2002 - 2008 : Ege Üniversitesi Tıp Fakültesi, İZMİR
2008 - 2013 : Dokuz Eylül Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, İZMİR
2013 - : Bozyaka Eğitim ve Araştırma Hastanesi, İZMİR
2013 - 2014 : Gaziemir Devlet Hastanesi, İZMİR
2014 - 2015 : Sakarya Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi
2015 - : Özel Tınaztepe Hastanesi
Uluslararası Bilimsel Yayınlar:
TEI index in elite sprinters and endurance athletes, Tuzun N, Ergun M, Alioglu E, Edem E, Tengız I, et al. J Sports Med Phys Fitness 2014
Well-described concertina effect during coronary angioplasty, Edem E, et al. BMJ Case Rep. 2015
Acute myocardial infarction due to simultaneous occlusions of the left anterior descending artery and right coronary artery, , Edem E, et al. BMJ Case Rep. 2015
Does ‘’Smoker’s Paradox’’ exist in clopidogrel-treated Turkish patients with acute coronary syndrome, Edem E, et al. Platelets 2015
A novel tratment approach for common carotid artery bifurcation aneurysms, Edem E, et al. Postepy Kardiol Interwencyjnej, 2015
Ulusal Bilimsel Yayınlar
Latent Clinical Outcomes of Appropriate and Inappropriate ICD Shocks, Edem E, Gürsoy MO, Pabucu MT, Taş S, Can Y, et al. Koşuyolu Heart Journal 2014
P Dalga Dispersiyonunun İnfarkt İlişkili Açıklığını Saptamadaki Prediktif Değeri, Tas Ü, Taş S, Edem E, Ünal B, Tanrıverdi Z, et al. Koşuyolu Kalp Dergisi 2014
Technical Innovation in Communication Systems Can Be Life-Saving in Cardiac Emergencies, Gürsoy MO, Edem E. Koşuyolu Heart Journal 2015
Intracardiac Thrombosis due to Antiphospholipid Syndrome, Tuzun N, Edem E, Pabucu MT. Koşuyolu Heart Journal 2015
Bilimsel Etkinliklerde Sunulmuş Bildirileri:
E. Edem, Myocardial Bridging as a Cause of Thrombus Formation and Myocardial Infarction, 4. Ulusal Kardiyoloji-kalp damar Cerrahi Zirvesi, Kıbrıs 2015
E. Edem, Medical Treatment of Massive Pericardial Effusion Induced by Warfarin Intoxication, 4. Ulusal Kardiyoloji-Kalp Damar Cerrahi Zirvesi, Kıbrıs 2015
E. Özpelit, Ö. Badak, E. Edem, Ö. Göldeli,"Ergotamine induced Takatsubo
Cardiomyopathy","INTERNATIONAL JOURNAL OF CARDIOLOGY, Volume 163 Supplement 1 March
2013",9th International Congerss of Update in Cardiology and Cardiovascular Surgery,
KEMER/ANTALYA, Mart 2013, INTERNATIONAL JOURNAL OF CARDIOLOGY,161-2, Uluslararası
organizasyon
E. Edem, Ö. Aslan, Ö. Göldeli, S. Güneri, E. Özpelit, F. Aytemiz,"Mortality Determinants in ICD
(Implantable Cardioverter Defibrillator) implanted patients","INTERNATIONAL JOURNAL OF
CARDIOLOGY, Volume 163 Supplement 1 March 2013",9th International Congress of update in
Cardiology and Cardiovascular Surgery, KEMER/ANTALYA, Mart 2013, INTERNATIONAL JOURNAL
OF CARDIOLOGY,161-2, Uluslararası organizasyon
E. Edem, Ö. Göldeli, F. Aytemiz, S. Taş, Ü. Tas, Z. Tanrıverdi, B. Ünal, S. Gül, M. Yılmaz,"The most
appropriate vascular access for primary percutaneous coronary intervention (PCI) in patients with
peripheral vascular disease: axillary approach","INTERNATIONAL JOURNAL OF CARDIOLOGY,
161-162",9th International Congress of update in Cardiology and Cardiovascular Surgery,
KEMER/ANTALYA, Mart 2013, INTERNATIONAL JOURNAL OF CARDIOLOGY,161, Uluslararası organizasyon
Tanrıverdi Z, Şimşek M, Dursun H, Ünal B, Tas Ü, Edem E, Aytemiz F, Koyuncu M, Ekinci M, Kozan Ö, Kaya D. Can Fragmanted QRS on 12 Derivation ECG Be Used As a Predictor of Hospital Mortality in Patients Admitted with Acute ST Elevated Myocardial Infarction? J Am Coll Cardiol. 2013;62(18_S2):C211-C212. doi:10.1016/j.jacc.2013.08.599, Uluslararası organizasyon
