1963 : Misakımilli İlkokulu, Akhisar
1966 : Buca Ortaokulu, İzmir
1969 : İzmir Atatürk Lisesi
1975 : Ege Üniversitesi Tıp Fakültesi,İzmir
1975 - 1979 : Buca SSK Hastanesi, İzmir
1978 - 1980 : Tepecik SSK Hastanesi, İzmir
1980 - 1981 : Askeri Hastane, Isparta
1981 - 1984 : ASS. İzmir Devlet Hastanesi, İzmir
1984 - 1988 : Buca SSK Hastanesi
1988 - 2017 : Dokuz Eylül Üniversitesi Tıp Fakültesi
Complications and Toxicities After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
By
Canda, AE (Canda, Aras Emre) [1] ; Sokmen, S (Sokmen, Selman) [1] ; Terzi, C (Terzi, Cem) [1] ; Arslan, C (Arslan, Cigdem) [1] ; Oztop, I (Oztop, Ilhan) [2] ; Karabulut, B (Karabulut, Bulent) [3] ; Ozzeybek, D (Ozzeybek, Deniz) [4] ; Sarioglu, S (Sarioglu, Sulen) [5] ; Fuzun, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
Volume
20
Issue
4
Page
1082-1087
DOI
10.1245/s10434-012-2853-x
Published
APR 2013
Indexed
2013-05-07
Document Type
Article
Abstract
The purpose of our study was to evaluate the perioperative complications, toxicity, mortality rates after cytoreductive surgery (CRS), and effects of hyperthermic intraperitoneal chemotherapy (HIPEC) used in the treatment of peritoneal surface malignancies.
Between September 2007 and March 2012, we performed 118 CRS and HIPEC with the closed abdominal technique on 115 patients with peritoneal carcinomatosis (PC). Systemic toxicities were graded according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 criteria and were analyzed from a prospectively collected database.
The mean age of patients was 53.4 (range, 20-82) years; 76.3 % were female. PC was synchronous to primary cancer in 53.4 % of patients, metachronous in 41.5 %, and recurrent in 5.1 % of the patients. PCI was a parts per thousand yen15 in 53.4 % of the patients, and CC-0 cytoreduction was achieved in 68.5 % of the patients. Perioperative mortality was observed in 9 (7.6 %) patients. A total of 98 complications were observed in 46 (39.0 %) patients, and 4 patients underwent 6 reoperations for perioperative surgical complications. We observed toxicity in 25.4 % of the patients, nephrotoxicity in 18.6 %, and hematological toxicity in 13.6 % of patients. No significant difference was observed among age, gender, PCI and CC scores, origin of the primary tumor, and occurrence of toxicity and surgical complications. Prolonged operation times resulted in higher complication and/or toxicity rates (P < 0.01).
Cytoreductive surgery and HIPEC is a combined treatment strategy for peritoneal surface malignancies with acceptable complication and toxicity rates.
Keywords
Keywords Plus
PERITONEAL SURFACE MALIGNANCY COLORECTAL-CANCER MORTALITY ANALYSIS
Infectious Complications after Cytoreductive Surgery and Hyperthermic Intra-Peritoneal Chemotherapy
By
Arslan, NC (Arslan, Naciye Cigdem) [1] ; Sokmen, S (Sokmen, Selman) [2] ; Avkan-Oguz, V (Avkan-Oguz, Vildan) [3] ; Obuz, F (Obuz, Funda) [4] ; Canda, AE (Canda, Aras Emre) [2] ; Terzi, C (Terzi, Cem) [2] ; Fuzun, M (Fuzun, Mehmet) [2]
(provided by Clarivate)
Source
Volume
18
Issue
2
Page
157-163
DOI
10.1089/sur.2016.102
Published
FEB-MAR 2017
Indexed
2017-04-05
Document Type
Article
Abstract
Background: The aim of this study was to review the post-operative and infectious complications and determine the risk factors associated with infections in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Patients and Methods: Between October 2007 and December 2013, patients who underwent CRS and HIPEC with a curative intent were included in the study. The Centers for Disease Control and Prevention's National Nosocomial Infections Surveillance System definitions were used to identify post-operative nosocomial infections.
