2003-2004     Edirne Süleoğlu Sağlık Ocağı, Pratisyen Hekim

2010-2011      Kocaeli Gölcük Askeri Hastanesi, Çocuk Sağlığı ve Hastalıkları Uzmanı

2010-2011      Kocaeli Acıbadem Hastanesi, Çocuk Sağlığı ve Hastalıkları Uzmanı, yarı zamanlı

2014-2016      Niğde Eğitim Araştırma Hastanesi, Neonatoloji Yan Dal Uzmanı, Yenidoğan Yoğun Bakım Sorumlu Hekimi

2016-2018      İstinye Üniversitesi Bahçeşehir Liv Hospital, İstanbul, Yrd Doç Dr, Yenidoğan Yoğun Bakım Kurucu Hekimi

UZM. DR. BURÇİN İŞCAN

GÖREV ALDIĞI BÖLÜMLER

ÇOCUK SAĞLIĞI VE HASTALIKLARI

Postnatal growth and extrauterine growth retardation (EUGR) in extremely low gestational age newborns (ELGAN) with a 2-year follow-up

By

Iscan, B (Iscan, Burcin) [1]

 (provided by Clarivate) 

Source

TRENDS IN PEDIATRICS

Volume

6

Issue

1

Page

33-39

DOI

10.59213/TP.2025.206

Published

MAR 20 2025

Indexed

2025-05-05

Document Type

Article

Abstract

Objective: The primary objective of our study was to investigate the growth patterns of extremely low gestational age newborns (ELGAN) in the Neonatal Intensive Care Unit (NICU), assess the prevalence of Extrauterine Growth Restriction (EUGR) among them, and identify factors influencing its development. Additionally, the study aimed to evaluate the consistency between cross-sectional and longitudinal EUGR in ELGANs and assess catch-up growth at corrected 24 months. Method: Growth patterns of ELGANs and additional clinical data were retrospectively collected from January 2021 to January 2022 at a single tertiary NICU. EUGR was defined using two methods: cross-sectional EUGR and longitudinal EUGR. Infants were classified into two groups-EUGR and non-EUGR-based on whether their weight z-score was below-1.28 at the time of evaluation (either at a corrected gestational age (CGA) of 36 weeks or at discharge, whichever occurred first) or if the z-score decline (Delta Z score) exceeded 1 standard deviation (SD) between birth and the time of evaluation. According to WHO Child Growth Standards, catch-up growth was assessed at the age of two. Results: The study included 66 ELGANs. The incidence of EUGR was 51.5% (34 out of 66) based on the cross-sectional definition, increasing to 74.2% (49 out of 66) under the longitudinal definition. Using the criterion of a Delta Z weight < -1, the EUGR group took longer to achieve total enteral nutrition and required more days of total parenteral nutrition than the non-EUGR group. Additionally, the average weight growth velocity (GV) was significantly lower in the EUGR group. Late-onset sepsis (LOS), cumulative antibiotic exposure, and feeding intolerance (FI) were significantly more prevalent in the EUGR group. Among ELGANs discharged with EUGR (based on the longitudinal definition), 53% achieved catch-up growth in weight by one year of age and 77% by two years. Conclusion: The present study highlights the importance of LOS as an independent risk factor for developing EUGR and underscores the need for interventions to reduce its incidence. Additionally, enhanced enteral nutrition support and strategies to promote higher growth velocity may effectively reduce the incidence of extrauterine growth restriction in ELGANs. Approximately 25% of ELGAN infants are expected to remain underweight by the age of two years, while the majority achieve normalization of head circumference.

Keywords

Author Keywords

extremely low gestational age newborns (ELGAN)extrauterine growth Restriction (EUGR)postnatal growthcatch-up growth

Respiratory Support of Extremely Low Gestational Age Newborns from Delivery Room to the Neonatal Intensive Care Unit

By

Isçan, B (Iscan, Burcin) [1] ; Duman, N (Duman, Nuray) [2]

Edited by

Arsan, S (Arsan, S)

