: The objective of the studywas to evaluate perioperative and oncologic outcomes of laparoscopywithout the use of uterine manipulators and laparotomy in high-grade and serous endometrial cancer. METHODS: Patients with grade III endometrioid adenocarcinoma and serous carcinoma between 2018 and 2022 were included in the study. Preoperative staging with positron emission tomography/computed tomography or thoracoabdominal computed tomography and pelvic magnetic resonance imaging was performed. All patients underwent staging surgery including hysterectomy, bilateral salpingo-oophorectomy, peritoneal washing, omentectomy, and pelvic and paraaortic lymphadenectomy up to the renal vein. No uterine manipulator was used for laparoscopic hysterectomy. Age, CA 125 level, body mass index, accompanying diseases, pathologic data including stage, lymphovascular invasion, number of pelvic and paraaortic lymph nodes, and surgical data including surgical time, surgical complications, and adjuvant therapies were collected from the hospital database retrospectively. RESULTS: Notably, 89 patients were included in the study: 34 underwent laparotomy and 55 underwent laparoscopy. Surgical times were similar between the groups. The mean pelvic lymph node count in the laparotomy and laparoscopy groups was 33 and 34, respectively. The mean paraaortic lymph node counts in the laparotomy and laparoscopy groups were 23 and 22, respectively. Red blood cell transfusion, hemorrhage, urinary tract infection, postoperative fever, bladder atony, bladder injury, and chylous leakage showed no significant differences between the groups. However, ileus, intestinal injury, and evisceration were significantly higher in the laparotomy group. Hospital stay was significantly longer in the laparotomy group compared with the laparoscopy group. Overall and recurrence-free survival were similar between the groups. CONCLUSION: Laparoscopic surgery, performed without manipulators, provides comparable oncologic outcomes to open surgery in the treatment of endometrial cancer, while also results.
Keywords
Author Keywords
Endometrial cancer Laparoscopy Laparotomy
Impact of sympathetic denervation via paraaortic lymphadenectomy on blood pressure in endometrial cancer patients
By
Erkilinç, S (Erkilinc, Selcuk) [1] ; Iscan, SC (Iscan, Serhan Can) [2] ; Özcan, S (Ozcan, Sena) [3] ; Öztürk, B (Ozturk, Betuel) [4] ; Atlihan, U (Atlihan, Ufuk) [5] ; Ata, C (Ata, Can) [1] ; Avsar, HA (Avsar, Huseyin Aytug) [6] ; Bildaci, TB (Bildaci, Tevfik Berk) [1] ; Çakir, I (Cakir, Ilker) [1]
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Source
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume
22
Issue
1
Page
13-18
DOI
10.4274/tjod.galenos.2025.32654
Published
MAR 2025
Indexed
2025-03-26
Document Type
Article
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Abstract
Translate Objective: To evaluate the effect of para-aortic lymphadenectomy on blood pressure changes in endometrial cancer patients. Materials and Methods: This retrospective study included patients with endometrial cancer treated surgically between 2017 and 2023. Patients undergoing para-aortic lymphadenectomy, up to the renal artery, in a non-nerve-sparing fashion, were compared with those undergoing pelvic lymphadenectomy or sentinel lymph node mapping. Data collected included age, body mass index, comorbidities including hypertension, diabetes mellitus, coronary artery disease, operative time, number of lymph nodes removed, tumor size, and postoperative complications. Preoperative blood pressure was recorded during outpatient visits, and postoperative measurements were collected daily during hospitalization and at follow-up visits. Statistical analyses assessed differences in systolic and diastolic blood pressure changes, operative outcomes, and complications. Results: A total of 264 patients were analyzed. Patients in the para-aortic group had significantly longer operative times. Tumor size was larger in the paraaortic group than in another group. Systolic blood pressure decreased significantly in the para-aortic group compared to the control group (para-aortic:-17 mmHg vs. non-para-aortic:-1.10 mmHg, p<0.05), with a similar trend for diastolic pressure (-8.00 mmHg vs.-0.80 mmHg, p<0.05). Chylous ascites (15.6% vs. 5.6%) and ileus (0% vs. 12%) were more common in the para-aortic group, along with the administration of radiotherapy and chemotherapy. Both systolic and diastolic blood pressures were significantly lower in paraaortic group, in both early and late postoperative follow-up measures (p<0.005). Conclusion: Aortic lymphadenectomy is associated with decreased blood pressure and may have therapeutic potential for hypertensive patients, highlighting the need for prospective randomized studies to explore this effect further.