Results: One hundred and sixty-nine CRS and HIPEC procedures were performed. Overall, 155 complications were observed in 82 (48.5%) patients. Grade 3-4 morbidity rate was 25.5% (n = 43). Seventy infections occurred in 47 patients. Surgical site infection was the most common infectious complication. The most common microorganism isolated from the cultures was Escherichia coli. Age (odds ratio [OR] 1.039, confidence interval [CI] 1.006-1.073), the mean total number of staff scrubbing in the operation(OR 2.241, CI 1.415-3.548), and intensive care unit stay (OR 1.325, CI 0.953-1.842) were independent risk factors for infectious complications.
Conclusions: Infectious complications are the most important cause of peri-operative morbidity and death in CRS and HIPEC. As well as patient and tumor characteristics, surgeon/center-related factors play an important role in infectious morbidity. Patients with peritoneal carcinomatosis should be considered as a complex oncologic group at high risk of infectious complications.
Keywords
Author Keywords
hyperthermic intra-peritoneal chemotherapy infection morbidity oncology peritoneal
Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients
By
Canda, AE (Canda, Aras Emre) [1] ; Terzi, C (Terzi, Cem) [1] ; Gorken, IB (Gorken, Ilknur B.) [2] ; Oztop, I (Oztop, Ilhan) [3] ; Sokmen, S (Sokmen, Selman) [1] ; Fuzun, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Volume
25
Issue
2
Page
197-204
DOI
10.1007/s00384-009-0807-y
Published
FEB 2010
Indexed
2010-02-01
Document Type
Article
Abstract
Deterioration of anorectal function after long-course preoperative chemoradiotherapy combined with surgery for rectal cancer is poorly defined. We conducted a prospective study to evaluate the acute and long term effects of preoperative chemoradiotherapy on anorectal function and quality of life of the patients.
There were 26 patients in surgery group and 31 patients in preoperative chemoradiotherapy group. Anorectal function and quality of life of the patients were assessed by anorectal manometry, incontinence score, quality of life questionnaire.
Significant lower resting pressures in both groups and lower maximal squeeze pressures in the preoperative chemoradiotherapy group were observed after postsurgical evaluations compared with the paired pretreatment ones. In the surgery group, both the Wexner continence score, FIQL score, and the rectoscopy score were comparable before and after surgery, whereas significant worsening in the Wexner score was observed in the preoperative chemoradiotherapy group postoperatively (P < 0.01). Significant reduction in anal canal resting pressures and squeeze pressures, Wexner score, and FIQL score were observed immediately after the completion of preoperative chemoradiotherapy. Significant lower maximal squeeze pressures and worsening of the Wexner scores were observed in the preoperative chemoradiotherapy group compared to the surgery group during the postoperative assessments (P < 0.05 and P < 0.01, respectively).
Both total mesorectal excision and preoperative chemoradiotherapy may adversely affect the anorectal function. Careful selection of the patients who will benefit from neoadjuvant therapy and identifying the patients with a high risk of developing functional problems may help to improve functional outcomes for the treatment of rectal cancer.
Keywords
Author Keywords
Rectal cancer Preoperative chemoradiotherapy Anorectal manometry Quality of life
Treatment of intraoperatively detected peritoneal carcinomatosis of colorectal origin with cytoreductive surgery and intraperitoneal chemotherapy
By
Canda, AE (Canda, Aras Emre) [1] ; Arslan, C (Arslan, Cigdem) [1] ; Terzi, C (Terzi, Cem) [1] ; Sokmen, S (Sokmen, Selman) [1] ; Yavuzsen, T (Yavuzsen, Tugba) [2] ; Ozkardesler, S (Ozkardesler, Sevda) [3] ; Unlu, M (Unlu, Mehtat) [4] ; Obuz, F (Obuz, Funda) [5] ; Fuzun, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
WORLD JOURNAL OF SURGICAL ONCOLOGY
Volume
16
DOI
10.1186/s12957-018-1369-7
Article Number
70
Published
MAR 27 2018
Indexed
2018-04-19
Document Type
Article
Abstract
Background: Diagnosis of peritoneal carcinomatosis (PC) may be missed by preoperative imaging. We are presenting our experience with incidentally detected PC of colorectal origin treated with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) at the same operation.