Aytemiz F, Edem E, Tanrıverdi Z, Tas Ü, B. Ünal, Kırımlı Ö. Retrospectively, Compared Percutaneous Coronary Intervention and Surgical Revascularization Results for the Treatment of Multivessel Coronary Artery Disease According to Syntax Scores Groups J Am Coll Cardiol. 2013;62(18_S2):C194-C195. doi:10.1016/j.jacc.2013.08.554, Uluslararası organizasyon
Edem E, Kaya D, Kozan Ö, İyilikçi L,"Well described coronary artery spasm induced by general
anesthesia during PFO closure - A case report",28. Ulusal Kardiyoloji Kongresi, ANTALYA, Ekim
2012
Üzel H, Özpelit E, Badak Ö, Aytemiz F, Edem E, Şimşek M, Akdeniz B, Barış N, Aslan Ö, Kırımlı Ö,
Göldeli Ö, Güneri S,"Ortalama trombosit hacminin klopidogrel direncini öngördürmedeki yeri",27.
Ulusal Kardiyoloji Kongresi, İSTANBUL, Ekim 2011
Kitap Bölümleri / Çevirileri
Hurst’s The HEART 13th EditionTextbook Yardımcı Çeviri editörlüğü Prof. Dr. Ömer Kozan Uzm. Dr. Efe Edem
Lisansüstü öğrenimlerindeki Tez Bilgileri
Tıpta Uzmanlık Tezi : ICD implante edilmiş olgularda mortalite belirleyicileri
Tezin Danışmanı, Başlama-Bitiş Tarihleri : Prof.Dr. Özgür ASLAN , Ocak 2009 - Ocak 2013
Katıldığı / Görev aldığı Mesleki / Bilimsel / Sanatsal Etkinlikler
9.Uluslarası Kardyoloji ve Kardivasküler Cerrahide Yenilikler Kongresine Katılmak Üzere,
Antalya, Mart 2013(Tebliğ / Bildiri Sunma (Poster, Sözlü v.b.))
28.Ulusal Kardiyoloji Kongresine Katılmak Üzere, Antalya, Ekim 2012 (Tebliğ / Bildiri Sunma
(Poster, Sözlü v.b.)
14.Kardiyak Görüntüleme Çalışma Grubu Toplantısına Katılmak Üzere, Mardin, Mayıs
2011 (İzlenimci - Katılımcı Olarak)
SOLID TIMI 52 İlaç Araştırma Konulu Toplantıya Katılmak Üzere, ATİNA, Yunanistan,
Haziran 2010 (İzlenimci - Katılımcı Olarak)
Girişimsel Kardiyoloji Kursuna Araştırma ve İncelemelerde Bulunmak Üzere, İstanbul,
Haziran 2010 (İzlenimci - Katılımcı Olarak)
Kalp ve Kapak Hastalıkları ve Erişkin Konjenital Kalp Hastalıkları Çalışma Grupları Eğitim
Toplantısına Katılmak Üzere, Çanakkale, Mayıs 2010 (İzlenimci - Katılımcı Olarak)
Kardiyolojide Acil Yaklaşımlar Eğitimine Katılmak Araştırma ve İncelemelerde Bulunmak
Üzere, Ankara, Ocak 2010 (İzlenimci - Katılımcı Olarak)
25. Ulusal Kardiyoloji Kongresi, İstanbul, Ekim 2009 (İzlenimci - Katılımcı Olarak)
Erişkin Konjenital Kalp Hastalıkları Kongresi, Adana, Nisan 2009(İzlenimci – Katılımcı Olarak)
İlgi Alanı:
Transözafagial Ekokardiyografi, Geçici-Kalıcı Pacemaker, ICD, Perkutan Koroner Girişim, Perkutan ASD-VSD Kapatılması
PROF. DR. EFE EDEM
Görev Aldığı Bölümler
Kardiyoloji
The Relationship between Nocturnal Dipping Status, Morning Blood Pressure Surge, and Hospital Admissions in Patients with Systolic Heart Failure
By
Tas, U (Tas, Umme) [1] ; Tas, S (Tas, Sedat) [2] , [4] ; Edem, E (Edem, Efe) [3]
Source
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
Volume
120
Issue
9
DOI
10.36660/abc.20220932
Article Number
e20220932
Published
2023
Indexed
2023-10-22
Document Type
Article
Abstract
Background: Hypertension is a known risk factor for developing heart failure. However, there is limited data to investigate the association between morning blood pressure surge (MBPS), dipping status, echocardiographic parameters, and hospital admissions in patients with systolic heart failure.
