Tınaztepe

Prostate cancer aggressiveness magnetic resonance imaging apparent diffusion coefficient value PI-RADSv2 1

Volume

Issue

Page

28-34

DOI

10.4274/uob.galenos.2022.2022.4.2

Published

MAR 2023

Indexed

2022-03-01

Document Type

Article

Abstract

Objective: This retrospective study reveals whether a lesion is a benign pathological process or malignant by measuring apparent diffusion coefficient (ADC) values following prostate imaging reporting and diagnostic system version 2.1 (PI-RADSv2.1) guide on multiparametric magnetic resonance imaging (MpMRI) examinations. Furthermore, this study aims to determine the cut-off ADC values (ADCv) that may exist to help identify and distinguish between benign and the malignant lesions. Additionally, the paper evaluates whether there is a correlation between malignant lesions' International Society of Urological Pathology (ISUP) score and ADCv, and whether ADCv provide information about prostate cancer (PCa) aggressiveness without requiring invasive procedures.Materials and Methods: The study group consised of 243 patients. The lesions were diagnosed using transrectal ultrasound-guided cognitive MRI fusion. MpMRI images before the biopsy were evaluated according to PI-RADSv2.1 guideline by a radiologist. Three groups, benign prostatic tissue, prostatitis, and PCa were obtained according to the histopathological results.Results: When the cut-off value for ADC was 780x10-3, sensitivity was 80%. When the cut-off value was taken as 668x10-3, the sensitivity and specificity were 72% and 62%, respectively. When the cut-off ADCv was taken as 647x10-3, the sensitivity was 83% and the specificity was 48.5%. ADCv varied significantly depending on the ISUP groups (p=0.003). It was determined that the ISUP 1 group was significantly higher compared to other groups. ADC group mean values were not significantly different between groups 2, 3, 4, and 5.Conclusion: ADCv may be a suitable tool for estimating PCa aggressiveness, and it shows a significant potential to improve the diagnostic accuracy.

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Rare Case; Primary Epididymal Adenocarcinoma

Eker, A (Eker, Anil) [1] ; Muratoglu, M (Muratoglu, Murathan) [1] ; Sefik, E (Sefik, Ertugrul) [2] ; Tasli, F (Tasli, Funda) [3]

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Epididymal adenocarcinoma paratesticular masses epididymal cancer

Volume

Issue

Page

123-125

DOI

10.4274/uob.galenos.2023.2023.1.5

Published

SEP 2023

Indexed

2024-02-24

Document Type

Article

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Abstract

Paratesticular masses constitute 2-3% of the scrotal masses. Epididymal masses constitute only 5% of prescrotal masses, and the most common type of tumor is adenotoid tumor, which is benign. Malignancies of the epididymis are rare. Epididymal adenocarcinoma is much less common. It can be primer and metastatic, and there are fewer than 40 cases in the literature in both groups. Primary epididymal adenocarcinoma is extremely rare, with only 23 cases reported. The disease diagnostic process, findings, and treatment are still unknown. In this article, we aimed to present a case of epidimal adenocarcinoma with primary origin from the epididymis.

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Comparison of the effect of hyperbaric oxygen therapy and tadalafil daily use on erectile function: a prospective, double controlled study

Eker, A (Eker, Anil) [1] ; Celik, S (Celik, Serdar) [1] ; Ozer, EE (Ozer, Elif Ebru) [2] ; Basmaci, I (Basmaci, Ismail) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Gunlusoy, B (Gunlusoy, Bulent) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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INTERNATIONAL UROLOGY AND NEPHROLOGY

Volume

Issue

Page

867-876

DOI

10.1007/s11255-023-03852-2

Published

MAR 2024

Early Access

NOV 2023

Indexed

2023-11-20

Document Type

Article

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Abstract

Purpose Erectile dysfunction (ED) is a worldwide health problem. Oral phosphodiesterase type 5 inhibitors (PDE5I) are used in its first-line treatment. This study aimed to compare the effects of hyperbaric oxygen (HBO) treatment with PDE5I treatment and determine the patient-dependent factors affecting the efficacy of the HBO treatment and duration of action of HBO treatment.Methods Adult male patients who presented to the HBO unit for HBO treatment with non-urological indications and had ED based on the International Index for Erectile Function (IIEF-5) constituted the target population of this study. Participants were given HBO treatment (Group 1), no treatment (Group 2), or daily oral tadalafil 5 mg treatment (Group 3). The treatment duration was 1 month. Patients were assessed by IIEF-5 both initially and after the completion of 1 month.Results There were significant increases in the mean IIEF-5 scores of the patients in Group 1 and Group 3 (p < 0.001, p < 0.001). However, there was no significant improvement in Group 2 (p = 0.496). Also, the post-treatment IIEF-5 scores of Group 1 and Group 3 were significantly higher than Group 2 (p < 0.001). There was no significant difference between the IIEF-5 scores and increment IIEF-5 values of Group 1 and Group 3 (p = 0.166, p = 0.093). Evaluation regarding comorbidities revealed that patients with the peripheral vascular disease did not improve with HBO treatment (p = 0.285).Conclusion HBO can improve erectile functions, and it can be a reasonable alternative for patients who cannot use PDE5Is due to comorbidities or treatment side effects.

Keywords

Author Keywords

Erectile dysfunction Hyperbaric oxygen treatment Phosphodiesterase type 5 inhibitor Tadalafil

A novel use of attenuation value (Hounsfield unit) in non-contrast CT: diagnosis of pyonephrosis in obstructed systems

Basmaci, I (Basmaci, Ismail) [1] ; Sefik, E (Sefik, Ertugrul) [1]

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INTERNATIONAL UROLOGY AND NEPHROLOGY

Volume

Issue

Page

9-14

DOI

10.1007/s11255-019-02283-2

Published

JAN 2020

Indexed

2020-02-25

Document Type

Article

Abstract

Purpose To evaluate the predictive value of attenuation value (HU) in renal pelvis urine for detecting renal pelvis urine culture (RPUC) positivity in obstructed urinary systems. Methods The study group consisted of patients who had nephrostomy insertion performed because of obstructed system and suspicion of pyonephrosis and percutaneous nephrolithotomy (PCNL) patients who had obstructed calculi. Group 1 consisted of RPUC positive 28 patients during nephrostomy insertion or needle access in PCNL and group 2 consisted of 23 patients with negative RPUC. RPUC results and non-contrast computed tomography measurements [Hounsfield unit (HU)] were compared between group 1 and group 2. A cut-off value was determined for HU. All patients were grouped according to whether they were above or below this value. Results The median HU calculated from the renal pelvis was - 8.5 (range - 29/- 1) and 10 (range- 4/+ 17) (p < 0.001) in group 1 and group 2, respectively. The cut-off value of HU that predicted positive RPUC was 0. Sensitivity and specificity of HU when considering this cut-off value were 100% and 96%, respectively (p < 0.001). Whereas RPUC positivity was found in 96.6% (28/29) of patients with HU < 0, there were no patients with HU > 0 where RPUC positivity was detected (p < 0.001). Conclusion In this cohort, we found that HU of the urine in the renal pelvis can be used to predict RPUC positivity.

