PROF. DR. DENİZ SELÇUKİ
GÖREV ALDIĞI BÖLÜMLER
NÖROLOJİ
Additional contribution of phonophoresis and low-level laser therapy to exercise in the treatment of carpal tunnel syndrome: A clinical, electrophysiological, and ultrasonographic evaluation
By
Karaman, N (Karaman, Nazli) [1] , [4] ; Unlu, Z (Unlu, Zeliha) [2] ; Selçuki, D (Selcuki, Deniz) [3] ; Cerrahoglu, L (Cerrahoglu, Lale) [2]
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AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY
Volume
36
Issue
1
Page
29-37
DOI
10.14744/agri.2023.00878
Published
JAN 2024
Indexed
2024-04-09
Document Type
Article
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Abstract
Objectives: Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression syndrome. This study aims to evaluate the additive contribution of phonophoresis and low-level laser therapy (LLLT) to tendon and nerve gliding exercises electrophysiologically, ultrasonographically, and clinically in the treatment of moderate CTS. Methods: The sample consisted of 45 patients with moderate CTS, randomized into three groups. Group 1 received phonophoresis and exercise, Group 2 received LLLT and exercise, and Group 3 received exercise alone. Participants were evaluated electrophysiologically, clinically, and ultrasonographically before treatment and at the 6th and 12th weeks after the treatment. Results: An improvement was observed in clinical parameters (Boston Functional Status Scale, Boston Symptom Severity Scale, visual analog scale at rest, and visual analog scale during activity) for all groups at the 6th and 12th weeks after the treatment (p<0.05). An improvement was also noted in the ultrasonographic parameter (cross-sectional area) for all groups at the 12th week after the treatment (p=0.017). Conclusion: Phonophoresis and LLLT do not provide additional effects to exercise therapy. Exercise therapy alone may positively contribute to ultrasonographic and clinical outcomes in the treatment of moderate CTS.
Keywords
Author Keywords
Carpal tunnel syndrome electromyograph yexercise median neuropathy nerve compression
Evaluation of the visual system with visual evoked potential and optical coherence tomography in patients with idiopathic Parkinson's disease and with multiple system atrophy
By
Batum, M (Batum, Melike) [1] ; Ak, AK (Ak, Aysin Kisabay) [1] ; Ari, MS (Ari, Mehmet Semih) [1] ; Mayali, H (Mayali, Huseyin) [2] ; Kurt, E (Kurt, Emin) [2] ; Selçuki, D (Selcuki, Deniz) [1]
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Source
Volume
145
Issue
2
Page
99-112
DOI
10.1007/s10633-022-09887-7
Published
OCT 2022
Early Access
JUL 2022
Indexed
2022-08-01
Document Type
Article
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Abstract
Background In addition to motor findings, non-motor findings including alterations in visual acuity, decrease in blink reflex, and pupil reactivity cause the impaired quality of life in idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA). Our study aimed to examine possible latency and amplitude changes in pattern visual evoked potentials (pVEP) along with retinal and macular changes in optical coherence tomography (OCT) in PD and MSA groups. We also intended to investigate whether any OCT parameters could be a biomarker for Parkinson's or MSA. Methods Our study included 50 patients with PD, 15 with MSA, and 50 healthy control subjects. All patients in the study underwent neurological and ophthalmological examination and investigations of OCT to measure the retinal and macular thickness and pVEP to assess visual pathways. Results When PD, MSA, and control groups were compared, a significant difference was found in all retinal thickness values in average, nasal, and superior retinal nerve fiber thickness (pRNFL), and in all macular thickness values except nasal outer and inferior outer quadrants and in ganglion cell complex (GCC) thicknesses (p < 0.05). Moreover, a significant difference was found in N75, P100, and N145 latencies and N75-P100 amplitude (p < 0.05). The thickness of both pRNFL, inner and outer macular quadrants, was thinner in the MSA group than in PD but GCC thickness was thinner in PD group. Conclusions The present study compared pVEP and OCT parameters in PD and MSA groups. It was concluded that pVEP and OCT examinations were of importance in that they were easily accessible, affordable, noninvasive biomarkers that might be used in early periods and progression of the disease and in follow-up.