Objectives: To evaluate the relationship between morning blood pressure surge, non-dipper blood pressure pattern, echocardiographic parameters, and hospital admissions in patients with systolic heart failure.
Methods: We retrospectively analyzed data from 206 consecutive patients with hypertension and a left ventricular ejection fraction below 40%. We divided the patients into two groups according to 24-hour ambulatory blood pressure monitoring (ABPM) results: dippers (n=110) and non-dippers (n=96). Morning blood pressure surge was calculated. Echocardiographic findings and hospital admissions during follow-up were noted. Statistical significance was defined as p < 0.05.
Results: The study group comprised 206 patients with a male predominance and mean age of 63.5 +/- 16.1 years. The non-dipper group had significantly more hospital admissions compared to dippers. There was a positive correlation between MBPS and left atrial volume index (r=0.331, p=0.001), the ratio between early mitral inflow velocity and flow propagation velocity (r= 0.326, p=0.001), and the ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/Em) (r= 0.314, p=0.001). Non-dipper BP, MBPS, and E/Em pattern were found to be independently associated with increased hospital admissions.
Conclusion: MBPS is associated with diastolic dysfunction and may be a sensitive predictor of hospital admission in patients with systolic heart failure.
Keywords
Author Keywords
Blood Pressure Monitoring Ambulatory Arterial Pressure Heart Failure Hospitalization
Coronary Endarterectomy: Postoperative Angiographic Results
By
Edem, E (Edem, Efe) [1] ; Reyhanoglu, H (Reyhanoglu, Hasan) [2]
(provided by Clarivate)
Source
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
Volume
32
Issue
8
Page
969-974
DOI
10.29271/jcpsp.2022.08.969
Published
AUG 2022
Indexed
2022-08-25
Document Type
Article
Abstract
Objective: To compare the postoperative graft patency rates of patients who had undergone coronary endarterectomies (CE) during coronary bypass surgery to those of patients who had not had CE, based on postoperative coronary angiography. Study Design: Comparative descriptive study. Place and Duration of Study: Coronary Angiography Unit, T??naztepe University Faculty of Medicine, Turkey, from November 2010 through June 2021. Methodology: Patients who had undergone CE during coronary bypass surgery were included. Postoperative morbidity results and the patency rates of the vessels with and without endarterectomy were evaluated via coronary angiographies that had been performed. Results: The patency rate in vessels that underwent coronary endarterectomy was determined to be 73.4% according to coro-nary angiographies performed after an average of 47.7 months. The patency rate in vessels without endarterectomy was 63.7%. The highest patency rate was found in the left anterior descending artery (LAD) in both CE and conventional bypass coro-nary arteries and the lowest patency rate was found in the diagonal artery (D) in both CE and conventional bypass coronary arteries. In the comparison of vessels with and without CE, the patency rate was found to be 66.6% in patients with CE on the right coronary artery (RCA) and 45.7% in patients without CE on the right coronary artery and the difference was statistically significant (p<0.037). Conclusion: Coronary endarterectomy should be used when it is believed that a simple anastomosis would not provide adequate patency during coronary bypass surgery because the primary goal should be to achieve full revascularization and a long-term patency rate.