Keywords

Author Keywords

Pyonephrosis Urinary tract obstruction Urine culture Computed tomography Attenuation value

Risk adapted strategy for choosing the right drug for antibiotic prophylaxis in percutaneous nephrolithotomy

Bozkurt, IH (Bozkurt, Ibrahim H.) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Eker, A (Eker, Anil) [1] ; Celik, S (Celik, Serdar) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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antibiotic prophylaxis cefazolin ceftriaxone percutaneous nephrolitholithotomy systemic

Volume

Issue

Page

39-44

Published

MAR 2023

Indexed

2023-11-10

Document Type

Article

Abstract

Objective: To create risk groups and compare the effectiveness of ceftriaxone and cefazolin for prophylaxis according to these risk groups

Design: Retrospective study

Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Turkey

Subjects: A total of 671 patients who underwent percutaneous nephrolithotomy (PCNL) for renal stones between January 2014 and July 2018 were included in the present retrospective study. Two hundred and twenty-three of the patients were given cefazolin, whereas 448 were given ceftriaxone as antibiotic prophylaxis. High-risk patients were defined as having >= 2 cm stone diameter plus one of the following: operation duration >= 120 min, multiple puncture (>= 2), recurrent urinary tract infection history, stone culture positivity or renal pelvic urine culture positivity. All patients were followed up for systemic inflammatory response syndrome (SIRS) criteria postoperatively.

Interventions: Percutaneous nephrolithotomy

Main outcome measures: SIRS

Results: Of all patients, 188 (28%) were in high risk group and 483 (72%) were in low risk group. No statistically significant difference was found between cefazolin and ceftriaxone group for SIRS in all patients and in low-risk group. However, in high-risk group, SIRS rates were significantly higher in cefazolin group compared to ceftriaxone group (P=0.001).

Conclusions: A risk adapted approach is important for selecting the type of antibiotic for prophylaxis in PCNL. In the present study, we found that ceftriaxone is superior to cefazolin in terms of post PCNL SIRS only in high-risk patients.

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Accuracy and Interobserver Agreement of the Correlation Between Prostate Imaging Reporting and Data System Version 2.1 and International Society of Urological Pathology Scores

Oguzdogan, GY (Oguzdogan, Gulsen Yucel) [1] ; Adibelli, ZH (Adibelli, Zehra Hilal) [1] ; Sefik, E (Sefik, Ertugrul) [2] ; Mollamehmetoglu, H (Mollamehmetoglu, Hulya) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [2] ; Vardar, E (Vardar, Enver) [3] ; Gunlusoy, B (Gunlusoy, Bulent) [2] ; Tuncez, HC (Tuncez, Hulya Cetin) [1]

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HONG KONG JOURNAL OF RADIOLOGY

Volume

Issue

Page

100-110

DOI

10.12809/hkjr2317452

Published

JUN 2023

Indexed

2023-07-24

Document Type

Article

Abstract

Introduction: This research aims to evaluate accuracy and interobserver agreement on the correlation between the Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1) and the International Society of Urological Pathology (ISUP) scores. Methods: We examined patients who underwent prostate multiparametric magnetic resonance imaging (MpMRI) prior to transrectal ultrasound-guided cognitive fusion biopsy between April and December 2019. MpMRI examinations were evaluated by two radiologists according to PI-RADS v2.1. Interobserver agreement was recorded and the final PI-RADS category was decided by consensus. The correlation of cognitive fusion biopsy results with PI-RADS v2.1 score was evaluated. Lesions with Gleason score & GE;7 were considered to be clinically significant prostate cancer.Results: A total of 84 patients with 106 lesions were included in the study. The rates of prostate cancer in the PI -RADS groups 1, 2, 3, 4, and 5 were 0%, 0%, 22.2%, 56%, and 94.45%, respectively. There was a positive correlation with an area under the curve value of 0.814 between the PI-RADS v2.1 and the ISUP score. Using PI-RADS & GE;3 as the cut-off value in the peripheral zone (PZ) and the whole gland, the negative predictive value for malignancy was 100%. For PI-RADS & GE;4, it was 76.47% for PZ and 80.65% for the whole gland. Without applying cut-off values, the interobserver agreement for PI-RADS score was & kappa; = 0.562.Conclusion: Our data support the notion that PI-RADS v2.1 facilitates the evaluation of MpMRI and improves interobserver agreement.

Keywords

Author Keywords

Biopsy Histology Magnetic resonance imaging Neoplasm grading Prostatic neoplasms

On-demand use of fesoterodine: a new paradigm for extended release antimuscarinics

Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Sefik, E (Sefik, Ertugrul) [2] ; Celik, S (Celik, Serdar) [1] ; Yesilova, A (Yesilova, Arda) [1] ; Koras, O (Koras, Omer) [3] ; Degirmenci, T (Degirmenci, Tansu) [1]

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INTERNATIONAL UROGYNECOLOGY JOURNAL

Volume

Issue

Page

2127-2132

DOI

10.1007/s00192-022-05250-1

Published

AUG 2022

Early Access

JUN 2022

Indexed

2022-06-13

Document Type

Article

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Abstract

Introduction and hypothesis We aimed to compare on-demand and continuous use of fesoterodine 4 mg concerning efficacy and adverse effects. Methods A total of 100 patients who were diagnosed with non-neurogenic overactive bladder (OAB) syndrome were included in the study. All patients were evaluated with MMSE, ICIQ-SF, SEAPI quality of health and OAB-V8 questionnaires, at the beginning, 1st month and 4th month. Fesoterodine 4 mg was started for treatment. At the end of the 1st month, patients who obtained benefit from the treatment were 1:1 randomized into two groups. In group 1, fesoterodine 4 mg was given 1 x 1 in a standard manner whereas in group 2 patients took the pills on demand. Both groups were evaluated for efficacy and adverse events at 4 months. Results Final analyses included 69 patients. At 4-month follow-up, OAB-V8 scores were significantly improved compared to 1 month in both groups. Again at h months, no difference was detected between the two groups for MMSE, ICIQ-SF and SEAPI scores. In continuous usage group, 4th month MMSE scores were significantly lower than 1st month scores. At 4 months, dry mouth and constipation were lower in the on-demand group compared to continuous usage group. Conclusions Compared to standard continuous usage, on-demand usage of fesoterodine showed similar efficacy with fewer adverse events.

Keywords

Author Keywords

Overactive bladder Fesoterodine On-demand therapy Continuous use Antimuscarinics

Does leaving residual fragments after percutaneous nephrolithotomy in patients with positive stone culture and/or renal pelvic urine culture increase the risk of infectious complications?