Source

INDIVIDUALIZED AND PRECISION APPROACH TO THE NEWBORN INFANT

Page

20-29

Published

2023

Indexed

2023-01-01

Document Type

Article; Book Chapter

Abstract

While advances in the care of extremely preterm infants have led to increased survival rates, extremely low gestational age newborns (ELGANs) present new challenges in respiratory support, necessitating a specialized approach. The optimal strategy for aiding postnatal respiratory adaptation in ELGANs should not only facilitate successful adaptation but also prioritize the avoidance of lung injury. Early use of non-invasive ventilation (NIV) and less invasive surfactant administration (LISA) are recognized as the accepted approaches for preterm infants but most ELGANs require intubation and invasive mechanical ventilation due to their immature respiratory system. Given the limited availability of data and the complexity of trials involving ventilator management, there is currently no consensus on the best initial mechanical ventilation approach for extremely preterm infants. If invasive mechanical ventilation cannot be avoided, a lung-protective ventilation strategy should be implemented, and the duration of invasive mechanical ventilation should be shortened. In this review, we have also summarized some experiences from centers that have achieved the best outcomes for the most immature infants, as well as with limited evidence-based data.

Keywords

Author Keywords

Respiratory support extremely low gestational age neonates ELGAN preterm newborn delivery room
 

Evaluation of health-related quality of life and affecting factors in child with enuresis

By

Iscan, B (Iscan, Burcin) [1] ; Ozkayin, N (Ozkayin, Nese) [2]

 (provided by Clarivate) 

Source

JOURNAL OF PEDIATRIC UROLOGY

Volume

16

Issue

2

DOI

10.1016/j.jpurol.2019.12.018

Article Number

195

Published

APR 2020

Indexed

2020-06-18

Document Type

Article

Abstract

Background

Enuresis is a common problem in children and distressing condition that can have an impact on the child's behavior and on their emotional and social life. Health-related quality of life (HRQoL) is defined as an individual's perception of the impact of the disease and treatment.

Objective

The aim of this study was to evaluate the HRQoL in Turkish children with enuresis and to investigate the effect of independent sociodemographic and clinical variables on HRQoL in children with enuresis. Study desing 110 children with enuresis and their mothers and 120 healthy children and their mothers were included in the study. The German quality of life questionnaire (KINDL (R)) scales were used to assess the children's HRQoL. For comparing the data of children with enuresis and healthy children, a two-sided unpaired t-test and linear regression model were used.

Result

The total HRQoL score for the children with enuresis group was 63.14 +/- 21.98 and for the children in the control group was 75.6 +/- 10.1 (P < 0.001). After adjusting for sex and age using the unstandardized coefficient of regression model, HRQoL score for the children with enuresis still remained statistically significant lower than that for healthy peers (64.21 +/- vs 75.11 +/- P < 0.001). The HRQoL subscale scores showed that children with enuresis had lower emotional well-being scores (64.23 +/- 14.2 vs 78.9 +/- 11.4, P < 0.001), self-esteem score (62.23 +/- 11 vs 68.6 +/- 17.4, P = 0.001), family relationship score (76.23 +/- 2 vs 83.4 +/- 12.2, P = 0.042), and friendship score (62.4 +/- 13.2 vs 68.8 +/- 15.3, P = 0.023) compared to the control group. When the effects of independent sociodemographic factors and clinical variables on HRQoL were evaluated, it was seen that the presence of lower urinary tract symptoms (LUTS) negatively affected total HRQoL score (59.89 +/- 11.2 vs 69.29 +/- 10.9 P = 0.028). Also the total HRQoL score was higher in treated children with enuresis than in nontreated children (65.96 +/- 12.1 vs 55.27 +/- 10.1 P = 0.032). Among the treated children, complete treatment response group had higher total HRQoL score compared to partial treatment response group and nonresponse group (respectively, 70.98 +/- 9.7, 65.25 +/- 10.1, 60.45 +/- 10.9, P = 0.034, P = 0.01) (Summary Figure). Family income level affected total HRQoL score, low-income group had lower total HRQoL score compared to high-income group (62.17 +/- 11.9 vs 69.25 +/- 10 P = 0.039).

Discussion

This study demonstrated that enuresis negatively affects the HRQoL of children and most affected domains in HRQoL were self-esteem, emotional well-being, and their relationship for family and friends. Our presented study showed that HRQoL was lower in non-primary monosymptomatic nocturnal enuresis (non-PMNE) children, nontreated patients. Also there were higher HRQoL scores in patients who had a total or partial response to treatment.