Methods: Between January 2010 and September 2016, 19 patients underwent CRS and IPC due to incidentally detected PC of colorectal origin. Data were analyzed from a prospectively collected database.
Results: The median age was 59 (29-78). In three patients, PC was diagnosed during emergency surgery. The primary tumor was located in the rectum (three patients; one with recurrent disease), left colon (9 patients), and right colon (7 patients). All patients underwent CRS and IPC, and one patient operated laparoscopically. Median peritoneal cancer index (PCI) was 5 (range, 3-14), and complete cytoreduction (CC-0) was achieved in 14 patients. After CRS, 8 patients received early postoperative intraperitoneal chemotherapy (EPIC), 7 patients received hyperthermic intraperitoneal chemotherapy (HIPEC), and 4 patients received both HIPEC and EPIC. The median hospital stay was 9 (6-29) days. Postoperative complications occurred in 6 patients. There was no postoperative mortality. Median follow-up was 40.2 (12-94) months. Five-year overall survival was 63.2%. Estimated mean survival time is longer in patients who underwent complete cytoreduction compared to patients having CC-1 or CC-2 cytoreduction (87.7 vs. 20.3 months; p < 0.001).
Conclusion: Cytoreductive surgery and IPC can be performed safely in patients with intraoperatively detected incidental PC of colorectal origin.
Keywords
Author Keywords
Peritoneal carcinomatosis Intraperitoneal chemotherapy HIPECEPIC Colorecta
The Prognostic Implications of FIX and FLO Patterns in Mucinous Colon Carcinomas
By
Sarioglu, S (Sarioglu, Sulen) [1] ; Akturk, G (Akturk, Guray) [1] , [2] ; Sokmen, S (Sokmen, Selman) [3] ; Ellidokuz, H (Ellidokuz, Hulya) [4] ; Canda, AE (Canda, Aras Emre) [3] ; Unlu, M (Unlu, Mehtat) [1] ; Sirin, AH (Sirin, Abdullah Haluk) [3] ; Sagol, O (Sagol, Ozgul) [1] ; Terzi, C (Terzi, Cem) [3] ; Fuzun, M (Fuzun, Mehmet) [3]
(provided by Clarivate)
Source
JOURNAL OF GASTROINTESTINAL CANCER
Volume
50
Issue
2
Page
254-259
DOI
10.1007/s12029-018-0059-6
Published
JUN 2019
Indexed
2019-05-17
Document Type
Article
Abstract
PurposeColon mucinous carcinomas (MUCs) have two morphological patterns: (i) glands lined by mucinous epithelium with direct contact to the stroma (FIX) and (ii) carcinoma cells floating in mucin (FLO). In this study, we evaluated the prognostic value of these patterns.MethodsDigital images were captured from the 38 MUC's tissue sections. A grid with 140 points was laid over the computer screen. Totally, 100 points, falling on tumor cells floating in mucin (FLO patterned cells) or on cells contacting stroma (FIX patterned cells), were counted. Tumors were grouped according to the median value of the FIX patterned cells. Cases with more than this value were grouped as FIX and less were grouped as FLO cases. The prognostic value of FIX and FLO pattern was evaluated.ResultsThe median for FIX patterned cells was 66%, and the cases with lower values than this were grouped as FLO (N=18; 47.37%), while the rest were grouped as FIX cases. There was no significant difference between FIX and FLO cases for overall survival cases (p=0.167). For FIX cases, 62.7 and 51.3% of the patients were alive at second and third years, while this was 78.9 and 72.4% for the FLO group, respectively.ConclusionsThis is the first study using a quantitative methodology depending on count pointing to evaluate FIX/FLO feature of MUCs to the best of our knowledge, although we could not observed any prognostic and clinicopathologic relationship statistically. This distinctive feature should be studied in larger cohorts with prognostic information, with a quantitative method, like the one that was applied in this study, in order to achieve strict conclusions.