Keywords
Author Keywords
Idiopathic Parkinson's disease Multiple system atrophy Visual evoked potential Optic coherence tomography Retinal nerve fiber layer Macula
Prognostic factors in patients with cerebral sinus venous thrombosis presenting with hemorrhage and papilledema
By
Saritas, AS (Saritas, Aysegul Seyma) [1] ; Batum, M (Batum, Melike) [1] ; Ataç, C (Atac, Ceyla) [2] ; Öztürk, U (Ozturk, Uzeyir) [1] ; Yilmaz, H (Yilmaz, Hikmet) [1] ; Mavioglu, H (Mavioglu, Hatice) [3] ; Selçuki, D (Selcuki, Deniz) [3] ; Ak, AK (Ak, Aysin Kisabay) [1]
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CLINICAL NEUROLOGY AND NEUROSURGERY
Volume
234
DOI
10.1016/j.clineuro.2023.108013
Article Number
108013
Published
NOV 2023
Early Access
OCT 2023
Indexed
2023-11-26
Document Type
Article
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Abstract
Objective: The thromboinflammatory process is considered to play a role in the pathogenesis and prognosis of cerebral sinus vein thrombosis (CSVT). The purpose of the study was to compare the thromboinflammatory parameters between individuals with CSVT and healty controls. Additionally, the study sought to compare these parameters among CSVT subgroups with and without haemorrhage, as well as with and without papilledema. Furthermore, the investigation also aimed to identify which parameters had a more significant impact on the risk of hemorrhage and the development of papilledema in CSVT.Methods: Thromboinflammatory parameters were compared retrospectively between the CSVT group of 88 patients and 80 age- and sex-matched healthy controls, and in the CSVT subgroups with (n = 35) /without hemorrhage (n = 53) and with (n = 52) /without papilledema (n = 36) after ethics committee approval. In both groups, parameters contributing to the risk of hemorrhage and papilledema development were determined by univariate and multivariate analyses.Results: Regarding the risk of hemorrhage in CSVT patients, the most significant factors included hematocrit of <30.2 (%), mean platelet volume of <= 8.9 fL, neutrophil count of >5600, and hsCRP of >9 mg/L. Regarding the risk of papilledema development, the most important risk factors were age of <= 49, presence of vomiting, presence of blurred vision, HDL of >47 mg/dL, and D-dimer of >178 ng/mL.Conclusion: It was suggested that evaluating serum thromboinflammatory parameters, as well as demographic characteristics and neurological examination findings, had a critical role regarding prognosis and predictive factors in CSVT.
Keywords
Author Keywords
Cerebral sinus vein thrombosis Inflammation Thromboinflammatory parameters
CADASIL with Atypical Clinical Symptoms, Magnetic Resonance Imaging, and Novel Mutations: Two Case Reports and a Review of the Literature
By
Sari, US; Kisabay, A; Selcuki, D
Source
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume
68
Issue
4
Page
529-538
DOI
10.1007/s12031-019-01313-z
Published
AUG 2019
Document Type
Review
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy with adult onset caused by a missense mutation in the NOTCH3 gene in chromosome 19p13. It presents with autosomal dominant arteriopathy, subcortical infarctions, and leukoencephalopathy. Its common clinical presentations are seen as recurrent strokes, migraine or migraine-like headaches, progressive dementia, pseudobulbar paralysis, and psychiatric conditions. Two patients with CADASIL syndrome, whose diagnosis was made based on clinical course, age of onset, imaging findings, and genetic assays in the patients and family members, are presented here because of new familial polymorphisms. The first patient, with cerebellar and psychotic findings, had widespread non-confluent hyperintense lesions as well as moderate cerebellar atrophy in cranial magnetic resonance scanning. The other patient, with headache, dizziness, and forgetfulness, had gliotic lesions in both cerebral hemispheres. CADASIL gene studies revealed a new polymorphism in exon 33 in the first patient. In the other patient, the NOTCH3 gene was identified as a new variant of p.H243P (c.728A>C heterozygous). By reporting a family presenting with various clinical symptoms in the presence of new polymorphisms, we emphasize that CADASIL syndrome may present with various clinical courses and should be considered in differential diagnoses.