Conclusion

Our study may indicate that, low-income children with enuresis, nontreated enuretic children, and presence of LUTS should be considered as a risk group for low HRQoL.

Keywords Health-related quality of life Enuresis Urinary incontinence
 

Volume Guarantee High-Frequency Oscillatory Ventilation in Preterm Infants With RDS: Tidal Volume and DCO₂ Levels for Optimal Ventilation Using Open-Lung Strategies

By

Tuzun, F (Tuzun, Funda) [1] ; Deliloglu, B (Deliloglu, Burak) [1] ; Cengiz, MM (Cengiz, Merve Meryem) [1] ; Iscan, B (Iscan, Burcin) [2] ; Duman, N (Duman, Nuray) [1] ; Ozkan, H (Ozkan, Hasan) [1]

 (provided by Clarivate) 

Source

FRONTIERS IN PEDIATRICS

Volume

8

DOI

10.3389/fped.2020.00105

Article Number

105

Published

MAR 24 2020

Indexed

2020-12-24

Document Type

Article

Abstract

High frequency oscillatory ventilation with volume-guarantee (HFOV-VG) is a promising lung protective ventilator mode for the treatment of respiratory failure in newborns. However, indicators of optimal ventilation during HFOV-VG mode are not identified yet. In this study, we aimed to evaluate optimal high-frequency tidal volume (VThf) and the dissociation coefficient of CO2 (DCO2) levels to achieve normocapnia during HFOV-VG after lung recruitment in very low birthweight infants with respiratory distress syndrome (RDS). Preterm babies under the 32nd postmenstrual week with severe RDS that received HFOV-VG using open-lung strategy between January 2014 and January 2019 were retrospectively evaluated. All included patients were treated with the Drager Babylog VN500 ventilator in the HFOV-VG mode. In total, 53 infants with a mean gestational age of 26.8 +/- 2.3 weeks were evaluated. HFOV mean optimal airway pressure (MAPhf) level after lung recruitment was found to be 10.2 +/- 1.7 mbar. Overall, the mean applied VThf per kg was 1.64 +/- 0.25 mL/kg in the study sample. To provide normocapnia, the mean VThf was 1.61 +/- 0.25 mL/kg and the mean DCO(2)corr was 29.84 +/- 7.88 [mL/kg](2)/s. No significant correlation was found between pCO(2) levels with VThf (per kg) or DCO(2)corr levels. VThf levels to maintain normocarbia were significantly lower with 12 Hz frequency compared to 10 Hz frequency (1.50 +/- 0.24 vs. 1.65 +/- 0.25 mL/ kg, p < 0.001, respectively). A weak but significant positive correlation was found between mean airway pressure (MAPhf) and VThf levels. To our knowledge, this is the largest study to evaluate the optimal HFOV-VG settings in premature infants with RDS, using the open-lung strategy. According to the results, a specific set of numbers could not be recommended to achieve normocarbia. Following the trend of each patient and small adjustments according to the closely monitored pCO(2) levels seems logical.

Keywords

Author Keywords

HFOV volume guarantee lung recruitment VThfDCO2 frequency RDS lung-protective strategies
 

Keywords Plus

GUIDELINES

Impact of Volume Guarantee on High-Frequency Oscillatory Ventilation in Preterm Infants: A Randomized Crossover Clinical Trial

By

Iscan, B (Iscan, Burcin) [1] ; Duman, N (Duman, Nuray) [1] ; Tuzun, F (Tuzun, Funda) [1] ; Kumral, A (Kumral, Abdullah) [1] ; Ozkan, H (Ozkan, Hasan) [1]

 (provided by Clarivate) 

