01/09 / 1994–01 / 06/2000 Medical Doctor
Ege University Faculty of Medicine, Izmir (Turkey)
01/11/2013 – Continuing Specialist Doctor
Batı Anadolu Central Hospital, Izmir (Turkey)
In addition to polyclinic and ward services, I also worked as a doctor in charge of the invasive intensive care unit of the hospital.
Because of these responsibilities, I actively implement the clinical and interventional procedures required by my specialty.
01/08 / 2011–01 / 09/2013 Specialist Doctor
Universal Hospitals Group, Kusadasi (Turkey)
The fact that Kuşadası is a tourism center and with the provision of polyclinic and services, I took care of patients coming from abroad especially in the tourism season.
01/09 / 2006–01 / 06/2011 Specialist Doctor
Çarşamba State Hospital, Samsun (Turkey)
I gave polyclinic and emergency medical services at Çarşamba State Hospital where I was assigned for my compulsory service.
01/05 / 2006–30 / 08/2006 Specialist Doctor
Ege University Faculty of Medicine, Department of Pulmonary Diseases, Izmir (Turkey)
I gave polyclinic and service. I had to leave due to my compulsory service.
01/10 / 2000–30 / 04/2006 Junior Doctor
Ege University Faculty of Medicine, Department of Pulmonary Diseases, Izmir (Turkey)
In addition to theoretical and practical training within 5 years, I gave medical services under the supervision of our doctors.
By
Biyikli, OO (Biyikli, Oguz Oben) [1] ; Baysak, A (Baysak, Aysegul) [2] ; Ece, G (Ece, Gulfem) [3] ; Oz, AT (Oz, Adnan Tolga) [2] ; Ozhan, MH (Ozhan, Mustafa Hikmet) [4] ; Berdeli, A (Berdeli, Afig) [5]
(provided by Clarivate)
Source
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
Volume
9
Issue
10
DOI
10.5812/jjm.20224
Article Number
e20224
Published
OCT 2016
Indexed
2017-02-21
Document Type
Article
Abstract
Background: One-third of the world's population is infected with Mycobacterium tuberculosis. Investigation of Toll-like receptors (TLRs) has revealed new information regarding the immunopathogenesis of this disease. Toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. Toll-like receptor 2 and TLR-4 have been identified in association with tuberculosis infection.
Objectives: The aim of our study was to investigate the relationship between TLR polymorphism and infection progress.
Methods: Twenty-nine patients with a radiologically, microbiologically, and clinically proven active tuberculosis diagnosis were included in this 25-month study. Toll-like receptor 2 and TLR-4 polymorphisms and allele distributions were compared between these 29 patients and 100 healthy control subjects. Peripheral blood samples were taken from all patients. Genotyping of TLR-2, TLR-4, and macrophage migration inhibitory factor was performed. The extraction step was completed with a Qiagen mini blood purification system kit (Qiagen, Ontario, Canada) using a peripheral blood sample. The genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism.
Results: In total, 19 of the 29 patients with tuberculosis infection had a TLR-2 polymorphism, and 20 of the 100 healthy subjects had a TLR-2 polymorphism (P < 0.001). The TLR-4 polymorphism and interferon-gamma allele distributions were not statistically correlated.
Conclusions: Toll-like receptor 2 polymorphism is a risk factor for tuberculosis infection. The limiting factor in this study was the lack of investigation of the interferon-gamma and tumor necrosis factor-ff levels, which are important in the development of infection. Detection of lower levels of these cytokines in bronchoalveolar lavage specimens, especially among patients with TLR-2 defects, will provide new data that may support the results of this study.
Keywords
Author Keywords
Toll-Like Receptor Infection Genetic Polymorphism Mycobacterium tuberculosis