Keywords
Author Keywords
Coronary angiography Coronary bypass grafting Endarterectomy Patency rate
Association of Epicardial Fat Tissue with Coronary Artery Disease and Left Ventricle Diastolic Function Indicators
By
Tekin, I (Tekin, Isik) [1] ; Edem, E (Edem, Efe) [2]
Source
Volume
24
Page
6367-6374
DOI
10.12659/MSM.910989
Published
SEP 11 2018
Indexed
2018-09-11
Document Type
Article
Abstract
Background: Epicardial fat tissue (EAT) acts as brown adipose tissue and protects the heart and coronary arteries against hypothermia. Recent studies demonstrated that EAT is a source of both anti-inflammatory and atherogenic cytokines. In this study, our aim was to investigate the association of vertical, horizontal, and area measurements of EAT thickness and their association with coronary artery disease, diastolic function, and myocardial performance index in patients who underwent coronary angiography.
Material/Methods: The study population consisted of patients who presented to our outpatient clinic with chest pain and whose non-invasive stress tests were positive between June 2015 and July 2017. Echocardiographic examinations were performed prior to the angiography. Coronary angiograms were performed using Judkins method from the femoral artery.
Results: Mean vertical thickness of EAT was 0.6 cm in patients with CAD and 0.46 cm in those without CAD (p=0.0001). Mean horizontal length of EAT was 2.91 cm in patients with CAD and was 2.41 cm in the subjects without CAD (p=0.001). ROC analysis showed 81% sensitivity and 53% specificity for a cut-off value of 0.45, and 67% sensitivity and 71% specificity for a cut-off value of 0.55 for EAT vertical (cm). Multivariate analysis showed that EAT is an independent risk factor for coronary artery disease.
Conclusions: Echocardiography is an inexpensive routine assessment for most patients. EAT thickness determined by echo- cardiography may be a useful indicator of increased CAD risk, but not diastolic dysfunction, of the left ventricle.
Keywords
Author Keywords
Coronary Artery Disease Echocardiography Heart Failure, Diastolic
Relationship between alkaline phosphatase and impaired coronary flow in patients with ST-segment elevated myocardial infarction
By
Edem, E (Edem, Efe) [1]
Source
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume
46
Issue
9
Page
3918-3927
DOI
10.1177/0300060518785544
Published
SEP 2018
Indexed
2018-09-20
Document Type
Article
Abstract
Objective Recent studies have shown that alkaline phosphatase (ALP) might play a negative role in clinical outcomes of patients with peripheral and coronary artery disease. This study aimed to investigate the relationship between serum ALP levels and coronary thrombolysis in myocardial infarction (TIMI) frame counts in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention (PCI).
Methods A total of 198 patients were enrolled in the current study. Serum ALP levels were measured in lithium-heparin plasma samples via a standardized, colorimetric enzyme assay. Coronary TIMI flow was evaluated by counting the number of cine frames that were required for contrast to reach a standardized distal coronary landmark in the culprit vessel.
Results The Spearman correlation coefficient test showed strong positive relationships between coronary TIMI frame counts after primary PCI and serum ALP levels on admittance for the left anterior descending, circumflex, and right coronary arteries (r=0.774, r=0.831, and r=0.730, respectively).
Conclusion Elevated serum ALP levels appear to be a predictor of impaired coronary TIMI frame count in patients suffering from ST-segment elevated myocardial infarction.
Keywords
Author Keywords
Alkaline phosphatase myocardial infarction atherosclerosis percutaneous coronary intervention thrombolysis in myocardial infarction artery
Are P Wave and QT Dispersions Related to Severe Peripheral Artery Disease?
By
Edem, E (Edem, Efe) [1] ; Reyhanoglu, H (Reyhanoglu, Hasan) [2]
(provided by Clarivate)
Source
Volume
24
Page
5242-5246
DOI
10.12659/MSM.910107
Published
JUL 28 2018
Indexed
2018-08-07
Document Type
Article
Abstract
Background: The aim of this study was to evaluate the relationship between P wave and QT dispersions (PWD and QTD) during the course of severe peripheral artery disease (PAD).
Material/Methods: We recruited 163 patients who underwent peripheral angiography (PA) between August 2011 and March 2017, and they were divided into 2 groups according to the severity of PAD on PA. PWD and QTD were investigated using 12-lead electrocardiograms. Group One consisted of patients diagnosed with <70% stenosis on PA, who eventually received medical treatment; Group Two consisted of patients diagnosed with >= 70% stenosis on PA, who eventually underwent surgery.