Source

NEONATOLOGY

Volume

108

Issue

4

Page

277-282

DOI

10.1159/000437204

Published

2015

Indexed

2015-12-02

Document Type

Article

Abstract

Background: High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) is a new ventilation mode that allows the clinician to set a mean tidal volume to be delivered. Objective: This study aimed to investigate whether HFOV with a VG option may result in constant tidal volume delivery and less fluctuant CO2 levels compared to HFOV alone in premature infants with respiratory distress syndrome (RDS). Methods: Inborn infants at less than 32 weeks of gestation with RDS requiring invasive mechanical ventilation were eligible. Patients were randomized to receive HFOV + VG or HFOV alone as the initial ventilator mode and then crossed over to the other mode. HFOV was performed with 'optimal lung volume strategy' during both of the periods. Results: Twenty infants were evaluated. The mean highfrequency tidal volume (VT hf) and CO2 diffusion coefficient (DCO2) were significantly higher in the HFOV + VG mode than HFOV alone. HFOV + VG maintains VThf within the target range more consistently than HFOV. The incidences of hypocarbia and hypercarbia were lower in HFOV with VG than HFOV alone. Conclusion: This is the first prospective, randomized, short-term crossover clinical study that compared HFOV with and without VG in infants with acute RDS. Because of the lower VThf fluctuation and lower incidences of out-of-target PCO2 levels, HFOV combined with VG seems to be feasible for preterm infants. However, the results should be interpreted with caution due to the small sample size and short-term crossover design of the study. (C) 2015 S. Karger AG, Basel

Keywords

Author Keywords

High-frequency oscillatory ventilation Hypocarbia Optimal lung volume strategy Randomized controlled trial Premature infant Ventilator-induced lung injury Volume guarantee Volume-targeting ventilation
 

Keywords Plus

MODEL

Intravenous levetiracetam for treatment of seizures in term and preterm neonates

By

Karaoglu, P (Karaoglu, Pakize) [1] ; Hiz, S (Hiz, Semra) [1] ; Iscan, B (Iscan, Burcin) [2] ; Polat, AI (Polat, Ayse, I) [1] ; Ayanoglu, M (Ayanoglu, Muge) [1] ; Duman, N (Duman, Nuray) [2] ; Yis, U (Yis, Uluc) [1]

 (provided by Clarivate) 

Source

JOURNAL OF PEDIATRIC NEUROSCIENCES

Volume

15

Issue

1

Page

15-20

DOI

10.4103/jpn.JPN_66_19

Published

JAN-MAR 2020

Indexed

2020-04-10

Document Type

Article

Abstract

Context: Seizures are the most frequent neurological disturbance in the neonatal period, and there are no evidence-based guidelines for the treatment of neonatal seizures. Here we report a study on the use of levetiracetam as second-line therapy in the treatment of seizures in term and preterm neonates. Aim: The aim of this study was to assess the efficacy and safety of levetiracetam for seizures of term and preterm neonates. Settings and Design: We retrospectively analyzed data of the patients who had seizures and who were treated with levetiracetam as an add-on therapy to phenobarbital during the neonatal period. Statistical Analysis: The Statistical Package for the Social Sciences (SPSS) software, version 15.0 (SPSS, Chicago, Illinois), was used for statistical analysis. Continuous variables were expressed as mean values and standard deviations. Results: Thirty-six patients (8 term and 28 preterm) received levetiracetam. Mean dose of levetiracetam was 31.67 +/- 14.83mg/kg/day. Twenty-five of the patients (69.4%) were seizure free with levetiracetam treatment. Electroencephalography recordings improved in 28 (77.8%) of the patients after levetiracetam. No severe adverse effects were observed. Conclusion: Our data suggest that levetiracetam may be a safe and effective treatment for neonatal seizures, which are unresponsive to phenobarbital.

Keywords

Author Keywords

Levetiracetam neonatal convulsions neonatal seizures neonates treatment
 

Effects of maternal folic acid supplementation on airway remodeling and allergic airway disease development

By

Iscan, B (Iscan, Burcin) [1] ; Tuzun, F (Tuzun, Funda) [1] ; Filibeli, BE (Filibeli, Berna Eroglu) [1] ; Micili, SC (Micili, Serap Cilekar) [2] ; Ergur, BU (Ergur, Bekir Ugur) [2] ; Duman, N (Duman, Nuray) [1] ; Ozkan, H (Ozkan, Hasan) [1] ; Kumral, A (Kumral, Abdullah) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