Keywords
Author Keywords
CADASILNOTCH3Genetic testing Small vessel disease Headache MRI
Role of acetazolamide in treatment of patients with menstrual migraine
By
Çetin, G (Cetin, Guldeniz) [1] ; Kisabay, AA (Kisabay, Aysin Ak) [1] ; Özyurt, BC (Ozyurt, Beyhan Cengiz) [2] ; Selçuki, D (Selcuki, Deniz) [1]
Source
Volume
26
Issue
4
Page
751-759
DOI
10.54029/2021hmm
Published
DEC 2021
Indexed
2022-01-18
Document Type
Article
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Abstract
Objective: According to the ICHD-3 criteria, menstrual migraine (MM) is divided into two groups: pure menstrual migraine (PMM) and menstrually-related migraine (MRM). The present study aimed to evaluate and compare the severity of headache using a visual analog scale (VAS) and the effect on quality of life using the Headache Impact Test (HIT) and Migraine Disability Assessment (MIDAS) tests before and after 3 months of treatment in using short-term prophylaxis with acetazolamide. Methods: Patients who presented to the headache outpatient clinic of the neurology department with a diagnosis of MM were retrospectively reviewed. Acetazolamide was given at a dosage of 500 mg daily for 5 days starting two days before the predicted onset of the menstrual cycle as a short-term prophylactic treatment. VAS, MIDAS, and HIT assessments were performed before and after treatment. Results: A total of 26 patients with PMM and 26 patients with MRM were identified. After acetazolamide treatment, statistically significant improvement was found in MIDAS, VAS and HIT scores in both groups of patients. The post-treatment MIDAS score was significantly lower in the MRM group, but there was no significant difference in post-treatment VAS and HIT scores between the groups. Conclusion: Using acetazolamide for short-term prophylaxis in patients with MM leads to decreased severity and frequency of headache and improvement in quality of life. The study is the first in the literature to use acetazolamide for short-term prophylaxis in patients diagnosed with MM.
Keywords
Author Keywords
menstrual migraine acetazolamide short-term prophylaxis VAS MIDAS HIT
Evaluation of cognitive functions in idiopathic Parkinson's disease and multiple system atrophy
By
Batum, M (Batum, Melike) [1] ; Ak, AK (Ak, Aysin Kisabay) [1] ; Ari, MS (Ari, Mehmet Semih) [1] ; Selçuki, D (Selcuki, Deniz) [1]
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Source
Volume
26
Issue
1
Page
85-93
Published
MAR 2021
Indexed
2021-05-13
Document Type
Article
Abstract
Background & Objective: Cognitive impairment is one of the non-motor symptoms impairing life quality in idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA). In our study, both groups' possible cognitive impairments were evaluated and compared, and the relationship between cognitive profile and motor, non-motor scores, and disease duration was evaluated. Methods: Fifty two PD, 18 MSA, 30 healthy controls were included in the study. Demographic information, scores of Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ), Addenbrooke's Cognitive Examination-Revised (ACE-R), and Frontal Assessment Battery (FAB) tests were recorded. In addition to the ACE-R test's total scores, sub-scores measuring attention-orientation, memory, verbal fluency, language, and visual-spatial abilities were also evaluated. Results: There was no difference between the groups in age, gender, years of education, and levodopa dose in treatment (p> 0.05). In the inter-group comparison, FAB, ACE-R total, ACE-R sub-scores and PDQ values were significantly different (p <0.05). Significant impairment was found in FAB, ACE-R total, memory, verbal fluency, speaking, and PDQ scores in PD and in all tests in MSA compared to the control group (p <0.05). All tests except memory were more impaired in the MSA group than the PD group. The motor scores in PD showed a strong correlation with FAB, ACE-R total, visual-spatial abilities, speaking, and PDQ scores, whereas motor scores in MSA only correlated poorly with PDQ scores. Conclusion: MSA progressing with multi-systemic involvement showed worse cognitive performance than PD in executive functions and visual-spatial functions, regardless of the disease duration.