Results: ROC curve analysis of the 2 groups demonstrated that PWD was significantly higher in Group Two (AUC: 0.913505; 95% confidence interval (CI): 0.859365 to 0.951788; p<0.0001). The Youden index showed that a cut-off PWD value of >35 msn predicted a peripheral artery stenosis of >= 70% with a sensitivity of 88.89% and a specificity of 85.37% (+LR: 6.07, -LR: 0.13). Moreover, QTD was significantly higher in Group Two (AUC: 0.884749; 95% CI: 0.825489 to 0.929391; p<0.0001). Youden index showed that a cut-off QTD value of >75 msn predicted a peripheral artery stenosis of >= 70% with a sensitivity of 76.54% and a specificity of 85.37% (+LR: 5.23, -LR: 0.27). Comparison of ROC curves showed no difference in terms of predicting peripheral artery stenosis of 70% between PWD and QTD (p=0.3308).
Conclusions: Interpreting PWD and QTD offers a non-invasive and cost-effective assessment method for detecting patients at high risk for coronary artery disease in the context of severe PAD.
Keywords
Author Keywords
Coronary Artery Disease Electrocardiography Peripheral Arterial Disease
Effect of Heart Rate-Oriented Therapy on Diastolic Functions in Patients with Heart Failure with Reduced Ejection Fraction
By
Tas, S (Tas, Sedat) [1] ; Tas, Ü (Tas, Ummu) [2] ; Özpelit, E (Ozpelit, Ebru) [3] ; Edem, E (Edem, Efe) [4] ; Akdeniz, B (Akdeniz, Bahri) [3]
(provided by Clarivate)
Source
Volume
34
Issue
3
Page
251-258
DOI
10.6515/ACS.201805_34(3).20180129A
Published
MAY 2018
Indexed
2018-06-05
Document Type
Article
Abstract
Background: Resting heart rate (HR) is a strong predictor of cardiovascular mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF). However, the effects of HR-lowering therapy on diastolic function in HFrEF patients are not well described. In this study, we aimed to investigate the effect of lowering HR on diastolic function in HFrEF patients with sinus rhythm.
Methods: Fifty patients with HFrEF with coexisting diastolic dysfunction and sinus rhythm with resting HR > 70 bpm were prospectively included in the study. All patients were treated with intended HR-lowering therapy, which targeted a HR below 70 bpm. We divided the whole population according to the resting HR achieved with strict rate control (group 1) and to that achieved without strict rate control (group 2; HR > 70 bpm) at the end of the study. Left ventricular diastolic function and B-type natriuretic peptide (BNP) values at baseline and at the end of the study were compared in both groups.
Results: No significant differences were found between the groups in terms of baseline parameters except for lower diastolic blood pressure in group 2. At the end of follow-up, E/Em ratio, E/A ratio and left atrial area significantly decreased with an increased deceleration time in group 1. The changes in HR (delta HR) were correlated with E/Em (r = 0.67, p < 0.001) and delta BNP level (r = 0.49, p < 0.001).
Conclusions: This study showed that an effective HR lowering in patients with HFrEF can lead to improvements in diastolic function.
Keywords
Author Keywords
Brain natriuretic peptide Diastolic dysfunction Heart failure Heart rate
Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia
By
Simsek, Ö (Simsek, Ozgur) [1] ; Çarlioglu, A (Carlioglu, Ayse) [1] ; Alisik, M (Alisik, Murat) [2] ; Edem, E (Edem, Efe) [3] ; Biçer, CK (Bicer, Cemile Koca) [2]
(provided by Clarivate)
Source
CARDIOLOGY RESEARCH AND PRACTICE
Volume
2018
DOI
10.1155/2018/9042461
Article Number
9042461
Published
2018
Indexed
2018-07-09
Document Type
Article
Abstract
Objective. Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage. Methods. In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects. Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf lubes, and preserved al -80 degrees C. Results. This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index). This means that in such patients, the thiol/disulfide balance changes in favour of disulfide. Conclusions. In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide.