Degirmenci, T (Degirmenci, Tansu) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Celik, S (Celik, Serdar) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Sefik, E (Sefik, Ertugrul) [1]

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UROLITHIASIS

Volume

Issue

Page

371-375

DOI

10.1007/s00240-018-1063-9

Published

AUG 2019

Indexed

2019-08-02

Document Type

Article

Abstract

The residual fragments in patients with preoperative and intraoperative culture positivity may serve as an infection focus. The aim of this study was to assess the importance of residual fragments for developing SIRS in patients with stone culture and/or RPUC positivity. After obtaining institutional review board approval, a total of 729 patients who undergone PCNL for renal stones were included in this study. Residual fragments accepted to be positive if any fragment was detected irrespective of size. All patients were followed-up postoperatively for SIRS criteria. The patients were then followed-up for residual stone-related events and infectious complications. 94 of the 729 patients have developed SIRS postoperatively. SIRS positivity was more common among males and found to be associated with higher stone burden and presence of staghorn stone. Patients with residual fragments after PCNL also had higher rates of SIRS. In the subgroup analysis of 203 patients who had post-PCNL residual fragments, the peroperative stone and/or RPUC positivity was not found to be associated with the development of the SIRS. Although presence of residual fragments after PCNL is associated with SIRS development, stone culture and/or RPUC positivity has no additional risk for development of post-PCNL infectious complications in patients with residual fragments.

Keywords

Author Keywords

Systemic inflammatory response syndrome Stone culture Renal pelvic urine culture Percutaneous nephrolithotomy

External validation of a new nomogram for prediction of cancer specific and all-cause mortality in bladder cancer patients undergoing radical cystectomy

Sefik, E (Sefik, Ertugrul) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Celik, S (Celik, Serdar) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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bladder cancer cancer specific survival nomogram overall survival

Volume

Issue

Page

306-311

Published

SEP 2021

Indexed

2021-10-07

Document Type

Article

Abstract

Objective: To externally validate a new nomogram (Williams SB, Huo J, Chu Y, et al. Mortality in bladder cancer patients undergoing radical cystectomy: Development and validation of a nomogram for treatment decision-making. Urology 2017; 110:76-83) in our patient cohort

Design: Retrospective study

Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey

Subjects: A total of 146 patients who were diagnosed with muscle invasive bladder cancer between March 2006 and October 2016 were enrolled in this study.

Interventions: Radical cystectomy

Main outcome measures: The predicted cancer specific survival (CSS) and overall survival (OS) by the recent nomogram were compared with the actual CSS and OS of the patients in our single center sample.

Results: Mean overall survival of the patients was 54.5 +/- 4.4 months; the 3-year and 5-year OS rates were found to be 46.2% and 42.3%. Mean CSS of the patients was 66.5 +/- 4.8 months and 3-year and 5-year CSS rates were found to be 59.2% and 53%. Three-year and 5-year OS and CSS results according to the nomogram were found as 54.8% (+/- 12.6), 38.6% (+/- 10.8) and 75.3% (+/- 11.6), 62.8% (+/- 12), respectively. Statistically significant difference was found between the actual values and nomogram results for 3-year and 5-year OS and CSS rates.

Conclusion: The recent nomogram failed to estimate both OS and CSS in our group of patients that have more likely underwent cystectomy and have relatively homogenous age distribution.

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Author Keywords

What is the best cut-off time to prevent worsening prognosis in muscle-invasive bladder cancer?

Sefik, E (Sefik, Ertugrul) [1] ; Celik, S (Celik, Serdar) [1] ; Gunlusoy, B (Gunlusoy, Bulent) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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muscle-invasive bladder cancer radical cystectomy survival waiting time

Volume

Issue

Page

259-264

Published

SEP 2021

Indexed

2021-10-07

Document Type

Article

Abstract

Objective: To assess the effect and outcomes of the delay interval between transurethral bladder tumor resection (TURBT) and radical cystectomy (RC) on pathologic upstaging and the survival of the patients

Design: Retrospective study

Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey

Subjects: We enrolled 145 patients who underwent RC between March 2006 and October 2016 with stage >= T2 after TURBT in our tertiary reference center.

Interventions: Radical cystectomy

Main outcome measures: Time to RC and the effects of delay in RC on cancer-specific survival (CSS) and overall survival (OS).

Results: A cut-off value for time to RC on pathologic upstaging in receiver operating characteristic curve analyses was found to be 40.5 days. There were 68 patients in group 1 (<= 40.5 days) and 77 patients in group 2 (>40.5 days) according to waiting time. Postoperative creatinine at third month after RC, pathological stage and surgical margin positivity was higher in group 2 than group 1 (P=.003, P=.018, P=.003). OS was 61.7 +/- 6.2 months and 43.1 +/- 5.8 months; CSS was 70.8 +/- 6.4 months and 57 +/- 6.9 months in group 1 and group 2 respectively (P=.013, P=.044).

Conclusion: Prolonged surgical wait times resulted in worse overall survival. The suggested optimum waiting time from transurethral bladder tumor resection to radical cystectomy was <6 weeks (40.5 days).

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Author Keywords

Anxiety and depression associated with a positive prostate biopsy result: A comperative, prospective cohort study

Sefik, E (Sefik, Ertugrul) [1] ; Gunlusoy, B (Gunlusoy, Bulent) [1] ; Eker, A (Eker, Anil) [1] ; Celik, S (Celik, Serdar) [1] ; Ceylan, Y (Ceylan, Yasin) [1] ; Koskderelioglu, A (Koskderelioglu, Asli) [2] ; Basmaci, I (Basmaci, Ismail) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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Prostate-Specific Antigen Biopsy Anxiety Depression

Volume

Issue

Page

993-1005

DOI

10.1590/S1677-5538.IBJU.2019.0719

Published

NOV-DEC 2020

Indexed

2020-09-18

Document Type

Article

Abstract

Purpose: To investigate the course of anxiety and depression before and after transrectal ultrasound-guided prostate biopsy (TRUS-Bx) and in the postoperative 1st month when the histopathological biopsy result was obtained.

Methods: In between June 2017- January 2019, 204 patients who underwent TRUS-Bx and completed the questionnaires assessing anxiety and depression were included in the study. Questionnaires were completed immediately before the biopsy, immediately after the biopsy and at the end of the first month when the histopathological biopsy results were given. State-Trait Anxiety Inventory (STAI), Hospital Anxiety and Depression Scale (HAD S) and perceived stress scale (PSS) forms were used to assess anxiety and depression. After the histopathological examination patients were divided into two groups as patients without cancer (Group 1) and with cancer (Group 2). Data was compared between the groups.

Results: PSA level was negatively correlated with STAI TX-1 scores of the patients immediately after TRUS-Bx, whereas it was positively correlated with STAI TX-1 and TX-2 30 days after the TRUS-Bx. PSA level was positively correlated with HADS-A and HADS-D scores immediately before and 30 days after TRUS-Bx. Biopsy results showed a significant difference in 30 day post-biopsy related data. STAI TX-1, STAI TX-2, HADS-A, HADS-D and PSS scores were higher in Group 2 compared with Group 1.

Conclusions: Pre-biopsy anxiety disappeared after bx, but there was a significant increase in anxiety and depression in patients after the diagnosis of malignancy. Patients were seriously concerned about the diagnosis of prostate cancer.

