2002 - 2007 Assistant Doctor, Diskapi SSK Training and Research Hospital, Department of Anesthesiology and Reanimation, Ankara

2007 - 2008 Anesthesiology and Reanimation Specialist, Gölbaşı State Hospital Ankara (Compulsory service)

2008 - 2009 Anesthesiology and Reanimation Specialist, Kadirli State Hospital Kadirli/Osmaniye (Compulsory service)

2009 - 2010 Military Service, Anesthesiology and Reanimation Specialist, Edremit Military Hospital Edremit/Balıkesir

2010 - 2011 Anesthesiology and Reanimation Specialist, Kadirli State Hospital Kadirli/Osmaniye

2011 - 2013 Kadirli Private 7 Mart Hospital

2013 - 2016 Private Gediz Surgical Medical Center

2016 - Private Tinaztepe Hospital

Co-existance of Lymph Node Tuberculosis and Pulmonary Embolism: A Case Reportn

By

Koç, I (Koc, Ibrahim) [1] ; Dogan, S (Dogan, Serdar) [2] ; Dogan, Y (Dogan, Yusuf) [3] ; Ulusan, A (Ulusan, Ahmet) [4]

 (provided by Clarivate) 

Source

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE

Volume

6

Page

650-652

Supplement

5

DOI

10.4328/JCAM.3758

Published

OCT 2015

Indexed

2015-10-01

Document Type

Article

Abstract

Pulmonary embolism is occlusion of pulmonary arteries with a material originating from another part of the body and has a high fatality rate if not diagnosed and managed early. Tuberculosis is an infection caused by mycobacterium tuberculosis, generally effecting lungs but involvement of other parts of the body is possible. Here we report a sixty three years old woman who admitted to our clinic with complaints of shortness of breath, weight loss and night sweats. Weight loss and night sweats in old age were suggestive of a malignancy but tumor markers were negative. Low oxygen saturation in a non-smoking previously healty person arise suspicion of pulmonary embolism. Computed tomography pulmonary angiography revealed lymphadenopathy and pulmonary embolism. Pathology of the servical lymph node revealed caseation necrosis. In conclusion in patients with pulmonary embolism who has weight loss and low oxygen saturation beside the malignancy tuberculosis also should be excluded.

Keywords

Author Keywords

Pulmonary Embolism Lymph Node Tuberculosis

Pulmonary Embolism Mimicking Community Acquired Pneumonia: A Case Report

By

Koç, I (Koc, Ibrahim) [1] ; Dogan, Y (Dogan, Yusuf) [2] ; Çakmak, O (Cakmak, Onur) [3] ; Bulut, G (Bulut, Gokhan) [4]

Source

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE

Volume

6

Page

662-664

Supplement

5

DOI

10.4328/JCAM.3770

Published

OCT 2015

Indexed

2015-10-01

Document Type

Article

Abstract

Acute pulmonary trombo embolism is a form of venous thromboembolism that is common and sometimes even may be fatal. Patients might present with variable clinical presentation and often have non-specific complaints which make the diagnosis challenging. Here we aimed to report a thirty years old male who was diagnosed with community acquired pneumonia but further invent get revealed pulmonary embolism A thirty years old male presented to our clinic with right sided chest pain and shortness of breath. Chest radiograph revealed right sided consolidations and pleural effusion. His physical examination revealed high body temperature (38 C degrees) and oxygen saturation on room air was 85 %. The patient did not respond to the antibiotherapy and oxygen supply. Computed tomography angiography of the chest revealed right sided pulmonary embolism with pneumonia. Blood and sputum cultures revealed no bacteria. Cardiovascular disease panel revealed heterozygous mutation in prothrombine 020210A and metilentetrahidrofolate reductase (MTHFR) C677T. In conclusion pulmonary embolism may mimic community acquired pneumonia thus clinicians must be carefull during the diagnostic process.

