1993 Ege Üniversitesi Tıp Fakültesi, İZMİR
1993 - 1998 Ege Üniversitesi Tıp Fakültesi Nöroloji ABD Uzmanlık Eğitimi, İZMİR
1999 - 2011 Saruhanlı Devlet Hastanesi, MANİSA
2011 - Tınaztepe Buca Hastanesi, İZMİR
2019- Tınaztepe Galen Bayraklı Hastanesi, İZMİR
Uluslarası Yayınlar :
· Frovatriptan vs rizatriptan in the treatment of migraine attacks. Poster presentation. 15 th Congress of The Eurepean Federation of Neurological Societies. Egemen Vardarlı. Budapest, 2011.
· Prophylactic treatment of choronic tension-type headache; amitriptyline vs escitalopram. Poster presentation. 13 th Congress of The Eurepean Federation of Neurological Societies. Egemen Vardarlı. Florence, 2009.
· Diagnostıc importance of awakening from sleep at nights with discomfort in the hands for carpal tunnel syndrome. Poster presentation. 10 th Congress of The Eurepean Federation of Neurological Societies. Egemen Vardarlı. Glasgow, 2006
· Cerebrovascular Diseases. (1998); 8: 278-288. Ege stroke registry. E. Kumral, B. Özkaya, A. Sağduyu, H. Şirin, Egemen Vardarlı, M. Pehlivan.
Ulusal Yayınlar :
· Türk Nöroloji Dergisi Kongre Özel Sayısı. Restless legs sendromunda gabapentin kullanımı. Sayfa: 158. (2002)
· Parkinson Hastalığı ve Hareket Bozuklukları Dergisi. Tremorun nadir bir formu, periferik nöropati ve tremor. Cilt: 1, Sayı 1, sayfa: 56-59. (1998) Egemen Vardarlı, Ö. Akyürekli, Y. Alper, B. Uludağ.
· Türk Nöroloji Dergisi. Çocukluk çağı dirençli epilepsilerinde nöbeti tetikleyen faktörler. Cilt: 4 özel sayı, sayfa 75. (1998) Egemen Vardarlı, A. Gökçay, Ö. Ekmekçi, H. Karasoy, A. Ülkü.
· Çocukluk çağı direnli epilepsilerinde video EEG monitorizasyonunun önemi. Uzmanlık tezi. Egemen Vardarlı, A. Ülkü. (1998)
· Türk Nöroloji Dergisi. Subakut miyelo optik nöropati, olgu sunumu. Cilt: 4 sayı 3-4. (1998) Egemen Vardarlı, G. Gümüşdiş, F. Oksel, V. İnal, S. Tavus.
· Türk Nöroloji Dergisi. Kaudat nukleus enfarktına bağlı pür hemikore ve tedavisinde olanzapin kullanımı. Cilt: 3 kongre özel sayısı, sayfa 39. (2000) Egemen Vardarlı.
· Türk Nöroloji Dergisi. Ege inme veri tabanı. 2000 inme hastasının analizi. Cilt:3, sayı 1-2. sayfa: 3-13. (1997) E. Kumral, B. Özkaya, Egemen Vardarlı.
· Türk Nöroloji Dergisi. Lamotrijin; glossofaringeal nevralji tedavisinde yeni bir ilaç, olgu sunumu. Cilt: 2, sayı 3-4 sayfa: 128-130. (1996) Egemen Vardarlı, S. Bilgin, Z. Çolakoğlu, B. Uludağ.
· Türk Nöroloji Dergisi. Menkes Hastalığı. Olgu sunumu. Cilt: 2, Özel sayı, sayfa:73. (1996) A. Gökçay, Egemen Vardarlı, A. Ülkü.
· Türk Nöroloji Dergisi. İntradural yayılım gösteren idiopatik orbital enflamasyon. Olgu sunumu. Cilt: 1, Sayı 4, sayfa: 232-235. (1995) A. Özkaya, Egemen Vardarlı, Ö. Akyürekli.
· Nörolojik Bilimler Dergisi. Metanol entoksikasyonu. Cilt: 12, Sayı: 1-2, Sayfa: 173-175. (1995) Egemen Vardarlı, T. Tunçbay, Z. Çolakoğlu.