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Author Keywords

External validation and comparison of current scoring systems in retrograde intrarenal surgery: Multi-institutional study with 949 patients

Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Karakoyunlu, AN (Karakoyunlu, Ahmet Nihat) [2] ; Koras, O (Koras, Omer) [3] ; Celik, S (Celik, Serdar) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Cakici, MC (Cakici, Mehmet Caglar) [4] ; Degirmenci, T (Degirmenci, Tansu) [1] ; Imamoglu, MA (Imamoglu, Muhammed Abdurrahim) [2]

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INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Volume

Issue

DOI

10.1111/ijcp.14097

Article Number

e14097

Published

JUN 2021

Early Access

FEB 2021

Indexed

2021-03-14

Document Type

Article

Jump to

Abstract

Objectives To externally validate and compare Resorlu-Unsal stone score (RUSS), modified Seoul National University Renal Stone Complexity Score(S-ReSC), Ito's nomogram, and Retrograde Intra-Renal Surgery (R.I.R.S.) scoring systems for predicting capabilities of both the stone-free status and complications in a multi-institutional study.

Materials and Methods We performed a retrospective analysis of 949 patients who underwent flexible ureterorenoscopy (f-URS) and laser lithotripsy for renal stones in two institutions between March-2015 and June-2020. The RUSS, modified S-ReSC, Ito's nomogram, and R.I.R.S. scores were calculated for each patient by the same surgeon on imaging methods. Results were compared for their predictive capability of stone-free status and complications.

Results Of 949 patients 603 were male and 346 were female with a mean age of 47.2 +/- 14.3 (range 2-84 years). Mean stone burden was 102.6 +/- 42.2 (48-270 mm(2)). All nomograms predicted stone-free status (Area Under Curve (AUC) were 0.689, 0.657, 0.303, and 0.690, respectively). All four scoring systems predicted complications with AUC values of 0.689, 0.646, 0.286, and 0.664 for RUSS, modified S-ReSC, Ito's nomogram, and R.I.R.S., respectively. Although all scoring systems were able to predict complications only Ito's nomogram was able to predict Clavien >= 2 complications.

Conclusion All four scoring systems (RUSS, modified S-ReSC, Ito's nomogram, and R.I.R.S.) could predict stone-free status after f-URS, however, the AUC values are not satisfactory in our large patient cohort. Although these scoring systems were not developed for predicting post-operative complications, they were associated with complications in our study. However, these four scoring systems have some significant limitations. The ideal scoring system is yet to be developed.

The potential role of neutrophil to lymphocyte ratio in predicting prostate cancer in patients who underwent transrectal ultrasonography guided biopsy

Basmaci, I (Basmaci, Ismail) [1] ; Bozkurt, IH (Bozkurt, Ibrahim H.) [1] ; Aydogdu, O (Aydogdu, Ozgu) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Celik, S (Celik, Serdar) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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Neutrophil lymphocyte ratio prostate cancer TRUS bx

Volume

Issue

Page

93-97

Published

MAR 2022

Indexed

2022-03-24

Document Type

Article

Abstract

Objective: To investigate the relation of neutrophil lymphocyte ratio (NLR) with the diagnosis of prostate cancer (PCa) in patients who underwent transrectal ultrasonography guided biopsy (TRUS-bx)

Design: Retrospective study

Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey

Subjects: This retrospective analysis included data from 172 consecutive patients who underwent TRUS-bx.

Interventions: Transrectal ultrasonography guided biopsy

Main outcome measures: The correlation of pre-biopsy NLR and finding PCa in TRUS-bx

Results: Group 1 was composed of 115 patients in whom pathology was reported benign, and group 2 included 57 patients in whom pathology was reported as PCa. There was no statistically significant difference in NLR between the benign disease subgroups. Group 2 was divided into three subgroups according to Gleason score and total prostate specific antigen (PSA). Mean NLR was not significantly different between these subgroups. A receiver operating characteristic curve analysis was used to calculate a cut-off value for NLR and the threshold provided by the analysis was 2.23. We identified 89 patients (51.7%) with a high NLR (>= 2.23) and 83 patients (48.3%) with a low NLR (<2.23). A high NLR was significantly associated with finding PCa in TRUSbx (P=0.006), older age (P=0.038), total PSA >10 (P=0.002), but not with prostate volume, benign disease subgroups or Gleason score (Gleason score=6 vs. Gleason score>6).

Conclusions: NLR may be used to predict potential PCa in patients who underwent TRUS bx.

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Author Keywords

The Histopathologic Correlation of Bosniak 3 Cyst Subclassification

Sefik, E (Sefik, Ertugrul) ; Bozkurt, IH (Bozkurt, Ibrahim Hall) ; Adibelli, ZH (Adibelli, Zehra Hilal) ; Aydin, ME (Aydin, Mehmet Erhan) ; Celik, S (Celik, Serdar) ; Oguzdogan, GY (Oguzdogan, Gulsen Yucel) ; Basmaci, I (Basmaci, Ismail) ; Gorgel, SN (Gorgel, Sacit Nuri) ; Vardar, E (Vardar, Enver) ; Gunlusoy, B (Gunlusoy, Bulent) ;

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Source

UROLOGY

Volume

129

Page

126-131

DOI

10.1016/j.urology.2019.04.016

Published

JUL 2019

Indexed

2019-08-02

Document Type

Article

Abstract

OBJECTIVE To evaluate the histopathologic correlation of recently described subclassification of Bosniak category 3 cysts (3s and 3n).

MATERIALS AND METHODS A total of 106 patients who underwent partial/radical nephrectomy due to a complex renal cyst (>= Bosniak 3) were retrospectively reviewed. All the scans of the patients were reevaluated by 2 experienced uroradiologists. Bosniak 3 cysts were reclassified as 3n (nodularity on the cyst wall/septae) and 3s (septated cysts without nodularity) as described in a recently published paper. Group 1 consisted of patients with Bosniak 3s, Group 2 consisted of patients with Bosniak 3n, and Group 3 consisted of patients with Bosniak 4 cysts. Three groups were compared according to patients' characteristics, radiological findings, histopathologic results, and survival outcomes.

RESULTS There were 52 patients in Bosniak 3 group and 54 patients in Bosniak 4 group. Mean follow-up was 35.3 months. Among Bosniak 3 cysts, 37 lesions were classified in 3s and 15 were classified in 3n. Malignancy was higher in 3n group than 3s (86.7% vs 54.1%, P= .026). Lesion size was significantly lower for malignant cysts compared to benign ones in the patients with Bosniak 3 lesions (44.2 +/- 27.5 vs 80 +/- 55.9 P= .005). In the subgroups, malignant lesions were significantly smaller than benign lesions in 3s group similar to general Bosniak 3 group. Most of the Bosniak 3 lesions were organ confined and low grade.

Keywords

Keywords Plus

COMPLEX RENAL CYSTS CLASSIFICATION OUTCO MES MASSES

The significance of preoperative estimated glomerular filtration rate on survival outcomes in patients who underwent radical cystectomy and non-continent urinary diversion

Sefik, E (Sefik, Ertugrul) [1] ; Celik, S (Celik, Serdar) [1] ; Gunlusoy, B (Gunlusoy, Bulent) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Bozkurt, IH (Bozkurt, Ibrahim H.) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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Urinary Bladder Neoplasms Cystectomy Urinary Diversion

Volume

Issue

Page

566-574

DOI

10.1590/S1677-5538.IBJU.2019.0205

Published

JUL-AUG 2020

Indexed

2020-05-18

Document Type

Article

Abstract

Purpose: To evaluate the influence of preoperative renal function on survival outcomes in patients who underwent radical cystectomy (RC) with non-continent urinary diversion (UD).