Keywords
Author Keywords
Mucinous carcinoma Colon Prognosis FIXFLO
Core curriculum illustration: colonic intussusception due to pedunculated lipoma
By
Altay, C (Altay, Canan) [1] ; Unlu, M (Unlu, Mehtat) [2] ; Fuzun, M (Fuzun, Mehmet) [3] ; Secil, M (Secil, Mustafa) [1]
(provided by Clarivate)
Source
Volume
27
Issue
4
Page
461-462
Special Issue
SI
DOI
10.1007/s10140-018-1613-z
Published
AUG 2020
Indexed
2020-07-21
Document Type
Article
Abstract
This is the 48th installment of a series that will highlight one case per publication issue from the bank of cases available online as a part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for study online at.
Keywords
Author Keywords
Colo-colonic intussusception Lipoma
Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer:: relationship to clinicopathological variables
By
Islekel, H (Islekel, Huray) ; Oktay, G (Oktay, Gulgun) ; Terzi, C (Terzi, Cem) ; Canda, AE (Canda, Aras Emre) ; Füzün, M (Fuzun, Mehmet) ; Küpelioglu, A (Kupelioglu, Ali)
(provided by Clarivate)
Source
CELL BIOCHEMISTRY AND FUNCTION
Volume
25
Issue
4
Page
433-441
DOI
10.1002/cbf.1325
Published
JUL-AUG 2007
Indexed
2007-07-01
Document Type
Article
Abstract
The balance between matrix metalloproteinases (MMPs) and their physiological tissue inhibitors of matrix metalloproteinases (TIMPs) is crucial in tumour invasion and progression. The aim of this study was to investigate the levels of MMP-9, MMP-3 and TIMP-1 in colorectal cancer (CRC) and to evaluate these proteinases and their inhibitor with respect to clinicopathological variables. Activities of pro- and active MMP-9 were measured in paired turnout and distant normal tissue specimens from 43 patients with CRC using gelatin zymography. ELISA was employed for the determination of MMP-9, MMP-3 and TIMP-1 protein expressions. The activity levels of pro- and active MMP-9 and protein expression levels of MMP-9, MMP-3 and TIMP-1 were higher in tumour tissues than in the corresponding normal tissues; the differences being significant for all (p < 0.05), except TIMP-1. Similarly, active MMP-9/proMMP-9 and the ratio of protein expression level of MMP-9-TIMP-1 were found to be significantly higher in tumour tissues (p < 0.0 1). Among all the clinicopathological variables investigated, significant correlations were found between MMP-9 and presence of perineural invasion, MMP-3 and lymph node status, TIMP-1 and tumour differentiation, MMP-9/TIMP- I ratio and histological types (p < 0.05). In conclusion, MMP-3 was not as notably increased as MMP-9 in tumour tissues. However, different roles may be attributed to MMP-9 and MMP-3 in CRC development and progression. Additionally, assessment of TIMP-1 in relation to MMPs appeared to be crucial in CRC studies to provide a basis for the re-evaluation of the clinical usefulness of TIMP-1 in colorectal cancer. Copyright (C) 2006 John Wiley & Sons, Ltd.
Keywords
Author Keywords
matrix metalloproteinase-9 matrix metalloproteinase-3 tissue inhibitors of matrix
Efficacy of High Resolution Magnetic Resonance Imaging in Preoperative Local Staging of Rectal Cancer
By
Uçar, A (Ucar, Aysun) [1] ; Obuz, F (Obuz, Funda) [1] ; Sökmen, S (Sokmen, Selman) [2] ; Terzi, C (Terzi, Cem) [2] ; Sagol, Ö (Sagol, Ozgul) [3] ; Sarioglu, S (Sarioglu, Sulen) [3] ; Füzün, M (Fuzun, Mehmet) [2]
(provided by Clarivate)
Source
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Volume
22
Issue
2
Page
42-48
DOI
10.4274/Mirt.43153
Published
AUG 2013
Indexed
2013-08-01
Document Type
Article
Abstract
Objective: To assess the efficacy of high-resolution magnetic resonance imaging (HRMRI) for preoperative local staging in patients with rectal cancer who did not receive preoperative radiochemotherapy.
