The Effect of Age on High-Dose Therapy with Autologous Stem Cell Support in Multiple Myeloma: A Single-Center Experience
By
Yucel, EE (Yucel, Elcin Erdogan) [1] ; Kirmaz, AT (Kirmaz, Ayse Tugce) [2] ; Kakci, M (Kakci, Merve) [3] ; Yavuz, AF (Yavuz, Aylin Fatma) [3] ; Sencelikel, T (Sencelikel, Tugce) [4] ; Alacacioglu, I (Alacacioglu, Inci) [3] ; Ozsan, GH (Ozsan, Guner Hayri) [3]
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Source
Volume
13
Issue
14
DOI
10.3390/jcm13144142
Article Number
4142
Published
JUL 2024
Indexed
2024-08-04
Document Type
Article
Jump to
Abstract
Background: This retrospective one-center study demonstrates the complications related to high-dose therapy with autologous stem cell support (HDT) and the survival of multiple myeloma (MM) patients according to age groups. Methods: We categorized the patients into two groups: those who were <= 65 years old (group 1) (N = 115) and those who were >65 years old (group 2) (N = 26). The mean duration of follow-up was 48 (1-125) months. Results: In group 2 patients, the use of a reduced dosage of melphalan (12 [46%] versus 30 [26%]) was more frequent in comparison to group 1 (p = 0.046). There was a statistically significant difference between the two groups regarding the neutrophil engraftment days (p = 0.001) and the median progression-free survival (PFS) (p = 0.02). The PFS was 44 months for group 1 and 30 months for group 2. There was no statistically significant difference between the groups in relation to the median duration of hospitalization, presence of bacteremia, intravenous antibiotic administration, and overall survival (OS). Conclusions: The study's results indicate that HDT is a reliable method of treatment for older patients with MM, provided that they obtain a suitable conditioning regimen and, furthermore, these patients achieved a comparable OS rate to that of younger patients.
Keywords
Retrospective Evaluation of Clinical, Demographic, and Radiological Data of Orbital Lymphoma Patients: A Single Tertiary Center Experience
By
Ozizmirliler, D (Ozizmirliler, Denizcan) [1] ; Karakaya, B (Karakaya, Burak) [2] ; Yaman, A (Yaman, Aylin) [3] ; Bajin, MS (Bajin, Meltem Soylev) [1] ; Men, S (Men, Suleyman) [4] ; Demirkan, F (Demirkan, Fatih) [5] ; Ozsan, GH (Ozsan, Guner Hayri) [5] ; Utine, CA (Utine, Canan Asli) [1] , [6]
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Source
BEYOGLU EYE JOURNAL
Volume
10
Issue
1
Page
25-33
DOI
10.14744/bej.2024.84829
Published
2025
Indexed
2025-11-17
Document Type
Article
Jump to
Abstract
Objectives: The objective of the study was to present different clinical presentations, clinical and histopathological features, and treatment outcomes of intraorbital lymphoma. Methods: Medical records of 18 eyes of 17 patients with histopathologically proven diagnoses of intraorbital lymphoma at Dokuz Eyl & uuml;l University Ophthalmology Department, between 2007 and 2022, were reviewed retrospectively. The age, from initial symptoms to diagnosis, follow-up time, and survival times were recorded. Visual acuities at the time of diagnosis and following treatment were evaluated. Results: The mean age of the patients was 63 +/- 19.11 (range: 15-79, median age 65). The most common presenting findings were periorbital swelling, conjunctival mass, and ptosis. Periorbital region involvement was present in 10 of 17 cases (58.8%) and conjunctival involvement was present in 7 cases (41.2%). Biopsy samples were taken from all cases. Non-Hodgkin lymphoma was the most common type of lymphoma, whereas the most common histopathological diagnoses were marginal zone lymphoma and diffuse large B-cell lymphoma. One case was diagnosed with mature T-cell lymphoma. Nine cases had bone marrow involvement. While two cases refused treatment, two cases were not treated due to age and comorbid diseases. Nine cases received chemotherapy, two cases received radiotherapy (RT), 1 case received chemotherapy and RT, and one case received antibiotherapy treatment. In one case with proptosis and exposure keratitis, lateral canthatomy, temporary tarsorrhaphy, and aggressive topical treatment resulted in complete epithelialization of the cornea. Conclusion: Orbital lymphoma is a painless and slowly progressive clinical picture that requires high clinical suspicion because it is a common tumor of the orbit. Although clinical symptoms and findings vary according to the intraorbital location of lymphoma, patients should be examined for systemic involvement and followed up in a multidisciplinary manner.
Keywords
Author Keywords
Intraorbital lymphoma lymphoma orbit orbital lymphoma Intraorbital lymphoma lymphoma
Effects of 27.12 MHz short-waves on fibroblast cell culture and K-562 and ML-1 neoplastic cell lines
By
Muluk, SY (Muluk, Selkin Yilmaz) [1] ; Özsan, GH (Ozsan, Guner Hayri) [2] ; Öncel, S (Oncel, Sema) [3] ; Ates, H (Ates, Halil) [2]
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Source
TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
Volume
71
Issue
1
Page
83-91
DOI
10.5606/tftrd.2024.14635
Published
2025
Early Access
JUL 2024
Indexed
2024-11-14
Document Type
Article
Jump to
Abstract
Objectives: This study aimed to assess the effect of short-wave therapy (SWT) devices emitting radiofrequency (RF) waves on the proliferation rates of fibroblasts and neoplastic cells. Patients and methods: In this experimental study, fibroblasts cultured from sternal mesenchymal cells of a bypass surgery patient were enriched using stem cell techniques between January 2004 and February 2004. The K-562 and ML-1 neoplastic cell lines were prepared for analysis. Fibroblasts and neoplastic cell lines were exposed to 27.12 MHz short-waves at different energy levels. Continuous short-wave (CSW) was applied at 200 W power, and pulsed short-wave (PSW) was applied at three different mean powers: 1.6 W (PSW-1), 14.9 W (PSW-2), and 54 W (PSW-3). Fibroblast colonies were counted using inverted microscopy, and neoplastic cell proliferation rates were measured using enzyme-linked immunosorbent assay. All short-wave-exposed cells were compared to the controls with no exposure. Results: Short-waves increased the number of fibroblast colonies three- to four-fold across all power levels (1.6 W, 14.9 W, 54 W, and 200 W). They significantly increased K-562 cell proliferation only at 1.6 W and 54 W power levels (p=0.044 and p=0.004, respectively). In contrast, there was no significant increase in ML-1 cell proliferation at any power level tested (p>0.05). Conclusion: This study found that short-waves can boost fibroblast proliferation, potentially aiding tendon healing. However, it also had unpredictable proliferative effects on K-562 cells, as an inconsistent correlation with energy levels was observed. The ML-1 cells were not affected by short-waves, suggesting variability in tumor biology. These findings emphasize the need for precise dosing and personalized treatment strategies when using SWT devices.