Materials and Methods: A total of 132 patients with bladder cancer who underwent RC with non-continent UD due to urothelial carcinoma from January 2006 to March 2017 at our tertiary referral center were retrospectively evaluated. Patients were divided into 2 groups as those with estimated glomerular filtration rate (eGFR) <60mL/min/1.73 m2 and >= 60mL/min/1.73 m2 according to preoperative eGFR levels. Patients' characteristics, preoperative clinical data, operative data, pathologic data, oncologic data and complications were compared between the groups.

Results: The mean age was 64.5 +/- 8.7 (range: 32 - 83) years and the median follow-up was 30.9 +/- 31.7 (range: 1-113) months. There were 46 patients in Group 1 and 86 patients in Group 2. There was no difference in cancer-specific mortality (45.6% for group 1 and 30.2% for group 2, p=0.078) and survival (56.8 +/- 8.3 months for group 1 and 70.5 +/- 5.9 months for group 2, p=0.087) between the groups. Overall mortality was higher (63% for group 1 and 40.7% for group 2, p=0.014) and overall survival (43.6 +/- 6.9 months for group 1 and 62.2 +/- 5.8 months for group 2, p=0.03) was lower in Group 1 compared to Group 2.

Conclusions: Overall mortality was higher and overall survival was lower in patients with preoperative eGFR <60mL/s. More patients had preoperative hydronephrosis with eGFR<60mL/s.

Keywords

Author Keywords

Retrospective Analysis of the Factors Affecting Intraoperative and Immediate Postoperative Complications of Retrograde Intrarenal Surgery Classified by the Clavien and Satava Grading Systems

Koras, O (Koras, Omer) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [2] ; Karakoyunlu, AN (Karakoyunlu, Ahmet Nihat) [3] ; Celik, S (Celik, Serdar) [2] ; Sefik, E (Sefik, Ertugrul) [2] ; Yarimoglu, S (Yarimoglu, Serkan) [2] ; Polat, S (Polat, Salih) [4] ; Sahan, M (Sahan, Murat) [2] ; Degirmenci, T (Degirmenci, Tansu) [2]

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JOURNAL OF ENDOUROLOGY

Volume

Issue

Page

1764-1772

DOI

10.1089/end.2021.0238

Published

DEC 2021

Indexed

2022-02-20

Document Type

Article

Jump to

Abstract

Background: To classify intraoperative and postoperative complications using the modified Clavien classification system (MCCS) and modified Satava classification system (SCS) and to evaluate the parameters associated with complications in patients undergoing retrograde intrarenal surgery (RIRS) for renal and proximal ureteral stones. Materials and Methods: We performed a retrospective analysis of 949 patients who underwent RIRS for renal stones and proximal ureteral stones at two institutions between March 2015 and June 2020. Intraoperative complications were assessed using the SCS, and postoperative complications were graded according to the MCCS. Univariate and multivariate analyses were undertaken to determine predictive factors affecting complication rates. Results: The median stone size was determined as 13mm (range 10-20mm). The stone-free rate was 83.6% after the first intervention. Reprocedure was applied to 89 of the patients with residual stones and the final stone-free rate was 94.4% after reprocedure. According to SCS, the number of intraoperative events and complication incidences was 153 (16.1%). MCCS revealed postoperative complications in 121 (12.8%) patients. Major complications were observed in 18 (1.9%) patients. The rate of complications was higher in patients with renal anomalies (9.9% vs 3.4%, p=0.001). Stone location, stone size, stone burden, stone number, stone density, and residual fragments were determined to be associated with the development of complications (p<0.001, p<0.001, p<0.001, p<0.001, p=0.002, and p<0.001, respectively). In addition, the multivariate analysis revealed that only the presence of residual fragments was a significant predictor of complication development for the patients with Grade 3 complications according to MCCS (p=0.032). However, significant predictors were stone burden (p<0.001), stone density (p=0.002), and fluoroscopy time (p<0.001) for those with Grade >= 2b complications according to SCS. Conclusion: This study showed that abnormal kidney anatomy, operation time, stone burden, and residual fragments were reliable predictors of complication development during and after RIRS. Appropriate preoperative management should be planned according to these predictors to prevent intraoperative and postoperative complications.

Keywords

Author Keywords

retrograde intrarenal surgery complication Clavien Satava renal stone

Predictive Value of Additional Clinical and Radiological Parameters for Discrimination of Malignancy in Bosniak 3 Cysts

Sefik, E (Sefik, Ertugrul) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Oguzdogan, GY (Oguzdogan, Gulsen Yucel) [2] ; Celik, S (celik, Serdar) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Gorgel, SN (Gorgel, Sacit Nuri) [3] ; Aydin, E (Aydin, Erhan) [1] ; Adibelli, ZH (Adibelli, Zehra Hilal) [2] ; Vardar, E (Vardar, Enver) [4] ; Gunlusoy, B (Gunlusoy, Bulent) [1] ;

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Source

UROLOGIA INTERNATIONALIS

Volume

105

Issue

1-2

Page

118-123

DOI

10.1159/000510243

Published

JAN 2021

Early Access

NOV 2020

Indexed

2020-12-17

Document Type

Article

Abstract

Introduction: Almost half of the cystic renal lesions are still overdiagnosed and overtreated. New clinical and radiological parameters are needed to distinguish the malignant Bosniak 3 lesions from the benign ones. We aimed to evaluate the clinical and radiological parameters that may be related to malignancy risk for Bosniak category 3 renal cysts. Materials and Methods: Patients who underwent surgical resection of a histopathologically confirmed Bosniak 3 renal cyst between March 2007 and September 2019 were evaluated. Two experienced uro-radiologists have reevaluated the last preoperative computed tomography and/or MRI images of the patients and reclassified the lesions according to the Bosniak classification. They also reported cystic features such as nodularity, septation, focal thickening, enhancement, and calcification. Clinical, pathological, and oncological outcomes were recorded. Then patients were divided into 2 groups as Group 1 (benign pathology) and Group 2 (malignant pathology) according to final histopathological report. Results: A total of 79 patients were included in this study. Mean follow-up time was 47 +/- 34 months. There were 30 patients in Group 1 and 49 patients in Group 2. Hypertension (p = 0.001) and smoking history (p = 0.008) were more common in malignant group. Among the radiological findings, lower tumor diameter (p = 0.024), presence of cyst wall enhancement (p = 0.025), presence of nodularity (p = 0.002), and presence of focal thickening (p = 0.031) were found to be statistically significant for malignancy. Most of the tumors were at pathological T1 stage and Fuhrmann Grade 1-2. Only nodularity was found to be independent predictive factor for malignancy in multivariate analysis. Conclusion: Clinical factors including hypertension and smoking, radiological factors including lower lesion size, cyst wall enhancement, nodularity, and focal thickening were predictors for malignancy of Bosniak 3 cysts.