Keywords

Author Keywords

Computed Tomography Angiography Pneumonia Pulmonary Embolism

Importance of mean platelet volume in patients with chronic obstructive pulmonary disease

By

Koç, I (Koc, Ibrahim) [1] ; Karatas, ZA (Karatas, Zeynel Abidin) [2] ; Mandollu, E (Mandollu, Eray) [3] ; Mermer, A (Mermer, Aydin) [3] ; Kaya, A (Kaya, Abdulaziz) [3] ; Dökme, A (Dokme, Aysen) [1] ; Bayraktar, A (Bayraktar, Adem) [4] ; Dogan, Y (Dogan, Yusuf) [5]

 (provided by Clarivate) 

Source

EUROPEAN JOURNAL OF THERAPEUTICS

Volume

20

Issue

4

Page

294-298

DOI

10.5455/GMJ-30-154104

Published

NOV 2014

Indexed

2014-11-01

Document Type

Article

Abstract

Chronic obstructive pulmonary disease (COPD) is an important public health problem and it is associated with systemic inflammation. Mean platelet volume (MPV) is one of the markers indicating platelet activation, and there are different results in different diseases related to inflammation. As for COPD some studies found it to be high whereas others found low results. In this study, we aimed to study parameters like MPV, platelet distribution volume (PDW), red blood cell (RBC), which are studied in the complete blood count testing routinely of patients with COPD, smoking and nonsmoking subjects without chronic diseases. Data of 121 patients with COPD, 101 nonsmoking subjects and 102 smoking subjects were retrospectively enrolled. Results were statistically analyzed. MPV levels were lower in patients with COPD compared with smokers (P<0.001) and nonsmoking subjects (P<0.001) but platelet levels were not significantly different. PDW levels found to be lower in COPD group compared with smokers (P<0.013) and nonsmokers (P<0.001). White blood cells were higher in patients with COPD as were expected (P<0.001). Neutrophil levels also were higher in patients with COPD compared with smokers (P<0.003) and nonsmokers (P<0.0001). RBC levels were lower in patients with COPD when compared with nonsmokers (P<0.001). The results of this study suggest that the decreased MPV and PDW may be used as negative reactants for evaluation of COPD.

Keywords

Author Keywords

Chronic obstructive pulmonary disease complete blood count mean platelet volume

Effects of Restraint Stress and Nitric Oxide Synthase Inhibition on Learning and Strategy Preference in Young Adult Male Rats

By

Dagdeviren, M (Dagdeviren, Melih) [1] ; Dogan, YH (Dogan, Yusuf Hakan) [2] ; Kanit, L (Kanit, Lutfiye) [3]

 (provided by Clarivate) 

Source

BALKAN MEDICAL JOURNAL

Volume

29

Issue

4

Page

376-380

DOI

10.5152/balkanmedj.2012.100

Published

DEC 2012

Indexed

2013-03-13

Document Type

Article

Abstract

Objective: The aim of this study was to investigate the effects of restraint stress and nitric oxide synthase (NOS) inhibition by N omega Nitro-L-Arginine (LNA) on learning and strategy preference.

Material and Methods: Rats were randomly divided into four groups (Saline, Saline+Stress, LNA, LNA+Stress). Stress was applied for one hour in glass cylinders during 13 days. One hour after this stress application, water maze experiments were started. Injections (saline 1 ml/kg or 50 mg/kg LNA) were given 10 minutes before each experiment. The platform was kept visible or hidden (on the 4th, 8th, 12th days) at the same position. On the 13th day the platform was located on the opposite quadrant.

Results: Saline groups exhibited significantly better performances (F-(1.31)=174.038 p<0.05) at the beginning compared to the NOS inhibited groups. For initial hidden platform days; stress was determined as an impairment factor (F-(1.31)=5.190 p=0.012). At the end, acquisition occurred on both visible and hidden platform days for all groups. There was no significant strategy preference difference between the groups.Development of the stress and NOS inhibition impairments were seen, particularly at different periods of the acquisition.