Keywords
Author Keywords
Cell proliferation fibroblast cell radiofrequency short-wave therapy
EVALUATION OF CMV DNA ANTIGENEMIA STATUS IN PATIENTS WITH ALLOGENEIC BONE MARROW TRANSPLANT
By
Keskinkilic, M (Keskinkilic, Merve) [1] ; Solmaz, S (Solmaz, Serife) [2] ; Seyhanli, A (Seyhanli, Ahmet) [3] ; Appak, O (Appak, Ozgur) [4] ; Sayiner, AA (Sayiner, Ayca Arzu) [4] ; Ozsan, GH (Ozsan, Guner Hayri) [5] ; Alacacioglu, I (Alacacioglu, Inci) [5]
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Source
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
Volume
8
Issue
2
Page
236-243
DOI
10.30621/jbachs.1075229
Published
2024
Indexed
2024-07-20
Document Type
Article
Jump to
Abstract
Purpose: The risk of cytomegalovirus (CMV) reactivation following allogeneic hematopoietic stem cell transplantation (ASCT) reaches 30-50%, and there are numerous diagnostic tests to detect CMV replication. The most common tests used in this group of patients include 65kDa phosphoprotein (pp65) antigenemia immunofluorescence assay and nucleic-acid-based quantitative CMV -DNA polymerase chain reaction (qPCR). Material and Methods: In this study, patients who underwent ASCT and developed CMV positivity from 2009 to 2016 in our hospital were evaluated retrospectively. The study included samples of the same patient with antigenemia and CMV -DNA qPCR test for up to 48 hours. The study aimed to determine the factors affecting CMV DNA antigenemia and compare CMV DNA PCR and pp65 antigenemia immunofluorescence assay. Results: The results of 138 specimens of 39 patients who underwent ASCT were evaluated. The mean value of CMV PCR, which was positive for both tests, was 57.887 copies/ml (70- 1.213.633 copies/ml) and a significant correlation was found between the two tests and the positive samples (p = 0.018). The ROC analysis showed that 322 copies/ml CMV viral load in plasma corresponds to >= 1 antigen-positive cells/200 thousand leukocytes (Sensitivity: 68.5%; Specificity: 31.5%). CMV infection was observed in 32 samples; CMV DNA cut-off values of the reference according to CMV DNA PCR and antigenemia results, compared to the development of CMV infection, presented a significant correlation (p=0.004). Conclusion: Although there is a common agreement between antigenemia and CMV DNA PCR tests, one should keep in mind that the sensitivity of antigenemia test is low especially in the neutropenic period.
Keywords
Author Keywords
Allogeneic Hematopoietic Stem Cell Transplantation (ASCT)
The effect of haemoglobin, albumin, lymphocyte and platelet score on the prognosis in patients with multiple myeloma
By
Solmaz, S (Solmaz, Serife) [1] ; Uzun, O (Uzun, Ozcan) [2] ; Sevindik, OG (Sevindik, Omur Gokmen) [3] ; Demirkan, F (Demirkan, Fatih) [4] ; Ozcan, MA (Ozcan, Mehmet Ali) [4] ; Ozsan, GH (Ozsan, Guner Hayri) [4] ; Alacacioglu, I (Alacacioglu, Inci) [4]
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Source
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Volume
45
Issue
1
Page
13-19
DOI
10.1111/ijlh.13958
Published
FEB 2023
Early Access
SEP 2022
Indexed
2022-09-08
Document Type
Article
Jump to
Abstract
Introduction In multiple myeloma cases, a variety of prognostic parameters have been identified, which contain the Durie-Salmon classification and the international staging system (ISS) that takes the serum ss2 microglobulin and albumin levels, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR). This study investigates the effect of haemoglobin, albumin, lymphocyte and platelet (HALP) score which is a marker of inflammation status and nutrition, at the time of diagnosis for the patients with multiple myeloma on prognosis. Methods A total of 200 multiple myeloma patients with HALP scores calculated from serum haemoglobin, albumin, lymphocyte count and platelet levels at the time of diagnosis were retrospectively examined. The effect of HALP score on overall survival (OS) and progression-free survival and its relationship between the previously evaluated prognostic parameters were investigated. Results The optimal cut-off value with the ROC curves for the HALP score was 28.8. The patients were divided into two groups according to the optimal value of the HALP score (low-score group: HALP <= 28.8 [n: 134] and high-score group HALP >28.8 [n: 66]). In the group with the high HALP score, the OS was statistically longer than the low HALP score group (84 months and 53 months; p = 0.0001). In addition, when the effects of NLR, PLR, HALP score and ISS stage on OS were examined by multivariate analysis, all these markers were found to be statistically significant predictors. Conclusions HALP score may be a valuable prognostic marker for patients with multiple myeloma.
Keywords
Author Keywords
HALP score multiple myeloma overall survival prognosis progression-free survival
Clinical Characteristics and Outcomes of COVID-19 in Turkish Patients with Hematological Malignancies
By
Bozdag, SC (Bozdag, Sinem Civriz) [1] ; Seval, GC (Seval, Guldane Cengiz) [1] ; Hindilerden, IY (Hindilerden, Ipek Yonal) [2] ; Hindilerden, F (Hindilerden, Fehmi) [3] ; Andiç, N (Andic, Neslihan) [4] ; Baydar, M (Baydar, Mustafa) [5] ; Kaynar, LA (Kaynar, Lale Aydin) [6] ; Toprak, SK (Toprak, Selami Kocak) [1] ; Göksoy, HS (Goksoy, Hasan Sami) [7] ; Aydin, BB (Aydin, Berrin Balik) [8] ;
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Source
Volume
39
Issue
1
Page
43-54
DOI
10.4274/tjh.galenos.2021.2021.0287
Published
2022
Indexed
2022-03-16
Document Type
Article
Abstract
Objective: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey. Materials and Methods: In this multicenter study, we included 340 adult and pediatric patients diagnosed with SARS-CoV-2 from March to November 2020. Diagnosis and status of primary disease, treatment schedules for hematological malignancies, time from last treatment, life expectancy related to the hematological disease, and comorbidities were recorded, together with data regarding symptoms, treatment, and outcome of SARS-CoV-2 infection. Results: Forty four patients were asymptomatic at diagnosis of SARSCoV-2 infection. Among symptomatic patients, fever, cough, and dyspnea were observed in 62.6%, 48.8%, and 41.8%, respectively. Sixtynine (20%) patients had mild SARS-CoV-2 disease, whereas moderate, severe, and critical disease was reported in 101 (29%), 71 (20%), and 55 (16%) patients, respectively. Of the entire cohort, 251 (73.8%) patients were hospitalized for SARS-CoV-2. Mortality related to SARS-CoV-2 infection was 26.5% in the entire cohort; this comprised 4.4% of those patients with mild disease, 12.4% of those with moderate disease, and 83% of those with severe or critical disease. Active hematological disease, lower life expectancy related to primary hematological disease, neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line therapy used for coronavirus disease-2019 treatment were found to be related to higher mortality rates. Treatments with hydroxychloroquine alone or in combination with azithromycin were associated with a higher rate of mortality in comparison to favipiravir use. Conclusion: Patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality.
Keywords
Author Keywords
COVID-19SARS-CoV-2 infection Hematological malignancy
Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells
By
Baykal-Köse, S (Baykal-Kose, Seda) [1] ; Acikgoz, E (Acikgoz, Eda) [2] , [3] ; Yavuz, AS (Yavuz, Ahmet Sinan) [4] ; Geyik, ÖG (Geyik, Oyku Gonul) [1] ; Ate, H (Ate, Halil) [5] ; Sezerman, OU (Sezerman, Osman Ugur) [6] ; Özsan, GH (Ozsan, Guner Hayri) [5] ; Yüce, Z (Yuce, Zeynep) [1]
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Source
Volume
15
Issue
2
DOI
10.1371/journal.pone.0229104
Article Number
e0229104
Published
FEB 27 2020
Indexed
2020-06-08
Document Type
Article
Abstract
Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate pressure. K562-IR cells are CD34(-)/CD38(-), BCR-Abl-independent, proliferate slowly, highly adherent and form intact tumor spheroids. Loss of CD45 and other hematopoietic markers reveal these cells have diverged from their hematopoietic origin. CD34 negativity, high expression of E-cadherin and CD44; decreased levels of CD45 and beta-catenin do not fully confer with the leukemic stem cell (LSC) phenotype. Expression analyses reveal that K562-IR cells differentially express tissue/ organ development and differentiation genes. Our data suggest that the observed phenotypic shift is an adaptive process rendering cells under TKI stress to become oncogene independent. Cells develop transcriptional instability in search for a gene expression framework suitable for new environmental stresses, resulting in an adaptive phenotypic shift in which some cells partially display LSC-like properties. With leukemic/cancer stem cell targeted therapies underway, the difference between treating an entity and a spectrum of dynamic cellular states will have conclusive effects on the outcome.