Keywords
Keywords Plus
THIOL-DISULFIDE HOMEOSTASIS OXIDATIVE STRESS INDICATOR RISK
Left ventricular twist was decreased in isolated left bundle branch block with preserved ejection fraction
By
Yilmaz, S (Yilmaz, Sabiye) [1] ; Kiliç, H (Kilic, Harun) [1] ; Agaç, MT (Agac, Mustafa Tarik) [1] ; Keser, N (Keser, Nurgul) [1] ; Edem, E (Edem, Efe) [2] ; Demirtas, S (Demirtas, Saadet) [1] ; Vatan, MB (Vatan, Mehmet Bulent) [1] ; Akdemir, R (Akdemir, Ramazan) [1] ; Gündüz, H (Gunduz, Huseyin) [1]
(provided by Clarivate)
Source
ANATOLIAN JOURNAL OF CARDIOLOGY
Volume
17
Issue
6
Page
475-480
DOI
10.14744/AnatolJCardiol.2017.7346
Published
JUN 2017
Indexed
2017-06-01
Document Type
Article
Abstract
Objective: Left ventricular (LV) rotation and twist play an important role in LV contraction and relaxation. Left bundle branch block (LBBB) deteriorates both diastolic and systolic functions. We evaluated the LV twist in patients with LBBB and preserved ejection fraction (EF) (>50%) to determine twist as a potential marker for subtle myocardial dysfunction.
Methods: This observational cross-sectional study included 34 LBBB patients with preserved EF who were free from ischemic and valvular disease (Group 1) and 36 healthy controls (Group 2). All patients underwent 2-D Doppler and 2-D speckle tracking echocardiography. LV apical, basal rotation, and twist were evaluated in both groups and compared accordingly. In addition, subjects were dichotomized considering the median twist value of the study population. Binary logistic regression analysis was performed to determine the independent variables associated with inframedian twist.
Results: Baseline clinical characteristics were similar in LBBB patients and controls. Mean apical rotation (2.5(degrees)+/- 1.9 degrees vs. 4.4 degrees +/- 2.9 degrees; p=0.002), basal rotation (-2.9 degrees +/- 2.3 degrees vs. -4.1 degrees +/- 2.7 degrees; p= 0.05), and twist (5.4 degrees +/- 3 degrees vs. 8.6 degrees +/- 3.3 degrees; p< 0.001) were decreased in group 1. Parameters related to intra- and interventricular mechanical dyssynchrony, such as longitudinal left ventricular dyssynchrony index (LVdys) and preejection interval of LV, interventricular mechanical delay (IVMD), and left posterior wall contractions (SPMWD) were significantly higher in the LBBB group. The median twist value of the studied population was 6.65 degrees. Binary logistic regression analysis showed that only presence of LBBB was independently associated with inframedian twist (OR=6.250; 95% CI: 2.215-17.632; p<0.001).
Conclusion: The LBBB might have induced the reduction of LV twist by diminishing the LV rotation before inducing a prominent effect on the left ventricular ejection fraction (LVEF). Therefore, twist may be considered as a marker for subtle LV dysfunction in LBBB with substantially normal EF.
Keywords
Author Keywords
speckle-tracking imaging left ventricular function left ventricular twist left bundle branch block
An investigation of pulse transit time as a blood pressure measurement method in patients undergoing carotid artery stenting
By
Can, Y (Can, Yusuf) [1] ; Kilic, H (Kilic, Harun) [1] ; Akdemir, R (Akdemir, Ramazan) [1] ; Acar, B (Acar, Bilgehan) [2] ; Edem, E (Edem, Efe) [1] ; Kocyigit, I (Kocyigit, Ibrahim) [1] ; Vatan, MB (Vatan, Mehmet B.) [2] ; Aksoy, M (Aksoy, Murat) [1] ; Can, N (Can, Nimet) [2] ; Gunduz, H (Gunduz, Huseyin) [1]
(provided by Clarivate)
Source
Volume
21
Issue
3
Page
168-170
DOI
10.1097/MBP.0000000000000182
Published
JUN 2016
Indexed
2016-06-08
Document Type
Article
Abstract
Introduction Pulse transit time (PTT) is the duration that a pulse wave takes to travel between two different arterial points, and it may be useful in estimating blood pressure. The aim of this study was to investigate the PTT during carotid artery stenting, as well as its value in blood pressure estimation.