Methods: In this retrospective study, 30 patients with biopsy proved primary rectal cancer were evaluated by HRMRI. Two observers independently scored the tumour and lymph node stages, and circumferential resection margin (CRM) involvement. The sensitivity, specificity, the negative predictive value and the positive predictive value of HRMRI findings were calculated within the 95% confidence interval. The area under the curve was measured for each result. Agreement between two observers was assessed by means of the Kappa test.
Results: In T staging the accuracy rate of HRMRI was 47-67%, overstaging was 10-21%, and understaging was 13-43%. In the prediction of extramural invasion with HRMRI, the sensitivity was 79-89%, the specificity was 72-100%, the PPV was 85-100%, the NPV was 73-86%, and the area under the curve was 0.81-0.89. In the prediction of lymph node metastasis, the sensitivity was 58-58%, the specificity was 50-55%, the PPV was 43-46%, and the NPV was 64-66%. The area under the curve was 0.54-0.57. When the cut off value was selected as 1 mm, the sensitivity of HRMRI was 38-42%, the specificity was 73-82%, the PPV was 33-42%, and NPV was 79-81% in the prediction of the CRM involvement. The correlation between the two observers was moderate for tumour staging, substantial for lymph node staging and predicting of CRM involvement.
Conclusion: Preoperative HRMRI provides good predictive data for extramural invasion but poor prediction of lymph node status and CRM involvement.
Keywords
Author Keywords
Rectum rectum cancer magnetic resonance imaging tumor staging
Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy
By
Terzi, C (Terzi, Cem) ; Canda, AE (Canda, Aras Emre) ; Sagol, O (Sagol, Ozgul) ; Atila, K (Atila, Koray) ; Sonmez, D (Sonmez, Devrim) ; Fuzun, M (Fuzun, Mehmet) ; Gorken, IB (Gorken, Ilknur B.) ; Oztop, I (Oztop, Ilhan) ; Obuz, F (Obuz, Funda)
(provided by Clarivate)
Source
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Volume
23
Issue
1
Page
37-45
DOI
10.1007/s00384-007-0376-x
Published
JAN 2008
Indexed
2008-01-01
Document Type
Article
Abstract
The ability to predict response to chemoradiotherapy before the treatment may allow protecting poorly responding patients from the side effects of neoadjuvant treatment. Several molecular markers have been proposed to radio and chemosensitivity of rectal cancer. In this study, from pre-irradiation tumor biopsies, a novel and promising candidate factor survivin, and p53 and Ki-67 were assessed as predictors of response to preoperative chemoradiotherapy.
Expression of each marker was evaluated by immunohistochemistry on pretreatment biopsies from 37 patients having rectal cancer treated with preoperative chemoradiotherapy and curative surgery. Treatment response was assessed histopathologically in the resected surgical specimen.
There was no correlation between expression of p53, Ki-67, and survivin with response to preoperative chemoradiotherapy and prognosis.
Our data suggest that these molecular markers are not helpful to identify patients who would have benefit from neoadjuvant treatment of rectal cancer. Further investigations are necessary to select patients for preoperative treatment based on analysis of the preoperative biopsies.