Keywords
Author Keywords
Idiopathic Parkinson's disease multiple system atrophy cognition quality of life
Tethered Cord Syndrome in Adults: Experience of 56 Patients
By
Selcuki, M (Selcuki, Mehmet) [1] ; Mete, M (Mete, Mesut) [1] ; Barutcuoglu, M (Barutcuoglu, Mustafa) [1] ; Duransoy, YK (Duransoy, Yusuf Kurtulus) [1] ; Umur, AS (Umur, Ahmet Sukru) [1] ; Selcuki, D (Selcuki, Deniz) [2]
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Source
Volume
25
Issue
6
Page
922-929
DOI
10.5137/1019-5149.JTN.11700-14.1
Published
NOV 2015
Indexed
2015-12-30
Document Type
Article
Abstract
AIM: The aim of this study was to describe the results of surgery performed in a group of adult patients with tethered cord syndrome with their outcomes.
MATERIAL and METHODS: This retrospective study included 56 patients. There were 38 females and 18 males. All patients were older than 18 years.
RESULTS: The mean age at referral was 36 years and 1 month. The mean follow-up period was 10 months 27 days. 95% of all patients with back and leg pains improved and 5% remained the same. Three patients with motor deficits remained the same in the postoperative period. Of the 16 patients with urological complaints, 10 improved, 5 unchanged and 1 patient died in the postoperative first day due to pulmonary embolism.
CONCLUSION: The syndrome of tethered cord may be a situation to be treated even in the elderly in case of normal level conus medullaris and filum terminale with a normal appearance as well as a low-lying conus and thick filum. To prevent overlooking the diagnosis of tethered cord and/or unnecessary spinal surgeries, the tethered cord syndrome should be remembered in the differential diagnosis list in the presence of back and leg pains, neurological deficits or urological complaints.
Keywords
Author Keywords
Tethered cord syndrome Adult Filum terminale Urodynamic study
Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome
By
Batum, M (Batum, Melike) [1] ; Kisabay, A (Kisabay, Aysin) [1] ; Mayali, H (Mayali, Huseyin) [2] ; Göktalay, T (Goktalay, Tugba) [3] ; Kurt, E (Kurt, Emin) [2] ; Selçuki, D (Selcuki, Deniz) [1] ; Yilmaz, H (Yilmaz, Hikmet) [1]
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Source
Volume
40
Issue
10
Page
2475-2485
DOI
10.1007/s10792-020-01426-0
Published
OCT 2020
Early Access
JUN 2020
Indexed
2020-06-19
Document Type
Article
Abstract
Introduction Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers. Objectives To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS. Materials and methods Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared. Results In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (p < 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75-P100 waves.
In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75-P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea. Discussion It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers.
Keywords
Author Keywords
Peripapillary retinal nerve fiber layer Macula Obstructive sleep apnea syndrome Pattern visual evoked potential Optic coherence tomography Positive airway pressure treatment
Scoliosis may be the first symptom of the tethered spinal cord
By
Barutçuoglu, M (Barutcuoglu, Mustafa) [1] ; Selçuki, M (Selcuki, Mehmet) [1] ; Umur, AS (Umur, Ahmet Sukru) [1] ; Mete, M (Mete, Mesut) [1] ; Gurgen, SG (Gurgen, Seren Gulsen) [2] ; Selcuki, D (Selcuki, Deniz) [3]
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Source
INDIAN JOURNAL OF ORTHOPAEDICS
Volume
50
Issue
1
Page
80-86
DOI
10.4103/0019-5413.173506
Published
JAN-FEB 2016
Indexed
2016-04-13
Document Type
Article
Abstract
Background: Tethered cord syndrome (TCS) is a progressive clinical entity that arises from abnormal spinal cord tension. Scoliosis may be a unique symptom in TCS. The aim of this study is to investigate prognosis after releasing the filum terminale in scoliosis due to TCS with/without findings in magnetic resonance imaging (MRI) and to draw attention to the importance of somatosensorial evoked potentials (SSEP) on the differential diagnosis of idiopathic scoliosis versus scoliosis due to TCS with normal appearance of filum terminale and conus medullaris. Materials and Methods: Eleven female and seven male patients with progressive scoliosis were included in the study. They were evaluated radiologically, SSEP and urodynamical studies. Preoperative and postoperative anteroposterior full spine X-rays were obtained for measuring the Cobb's angle. MRI was performed in all cases for probable additional spinal abnormalities. All patients underwent filum terminale sectioning through a L5 hemilaminectomy. The resected filum terminale were subjected to histopathological examination. Results: The mean Cobb angle was 31.6 degrees (range 18 degrees u45 degrees). Eight patients (44.45%) had a normal appearance of filum terminale and normal level conus medullaris in MRI, but conduction delay and/or block was seen on SSEP. In the histopathological examination of filum terminale dense collagen fibers, hyaline degeneration and loss of elastic fibers were observed. Postoperatively none of the patients showed worsening of the Cobb angle. Three patients showed improvement of scoliosis. Conclusion: In TCS presented with scoliosis, untethering must be performed prior to the corrective spinal surgery. Absence of MRI findings does not definitely exclude TCS. SSEP is an important additional guidance in the diagnosis of TCS. After untethering, a followup period of 6 months is essential to show it untethering helps in stopping the progress of the scoliotic curve. In spite of non progression (curve stopped lesser than 45 degrees) or even improvement of scoliosis, there may be no need for major orthopedic surgical intervention.