32

Issue

18

Page

2970-2978

DOI

10.1080/14767058.2018.1452904

Published

SEP 17 2019

Indexed

2019-08-19

Document Type

Article

Abstract

Objective: Maternal folic acid supplementation has been recommended prior to and during the first trimester of pregnancy to reduce the risk of infant neural tube defects. However, an uncertain relationship between folic acid supplementation during pregnancy and development of childhood asthma exists. Recent data show a methyl donor-rich diet could increase the risk of developing allergic airway disease through DNA methylation and aberrant gene transcription. This study evaluated the effect of folic acid supplementation during pregnancy on airway remodeling and allergic airway disease vulnerability in a mouse asthma model.Methods: BALB/c mice were divided into four groups according to gestational folic acid supplementation and postnatal ovalbumin (OVA) exposure: Group 1 (whole pregnancy folic acid supplementation+OVA-exposed group), Group 2 (first gestational week folic acid supplementation+OVA-exposed group), Group 3 (no folic acid supplementation+OVA-exposed group), and Group 4 (control group). Offspring were sacrificed on day 45 for immunohistological and ultrastructural tests.Results: In OVA challenged groups, folic acid supplementation led to a thicker epithelial and subepithelial smooth muscle layer than in the unsupplemented group. Moreover, folic acid supplementation during whole pregnancy (Group 1) was associated with a thicker epithelial and subepithelial smooth muscle layer than folic acid supplementation during the first week of pregnancy (Group 2), suggesting a duration-response relationship. Electron microscopic imaging revealed that structural changes including the loss of epithelial integrity, thickening of basement membrane, and subepithelial fibrosis were more prominent in the folic acid supplementation groups.Conclusions: This study suggested that maternal folic acid supplementation during pregnancy affects airway remodeling and increases the allergic responses induced by ovalbumin challenge in offspring. In addition, the effect size increased as the duration and cumulative dose increased.

Keywords

Author Keywords

Folic acid asthma maternal folic acid supplementation airway remodeling

Nasal intermittent positive pressure ventilation with or without very early surfactant therapy for the primary treatment of respiratory distress syndrome

By

Duman, N (Duman, Nuray) [1] ; Tüzün, F (Tuzun, Funda) [1] ; Sever, AH (Sever, Ali Haydar) [1] ; Arslan, MK (Arslan, Meltem Koyuncu) [1] ; Iscan, B (Iscan, Burcin) [1] ; Dilek, M (Dilek, Mustafa) [1] ; Kumral, A (Kumral, Abdullah) [1] ; Ozkan, H (Ozkan, Hasan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

29

Issue

2

Page

252-257

DOI

10.3109/14767058.2014.997203

Published

JAN 17 2016

Indexed

2015-12-25

Document Type

Article

Abstract

Aim: Current evidence suggests that nasal intermittent positive pressure ventilation (NIPPV) as a primary treatment for RDS reduces the duration of invasive mechanical ventilation (MV) comparing with nasal continuous airway pressure (NCPAP). We aimed to evaluate whether very early surfactant treatment decreases the need for MV when used in premature infants treated with early NIPPV soon after birth.Methods: The inclusion criteria of this prospective cohort study were a gestational age of 24-31(6/7) weeks and supplemental oxygen with the evidence of labored breathing within 60min. Infants were stabilized on NCPAP and then continued with NIPPV, following early surfactant treatment, or were only put on NIPPV. Thirty infants in the NIPPV group and 29 infants in the NIPPV+SURFACTANT group met the inclusion criteria. Primary end-point was the need of MV in the first 72h of life according to the predefined criteria.Results: The failure rate was significantly lower in the NIPPV+SURFACTANT group compared with the NIPPV group (37.9% and 66.7% respectively, p<0.05). All other results, including bronchopulmonary dysplasia and death, were similar between the groups.Conclusion: NIPPV failure was significantly lower when combined with surfactant treatment, which indicates the critical role of early surfactant treatment in reducing the need for invasive ventilation.