Keywords
Keywords Plus
CHRONIC MYELOGENOUS LEUKEMIA ERYTHROID-DIFFERENTIATION E-CADHERIN STEM-CELLS
Clinical Outcomes of CNS Lymphoma Treated with Ibrutinib-Based Therapy: A Real-Life Multicenter Experience on Off-Label Use of Ibrutinib
By
Iltar, U (Iltar, Utku) [1] ; Salim, O (Salim, Ozan) [1] , [13] ; Atas, U (Atas, Unal) [2] ; Vural, E (Vural, Ece) [1] ; Alhan, FN (Alhan, Fadime Nurcan) [1] ; Yucel, OK (Yucel, Orhan Kemal) [1] ; Sozel, H (Sozel, Hasan) [1] ; Guven, S (Guven, Serkan) [2] ; Geduk, A (Geduk, Ayfer) [4] ; Deveci, B (Deveci, Burak) [5] , [6] ;
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Source
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
Volume
33
Issue
4
Page
191-197
DOI
10.4999/uhod.237297
Published
2023
Indexed
2024-02-15
Document Type
Article
Abstract
Despite recent therapeutic advances, the prognosis of patients with relapsed/refractory (RR) primary (PCNSL) and secondary central nervous system lymphoma (SCNSL) remains poor. Therefore, the need for new treatment options in CNSL continues. Ibrutinib has been used in clinical trials for CNSL in recent years. However, there is no real -life data on this subject yet. We retrospectively evaluated the efficacy of ibrutinib alone or in combination with various treatment options in 39 patients, 21 with PCNSL and 18 with SCNSL. The median age was 62 years and the overall response rate (ORR) was 59%. The median overall survival (OS) was four months for all patients and 13 months for responder patients (p< 0.001). Invasive aspergillosis occurred in 10.2% of the patients. Lactate dehy- drogenase activity, response to treatment, and the presence of the invasive fungal infection were prognostic factors affecting OS on the ibrutinib therapy (p= 0.04, p= 0.02, and p= 0.048, respectively). There was no significant difference in prognosis between the IBR monotherapy and IBR combination groups. Compared to early -phase clinical studies, lower ORR, shorter OS, and a higher incidence of invasive fungal infections were observed in this real -life study of ibrutinib which was used alone or in a combination regimen in patients with RR PCNSL and SCNSL.
Keywords
Author Keywords
Ibrutinib Central nervous system lymphoma Relapsed/refractory Maintenance Aspergillosis
The Relationship Between Prognosis and Plasma Cell Percentage; Infiltration Pattern, Fibrosis and Microvascular Density in Bone Marrow Biopsies of Plasma Cell Myeloma Patients br
By
Ozmen, HI (Ozmen, Hazal Izol) [1] ; Seyhanli, A (Seyhanli, Ahmet) ; Ozsan, GH (Ozsan, Guner Hayri) [2] ; Ellidokuz, H (Ellidokuz, Hulya) [3] ; Ozkal, S (Ozkal, Sermin) [4]
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Source
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
Volume
33
Issue
1
Page
29-36
DOI
10.4999/uhod.236843
Published
2023
Indexed
2023-04-28
Document Type
Article
Abstract
Plasma cell myeloma is a monoclonal disease characterized by anemia, monoclonal protein in serum and or urine, osteolytic in bones, hypercalcemia, and renal failure. The study aims to evaluate the percentage of plasma cells in bone marro , the of bone marro involvement, the intensity of fibrosis and angiogenesis in bone marro , and to assess their relationship ith prognostic markers. In this study, bone marro biopsies of 135 plasma cell myeloma cases ere re-evaluated regarding plasma cell percentage and the pattern of bone marro involvement. Fibrosis as assessed in 132 cases ith reticulin staining and vessel density (M D) in 51 cases ith CD34 staining. The relation of these morphological parameters ith stage and survival lesions pattern clinical as analyzed. Plasma cell percentage, involvement pattern and micro-vessel density sho ed statistically significant micro -status correlation ith stage, hile bone marro fibrosis as not significantly correlated (p 0.05, p 0.001, p 0.011, p 0.05, respectively). percentage of plasma cells, diffuse pattern of bone marro involvement, and increase in the degree of fibrosis as correlated increase in M D (p 0.001, p 0.001, p 0.036 respectively). The present study suggested that evaluation of plasma cell infiltration pattern, fibrosis and micro-vessel density in bone marro biopsies of ne ly diagnosed plasma cell myeloma cases be useful tools in the management and maintenance of the treatment. Elevation in ith an percentage, might
Keywords
Author Keywords
Plasma cell myeloma Bone marro Angiogenesis Fibrosis
Clinical Outcomes and Treatment Patterns of Primary Central Nervous System Lymphoma: Multicenter Retrospective Analysis
By
Guven, S (Guven, Serkan) [1] , [6] ; Yavuz, B (Yavuz, Boran) [1] ; Yucel, EE (Yucel, Elcin Erdogan) [1] ; Karatas, AF (Karatas, Aylin Fatma) [1] ; Ozsan, GH (Ozsan, Guner Hayri) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Undar, B (Undar, Bulent) [1] ; Ozcan, MA (Ozcan, Mehmet Ali) [1] ; Kiper, HD (Kiper, Hatice Demet) [2] ; Cetintepe, T (Cetintepe, Tugba) [2] ;
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Source
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
Volume
7
Issue
1
Page
49-56
DOI
10.14744/ejmo.2023.64688
Published
2023
Indexed
2024-01-19
Document Type
Article
Jump to
Abstract
Objectives: Primary central nervous system lymphoma (PCNSL) is a rare malignant disease with poor prognosis. Its low incidence leads to challenges in decision-making for treatment. As a matter of fact, there is still no consensus on the appropriate treatment modalities. In this context, the objective of this study is to investigate and comparatively assess the efficacies of several treatment modalities in the treatment of PCNSL.Methods: Thirty-four patients diagnosed with PCNSL at 5 different hematology centers between 2007 and 2021 were included in the study. Patients' data from all five centers were collected retrospectively. Since ibrutinib is not approved for this indication in Turkey, consent for off-label use of ibrutinib is obtained from each patient. Ethics committee approval was obtained on June 9, 2021 with decision number 2021/18-05.Results: The median age of the patients was 59 (min.: 22, max.: 78) years. The male-to-female ratio was 1.26/1. Nineteen (55.9%) patients had Eastern Cooperative Oncology Group (ECOG) performance score of >= 2. Fifteen (44.1%) patients had normal lactate dehydrogenase (LDH) levels and only 14.7% of the patients had B symptoms at the time of diagnosis. Magnetic resonance imaging (MRI) revealed a single mass lesion in 14 (41.2%) patients. As an induction therapy, methotrexate-based regimen was administered in 29 (85.3%) patients. Only 14 of the 34 patients received 4 or more cycles of high-dose methotrexate (MTX). About 32.4% of the patients received radiation therapy (RT) during follow-up as a part of induction therapy. Five patients received only RT due to poor performance status. Ibrutinib was administered in 5 patients for refractory disease. It was determined that four or more cycles of MTX treatment increased progression-free survival (PFS) (p=0.031) and overall survival (OS) (p=0.012). Moreover, RT improved PFS (p=0.023). Considering that the complete response achieved by induction therapy influences long-term survival, achievement of the best response to the treatment regimens administered in combination with new agents may prolong survival (PFS: p=0.01, OS: p=0.023).Conclusion: The findings of this study indicate that the initial response to treatment is crucial. Additionally, it was found that high-dose MTX treatment should be administered for 4 cycles or more in order to achieve the best results. Furthermore, it was determined that ibrutinib monotherapy was well-tolerated in our patients with relapsed/refractory disease, with excellent clinical benefits. In conclusion, a combination therapy consisting of high-dose MTX, ibrutinib, and rituximab appears to be a promising initial treatment approach in appropriate patients.