Keywords

Author Keywords

Bosniak classifi cation Renal cyst Kidney cancer Malignancy

Factors affecting biochemical recurrence of prostate cancer after radical prostatectomy in patients with positive and negative surgical margin

Celik, S (Celik, Serdar) [1] , [2] ; Eker, A (Eker, Anil) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Bolat, D (Bolat, Deniz) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Degirmenci, T (Degirmenci, Tansu) [1] ; Günlüsoy, B (Gunlusoy, Bulent) [1]

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PROSTATE INTERNATIONAL

Volume

Issue

Page

178-184

DOI

10.1016/j.prnil.2020.08.003

Published

DEC 2020

Indexed

2021-01-11

Document Type

Article

Abstract

Purpose: To investigate the clinical and pathological predictive factors affecting biochemical recurrence (BCR) after radical prostatectomy (RP) in patients with positive and negative surgical margin (SM).

Methods: Patients who underwent RP were retrospectively reviewed for the study. Demographic, clinical, pathological and oncological data were evaluated. All data were compared between patients with positive SM and negative SM to detect factors associated with SM status. Later, patients were divided into two groups as BCR-negative and BCR-positive groups. Data were separately compared between BCR groups for all patients, SM-negative and SM-positive patients, respectively.

Results: A total of 254 patients with a mean age of 63.5 years and the mean prostate-specific antigen of 10.9 ng/ml were evaluated in the study. SM positivity was found to be an independent prognostic factor for BCR (p = 0.013, Odds Ratio (OR): 0.267, 95% Confidence Interval (CI): 0.094-0.755). In SM-positive patients, biopsy Gleason Score and International Society of Urological Pathology grade were found to be independent predictive factors for BCR (p < 0.05). However, only tumor to SM distance (TSMD) was found to be an independent risk factor for BCR (p = 0.024) in SM-negative patients. The predictive cutoff value of the TSMD was found to be 75 mm for BCR (100% sensitivity and 63.9% specificity) (AUC = 0.803, p = 0.024). Although all of 46 patients with >75 mm TSMD were recurrence free, 5 of 31 patients with <75 mm TSMD had BCR (p = 0.009; OR: 0.839 CI: 0.719-0.979).

Conclusion: High Gleason Score and International Society of Urological Pathology grade of biopsy were found to be associated with BCR in SM-positive patients. For SM-negative patients, only TSMD was found to be associated with BCR after RP. (C) 2020 Asian Pacific Prostate Society. Publishing by Elsevier B.V.

Keywords

Author Keywords

prostate cancer biochemical recurrence surgical margin positivity tumor to surgical margin distance (TSMD)

Effect of variant histology presence and squamous differentiation on oncological results and patient's survival after radical cystectomy

Sefik, E (Sefik, Ertugrul) [1] ; Celik, S (Celik, Serdar) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Yonguc, T (Yonguc, Tarik) [1] ; Gunlusoy, B (Gunlusoy, Bulent) [1]

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Source

ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA

Volume

Issue

Page

172-175

DOI

10.4081/aiua.2018.3.172

Published

2018

Indexed

2019-01-30

Document Type

Article

Abstract

Objective: To evaluate the effect of variant histology on pathological and survival findings in patients undergoing radical cystectomy due to muscle invasive bladder cancer.

Materials and methods: Data from 146 patients with radical cystectomy performed due to muscle-invasive urothelial carcinoma between January 2006 to November 2016 at our clinic were investigated. The preoperative and postoperative data of patients with variant histology were compared with nonvariant urothelial carcinoma patients. Then of patients with variant histology only those with squamous differentiation (SqD) were compared with nonvariant urothelial carcinoma patients in terms of preoperative, postoperative and survival data.

Results: Of the 146 patients, 23 had carcinoma with variant histology. Of these, 17 had SqD, 4 had glandular differentiation, 1 patient had plasmocytoid variant and 1 patient had sarcomatoid variant. In patients with variant histology, postoperative T stage and upstaging was higher, with no difference observed in terms of overall and cancer-specific survival compared with nonvariant urothelial cancer patients. SqD patients were observed to have higher postoperative T stage compared to nonvariant urothelial cancer patients, with no significant difference observed in terms of survival.

Conclusions: In cystectomy pathologies, patients with variant histology (especially SqD patients) were observed to have proportionally higher T stage compared to nonvariant urothelial carcinoma; however there were no significant differences for overall survival and cancer-specific survival.

Keywords

Author Keywords

Bladder cancer Radical cystectomy Squamous differentiation Variant histology Survival

Comparison of Guy's, STONE and CROES Scoring Systems for Predicting Percutaneous Nephrolithotomy Outcomes in Eldery Patients

Polat, S (Polat, Salih) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [2] ; Koras, O (Koras, Omer) [3] ; Sahan, M (Sahan, Murat) [2] ; Sefik, E (Sefik, Ertugrul) [2] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [2] ; Degirmenci, T (Degirmenci, Tansu) [2]

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JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN

Volume

Issue

Page

307-313

DOI

10.29271/jcpsp.2021.03.307

Published

MAR 2021

Indexed

2021-04-16

Document Type

Article

Abstract

Objective: To evaluate the efficacy and reliability of Guy's (GSS), S.T.O.N.E., and CROES scoring systems developed to predict percutaneous nephrolithotomy (PCNL) outcomes in aged patients.

Study Design: Descriptive study.

Place and Duration of Study: Department of Urology, Ministry of Health University Izmir Bozyaka Training and Research Hospital and Department of Urology, Faculty of Medicine, Amasya University, Turkey, from April 2011 to January 2020.

Methodology: Patients aged 65 years and over, who underwent PCNL for kidney stones, were retrospectively analysed. The patients' clinical and perioperative characteristics and the radiological features of the stones were obtained from the prospectively recorded data. GSS, S.T.O.N.E. and CROES nephrolithometry scores were calculated for each patient and their relation with stone-free status, complications, and perioperative findings were analysed.

Results: A total of 147 patients were included in the study. Stone-free status was achieved in 76.0% of the patients, and complications developed in 27.2%. All three scoring systems were associated with stone-free status and complication development. GSS (OR=0.213,p=0.005) and S.T.O. N.E. (OR=0.601, p=0.042) scores were detected as independent markers for stone-free status, while the CROES score was not an independent marker. Only diabetes mellitus was determined to be an independent marker for the development of complications (OR=2.375, p=0.045).

Conclusion: PCNL is an effective and safe treatment method with high stone-free rates in the treatment of large renal stones, but care should be taken in terms of cardiac risks. The results of this study showed that GSS and S.T.O.N.E. scoring systems were effective and reliable in predicting stone-free status.

Keywords

Author Keywords

Aged Nephrolithotomy Percutaneous Comorbidity Stone-free status Treatment outcome Complications Scoring systems

A novel method for prediction of stone composition: the average and difference of Hounsfield units and their cut-off values

Celik, S (Celik, Serdar) [1] , [2] ; Sefik, E (Sefik, Ertugrul) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Aydin, ME (Aydin, Mehmet Erhan) [1] ; Yonguc, T (Yonguc, Tarik) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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Source

INTERNATIONAL UROLOGY AND NEPHROLOGY

Volume

Issue

Page

1397-1405

DOI

10.1007/s11255-018-1929-3

Published

AUG 2018

Indexed

2018-12-28

Document Type

Article

Abstract

The purpose of the study was to investigate the predictive value of stone measurements by including a novel method on non-contrast computed tomography (NCCT) images for stone composition.