Keywords
Author Keywords
rectal cancer preoperative chemoradiotherapyradiosensitivityp53Ki-67 survivin
Survival Outcomes of Liver Metastasectomy in Colorectal Cancer Cases: A Single-Center Analysis in Turkey
By
Cokmert, S (Cokmert, Suna) [1] ; Ellidokuz, H (Ellidokuz, Hulya) [2] ; Demir, L (Demir, Lutfiye) [1] , [3] ; Fuzun, M (Fuzun, Mehmet) [4] ; Astarcioglu, I (Astarcioglu, Ibrahim) [4] ; Aslan, D (Aslan, Deniz) [5] ; Yilmaz, U (Yilmaz, Ugur) [6] ; Oztop, I (Oztop, Ilhan) [5]
(provided by Clarivate)
Source
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
Volume
15
Issue
13
Page
5195-5200
DOI
10.7314/APJCP.2014.15.13.5195
Published
2014
Indexed
2014-11-19
Document Type
Article
Abstract
Background: The purpose of this study was to analyze our series of liver resections for metastatic colorectal carcinoma (mCRC) to determine prognostic factors affecting survival and to evaluate the potential roles of neoadjuvant or adjuvant chemotherapy. Materials and Methods: Ninety-nine patients who underwent metastasectomy for liver metastases due to colorectal cancer at the Department of Medical Oncology, 9 Eylul University Hospital between 1996 and 2010 were evaluated in this study. The patients were followed through July 2013. Demographic, perioperative, laboratory, radiological and chemotherapy as well as survival data were obtained by retrospective chart review. Results: In 47 (47.5%) patients, liver metastases were unresectable at initial evaluation; the remaining 52 (52.5%) patients exhibited resectable liver metastases. Simultaneous hepatic resection was applied to 52 (35.4%) patients with synchronous metastasis, whereas 5 (64.5%) patients underwent hepatic resection after neoadjuvant chemotherapy. Forty-two patients with metachronous metastasis underwent hepatic resection following neoadjuvant chemotherapy. R0 resection was obtained in 79 (79.8%) patients. A second hepatectomy was performed in 22 (23.2%) patients. Adjuvant chemotherapy was given to 85 (85.9%) patients after metastasectomy. The median disease-free and overall survivals after initial metastasectomy were 12 and 37 months, respectively, the 1-year, 3-year and 5-year disease-free survival (DFS) and overall survival (OS) rates being 46.5%, 24.3% and 17.9% and 92.3%, 59.0% and 39.0%, respectively. On multivariate analysis, the primary tumor site, tumor differentiation, resection margin and DFS were independent factors predicting better overall survival. Conclusions: In selected cases, hepatic metastasectomy for mCRC to the liver can result in long-term survival. Neoadjuvant chemotherapy did not exert a positive effect on DFS or OS. Adjuvant chemotherapy also did not appear to impact DFS and OS.
Keywords
Author Keywords
Liver metastases colorectal cancer metastasectomy survival prognostic factors
Improvement of colonic healing by preoperative oral partially hydrolyzed guar gum (Benefiber) in rats which underwent preoperative radiotherapy
By
Sevinc, AI (Sevinc, Ali Ibrahim) [1] ; Aydogan, B (Aydogan, Baki) [1] ; Canda, AE (Canda, Aras Emre) [1] ; Cetinayak, O (Cetinayak, Oguz) ; Terzi, C (Terzi, Cem) [1] ; Oktay, G (Oktay, Gulgun) ; Gurel, D (Gurel, Duygu) ; Fuzun, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
Volume
22
Issue
3
Page
262-266
DOI
10.3109/1061186X.2013.866674
Published
APR 2014
Indexed
2014-05-06
Document Type
Article
Abstract
Background: Neoadjuvant radiotherapy in rectal cancer could interfere with anastomotic healing. We investigated the effects of preoperative oral administration of Benefiber on the healing irradiated colonic anastomosis.
Methods: Forty male Wistar rats were divided into four groups. Group I (control group), Group II (Benefiber (R) pretreatment group), Group III (preoperative radiotherapy group) and Group IV (preoperative radiotherapy and Benefiber (R) pretreatment group). All animals underwent 1 cm left colon resection and primary anastomosis. On the 3rd and 7th postoperative days, all the rats were anesthetized to assess the anastomotic healing clinically, mechanically, histologically and biochemically.
Results: The mean bursting pressure was significantly lower in-group III and significantly higher in-group II on day 7. The histologic parameters of anastomotic healing, such as epithelial regeneration and formation of granulation tissue, were significantly improved by use of preoperative Benefiber (R) on day 7. The amount of acid-soluble collagen concentrations significantly increased in-group IV compared to group III on day 3. The amount of salt-soluble collagen concentrations significantly increased in group II compared to group III on day 3.
Conclusions: Colonic anastomotic healing can be adversely affected by preoperative radiotherapy, but orogastric feeding with Benefiber may improve the healing process.