Keywords
Author Keywords
Cancer of endometrium hypertension lymph node excison
Evaluation of the Efficacy of Active Hexose Correlated Compound as an Adjuvant in Reducing Recurrence After Condyloma Cauterization
By
Atlihan, U (Atlihan, Ufuk) [1] ; Yavuz, O (Yavuz, Onur) [2] ; Ata, C (Ata, Can) [3] ; Avsar, HA (Avsar, Huseyin Aytug) [4] ; Bildaci, TB (Bildaci, Tevfik Berk) [5] ; Ozay, AC (Ozay, Ali Cenk) [6] ; Ersak, B (Ersak, Burak) [7] ; Solmaz, U (Solmaz, Ulas) [8] ; Erkilinc, S (Erkilinc, Selcuk) [9]
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Source
Volume
61
Issue
4
DOI
10.3390/medicina61040622
Article Number
622
Published
MAR 28 2025
Indexed
2025-05-11
Document Type
Article
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Abstract
Translate Background and Objectives: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted illnesses. HPV is responsible for genital condyloma lesions. A durable and effective systemic treatment regimen has not been established for HPV-related infections. In the present study, our purpose was to evaluate the role of active hexose correlated compound (AHCC) in preventing relapse in patients who underwent cauterization for condyloma accuminata. Materials and Methods: A total of 244 individuals admitted to our hospital between January 2019 and June 2022 were diagnosed as having condyloma acuminata, and those who underwent condyloma cauterization were evaluated retrospectively. We included 133 individuals who met the criteria. Patients who received AHCC were scheduled for follow-up examinations at regular intervals every three months. Patients were divided into two groups and analyzed based on whether they did or did not use AHCC. Results: The average age of AHCC non-users was significantly greater than that of AHCC users (p < 0.01). The number of condylomas and the maximum condyloma diameter of AHCC users before treatment were found to be significantly higher than in AHCC non-users (p = 0.006 and p = 0.004, respectively). Among participants with recurrence, the number and diameter of condylomas in AHCC users were significantly lower than in AHCC non-users (p = 0.019 and p = 0.042, respectively). Conclusions: Although the usage of AHCC is not expected to help prevent recurrence after the cauterization of condylomata acuminate in all patients, physicians may consider AHCC as a nutritional supplement and supportive therapy in the absence of other systemic treatments. Consequently, the duration of AHCC support necessary to optimize the effect of AHCC use on relapse prevention requires further evaluation on the basis of both target IFN-beta levels and HPV infection status.
Keywords
Author Keywords
active hexose correlated compound condylomata acuminate
Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases
By
Kurt, S (Kurt, Sefa) [1] ; Avsar, HA (Avsar, Huseyin Aytug) [1] ; Dogan, ÖE (Dogan, Omer Erbil) [1] ; Saatli, HB (Saatli, Hasan Bahadir) [1] ; Saygili, U (Saygili, Ugur) [1]
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Source
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
Volume
20
Issue
2
Page
84-88
DOI
10.4274/jtgga.galenos.2018.2018.0003
Article Number
PMID 29755032
Published
JUN 2019
Indexed
2019-06-14
Document Type
Article
Abstract
Translate Objective: To examine cases of mature cystic teratoma (MCT) that were diagnosed and treated in our clinic regarding their association with fertility, and to detect the rate of malignant degeneration and the types of malignancies.
Material and Methods: Patients who underwent surgery due to adnexal mass between April 2012 and August 2017 and were diagnosed as having MCT were retrospectively examined. The mean age of the 80 patients who met the inclusion criteria was 30.60 +/- 10.5 years. Nine had infertility according to hospital records. Sixty-seven percent of these (n=6) had accompanying endometriosis and MCT was bilateral in 55.5% (n=5). Malignant degeneration was present in 6.25% (n=5), all were monodermal tumors. Malignant degeneration was more common among patients with larger diameter adnexal masses (9.1 +/- 2.9 cm) and in those of postmenopausal age. Tumor markers were within the normal range for patients who developed malignancy. Malignant degeneration was not present among infertile patients with endometriosis.
Results: Although MCTs do not seem to negatively affect the ovarian reserve, infertility is prominent in patients with concurrent endometriosis. During assessment, concurrent endometriosis should be considered. Imaging findings, large adnexal masses, and postmenopausal period are important for the assessment of MCT concerning malignant degeneration. It should not be overlooked because tumor markers may be normal.
Conclusion: MCTs can be present concurrent with endometriomas. In such cases, infertility is more distinct. In MCT malignant degeneration, mass diameter, complex mass internal structure, and postmenopausal status are important factors.
Keywords
Author Keywords
Mature cystic teratoma malignant degenerationin fertility treatment