We retrospectively evaluated patients who had stone analysis, NCCT images, and underwent percutaneous nephrolithotomy between 2013 and 2016. Patient characteristics, stone measurements on NCCT images, and stone analysis results were evaluated. Hounsfield unit (HU) values (maximum (HUmax), minimum (HUmin), and average (HUave) of HU values) were investigated on NCCT images. HUdiff was calculated as the difference between the HUmax and the HUmin values. Patients were divided into seven stone groups and data were compared. Then patients were separately divided into two groups according to mineral complexity (mono-mineral and multi-mineral groups) and calcium-based (calcium and other stone groups) evaluation.

In the study, 115 patients were evaluated. Age, gender, HUmin, HUmax, and HUave were significantly different between the stone groups. HUdiff and HUave were found to be 341.5 HU (AUC = 0.719, p = 0.017) and 1051.5 HU (AUC = 0.701, p = 0.029) as cut-off, respectively. Seventy of 72 > 341.5 HUdiff patients and 64 of 67 > 1051.5 HUave patients had multi-mineral stones (p = 0.001, OR 9.26, and p = 0.028, OR 4.27), respectively. In multivariate analysis, > 341.5 HUdiff rate was significantly higher in multi-mineral and calcium stone groups; HUave was also significantly higher in the calcium stone group.

HUdiff and HUave were significant predictors of mineral complexity. HUdiff of < 341.5 HU showed 81.8% sensitivity and 67.2% specificity for identification of mono-mineral stones.

Keywords

Author Keywords

Non-contrast computed tomography (NCCT)Percutaneous nephrolithotomy (PNL)Prediction of

Effects of Lymphovascular Invasion on Overall and Cancer-specific Survival after Radical Cystectomy in Patients with Bladder Cancer

Cesur, G (Cesur, Gurkan) [1] ; Çelik, S (Celik, Serdar) [1] ; Yesilova, A (Yesilova, Arda) [1] ; Sefik, E (Sefik, Ertugrul) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [1] ; Günlüsoy, B (Gunlusoy, Bulent) [1] ; Degirmenci, T (Degirmenci, Tansu) [1]

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Bladder cancer lymphovascular invasion lymph node involvement overall survival cancer-specific

Volume

Issue

Page

174-178

DOI

10.4274/uob.galenos.2020.1774

Published

SEP 2021

Indexed

2021-09-08

Document Type

Article

Jump to

Abstract

Objective: We aimed to investigate the effects of lymphovascular invasion (LVI) on survival rate, as well as the relationship of this parameter with lymph node (LN) involvement and other prognostic factors, in patients undergoing radical cystectomy (RC) for bladder cancer.

Materials and Methods: Patients who underwent RC in our clinic for muscle invasive bladder cancer (MIBC) or high-risk non-muscle invasive bladder cancer (NMIBC) between 2006 and 2019 were retrospectively reviewed. Patients were divided into four groups: LVI (-) and LN (-) patients were in group 1, LVI (+) and LN (-) patients were in group 2, LVI (-) and LN (+) patients were in group 3, and LVI (+) and LN (+) patients were in group 4. All data were compared among the groups.

Results: A total of 177 patients with a mean age of 64.4 years and mean follow-up time of 30.2 months were evaluated in this study. The mean overall survival (OS) and cancer-specific survival (CSS) of the patients were 56.6 +/- 4.2 and 68.9 +/- 4.5 months, respectively. When factors affecting survival rates were analyzed, LN positivity was not a significant factor influencing the OS (p=0.570) and CSS (p=0.533) of the patients. However, LVI [p=0.002, hazard ratio (HR)=0.402] and surgical margin (SM) positivity (p=0.001, HR=0.321) were significant factors influencing OS. SM positivity (p=0.003, HR=0.314), LVI (p=0.011, HR=0.416), and adjuvant chemotherapy (ACT) (p=0.009, HR=0.460) were also found to be independent factors affecting CSS. ACT was higher in group 3 than in other groups, and overall and cancer-specific mortality rates were lower in group 1 than in other groups. OS and CSS in group 2 (15.3 +/- 2.9 and 21.2 +/- 4.6 months, respectively) and group 4 (21.5 +/- 7.2 and 24.5 +/- 8.1 months, respectively) were lower than those in other groups (p<0.001).

Conclusion: SM positivity and LVI are independent factors affecting OS and CSS. ACT, especially in group 3, could increase CSS. OS and CSS were lower in patients with LVI than in those without.

Keywords

Author Keywords

External validation and comparison of the scoring systems (STONE, GUY, CROES, S-ReSC) for predicting percutaneous nephrolithotomy outcomes for staghorn stones: A single center experience with 160 cases

Yarimoglu, S (Yarimoglu, Serkan) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [2] ; Aydogdu, O (Aydogdu, Ozgu) [2] ; Yonguc, T (Yonguc, Tarik) [2] ; Sefik, E (Sefik, Ertugrul) [2] ; Topcu, YK (Topcu, Yusuf Kadir) [2] ; Degirmenci, T (Degirmenci, Tansu) [2]

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Source

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Volume

Issue

Page

516-522

DOI

10.1016/j.kjms.2017.06.017

Published

OCT 2017

Indexed

2017-11-23

Document Type

Article

Abstract

The aim of this study was validation and comparison of stone scoring systems (S.T.O.N.E, GUY, CROES, S-ReSC) used to predict postoperative stone-free status and complications after percutaneous nephrolithotomy (PCNL) for staghorn stones. A total of 160 patients who had staghorn renal stones and underwent PCNL between January 2012 and August 2015 were included in the current retrospective study. Guy, S.T.O.N.E., S-ReSC (Seoul National University Renal Stone Complexity) and CROES (Clinical Research Office of the Endourological Society) nephrolithometry scores were calculated for each patient, and their potential association with stone-free status, operative and fluoroscopy time, and length of hospital stay (LOS) were evaluated. Postoperative complications were graded according to the modified Clavien classification, and the correlation of scoring systems with postoperative complications was also investigated. The mean CROES, S.T.O.N.E, Guy and S-ReSC scores were 143.5 +/- 33.6, 9.7 +/- 1.6, 3.5 +/- 0.5 and 6.2 +/- 2.0 respectively. The overall stone-free rate was 59%. All scoring systems were significantly correlated with stone-free status in univariate analysis. However, Guy and S-ReSC scores were the only significant independent predictor in multivariate analysis. And all four nomograms failed to predict complication rates. Current study demonstrated that Guy and S-ReSC scoring systems could effectively predict postoperative stone-free status for staghorn stones. However all four scoring systems failed to predict complication rates. Copyright (C) 2017, Kaohsiung Medical University.