Keywords

Author Keywords

Bronchopulmonary dysplasia NIPPV preterm respiratory distress syndrome surfactant

INTRANASAL SURFACTANT PROTEIN D AS NEUROPROTECTIVE RESCUE IN A NEONATAL RAT MODEL OF PERIVENTRICULAR LEUKOMALACIA

By

Kumral, A (Kumral, Abdullah) [1] ; Iscan, B (Iscan, Burcin) [1] ; Engur, D (Engur, Defne) [2] ; Tuzun, F (Tuzun, Funda) [1] ; Ozbal, S (Ozbal, Seda) [3] ; Ergur, BU (Ergur, Bekir Ugur) [3] ; Turkmen, MK (Turkmen, Munevver Kaynak) [2] ; Duman, N (Duman, Nuray) [1] ; Ozkan, H (Ozkan, Hasan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

30

Issue

4

Page

446-451

DOI

10.1080/14767058.2016.1174996

Published

2017

Indexed

2017-01-04

Document Type

Article

Abstract

Background: Periventricular leukomalacia (PVL) is the leading cause of neurocognitive deficits in children with prematurity. We previously hypothesized that surfactant protein D (SPD) with its ability to bind toll-like receptors may have a possible ameliorating effect in PVL.

Methods: Three groups were defined as: LPS-administered and postnatal intranasal saline administered group, LPS-administered and postnatal intranasal SPD-treated group, and control group. Twenty-eight offspring rats were reared with their dams until their sacrifice for histological evaluation on day 7.

Results: A significant loss of brain weight occurred in the LPS group compared with controls. The postnatal intranasal SPD treatment significantly reduced the number of TUNEL-positive cells in the periventricular white matter as compared with the LPS-treated group. Compared with the control group, LPS injection in the rat brain significantly reduced the MBP-positive staining. Postnatal SPD treatment greatly prevented LPS-stimulated loss of MBP staining.

Conclusions: Present study demonstrated a neuroprotective effect of SPD in a rat model of PVL. Our results offer future implications towards increasing our understanding about multifactorial mechanisms underlying periventricular leukomalacia and developing plausible therapeutic strategies in order to prevent neurocognitive deficits in preterm infants.

Keywords

Author Keywords

Nasal drug delivery newborn periventricular leukomalacia surfactant protein D

The effects of perinatal steroid therapy on growth factor levels during different stages of the developing brain

By

Iscan, B (Iscan, Burcin) [1] ; Tuzun, F (Tuzun, Funda) [1] ; Micili, SC (Micili, Serap Cilaker) [2] ; Tugyan, K (Tugyan, Kazim) [2] ; Duman, N (Duman, Nuray) [1] ; Ozkan, H (Ozkan, Hasan) [1] ; Kumral, A (Kumral, Abdullah) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

30

Issue

15

Page

1820-1828

DOI

10.1080/14767058.2016.1228051

Published

2017

Indexed

2017-06-19

Document Type

Article

Abstract

Objective: Excess glucocorticoid (GC) exposure on the fetal brain during critical stages of development has considerable effects on the development of the central nervous system (CNS). This study thus aimed to evaluate the differential effects of GC exposure on critical growth factor levels during different stages of brain maturation.Methods: For this purpose, forty-two rat pups were divided into six groups based on the timing of betamethasone administration. Rats in the treatment groups were exposed to intraperitoneal betamethasone injections beginning at different time points (postnatal days 1, 2, and 3). Rats in the placebo group received the same volume of 0.9% saline via the same fashion. Pups were sacrificed at 24h following the final injection for determining the neuronal density and immunohistochemical evaluation of critical growth factors.Results: In the groups treated with betamethasone on postnatal day 1 (P1) and P2, which correspond to 22-24 and 24-28 gestational weeks in humans, the neuronal count in the hippocampal regions was significantly lower than their control groups. However, if steroid therapy was administered on P3, corresponding to 28-32 weeks in humans, no difference was observed between the two groups. Growth factors were affected in different ways depending on the steroid administration time and evaluated region.Conclusions: The results suggest that the modulating effect of steroids on neuron count and growth factor response depends on the stage of brain development at the time of exposure. Therefore, this may be one of the key determinants affecting the deleterious and beneficial effects of GCs on the CNS.