Keywords
Author Keywords
Anastomosis Benefiber healing radiotherapy
Transanal Single-port Access Microsurgery (TSPAM)
By
Canda, AE (Canda, Aras Emre) [1] ; Terzi, C (Terzi, Cem) [1] ; Sagol, O (Sagol, Ozgul) [2] ; Sarioglu, S (Sarioglu, Sulen) [2] ; Obuz, F (Obuz, Funda) [3] ; Fuzun, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
Volume
22
Issue
4
Page
349-353
DOI
10.1097/SLE.0b013e3182571831
Published
AUG 2012
Indexed
2012-09-26
Document Type
Article
Abstract
Transanal single-port access microsurgery (TSPAM) is an emerging and feasible minimally invasive method for the transanal excision of large sessile adenomas and early-stage carcinomas of the rectum. Here we present our TSPAM experience on rectal adenomas (high-grade rectal adenomas in 5 cases and carcinoma in situ in 1 case). TSPAM is an innovative method that can be an affordable and disseminated alternative to transanal endoscopic microsurgery for the local excision of the rectal lesions.
Keywords
Author Keywords
transanal microsurgery single port polypectomy
A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: Case report
By
Demirkan, B (Demirkan, Binnaz) [1] ; Ünek, IT (Unek, Ilkay Tugba) ; Eriksson, B (Eriksson, Barbro) [8] ; Akarsu, M (Akarsu, Mesut) [2] ; Durak, H (Durak, Hatice) [3] ; Sagol, Ö (Sagol, Ozgul) [4] ; Obuz, F (Obuz, Funda) [5] ; Binicier, Ç (Binicier, Cilem) [6] ; Füzün, M (Fuzun, Mehmet) [7] ; Alakavuklar, M (Alakavuklar, Mehmet) [9]
(provided by Clarivate)
Source
TURKISH JOURNAL OF GASTROENTEROLOGY
Volume
20
Issue
3
Page
214-219
DOI
10.4318/tjg.2009.0010
Published
SEP 2009
Indexed
2009-09-01
Document Type
Article
Abstract
Pancreatic neuroendocrine tumors constitute about 2% of all gastrointestinal neoplasms. Approximately half of the pancreatic neuroendocrine tumors are nonfunctional. Due to lack of specific symptoms, most patients with nonfunctional pancreatic neuroendocrine tumors present with locally advanced or metastatic disease. Second primary malignancies are seen very rarely in these patients. Colon carcinoma ranks third in frequency among primary sites of cancer in both men and women in western countries. Presence of a metachronous colon adenocarcinoma in a patient with nonfunctional pancreatic neuroendocrine tumor has not been reported before. We present a patient who had an asymptomatic mass in the head of the pancreas, detected by ultrasonography in 1996. The patient did not consent to operation. In 2002, after the diagnosis of an unresectable, nonfunctional pancreatic neuroendocrine tumor, interferon alpha-2b and octreotide were started. A year after biological treatment, he refused further treatment. In 2004, during the evaluation of dissemination of the asymptomatic disease, positron emission tomography revealed a high uptake by the descending colon despite the failure of other imaging methods. After surgery for operable colon carcinoma, the patient received chemotherapy and biological therapy for both tumors. Since 2005, he has been doing well without any further treatment thus far. In conclusion, computerized tomography/magnetic resonance imaging and octreotide scintigraphy may be insufficient to show disseminated disease and asymptomatic second primary malignancies. Therefore, positron emission tomography is a valuable promising option for the evaluation of gastroenteropancreatic neuroendocrine tumors and concomitant or metachronous malignancies. Lifelong follow-up by a multidisciplinary oncology team is needed so that a long-term survival can be achieved with integrated multimodal systemic treatment approaches.
Keywords
Author Keywords
Pancreatic neuroendocrine tumor colon cancer positron emission tomography
Response to neoadjuvant chemoradiation in locally advanced rectal cancer: Dokuz Eylul University experience
By
Canda, AE (Canda, Aras Emre) [1] ; Terzi, C (Terzi, Cem) [1] ; Sarioglu, S (Sarioglu, Sulen) [1] ; Görken, IB (Gorken, Ilknur Bilkay) [1] ; Alanyali, H (Alanyali, Hilmi) [1] ; Obuz, F (Obuz, Funda) [1] ; Yilmaz, U (Yilmaz, Ugur) [1] ; Öztüp, I (Oztup, Ilhan) [1] ; Sökmen, S (Sokmen, Selman) [1] ; Füzün, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
Volume
24
Issue
4
Page
193-199
Published
OCT 2008
Indexed
2008-10-01
Document Type
Article
Abstract
Purpose: The aim of this study was to evaluate the response to neoadjuvant long course chemoradiotherapy (CRT) for patients with locally advanced rectal cancer with or without lymph node metastasis.