Kitap :
Bölüm yazarlığı. Klinik Romatoloji. Romatolojik patolojilerin tanısında EMG’nin yeri. Egemen Vardarlı. Sayfa: 189-192. (1999)
GÖREV ALDIĞI BÖLÜMLER
NÖROLOJİ
Factors affecting the optimal CPAP pressure level and a new prediction formula in patients with obstructive sleep apnea syndrome
Source
EURASIAN JOURNAL OF PULMONOLOGY
Volume
Issue
Page
DOI
Published
Indexed
Document Type
Abstract
BACKGROUND AND AIM: Continuous positive airway pressure (CPAP) treatment is routinely recommended for patients with Obstructive Sleep Apnea Syndrome (OSAS). This study aims to investigate the factors that affect the optimal CPAP pressure level in subjects with OSAS.
METHODS: The records of 100 subjects with OSAS who underwent successful manual titration for CPAP treatment were reviewed retrospectively. In addition to frequently researched variables such as age, Body Mass Index (BMI), Apnea-Hypopnea Index (AHI), and minimum oxygen saturation (SpO(2)) level, the effects of variables such as comorbidities, Rapid Eye Movement (REM) and/or position dependence, and type of abnormal respiratory events on optimal CPAP pressure level were analyzed. The descriptive values of the obtained data were calculated as mean +/- SD and median [Interquartile Range (IQR)]. The statistical significance level was set at p<0.05.
RESULTS: The mean age of the subjects was 49.17 +/- 10.4, and 81 of them were men. There was a positive relationship between optimal pressure and BMI, AHI, REM AHI, Non-Rapid Eye Movement Apnea-Hypopnea Index (NREM AHI), Supine AHI, and Non-supine AHI (p=0.001). A negative relationship was found between optimal pressure and minimum SpO(2) (p=0.001). Optimal pressure was higher in OSAS subjects without REM and position dependence than in those with position and REM dependence (p=0.001). Optimal pressure was significantly lower in subjects who used nasal masks than in those who used an oro-nasal mask (p=0.001). As a result, an optimal pressure prediction (Ppred) formula was developed: Ppred=9.366+0.117 BMI+0.043 AHI-0.062 Min SpO(2). While the mean optimal pressure (Popt) obtained by manual titration was 9.5 +/- 2.45 cmH(2)O, the mean pressure obtained by the new formula (Ppred) was 10.3 +/- 1.89 cmH(2)O (r=0.64, p<0.001).
CONCLUSIONS: In summary, the present study extensively examined the factors that affect optimal CPAP pressure, and a new prediction formula was developed. Also; "Can CPAP pressure prediction formulas be used in a pandemic?" the question has also been discussed.
Obstructive sleep apnea syndrome optimal CPAP pressure prediction formula
Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia
By
Vardarli, AT (Vardarli, Asli Tetik) ; Harman, E (Harman, Ece) ; Çetintas, VB (Cetintas, Vildan Bozok) ; Kayikçioglu, M (Kayikcioglu, Meral) ; Vardarli, E (Vardarli, Egemen) ; Zengi, A (Zengi, Ayhan) ; Küçükaslan, AS (Kucukaslan, Ali Sahin) ; Eroglu, Z (Eroglu, Zuhal)
(provided by Clarivate)
Source
ANATOLIAN JOURNAL OF CARDIOLOGY
Volume
Issue
Page
DOI
10.14744/AnatolJCardiol.2016.7142
Published
Indexed
Document Type
Abstract
Objective: The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms on lipid metabolism and diabetic dyslipidemia.
Methods: This case-control study included 217 patients with diabetic dyslipidemia and 212 healthy age-and gender-matched individuals. Genomic DNA isolation was performed from blood samples, and genotype analysis was performed using melting curve analysis on a LightCycler (R) 480 Instrument. The chi-square test was used to compare genotype distribution and allele frequencies between the groups.
Results: Significant associations were observed between LPL (rs320) (p<0.001), LIPC (rs2070895) (p<0.001), SCARB1 (rs5888) (p<0.001), LCAT (rs2292318) (p<0.001), CETP (rs708272) (p<0.001), ADIPOQ (rs1501299) (p=0.01), RETN (rs3745367) (p<0.001), and MNSOD (rs4880) (p<0.001) polymorphisms and diabetic dyslipidemia. However, no association was observed between PON1 (rs662) polymorphisms and diabetic dyslipidemia (p=0.611).
Conclusion: LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), and MNSOD (rs4880) polymorphisms play an important role in basic molecular metabolism in diabetic dyslipidemia. Therefore, these polymorphisms may be used as a predictive marker for diabetic dyslipidemia in high-risk patients.
Keywords
Author Keywords
diabetes mellitus dyslipidemia lipid metabolism genetic polymorphisms