Conclusion: NOS inhibition did not worsen restraint stress-induced learning impairments in rats. Lack of effect may be explained by the antidepressive consequences of NOS inhibition.

Keywords

Author Keywords

Learning NOS inhibition restraint stress strategy preference water maze

Efects of hormone replacement and tamoxifen on depression in ovariectomized rats

By

Terek, MC (Terek, Mustafa Cosan) [1] , [2] ; Kanit, L (Kanit, Lutfiye) [2] ; Dogan, YH (Dogan, Yusuf Hakan) [2] ; Gozen, O (Gozen, Oguz) [2] ; Zeybek, B (Zeybek, Burak) [1] ; Keser, A (Keser, Aysegul) [2] ; Ozsener, S (Ozsener, Serdar) [1] ; Pogun, S (Pogun, Sakire) [2]

 (provided by Clarivate) 

Source

GINEKOLOGIA POLSKA

Volume

83

Issue

7

Page

522-526

Published

JUL 2012

Indexed

2012-09-28

Document Type

Article

Abstract

Objectives: To determine the effects of tamoxifen and hormone replacement therapy in order to assess their role in depressive behavior

Material and Methods: Different protocols of hormone replacement therapies were administered to surgically ovariectomized rats. Intact rats were used for tamoxifen experiments, Properly assigned control groups were used and cognitive processes were studied on animal models of surgical menopause using the Porsolt Forced Swim Test and locomotor activity experiments,

Results: In the tamoxifen experiments, an interaction between treatment and days did not reach statistical significance, but indicated a trend in this direction [F(1,26)=3.557, p=0.071]. The number of repeated movements significantly decreased after the Porsolt test (F(1,44) = 8.483, P<0.006) in the hormone replacement experiments. In the tamoxifen experiments, the number of repeated movements significantly decreased after the Porsolt test (F(1,26) = 74.410, P<0.001).

Conclusions: While sequential hormone replacement is found to be protective against depression, tamoxifen seems to augment behavioral despair

Keywords

Author Keywords

tamoxifen hormone replacement depression menopause

The effects of hormone replacement and tamoxifen on spatial learning and active avoidance learning in ovariectimized rats

By

Terek, MC (Terek, Mustafa Cosan) [1] , [2] ; Keser, A (Keser, Aysegul) [2] , [3] ; Dogan, YH (Dogan, Yusuf Hakan) [2] , [3] ; Dagci, T (Dagci, Taner) [2] , [3] ; Zeybek, B (Zeybek, Burak) [1] ; Kanit, L (Kanit, Lutfiye) [2] , [3] ; Ozsener, S (Ozsener, Serdar) [1] ; Pogun, S (Pogun, Sakire) [3]

 (provided by Clarivate) 

Source

GINECO RO

Volume

7

Issue

4

Page

188-192

Published

2011

Indexed

2011-01-01

Document Type

Article

Abstract

Background/Aims. The aim of the present study is to investigate the effects of an estrogen receptor modulating agent tamoxifen, and different protocols of hormone replacement therapy that mimic clinical applications, on spatial learning and active avoidance learning in rats. Methods. We used 2 groups of normal rats for tamoxifen experiments (control group and drug group) and 4 groups for hormone replacement experiments: (1) ovariectomized rats with sesame oil injection, (2) ovariectomized rats with continuous estrogen injection, (3) ovariectomized rats with continuous combined estrogen and progesterone injection and (4) ovariectomized with continuous estrogen and intermittent (sequential) progesterone injection. Properly assigned control groups were used and cognitive processes were studied on animal models of surgical menopause using the Morris water maze and active avoidance learning paradigms. Results. In the Morris water maze no significant differences in spatial learning were observed between the hormone replacement and tamoxifen groups. Active avoidance learning was impaired by ovariectomy. Conclusions. In female ovariectomized rats, spatial learning is not influenced by circulating ovarian hormones and tamoxifen. On the other hand, active avoidance learning is impaired by the absence of gonadal hormones.