Method Thirty-four patients with critical carotid artery stenosis were enrolled in this study. The carotid PTT from the onset of the R-wave of electrocardiography to the pulse waveform at the carotid artery, obtained invasively during carotid artery catheterization, was measured. The carotid PTT was measured before and after stenting of the internal carotid artery.
Results The mean age was 70.4 +/- 8.0 years among the 34 patients enrolled (eight female patients, 21.9%). Measurements were obtained before and after carotid artery stenting. The heart rate (85.9 +/- 15.9 vs. 76.9 +/- 12.5 bpm, P < 0.01), systolic blood pressure (162.8 +/- 28.6 vs. 126.0 +/- 31.7 mmHg, P < 0.001), diastolic blood pressure (87.7 +/- 17.9 vs. 76.9 +/- 20.0 mmHg, P < 0.01), and mean blood pressure (112.7 +/- 18.6 vs. 93.2 +/- 22.7 mmHg, P < 0.001) were significantly decreased, whereas the carotid PTT (0.06 +/- 0.012 s vs. 0.07 +/- 0.012 s, P < 0.001) was significantly increased after carotid stenting. The difference between the PTTs was negatively correlated with the systolic blood pressure (r = -0.35, P = 0.02) and diastolic blood pressure (r = -0.4, P = 0.01).
Conclusion After carotid stenting, the PTT increases significantly because of the lowering of the blood pressure. However, the relationship is not strong enough for the PTT to be used for blood pressure estimation. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords
Author Keywords
blood pressure estimation carotid artery stenting pulse transit time
Acute Effusive Pericarditis due to Horse Chestnut Consumption
By
Edem, E (Edem, Efe) [1] ; Kahyaoglu, B (Kahyaoglu, Behlul) [2] ; Çakar, MA (Cakar, Mehmet Akif) [2]
Source
AMERICAN JOURNAL OF CASE REPORTS
Volume
17
Page
305-308
DOI
10.12659/AJCR.896790
Published
MAY 4 2016
Indexed
2016-06-22
Document Type
Article
Abstract
Patient: Male, 32
Final Diagnosis: Pericardial effusion related to the consumption of herbal product
Symptoms: Dyspnea
Medication: Horse chestnut (Aesculus hippocastanum L)
Clinical Procedure: Pericardial and pleural effusions were drained through a pericardiopleural window
Specialty: Cardiology
Objective: Unusual clinical course
Background: There are many well-known causes of pericardial effusion, such as cancer metastasis, bacterial or viral pericarditis, and uremic pericarditis; however, no reports exist in the literature demonstrating a pericardial effusion that led to cardiac tamponade following consumption of an herbal remedy.
Case Report: A 32-year-old male patient was referred to our cardiology outpatient clinic with a complaint of dyspnea. The patient's medical history was unremarkable; however, he had consumed 3 boxes of horse chestnut (Aesculus hippocastanum L) paste over the previous 1.5 months. His chest x-ray examination revealed an enlarged cardiac shadow and bilateral pleural effusion. On transthoracic echocardiographic examination, his ejection fraction was found to be 55% with circumferentially extended pericardial effusion that reached 3.9 cm at its maximal thickness. No growth had been detected in the pericardial and pleural biopsies or blood samples; there was no evidence of an infectious process in the physical examination. Based on this information, we diagnosed pericarditis resulting from the use of herbal remedies. This is the first report to demonstrate that herbal remedy consumption may cause this type of clinical condition.
Conclusions: Besides other well-known causes, pericardial effusion related to the consumption of herbal remedies should always be considered when treating patients with pericardial effusion caused by unclear etiologies.