Keywords
Author Keywords
Cobb angle scoliosis somatosensorial evoked potential stethered cord syndrome
Evaluation of retinal fiber thickness and visual pathways with optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome
By
Ak, AK (Ak, Aysin Kisabay) [1] ; Batum, M (Batum, Melike) [1] ; Göktalay, T (Goktalay, Tugba) [2] ; Mayali, H (Mayali, Huseyin) [3] ; Kurt, E (Kurt, Emin) [3] ; Selçuki, D (Selcuki, Deniz) [1] ; Yilmaz, H (Yilmaz, Hikmet) [1]
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Source
Volume
141
Issue
1
Page
33-43
DOI
10.1007/s10633-020-09749-0
Published
AUG 2020
Early Access
JAN 2020
Indexed
2020-02-03
Document Type
Article
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Abstract
Purpose To investigate the possible changes in retinal nerve fiber layer (RNFL) by optic coherence tomography and in the amplitudes and peak times (PTs) in pattern visual evoked potential (pVEP) and to compare them in obstructive sleep apnea syndrome (OSAS). Methods This prospective study included patients with mild OSAS (n = 30), severe OSAS (n = 30), and 30 control subjects. All patients were assessed after obtaining the approval from our hospital's ethics committee. Results There was no difference in age and gender between the groups (p = 0.184, p = 0.954). By analysis of variance, there was a significant difference in RNFL values among patients with mild OSAS, severe OSAS, and control for three measures of RNFL (average p = 0.044, nasal p = 0.003, inferior p = 0.027). In severe OSAS group, nasal and inferior quadrants of the RNFL were found to be thinner than the control group (p = 0.008, p = 0.031). We showed that the PT of P100 and N145 was prolonged in severe OSAS compared to the control group (p < 0.001) and that PT of P100 was prolonged in mild OSAS compared to the control group (p < 0.05). The amplitude of N75-P100 was significantly decreased in patients with both severe OSAS and mild OSAS compared to the control group (p < 0.001). Correlation of RNFL and pVEP values showed that the inferior quadrant RNFL thickness is correlated with both P100 and N145 PTs (r = 0.271*, p = 0.036 and r = 0.290*, p = 0.043, respectively) and N75-P100 amplitude (r = 0.378**, p = 0.003) in severe OSAS group. Conclusions In mild and severe stages of the disease, edema and inflammation were evident and VEP PT and amplitudes were affected in both groups. Furthermore, thinning in RNFL in the severe stage of the disease might be associated with higher atrophy levels and prolonged exposure to hypoxia.
Keywords
Author Keywords
Retinal nerve fiber layer Obstructive sleep apnea syndrome Pattern visual evoked potential Optic
Residual symptoms in bipolar disorder:: The effect of the last episode after remission
By
Kaya, E (Kaya, Ender) ; Aydemir, Ö (Aydemir, Oemer) ; Selcuki, D (Selcuki, Deniz)
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Source
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volum
31
Issue
7