Keywords

Author Keywords

tamoxifen hormone replacement Morris water maze spatial learning

Effects of IgM-enriched immunoglobulin and fluid replacement on nerve conduction velocity in experimental sepsis

By

Çankayali, I (Cankayali, Ilkin) [1] ; Dogan, YH (Dogan, Yusuf Hakan) [2] ; Solak, I (Solak, Ilhami) [3] ; Eris, O (Eris, Oguz) [1] ; Demirgören, S (Demirgoren, Serdar) [2] ; Moral, AR (Moral, Ali Resat) [1]

 (provided by Clarivate) 

Source

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY

Volume

16

Issue

1

Page

9-14

Published

JAN 2010

Indexed

2010-01-01

Document Type

Article

Abstract

BACKGROUND

Neuromuscular abnormalities in sepsis, termed critical illness polyneuropathy (CIP), have been suggested to be induced by inflammatory mechanisms and/or relative hypovolemia. CIP is characterized by early electrophysiological findings before the clinical symptoms. This study aimed to investigate the effect of intravenous immunoglobulin (IVIG) and volume replacement therapies on the possible nerve conduction velocity (NCV) alterations in the early phase of experimental sepsis.

METHODS

Forty-six Sprague-Dawley rats were randomly assigned to four groups. Cecal ligation/perforation was performed to induce experimental sepsis. NCV was assessed in the tail nerve.

RESULTS

There was no statistically significant difference in NCV levels within and among the Sham-operated, colloid-and IVIG-treated groups. In the sepsis without treatment group, there was a statistically significant decrease in NCV levels.

CONCLUSION

NCV is decreased in the early stage of experimental sepsis and it may be accepted as an early electrophysiological sign in CIP. Treatment with either IgM-enriched IVIG or early volume replacement appears to prevent the decrease in NCV in the early phase of experimental sepsis. Results were statistically indistinguishable between the IVIG- and colloid-treated groups. No statistical difference between these groups is noteworthy. There is a need to clarify the mechanisms of action with further randomized, clinical and experimental trials.

Neuromuscular deterioration in the early stage of sepsis in rats

By

Cankayali, I (Cankayali, Ilkin) ; Dogan, YH (Dogan, Yusuf Hakan) ; Solak, I (Solak, Ilhami) ; Demirag, K (Demirag, Kubilay) ; Eris, O (Eris, Oguz) ; Demirgoren, S (Demirgoren, Serdar) ; Moral, AR (Moral, Ali Resat)

 (provided by Clarivate) 

Source

CRITICAL CARE

Volume

11

Issue

1

DOI

10.1186/cc5139

Article Number

R1

Published

2007

Indexed

2007-01-01

Document Type

Article

Abstract

Introduction Critical illness polyneuropathy (CIP) is a clinical condition frequently seen in patients being treated in critical care units in the final stage of sepsis. The etiopathology of CIP is still unclear, and the onset time of appearance of the electrophysiological findings has not been elucidated. The very little research that has been carried out on this topic is limited to clinical electrophysiological and histopathological studies. In this study, electrophysiological alterations in the early stage of experimentally induced sepsis were investigated in septic rats.

Methods We conducted a prospective, randomized, controlled experimental study in an animal basic science laboratory with 30 male Sprague-Dawley rats, weighing 200 to 250 g. All of the rats were randomly assigned to one of two groups. In the sepsis group (n = 20), cecal ligation and puncture (CLP) was performed to induce experimental sepsis. In the sham-operated group (n = 10), laparotomy without CLP was performed. Before and 24 hours after CLP and laparotomy, the right sciatic nerve was stimulated from the sciatic notch and compound muscle action potentials (CMAPs) were recorded from the gastrocnemius muscle. Recordings of latency, amplitude, and duration of the CMAP were evaluated.