Keywords
Author Keywords
Aesculus Cardiotoxins Pericardial Effusion
Does "smoker's paradox" exist in clopidogrel-treated Turkish patients with acute coronary syndrome
By
Edem, E (Edem, Efe) [1] ; Kirdök, AH (Kirdok, Ali Hikmet) [1] ; Kinay, AO (Kinay, Ahmet Ozan) [1] ; Tekin, ÜI (Tekin, Umit Ilker) [1] ; Tas, S (Tas, Sedat) [2] ; Alpaslan, E (Alpaslan, Erkan) [2] ; Pabuccu, MT (Pabuccu, Mustafa Turker) [2] ; Akdeniz, B (Akdeniz, Bahri) [2]
(provided by Clarivate)
Source
Volume
27
Issue
3
Page
240-244
DOI
10.3109/09537104.2015.1083544
Published
APR 2 2016
Indexed
2016-04-27
Document Type
Article
Abstract
Previously conducted studies revealed that smoking enhanced the efficacy of clopidogrel by increasing formation of the active metabolite (AM) from the prodrug through induction of the cytochrome CYP1A2. The expression of cytochrome enzymes depends on genotype and no data exists in literature conducted in Turkish patients comparing the clopidogrel responsiveness between active smokers and non-active smokers treated with clopidogrel. In this study, our aim was to investigate the clopidogrel responsiveness in clopidogrel-treated Turkish acute coronary syndrome (ACS) patients according to their smoking status. We retrospectively enrolled 258 patients who were hospitalized due to ACS. Clinical variables of the patients, especially smoking status were recorded. Clopidogrel resistance was evaluated by using adenosine diphosphate (ADP) induced platelet aggregometry. Clopidogrel resistance was detected as a change in maximal aggregation <= 20% from baseline. A total of 139 patients were active smokers while 12 were former smokers. 107 patients did not have a history of smoking. Ten of the smokers were hyporesponsive to clopidogrel, whereas 36 of non-smokers were hyporesponsive to clopidogrel (p < 0.001). Receiver-operating characteristic curve analysis demonstrated that Au-min value >612.5 predicted the clopidogrel resistance with a sensitivity of 60% (OR: 100.65, %95 CI = 19.996-506.615 p < 0.001). Results of this study demonstrated that ADP responses were lower in smokers receiving clopidogrel and aspirin than in non-smokers receiving the same drug regimen. This finding indicates that smoking was related to an enhanced clopidogrel responsiveness in Turkish patients hospitalized due to ACS, suggesting that "smoker's paradox" probably exists in Turkish ACS patients.
Keywords
Author Keywords
2-oxo-clopidogreldrug resistance clopidogrel Acute coronary syndrome
Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis
By
Edem, E (Edem, Efe) [1] ; Reyhanoglu, H (Reyhanoglu, Hasan) [2] ; Küçükukur, M (Kucukukur, Murat) [4] ; Kirdök, AH (Kirdok, Ali Hikmet) [1] ; Kinay, AO (Kinay, Ahmet Ozan) [1] ; Tekin, ÜI (Tekin, Umit Ilker) [1] ; Özcan, K (Ozcan, Kaan) [2] ; Ertürk, M (Erturk, Murat) [2] ; Sentürk, Ç (Senturk, Cagin) [3] , [7] ; Kirilmaz, B (Kirilmaz, Bahadir) [5] ;
(provided by Clarivate)
Source
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
Volume
21
DOI
10.4103/1735-1995.192509
Article Number
93
Published
2016
Indexed
2017-03-24
Document Type
Article
Abstract
Background: Aortic valve stenosis (AVS) is the most common cause of left ventricular outflow obstruction, and its prevalence among elderly patients causes a major public health burden. Recently, platelet-to-lymphocyte ratio (PLR) has been recognized as a novel prognostic biomarker that offers information about both aggregation and inflammation pathways. Since PLR indicates inflammation, we hypothesized that PLR may be associated with the severity of AVS due to chronic inflammation pathways that cause stiffness and calcification of the aortic valve. Materials and Methods: We retrospectively enrolled 117 patients with severe degenerative AVS, who underwent aortic valve replacement and 117 control patients in our clinic. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. Severe AVS was defined as calcification and sclerosis of the valve with a mean pressure gradient of > 40 mmHg. Results: PLR was 197.03 +/- 49.61 in the AVS group and 144.9 +/- 40.35 in the control group, which indicated a statistically significant difference (P < 0.001). A receiver operating characteristic (ROC) curve analysis demonstrated that PLR values over 188 predicted the severity of aortic stenosis with a sensitivity of 87% and a specificity of 70% (95% confidence interval = 0.734- 0.882; P < 0.001; area under ROC curve: 0.808). Conclusion: We suggest that the level of PLR elevation is related to the severity of degenerative AVS, and PLR should be used to monitor patients' inflammatory responses and the efficacy of treatment, which will lead us to more closely monitor this high-risk population to detect severe degenerative AVS at an early stage.
Keywords
Author Keywords