Keywords
Author Keywords
PCNSL methotrexate radiotherapy ibrutinib
Can Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio at Day+100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation?
By
Medeni, SS (Medeni, Serife Solmaz) [1] ; Acar, C (Acar, Celal) [1] ; Olgun, A (Olgun, Aybuke) [2] ; Acar, A (Acar, Alev) [2] ; Seyhanli, A (Seyhanli, Ahmet) [2] ; Taskiran, E (Taskiran, Emin) [2] ; Sevindik, OG (Sevindik, Omur Gokmen) [3] ; Alacacioglu, I (Alacacioglu, Inci) [2] ; Piskin, O (Piskin, Ozden) [2] ; Ozcan, MA (Ozcan, Mehmet Ali) [2] ;
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Source
Volume
32
Issue
9
DOI
10.1111/ctr.13359
Article Number
e13359
Published
SEP 2018
Indexed
2018-10-03
Document Type
Article
Abstract
Background: Recent reports have showed that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are predictors of progression-free survival (PFS) and overall survival (OS) in many types of cancer. This study evaluates the predictive value of NLR, MLR, and PLR for survival in MM patients treated with to ASCT.
Methods: A set of data consisting of 150 patients who underwent autologous stem cell transplantation (ASCT) for MM was collected retrospectively. The prognostic value of NLR, MLR, and PLR was investigated with Kaplan-Meier method.
Results: The prognostic value of NLR, MLR, and PLR was analyzed by a receiver operating characteristic (ROC) curve established to determine the cutoff. These cutoff values of NLR, PLR, and MLR were found 1.46, 86, and 0.27, respectively, on the 100th day of post-transplantation period. The overall survival (OS) and the post-transplantation OS of the patients with high NLR, MLR, and PLR levels on the 100th day of post-transplantation were shorter than the other group (P = 0.05, P = 0.018 [NLR], P = 0.05, P = 0.002 [MLR], P = 0.000, P = 0.001 [PLR]). The post-transplantation progression-free survival (PFS) of the patients with high NLR, MLR, and PLR levels on the 100th day of post-transplantation was shorter as well (P = 0.036, P = 0.001, P = 0.001, respectively).
Conclusion: As increased NLR, MLR, and PLR predicted poor clinical outcome in MM patients with autologous transplantation in this study, they may serve as cost-effective and rapidly available prognostic biomarkers for these patients.
Keywords
Author Keywords
Monocyte Lymphocyte Ratio (MLR)Multiple myeloma Neutrophil-to-Lymphocyte Ratio (NLR)
Therapeutic plasma exchange in neurological diseases: Eleven years experience at a tertiary care center in Turkey
By
Seyhanli, A (Seyhanli, Ahmet) [1] ; Yavuz, B (Yavuz, Boran) [2] ; Selimoglu, I (Selimoglu, Ismail) [3] ; Sengun, IS (Sengun, Ihsan Sukru) [4] ; Aslan, AT (Aslan, Abdullah Taha) [4] ; Ozsan, GH (Ozsan, Guner Hayri) [2] ; Alacacioglu, I (Alacacioglu, Inci) [2] ; Demirkan, F (Demirkan, Fatih) [2]
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Source
THERAPEUTIC APHERESIS AND DIALYSIS
Volume
26
Issue
2
Page
465-470
DOI
10.1111/1744-9987.13703
Published
APR 2022
Early Access
JUN 2021
Indexed
2021-07-09
Document Type
Article
Jump to
Abstract
Therapeutic plasma exchange (TPE) is an apheresis procedure in which plasma is separated from the blood cellular components ex vivo, allocated, and replaced with another plasma or a plasma-replacing fluid. This study aimed to define the rate of complications and determine TPE distribution in various neurological diseases. Our study is a retrospective analysis of neurologic diseases requiring TPE between 2008 and 2019 that were selected using the medical records of neurology departments and apheresis units database. We performed 1459 TPE procedures on 207 patients between 2008 and 2019. TPE Procedure is most frequently applied in patients with Myasthenia-Gravis syndrome (34.7%). The complication ratio was 1.6% from a total of 1459 TPE procedures. The most commonly specified adverse event was allergic reactions 11 (5.3%), followed by hypotension 6 (2.9%). TPE was safe and tolerable, with manageable complications in experienced hands.
Keywords
Author Keywords
acute inflammatory demyelinating polyradiculoneuropathy (AIDP)chronic inflammatory
Evaluation of disease spectrum diagnosed with bone marrow biopsy at a tertiary healthcare center in Turkey Hematological diseases spectrum diagnosed with bone marrow biopsy
By
Seyhanli, A (Seyhanli, Ahmet) [1] ; Ozkan, YC (Ozkan, Yazgulu Cansu) [2] ; Ozkal, S (Ozkal, Sermin) [3] ; Ozsan, GH (Ozsan, Guner Hayri) [4] ; Demirkan, F (Demirkan, Fatih) [4] ; Alacacioglu, I (Alacacioglu, Inci) [4]
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Source
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
Volume
13
Issue
7
Page
788-791
DOI
10.4328/ACAM.21122
Published
JUL 2022
Indexed
2022-07-27
Document Type
Article
Jump to
Abstract
Aim: Bone marrow examination (BME) is commonly implemented to diagnose hemato-oncological diseases. There are only a few reports on diseases diagnosed via the BME and diagnostic yield in patients who applied to the hematology department This study aimed to identify the primary indications and diagnoses of BME in patients who underwent bone marrow biopsy at Dokuz Eylul University in Turkey.
Material and Methods: We retrospectively reviewed demographic and laboratory data of 505 patients from January 2014 to September 2021. The cases under the age of 18 years were excluded. The patients were also stratified according to demographic data and diagnoses.
Results: Among the 505 bone marrow biopsies (BMB) studied, 386 (76.4%) procedures were performed to evaluate suspected malignancy and 119 (23.6%) for non-malignant indications. The primary indications for BME were: cytopenia (117,23.2%), plasma cell neoplasm (PCN) (94, 18.6%), and myeloproliferative neoplasms (93, 18.4%). The most common diagnoses among all patients were PCN (110, 21.8%). Non-malignant outcomes comprised 3.2% of the total outcomes with 16 cases, of which thrombocytopenia due to peripheral destruction (immune thrombocytopenia) was the most common with eight (1.6%) patients. The majority of patients diagnosed with myelodysplastic syndrome and CLL were seen in patients aged 65 years and older.
Discussion: There is little published literature on the bone marrow profile, especially in geriatric patients. The higher incidence of hematological diseases in patients under 65 years of age can be attributed to more common BME procedures, which leads to earlier diagnosis.