Keywords

Author Keywords

Perinatal steroid betamethasone hippocampus brain development growth factors newborn rat

Prophylactic Fucose can Alleviate Lipopolysaccharide-Induced Cholestatic Liver Injury in Neonatal Rats

By

Baysal, B (Baysal, Bora) [1] ; Tüzün, F (Tuzun, Funda) [1] ; Engür, D (Engur, Defne) [2] ; Özbal, S (Ozbal, Seda) [3] ; Ergür, B (Ergur, BekirUgur) [3] ; Iscan, B (Iscan, Burcin) [1] ; Yücesoy, E (Yucesoy, Ebru) [1] ; Duman, N (Duman, Nuray) [1] ; Özkan, H (Ozkan, Hasan) [1] ; Kumral, A (Kumral, Abdullah) [1]

 (provided by Clarivate) 

Source

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES

Volume

14

Issue

5

Page

253-259

DOI

10.1055/s-0039-1694710

Published

OCT 2019

Indexed

2019-10-16

Document Type

Article

Abstract

Objectives Cholestasis is a common disease of the liver in premature infants and no specific preventive treatment is currently available. Fucose, one of the monosaccharide building blocks of human milk oligosaccharides, may prevent cholestatic hepatic injury by various mechanisms. The aim of this study was to investigate the protective effect of fucose treatment after endotoxin-induced cholestasis in a rat model. Methods Wistar rat pups were divided into four groups as: group I, control group; group II, fucose-supplemented group; group III, lipopolysaccharide (LPS)-administered group, and group IV, LPS-exposed and fucose-supplemented group. Fucose was given 100 mg/kg i.p. every other day between PN5-17. LPS was administered on PN19 to establish endotoxin-induced cholestasis model. On PN21, animals were sacrificed to evaluate liver cell damage and apoptosis. Results Fucose supplementation significantly improved the biochemical parameters that deteriorated in LPS-administered group, significantly increased the expression of bile salt export pump, reduced the number of apoptotic cell death, and greatly prevented LPS-induced cholestatic hepatic injury. Conclusion Given our results, fucose may be useful in reducing hepatic injury and might possess clinical relevance for the preventive treatment of inflammation-induced cholestatic injury in newborns.

Keywords

Author Keywords

fucose liver injury new born lipopolysaccharide neonatal cholestasis

BACILLUS CALMETTE-GUERIN VACCINATION: A NOVEL THERAPEUTIC APPROACH TO PREVENTING HYPEROXIC LUNG INJURY

By

Kumral, A (Kumral, Abdullah) [1] ; Iscan, B (Iscan, Burcin) [1] ; Tuzun, F (Tuzun, Funda) [1] ; Micili, SC (Micili, Serap Cilaker) [2] ; Arslan, MK (Arslan, Meltem Koyuncu) [1] ; Tugyan, K (Tugyan, Kazim) [2] ; Duman, N (Duman, Nuray) [1] ; Ozkan, H (Ozkan, Hasan) [1]

 (provided by Clarivate) 

Source

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

Volume

28

Issue

16

Page

1950-1956

DOI

10.3109/14767058.2014.973396

Published

2015

Indexed

2016-05-18

Document Type

Article

Abstract

Objective: A growing body of evidence suggests that vaccinations play a role in the normal maturation of the immune system and in both the development and balance of immune regulatory pathways that can impact health later in life. This study aimed to evaluate the effects of Bacillus Calmette-Guerin ( BCG) vaccine on the hyperoxia-induced neonatal rat lung injury.

Methods: Four groups were defined as hyperoxia-exposed BCG-vaccinated, hyperoxia-exposed placebo, room air-exposed control and room air-exposed BCG-vaccinated group. The validity of the hyperoxia-induced lung injury model used in this study was confirmed by histological and immunohistochemical test. Gene expression related with cytokine and growth factor was evaluated by real-time reverse transcription polymerase chain reaction.

Result: The mean alveolar surface area and quantification of secondary crest formation in the oxygen-exposed placebo group was significantly lower than that of the oxygen-exposed BCG-vaccinated group. Compared to the oxygen-exposed placebo group, the oxygen-exposed BCG-vaccinated group showed a significantly decreased alveolar septal fibrosis and smooth muscle actin expression. The expression of genes VEGF, FGF-BP1, IL-13, and NF kappa B1 ( p50) in the lungs of the hyperoxia-exposed BCG-vaccinated group was significantly higher than that of the hyperoxia-exposed placebo group.

Conclusion: Results suggest that BCG vaccination can protect against neonatal hyperoxic lung injury. These benefits may be interpreted to coincide with its immunomodulatory effects on pro-inflammatory and anti-inflammatory cytokine balance and expression of growth factors.

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