Keywords

Author Keywords

Percutaneous nephrolithotomy Guy scoring system CROES scoring system STONE scoring system

Sexual Function in Male Patients with Metabolic Syndrome and Effective Parameters on Erectile Dysfunction

Gorgel, SN (Gorgel, Sacit Nuri) [1] ; Gorgel, A (Gorgel, Ahmet) [2] ; Sefik, E (Sefik, Ertugrul) [3]

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Obesity Erectile Dysfunction Metabolic Syndrome X S moking

Volume

Issue

Page

56-61

DOI

10.1590/S1677-5538.IBJU.2014.01.08

Published

JAN-FEB 2014

Indexed

2014-06-04

Document Type

Article

Abstract

Purpose: We aimed to investigate the relationship between metabolic syndrome and sexual function and effective parameters on erectile dysfunction (ED).

Materials and Methods: A total of 1300 individuals were included in this study between January 2009 and July 2012. All of individuals were asked to fill in an International Index for Erectile Function (IIEF) questionnaire. The presence of metabolic syndrome was determined when any three or more of the five risk factors were present according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP)-III. Obese individuals were divided into six groups according to modified World Health Organization (WHO) definition. Effective parameters on erectile dysfunction were investigated in individuals with metabolic syndrome.

Results: Metabolic syndrome was detected in 455 individuals (35%). Mean domain scores of BEEF for all parameters were higher in individuals without metabolic syndrome than individuals with metabolic syndrome (p < 0.05). Mean domain scores of IMF were lower in individuals with class 3 obesity than individuals with other obese groups (p < 0.05) for erectile dysfunction. There was statistical difference in terms of mean score of IIEF-Erectile function between smoking and nonsmoking groups (p < 0.05). Seventy percent of individuals with metabolic syndrome and 45% of individuals without metabolic syndrome had ED (p < 0.001). Logistic regression analysis revealed that waist circumference (WC) was the most important criteria for ED (p < 0.05).

Conclusions: Metabolic syndrome, smoking and obesity seem to be potential risk factors for ED. We recommend individuals with metabolic syndrome, smoking and obesity should be questioned about ED.

Keywords

Author Keywords

Influence of preoperative hydronephrosis and ureteral orifice involvement in the survival of patients undergoing radical cystectomy: A retrospective comparative study

Sefik, E (Sefik, Ertugrul) [1] ; Çelik, S (Celik, Serdar) [1] ; Günlüsoy, B (Gunlusoy, Bulent) [1] ; Basmaci, I (Basmaci, Ismail) [1] ; Yarimoglu, S (Yarimoglu, Serkan) [1] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [1] ; Degirmenci, T (Degirmenci, Tansu) [1] ; Dinçel, C (Dincel, Cetin) [1]

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Source

TURKISH JOURNAL OF UROLOGY

Volume

Page

49-55

Supplement

DOI

10.5152/tud.2019.09515

Published

NOV 2019

Indexed

2019-12-30

Document Type

Article

Abstract

Objective: The aim of the present study was to evaluate the influence of preoperative hydronephrosis and ureteral orifice involvement (UOI) on survival of patients undergoing radical cystectomy ( RC) for bladder cancer (BC).

Material and methods: A total of 162 patients with BC underwent RC between January 2006 and March 2017. Patients were divided into two groups for both presences of preoperative hydronephrosis and orifice involvement at final pathology. Additionally, tumors with orifice involvement were subgrouped histopathologically after RC as those with only UOI and those with invasive to the ureter with an additional concurrent site at final pathology.

Results: Preoperative hydronephrosis was detected in 57 patients. Preoperative and postoperative creatinine on month 3 were higher in the preoperative hydronephrosis (+) group (p<0.001). In addition, postoperative T stage, surgical margin positivity, invasion of urethra, and pathological upstaging were higher in this group. Cancer-specific survival (CSS) and overall survival (OS) were better in the hydronephrosis (-) group than in the hydronephrosis (+) group (p=0.001 and p=0.001, respectively). Preoperative hydronephrosis was found to be an independent factor in pathological upstaging. Patients were divided into two groups according to the presence of UOI. Group 1 consisted of patients without UOI, and group 2 with UOI. Preoperative hydronephrosis, hydronephrosis grade, and T stage were statistically higher in tumors with UOI. Moreover, CSS and OS were lower in group 2 than in group 1.

Conclusion: Preoperative hydronephrosis and UOI are predicting factors on survival of patients undergoing RC for BC. Preoperative hydronephrosis was found to be an independent factor in pathological upstaging.

Keywords

Author Keywords

Orifice involvement preoperative hydronephrosis radical cystectomy survival

Evaluation of the Relationship between Pathology Results and Pain Scores in Patients Who Underwent Transrectal Ultrasound-Guided Prostate

Bolat, D (Bolat, Deniz) [1] ; Aydin, ME (Aydin, Mehmet Erhan) [1] ; Günlüsoy, B (Gunlusoy, Bulent) [1] ; Degirmenci, T (Degirmenci, Tansu) [1] ; Topçu, YK (Topcu, Yusuf Kadir) [1] ; Küçüktürkmen, I (Kucukturkmen, Ibrahim) [1] ; Ceylan, Y (Ceylan, Yasin) [1] ; Sefik, E (Sefik, Ertugrul) [1]

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Source

Prostate-specific antigen biopsy pain prostate

Volume

Issue

Page

86-89

DOI

10.4274/uob.666

Published

SEP 2016

Indexed

2017-08-22

Document Type

Article

Abstract

Objectives: In this study, we assessed the relationship between pain scores and the pathology results of patients who underwent transrectal ultrasound-guided prostate biopsy (TRUS-PBx).

Materials and Methods: A total of 198 patients who underwent prostate biopsy between October 2014 and April 2015 due to abnormal digital rectal examination findings and/or high prostate-specific antigen (PSA) levels (>= 2.5 ng/dL) were included in this study. Before the biopsy procedure, all patients underwent finger-guided transperineal periprostatic block with 10 mL of 2% prilocaine. A 10-point linear visual analogue scale (VAS) was used to assess the pain arising from probe insertion (VAS-1) and prostate sampling (VAS-2). After receiving the pathology results, the patients were grouped according to the presence of prostate cancer: Group 1: patients without prostate cancer and Group 2: patients with prostate cancer.

Results: The mean age of the patients was 64 +/- 7.3 (43-83) years, and the mean PSA value was 12.5 +/- 18.3 (0.6-142) ng/dL. Prostate cancer detection rate was 22.7%. The mean VAS-1 score in Group 1 and group 2 was 1.6 +/- 1.8 and 2.0 +/- 2.5, respectively (p=0.209). The mean VAS-2 score in Group 1 and Group 2 was 2.5 +/- 2.4 and 2.6 +/- 2.6, respectively (p=0,725).

Conclusion: The pain felt during TRUS-PBx is not related with the presence of prostate cancer on biopsy pathology.

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Effects of the transobturator tape procedure on overactive bladder symptoms and quality of life: a prospective study

Polat, S (Polat, Salih) [1] ; Yonguc, T (Yonguc, Tarik) [2] ; Yarimoglu, S (Yarimoglu, Serkan) [2] ; Bozkurt, IH (Bozkurt, Ibrahim Halil) [2] ; Sefik, E (Sefik, Ertugrul) [2] ; Degirmenci, T (Degirmenci, Tansu) [2]

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