Keywords
Author Keywords
Hematologic Diseases Trephine BiopsyBone Marrow
Computed tomography characteristics of multiple myeloma and other osteolytic metastatic bone lesions
By
Mutlu, U (Mutlu, Uygar) [1] ; Balci, A (Balci, Ali) [1] ; Özsan, GH (Ozsan, Guner Hayri) [2] ; Özkal, S (Ozkal, Sermin) [3] ; Seyhanli, A (Seyhanli, Ahmet) [2] ; Özgül, HA (Ozgul, Hakan Abdullah) [1]
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Source
Volume
62
Issue
12
Page
1639-1647
DOI
10.1177/0284185120977035
Article Number
0284185120977035
Published
DEC 2021
Early Access
DEC 2020
Indexed
2021-08-13
Document Type
Article
Jump to
Abstract
Background Differentiation of multiple myeloma (MM) from osteolytic metastatic (OM) bone lesions may be critical in patients with lytic bone lesions but can be challenging for radiologists. Purpose To determine whether computed tomography (CT) can be used to distinguish between MM and other OM bone lesions. Material and Methods In this retrospective study, 320 lesions of 207 patients diagnosed with MM or OM, based on biopsy or clinical examination, were evaluated. Eight qualitative features were evaluated by two radiologists blinded to the diagnoses. The chi-square and Fisher exact tests, and logistic regression analysis, were used to evaluate the relationships between the CT findings and diagnoses. Results High-density areas were more common in OM than MM lesions (85.2% and 19%, P < 0.001), as were perilesional sclerosis (38.9% vs. 13.2%, P < 0.001), heterogeneity (on non-contrast CT images, 60% vs. 19.1%, P < 0.001; on contrast enhanced CT images, 80.6% vs. 28.2%, P < 0.001), and ill-defined margins (34.6% vs. 9.1%, P < 0.001). Similarly, OM lesions showed high-density areas more than MM in evaluation of skeletal system subgroups (vertebrae, 93.8% vs. 29.8%, P < 0.0001; thoracic cage bones, 69.6% vs. 19.2%, P < 0.001; pelvic bones and sacrum, 84.8% vs. 7.7%, P < 0.001; peripheral skeletal bones, 81.5% vs. 8.3%, P < 0.001). Logistic regression analysis revealed that the presence of a high-density area in the lesion increased the probability of a metastasis 25.88-fold (R-2 = 0.516, P < 0.001). Conclusion MM and OM lesions can be differentiated by CT; OM lesions exhibit high- density areas.
Keywords
Author Keywords
Multiple myeloma osteolytic metastatic bone lesions computed tomography computed
Evaluation of using fresh frozen plasma for patients with cirrhosis at a tertiary healthcare center in Turkey: Strict transfusion policies are essential
By
Seyhanli, A (Seyhanli, Ahmet) [1] ; Ozkan, YC (Ozkan, Yazgulu Cansu) [2] ; Bengi, G (Bengi, Goksel) [3] ; Alacacioglu, I (Alacacioglu, Inci) [4] ; Ozsan, GH (Ozsan, Guner Hayri) [4] ; Demirkan, F (Demirkan, Fatih) [4]
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Source
TRANSFUSION AND APHERESIS SCIENCE
Volume
60
Issue
6
DOI
10.1016/j.transci.2021.103247
Article Number
103247
Published
DEC 2021
Early Access
DEC 2021
Indexed
2022-01-01
Document Type
Article
Abstract
Aim: Management of blood transfusions is a critical issue, especially in cirrhotic patients, because of the absence of national policies in many countries. Fresh frozen plasma (FFP) is a common blood component misused excessively in various clinical situations and cirrhosis patients without any scientific rationale. We evaluated the FFP transfusions in patients with cirrhosis at our tertiary care hospital.
Material and Method: The cases with cirrhosis diagnosed between 2014 and 2020 were selected using the hospital database. The appropriateness of FFP transfusion was determined based on the Practice Guidance by the American Association for the Study of Liver Diseases and Italian guidelines.
Result: Two hundred and six liver cirrhosis patients were identified who received FFP transfusion. The median age was 63 (22-94). Of the 206 patients, 79 (38.3 %) were female, and 127 (61.7 %) were men. The most common causes of liver cirrhosis were alcohol (27.7 %). 45.6 % of the patients were in Child-Pugh Class C. We found 62.1 % of FFP replacements were inappropriately used. Most inappropriate use of FFP (22.8 %, n = 47) occurred to correct prolonged INR in the absence of bleeding.
Conclusion: To avoid inappropriate usage of FFP, regular utilization reviews and formal education programs can be helpful. Our clinic has planned to arrange educational programs for physicians to use blood products appropriately and minimize transfusion-related side effects.
Keywords
Author Keywords
Fresh frozen plasma transfusion Patient blood management Liver cirrhosis
Prognostic Factors in Elderly Patients with Diffuse Large B-Cell Lymphoma and Their Treatment Results
By
Adiyaman, SC (Adiyaman, Suleyman Cem) [1] ; Alacacioglu, I (Alacacioglu, Inci) [2] ; Danyeli, AE (Danyeli, Ayca Ersen) [3] ; Türkyilmaz, D (Turkyilmaz, Dogus) [2] ; Sevindik, ÖG (Sevindik, Omur Gokmen) [2] ; Demirkan, F (Demirkan, Fatih) [2] ; Piskin, Ö (Piskin, Ozden) [2] ; Özcan, MA (Ozcan, Mehmet Ali) [2] ; Ündar, B (Undar, Bulent) [2] ; Özkal, S (Ozkal, Sermin) [3] ;
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Source
Volume
36
Issue
2
Page
81-87
DOI
10.4274/tjh.galenos.2019.2018.0219
Published
2019
Indexed
2019-05-17
Document Type
Article
Abstract
Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). The treatment of older NHL patients has always been a struggle; however, treatment statistics have begun showing favorable results similar to those of younger DLBCL patients thanks to newer treatment protocols. Here, we analyze the progress of our own elderly DLBCL patients who were followed between 2000 and 2016 in our center.
Materials and Methods: Eighty-seven DLBCL patients, who were diagnosed and treated in the Dokuz Eylul University Department of Hematology between 2000 and 2016, were included in this study. Median age was 72 (65-89) years and 13 (14.9%) patients were older than 80 years.
Results: Median follow-up time was 19 months and 45 patients (51.7%) died during the follow-up period. Median overall survival (OS) was 55 months and median progression-free survival was calculated as 27 months. Sixty-three patients (72.4%) received standard R-CHOP therapy. Complete response was seen in 46 (52.9%) patients. The median survival time for patients who had complete response was 136 months (p< 0.001); however, OS was not statistically different between older (> 80 years) and younger patients (p=0.236).
Conclusion: According to our findings, we think that being able to complete standard R-CHOP therapy is vital for the survival rate of elderly DLBCL patients.
Keywords
Lymphoid cell neoplasms B-Cell neoplasms Lymphomas Non-Hodgkin lymphoma
Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
By
Sevindik, ÖG (Sevindik, Omur Gokmen) [1] ; Alacacioglu, I (Alacacioglu, Inci) [1] ; Katgi, A (Katgi, Abdullah) [1] ; Solmaz, SM (Solmaz, Serife Medeni) [1] ; Acar, C (Acar, Celal) [1] ; Piskin, Ö (Piskin, Ozden) [1] ; Özcan, MA (Ozcan, Mehmet Ali) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Ündar, B (Undar, Bulent) [1] ; Özsan, GH (Ozsan, Guner Hayri) [1]
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Source
Volume
2015
DOI
10.1155/2015/425410
Article Number
425410
Published
2015
Indexed
2015-01-01
Document Type
Article
Abstract
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.