Materials and Methods: Between 1993 - 2007, 126 patients with locally advanced rectal cancer with or without lymph node involvement were treated at Dokuz Eylul University Medical Faculty Hospital. Prospectively collected data of patients were analyzed. All patients received concurrent CRT. Curative intend surgical resection was performed 4 to 8 weeks after the completion of CRT. Response to neoadjuvant CRT was assessed by comparing the preoperative clinical staging and postoperative pathological evaluation. Histopathological complete response (pCR) was defined as no tumor cells within the specimen. Downstaging of T and/or N stage of the tumor was defined as partial response (PR).
Results: Mean age was 57.9 years and 40,5% of patients were female, 59,5% of patients were male. Preoperative staging revealed T3 tumor in 54 (42,8%) of patients and T4 tumor in 58 (46%) of patients. In 32 (25,4%) patients there were no lymph node metastases (cN0) whereas in 94 (74,6%) patients lymph node involvement was detected (cN+). Tumor was located at lower rectum in 61,1% of patients, at mid-rectum in 25,4% of patients, and at upper rectum in 13,5% of patients. Sphincter saving resection was performed in 62,7% of patients. Histopathological complete response was observed in 13 (10,3%) patients. T stage downstaging was observed in 63 (% 63) patients, N stage downstaging was observed in 57 (45,2%) patients, and PR was observed in 76 (60,3%) patients. No significant difference was observed between the response to neoadjuvant CRT and tumor localization and sphincter saving resection (P -> 0.05).
Conclusion: Response to neoadjuvant CRT was obtained in majority of the patients. Downstaging was not associated with the rate of sphincter preserving surgery. Surgical resection is still the primary treatment of resectable rectal cancer.
Keywords
Author Keywords
Locally advanced rectal cancer neoadjuvant chemoradiotherapy downstaging
A case report of peritoneal carcinomatosis of colorectal cancer treated with cytoreduction and hyperthermic intraperitoneal chemotherapy, and an overview of related medical literature
By
Terzi, C (Terzi, Cem) [1] ; Yilmaz, U (Yilmaz, Ugur) [2] ; Yakut, C (Yakut, Can) [1] ; Özbilgin, M (Ozbilgin, Mcahit) [1] ; Obuz, F (Obuz, Funda) [3] ; Sarioglu, S (Sarioglu, Sulen) [4] ; Füzün, M (Fuzun, Mehmet) [1]
(provided by Clarivate)
Source
Volume
24
Issue
1
Page
33-41
Published
MAR 2008
Indexed
2008-03-01
Document Type
Article
Abstract
The peritoneum is one of the most frequent site of the metastasis of colorectal cancer. Until recently, treatment of peritoneal carcinomatosis has been limited to palliative surgery and systemic chemotherapy with a median survival 4-12 months. But, cytoreductive surgery (including peritonectomies) and hyperthermic intraperitoneal chemothereapy has resulted in an unprecedented median survival > 20 months. The use of hyperthermia as an adjunct to chemotherapy in the treatment of peritoneal carcinomatosis of colorectal cancer is a new and very promising technique. We, herein, report of the first case of Turkey who had cytoreductive surgery and hyperthermic intraperitoneal chemothereapy with the diagnosis of peritoneal carcinomatosis of colon cancer. We also present the description of technique of hyperthermic intraperitoneal chemothereapy and an overview of the releted medical literature.
Keywords
Author Keywords
Peritoneal carcinomatosis colorectal cancer hyperthermic intraperitoneal chemotherapy
Ege Cerrahi Derneği (Kurucu Üye ve Başkanlık)
Ulusal Cerrahi Derneği
Türk Kolon ve Rektum Cerrahi Derneği (Kurucu üye ve ikinci başkanlık)
International Ostomy Association
Society of University Colon and Rectal Surgeons
International Society For Regional Cancer Therapy