Results CMAP durations before and 24 hours after surgery were 0.45 +/- 0.05 ms and 0.48 +/- 0.05 ms, respectively, in the sham-operated group and 0.46 +/- 0.05 ms and 0.55 +/- 0.01 ms, respectively, in the sepsis group. Latency measurements in the sham-operated group were 0.078 +/- 0.010 ms and 0.080 +/- 0.015 ms, respectively, whereas measurements were found to be prolonged in the sepsis group: 0.094 +/- 0.015 ms and 0.149 +/- 0.054 ms before and 24 hours after surgery, respectively (p < 0.05). CMAP amplitudes in the sham-operated group before and 24 hours after surgery were 8.41 +/- 0.79 mV and 8.28 +/- 1.92 mV, respectively, whereas in the sepsis group the amplitude measurements decreased to 7.60 +/- 1.75 mV and 4.87 +/- 3.44 mV, respectively (p < 0.05).

Conclusion The results of the study indicate that electrophysiological alterations appear in the first 24 hours after experimental sepsis and are characterized by an increase in latency and a decrease in CMAP amplitude. The results also suggest that electrophysiological findings seen in patients with CIP might appear before clinical signs of CIP.

Increased urinary albumin excretion rates can be a marker of coexisting coronary artery disease in patients with peripheral arterial disease

By

Sonmez, K (Sonmez, K) ; Eskisar, AO (Eskisar, AO) ; Dernir, D (Dernir, D) ; Yazicioglu, MV (Yazicioglu, MV) ; Mutlu, B (Mutlu, B) ; Dogan, Y (Dogan, Y) ; Izgi, A (Izgi, A) ; Mansuroglu, D (Mansuroglu, D) ; Bakal, RB (Bakal, RB) ; Elonu, OH (Elonu, OH) ; 

 (provided by Clarivate) 

Source

ANGIOLOGY

Volume

57

Issue

1

Page

15-20

DOI

10.1177/000331970605700103

Published

JAN-FEB 2006

Indexed

2006-01-01

Document Type

Article

Abstract

Coexisting coronary artery disease (CAD) is an important cause of morbidity and mortality in patients with peripheral arterial disease (PAD). Clinical evaluation and noninvasive tests have some important limitations for the detection of CAD in patients with PAD. The purpose of this study was to investigate whether urinary albumin excretion (UAE) was a sign of atherosclerotic involvement of coronary arteries in patients with PAD. Our study consisted of 65 consecutive patients (56 men, 9 women, mean age; 59.7 +/- 7.9 years) with PAD who underwent coronary angiography. Urinary albumin excretion was measured in 24-hour urine samples by immunoprecipitation technique. PAD was defined as the presence of >= 50% stenotic lesions in at least 1 of the iliac, femoral, popliteal, tibialis anterior, tibialis posterior, or peroneal arteries. CAD was defined as 25% diameter stenosis in at least 1 coronary artery. Patients without any coronary lesions were accepted as having normal coronaries. Age, sex, distributions of coronary risk factors, and UAE rates were compared between patients with and without CAD. Mean UAE was 17.9 +/- 15.6 mg/day in the total population. Thirty-seven percent of patients had CAD, and 63% had no coronary lesion. UAE rates were 22.33 +/- 18.74 and 15.32 +/- 13.01 mg/day in patients with CAD and those with normal coronary arteries, respectively (p = 0.021). Microalbuninuria was detected in 25% in patients with CAD and 12% in those without coronary artery lesions (p=0.184). The difference was not statistically significant. The distributions of other risk factors and sex were not different between the 2 groups. These data suggest that in patients with PAD, urinary albumin excretion rates may be used to determine those with a high probability of CAD. Further studies are required to decide whether this noninvasive testing is appropriate in detecting high-risk patients.

Keywords

Keywords Plus

ABDOMINAL AORTIC-ANEURYSM PERIOPERATIVE MYOCARDIAL-INFARCTION VASCULAR-DISEASE