Keywords
Keywords Plus
What are the factors affecting survival after autologous stem cell transplantation in patients with multiple myeloma?
By
Solmaz, S (Solmaz, Serife) [1] ; Acar, C (Acar, Celal) [2] ; Seyhanli, A (Seyhanli, Ahmet) [2] ; Sevindik, OG (Sevindik, Omur Gokmen) [3] ; Piskin, O (Piskin, Ozden) [2] ; Ozcan, MA (Ozcan, Mehmet Ali) [2] ; Demirkan, F (Demirkan, Fatih) [2] ; Undar, B (Undar, Buelent) [2] ; Alacacioglu, I (Alacacioglu, Inci) [2] ; Ozsan, GH (Ozsan, Guner Hayri) [2]
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Source
INDIAN JOURNAL OF TRANSPLANTATION
Volume
14
Issue
1
Page
57-62
DOI
10.4103/ijot.ijot_15_19
Published
JAN-MAR 2020
Indexed
2021-04-25
Document Type
Article
Abstract
Introduction: High-dose chemotherapy (HDC) and autologous stem cell transplantation(ASCT) still remains in the treatment of myeloma patients even during the period of new agents. Materials and Methods: We analysed the prognostic affect of pretransplant characteristics and transplant modalities on response, in 150 autologous transplant of 144 multiple myeloma (MM) patients who were transplanted in our centre between 2008 to 2017. We evaluated the affect of age, type of MM, previous treatment regimens, status pre and postfrom transplantation, time of ASCT, neutrophil and platelet engraftmant days, dose of reinfused CD34+ cells, plasma cell infiltration, international staging system(ISS) and Durie -Salmon stage at diagnosis. We examined the affect of these status on overall survival(OS) and eventfree survival(EFS). Results: The median OS and EFS after transplanation were 41 and 28 months, respectively. Median OS after the diagnosis was 57 months. Transplant-related mortality was 3,3%. We found that the lower beta 2- microglobulin levels,lower ISS stage,lower plasma cell infiltration, achievement good responds at the +100th day of post transplant were statistically significant independent predictor factors for longer EFS and OS. When the patients were given chemotherapy regimen with bortezomib before transplantation, these patients were seen to be a better response rate. There was showed a relationship between the using of bortezomib before transplantation with EFS(P = 0.017), but there was no relationship with OS. Conclusions: Our analysis confirms HDCT-ASCT as an effective and safe therapeutic strategy in multiple myeloma patients. This results were independent of age, first line treatment regimens and renal insufficiency. Patients with a high ISS stage were found to have shorter survival(P = 0.002). However, the EFS and OS were longer of the patients whose have good response at the 100th day of transplantation(P = 0,002, P = 0,02).
Keywords
Author Keywords
Autologous stem cell transplantation event-free survival multiple myeloma overall survival
Prospective study of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma patients who are not suitable for stem cell transplant or multi-agent chemotherapy
By
Walewski, J (Walewski, Jan) [1] ; Hellmann, A (Hellmann, Andrzej) [2] ; Siritanaratkul, N (Siritanaratkul, Noppadol) [3] ; Ozsan, GH (Ozsan, Guner Hayri) [4] ; Ozcan, M (Ozcan, Muhit) [5] ; Chuncharunee, S (Chuncharunee, Suporn) [6] ; Goh, AS (Goh, Ai Sim) [7] ; Jurczak, W (Jurczak, Wojciech) [8] ; Koren, J (Koren, Jan) [9] ; Paszkiewicz-Kozik, E (Paszkiewicz-Kozik, Ewa) [1] ;
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Source
BRITISH JOURNAL OF HAEMATOLOGY
Volume
183
Issue
3
Page
400-410
DOI
10.1111/bjh.15539
Published
NOV 2018
Indexed
2018-12-28
Document Type
Article
Abstract
Some patients with relapsed/refractory Hodgkin lymphoma (HL) are not considered suitable for stem cell transplant (SCT) and have a poor prognosis. This phase IV study (NCT01990534) evaluated brentuximab vedotin (1 center dot 8 mg/kg intravenously once every 3 weeks) in 60 patients (aged >= 18 years) with CD30-positive relapsed/refractory HL, a history of >= 1 prior systemic chemotherapy regimen, who were considered unsuitable for SCT/multi-agent chemotherapy. Primary endpoint was overall response rate (ORR) per independent review facility (IRF). Secondary endpoints included duration of response (DOR), progression-free survival (PFS) per IRF, overall survival (OS), proportion proceeding to SCT and safety. The ORR was 50%, with 12% CR; 47% proceeded to SCT. Median DOR was 4 center dot 6 months and median duration of CR was 6 center dot 1 months. After a median follow-up of 6 center dot 9 and 16 center dot 6 months, median PFS and OS were 4 center dot 8 months (95% confidence interval, 3 center dot 0-5 center dot 3) and not reached, respectively; estimated OS rate was 86% at 12 months. Most common adverse events (>= 10%) were peripheral neuropathy (35%), pyrexia (18%), diarrhoea and neutropenia (each 10%). Brentuximab vedotin showed notable activity with a safety profile consistent with known toxicities, and may act as a bridge to SCT, enabling high-risk patients who achieve suboptimal response to frontline/salvage chemotherapy/radiotherapy to receive potentially curative SCT.
Keywords
Author Keywords
Hodgkin lymphoma relapsed/refractory novel anti-tumour agents brentuximab vedotin phase IV
Does Reinfusion of Stem Cell Products on Multiple Days Affect Engraftment?
By
Medeni, SS (Medeni, Serife Solmaz) [1] ; Türkyilmaz, D (Turkyilmaz, Dogus) [2] ; Acar, C (Acar, Celal) [1] ; Sevindik, ÖG (Sevindik, Omur Gokmen) [3] ; Yüksel, F (Yuksel, Faize) [2] ; Piskin, Ö (Piskin, Ozden) [2] ; Özcan, MA (Ozcan, Mehmet Ali) [2] ; Demirkan, F (Demirkan, Fatih) [2] ; Ündar, B (Undar, Bulent) [2] ; Alacacioglu, I (Alacacioglu, Inci) [2] ;
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Source
Volume
35
Issue
4
Page
271-276
DOI
10.4274/tjh.2018.0071
Published
DEC 2018
Indexed
2019-02-13
Document Type
Article
Abstract
Objective: High-doses of melphalan treatment with autologous stem cell transplantation in multiple myeloma (MM) remains a major treatment modality in suitable patients. A minimal dose of 2x10(6)/kg CD34+ cells is preferred to achieve engraftment. Some patients need multiple leukapheresis procedures to achieve the necessary number of CD34+ cells, but this can cause a high volume of stem cell product that cannot be given in a single day. Whether or not the number of infusion days affects engraftment has not been studied before. We aimed to evaluate the impact of reinfusion of stem cells on multiple days on engraftment results.
Materials and Methods: Demographic features, CD34+ cell doses, neutrophil and platelet engraftment days, hospitalization days, and number of infusion days of 149 autologous transplantations of 143 MM patients were evaluated retrospectively.
Results: The data of 143 MM patients who were transplanted were analyzed retrospectively. Median age was 55 +/- 8.5 (range: 26-70) years with a male/female ratio of 91/58. Hospitalization days for all patients were 24 +/- 6 (range: 14-50) days. Mean CD34+ cell number was (7.5 +/- 5.3) x10(6)/kg (range: 1.5-31x10(6)/kg). CD34+ cells were reinfused in 1 day in 80.5% (n=120) of the patients, 2 days in 18.2% of the patients (n=27), and 3 days in 1.3% of the patients (n=2). For 29 patients, reinfusion was applied in more than 1 day because of the high volume of stem cell product. We did not see any dimethyl sulfoxide toxicity, cardiac arrhythmia, or volume overload complications. Hypertensive attacks during infusion were easily controlled by furosemide treatment. In the group with multiple infusions, the infused CD34+ cell numbers had a mean of (4.8 +/- 2.8)x10(6)/kg, and in the single infusion group the mean was (8.1+5.5)x10(6)/kg. There were no statistical differences between the two groups regarding platelet and neutrophil engraftment days (p=0.850, r=0.820 and p=0.500, r=0.440). There was no statistical difference between the two groups for hospitalization days (p=0.060, r=0.050).
Conclusion: In cases with a high volume of stem cell product to acquire adequate stem cells, reinfusion can be safely applied across multiple days without any delay in engraftment.
Keywords
Author Keywords
Multiple myeloma Autologous transplantation Multiple reinfusion days
Hypoalbuminemia is a surrogate biomarker of poor prognosis in myelodysplastic syndrome even when adjusting for comorbidities
By
Sevindik, OG (Sevindik, Omur Gokmen) [1] ; Guc, Z (Guc, Zeynep) [2] ; Kahraman, S (Kahraman, Selda) [3] ; Solmaz, SM (Solmaz, Serife Medeni) [1] ; Katgi, A (Katgi, Abdullah) [1] ; Acar, C (Acar, Celal) [1] ; Alacacioglu, I (Alacacioglu, Inci) [1] ; Piskin, O (Piskin, Ozden) [1] ; Ozsan, GH (Ozsan, Guner Hayri) [1] ; Demirkan, F (Demirkan, Fatih) [1] ;
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Source
Volume
56
Issue
9
Page
2552-2555
DOI
10.3109/10428194.2015.1014362
Published
2015
Indexed
2016-03-02
Document Type
Article
Abstract
The serum albumin (SA) level has been reported to be an independent prognostic biomarker that may serve as a surrogate representative of disease biology in patients diagnosed with myelodysplastic syndrome (MDS). However, its prognostic ability has not been tested in a model adjusting for comorbidities. We analyzed 200 patients who were diagnosed as having de novo MDS. Median overall survival (OS) of all patients was 25 months and median leukemia-free survival (LFS) was 24 months. Median OS according to the SA level groups of <= 3.5, 3.6-4.0 and > 4.0 mg/dL were 24, 39 and 77 months, respectively. SA level remained an independent predictor of both LFS and OS even when adjusting for the hematopoietic cell transplant comorbidity index (HCT-CI) and the International Prognostic Scoring System (IPSS) or World Health Organization classification-based Prognostic Scoring System (WPSS). Our findings indicate that SA level at the time of diagnosis is a significant and independent predictor of LFS and OS even when adjusting for commonly used prognostic systems and comorbidities.
Keywords
Author Keywords
Myelodysplastic syndrome albumin HCT-CI leukemia-free survival overall survival
Hematopoietic recovery kinetics predicts for poor CD34+ cell mobilization after cyclophosphamide chemotherapy in multiple myeloma
By
Ozsan, GH (Ozsan, Guner Hayri) [2] ; Micallef, IN (Micallef, Ivana N.) [1] ; Dispenzieri, A (Dispenzieri, Angela) [1] ; Kumar, S (Kumar, Shaji) [1] ; Lacy, MQ (Lacy, Martha Q.) [1] ; Dingli, D (Dingli, David) [1] ; Hayman, SR (Hayman, Suzanne R.) [1] ; Buadi, FK (Buadi, Francis K.) [1] ; Wolf, RC (Wolf, Robert C.) [1] ; Gastineau, DA (Gastineau, Dennis A.) [1] ;
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Source
AMERICAN JOURNAL OF HEMATOLOGY
Volume
87
Issue
1
Page
1-4
DOI
10.1002/ajh.22179
Published
JAN 2012
Indexed
2012-03-10
Document Type
Article
Abstract
Autologous stem cell transplantation is an important part of therapy in patients with multiple myeloma. Some patients fail to collect the desired number of stem cells while others require multiple apheresis to reach the desired apheresis target. The aim of this study was to determine the predictive factors and if the hematopoietic kinetics of recovery were predictive for outcome of stem cell mobilization in cyclophosphamide + growth factor (CY-GF) mobilized patients. Three hundred and ninety six consecutive CY-GF mobilization attempts between January 2000 and December 2009 at Mayo Clinic, Rochester, MN were analyzed. Patients were divided into three groups: optimal (>5 x 106 CD34/kg), suboptimal (25 x 106 CD34/kg) and poor (<2 x 106/kg CD34+ cells) mobilization groups. About 86% of patients had optimal stem cell collection, whereas 8% had suboptimal collection and 6% had poor (or failed) collections. Age, Hb, WBC, and platelet levels had an impact on mobilization results. Time to peripheral blood (PB) CD34+cells >10/mu L predicted for efficiency of collection and the interval between recovery of WBC>1 post-CY to PB CD34+ cells>10 was shorter in the optimal collection groups. These findings suggest that for patients with a PB CD34+ cell count below 10/mu L on Day 13 following CY or 1 day after the WBC>1 x 109/L, addition of plerixafor may be helpful to salvage the mobilization attempt. Am. J. Hematol., 2012. (C) 2011 Wiley Periodicals, Inc.
Keywords
Keywords Plus
BLOOD PROGENITOR-CELLCOLONY-STIMULATING FACTOR PERIPHERAL-BLOOD STEM-CELLS
Effects of bone marrow fibrosis and angiogenetic structure on autologous hematopoietic stem cell engraftment
By
Büyükkurt, N (Buyukkurt, Nurhilal) [1] ; Özsan, GH (Ozsan, Guner Hayri) [2] ; Özkal, S (Ozkal, Sermin) [3] ; Seydaoglu, G (Seydaoglu, Gulsah) [4] ; Alacacioglu, I (Alacacioglu, Inci) [2] ; Özcan, MA (Ozcan, Mehmet Ali) [2] ; Demirkan, F (Demirkan, Fatih) [2] ; Piskin, Ö (Piskin, Ozden) [2] ; Ündar, B (Undar, Bulent) [2]
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Source
Volume
42
Issue
3
Page
499-506
DOI
10.17826/cutf.296629
Published
2017
Indexed
2017-11-23
Document Type
Article
Abstract
Purpose: Hematopoietic stem cell (HSC) engraftment is influenced by many factors. We investigated the effects of bone marrow fibrosis and angiogenetic structure on engraftment in patients with hematological malignancies.
Materials and Methods: Data were collected from 34 patients (20 males and 14 females) who underwent autologous HSC transplantation. Bone marrow myelofibrosis was graded from 0 to 3, angiogenesis was quantified using a stereological method in the most recent bone marrow biopsy before the transplantation. Patients were categorized into two groups according to intensity of angiogenesis parameters.
Results: Half of the patients had fibrosis and majority had multiple myeloma (73.5%). Eleven patients had grade 1, six had grade 2 myelofibrosis. The engraftment day (ED) for platelets and erythrocytes was significantly different between the grade 2 fibrosis and non-fibrosis groups. VSD and NVES levels were significantly higher in the grades 1 and 2 fibrosis groups than the no fibrosis group. While the overall survival time was shorter in the grade 2 fibrosis group than the others, the difference was not statistically significant.
Conclusion: Bone marrow fibrosis was found to be independent risk factor. It may have a negative effect on platelet and erythrocyte engraftment time of autologous transplantation process but this effect does not influence survival.
Keywords
Author Keywords
Bone marrow fibrosis angiogenesis autologous transplantation multiple myeloma
Study for the diagnostic screening of paroxsymal nocturnal hemoglobinuria in Turkey: Prospective multicentric evaluation of suspected patients
By
Ilhan, O (Ilhan, Osman) [1] ; Ozdemir, ZN (Ozdemir, Zehra Narli) [1] ; Ozet, G (Ozet, Gulsum) [1] ; Falay, M (Falay, Mesude) [1] ; Yenerel, M (Yenerel, Mustafa) [1] ; Tuglular, T (Tuglular, Tulin) [1] ; Turgut, M (Turgut, Mehmet) [1] ; Guvenc, B (Guvenc, Birol) [1] ; Unal, A (Unal, Ali) [1] ; Ayyildiz, O (Ayyildiz, Orhan) [1] ;
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Source
TRANSFUSION AND APHERESIS SCIENCE
Volume
58
Issue
5
Page
659-662
DOI
10.1016/j.transci.2019.08.021
Published
OCT 2019
Indexed
2020-01-09
Document Type
Article
Abstract
Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease presenting with variable and various clinical findings. PNH might be overlooked and diagnosis may be delayed due to low awareness about PNH. This is the first multicenter study in Turkey, investigating the efficiency of diagnostic screening of PNH by multiparameter flow cytometry (FCM) according to consensus guidelines.
Methods: We evaluate the efficiency of consensus clinical indications for PNH testing with FCM in 1689peripheral blood samples from 20 centers between January 2014 and December 2017.
Results: Overall, at the 20 centers contributing to this study, PNH clone were detected in 62/1689 samples (3.6%) by FCM test. 75.8% (n = 47) of patients with PNH clone had aplastic anemia, 3.2% (n = 2) had Coombs (-) hemolytic anemia, 6.5% (n = 4) had unexplained cytopenia, 3.2% (n = 2) had MDS with refractory anemia, 1.6% (n = 1) had hemoglobinuria and 9.7% (n = 6) had others (elevated LDH, splenomegaly, etc.). In contrast, we detect no PNH clone test in patients who were screened for unexplained thrombosis.
Conclusions: Our study showed that current clinical indications for PNH testing are highly efficient and diagnostic screening of suspected patients for PNH with FCM is recommended. However, advanced screening algorithms are required for patients presenting with unexplained thrombosis and normal complete blood count.
Keywords
Author Keywords
Paroxysmal nocturnal hemoglobinuria Multiparameter flow cytometry Diagnostic screening
Nilotinib Does Not Alter the Secretory Functions of Carotid Artery Endothelial Cells in a Prothrombotic or Antithrombotic Fashion
By
Katgi, A (Katgi, Abdullah) [1] ; Sevindik, ÖG (Sevindik, Omur Gokmen) [1] ; Gökbulut, AA (Gokbulut, Aysun Adan) [2] ; Özsan, GH (Ozsan, Guner Hayri) [1] ; Yüksel, F (Yuksel, Faize) [1] ; Solmaz, SM (Solmaz, Serife Medeni) [1] ; Alacacioglu, I (Alacacioglu, Inci) [1] ; Özcan, MA (Ozcan, Mehmet Ali) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Baran, Y (Baran, Yusuf) [2] ;
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Source
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Volume
21
Issue
7
Page
678-683
DOI
10.1177/1076029614550817
Published
OCT 2015
Indexed
2015-09-30
Document Type
Article
Abstract
Background: There have been concerns about the possible prothrombotic effects of nilotinib, especially in patients having cardiovascular risk factors. The potential mechanism behind the increased risk of thromboembolic events is still not clear.
Objectives: In this study, we aimed to evaluate possible harmful effects of nilotinib on endothelial cells. To this aim, we examined proliferative capacity and secretory functions of healthy human carotid artery endothelial cells (HCtAECs) in response to nilotinib.
Methods: 3-(4,5-Dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) cell proliferation method was used to determine antiproliferative effects of nilotinib on HCtAECs. The HCtAECs were incubated with 5, 10, and 100 nmol/L doses of nilotinib for 72 hours. Then, in order to assess the endothelial function, levels of nitric oxide (NO), von Willebrand factor (vWF), tissue plasminogen activator, plasminogen activator inhibitor 1 (PAI-1), and endothelin 1 (ET-1) were evaluated using enzyme-linked immunosorbent assay from tissue culture supernatants.
Results: There were slight but statistically significant decreases in cell proliferation in response to nilotinib. Nilotinib increased the secretion of t-PA, PAI-1, and vWF in a dose-dependent manner when compared with the untreated control group. The ET-1 secretion was lower in 5 nmol/L and higher in 10 and 100 nmol/L nilotinib-treated cells as compared to untreated cells. Regarding NO secretion, lower levels were observed in 5 and 10 nmol/L, and higher levels were detected in 100 nmol/L nilotinib-treated cells as compared to untreated control group cells.
Conclusion: Considering the results obtained in our study, nilotinib does not affect the functions of endothelial cells either in a prothrombotic or an antithrombotic fashion, despite a dose-dependent decline in cell viability.
Keywords
Author Keywords
nilotinib endothelial cells carotid artery function cell viability
Successful hematopoietic engraftment with gray platelets after allogeneic hematopoietic stem cell transplantation from gray platelet syndrome donor
By
Katgi, A (Katgi, Abdullah) [1] ; Ataca, P (Ataca, Pinar) [2] ; Kahraman, S (Kahraman, Selda) [1] ; Sevindik, OG (Sevindik, Omur Gokmen) [1] ; Sonmez, U (Sonmez, Ulker) [3] ; Solmaz, SM (Solmaz, Serife Medeni) [1] ; Piskin, O (Piskin, Ozden) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Ozsan, GH (Ozsan, Guner Hayri) [1]
(provided by Clarivate)
Source
BLOOD COAGULATION & FIBRINOLYSIS
Volume
24
Issue
2
Page
208-210
DOI
10.1097/MBC.0b013e32835aefc2
Published
MAR 2013
Indexed
2013-03-06
Document Type
Article
Abstract
Gray platelet syndrome (GPS) is a rare inherited disorder characterized by the absence of alpha-granules and their constituents. It may be present with thrombocytopenia and bleeding tendency. Platelets have a large and gray appearance under light and electron microscope. A 19-year old female patient with her second relapse acute lymphoblastic leukemia had to be consolidated with allohematopoietic stem cell transplantation (HSCT) after achieving remission with induction chemotherapy. The only available and one mismatch compatible donor was her brother, who was previously diagnosed as GPS. Allogeneic HSCT was performed from her brother in spite of GPS, and successful neutrophil and platelet engraftment achieved at the 12th and 42nd day of reinfusion, consecutively. The engrafted and circulating thrombocytes were large and gray and had little or no a-granules under electron microscope. The patient was well with no major bleeding event and increased need for thrombocyte replacement until developing bronchiolitis obliterans organizing pneumonia and respiratory distress syndrome. Thereafter death occurred. This is the first case of successful thrombocyte engraftment with documented gray thrombocyte megakaryopoiesis after allogeneic HSCT from a GPS donor. The only noteworthy issue was the slight prolongation of engraftment. Blood Coagul Fibrinolysis 24:208-210 (C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Keywords
Author Keywords
allogeneic hematopoietic stem cell transplantation gray platelet syndrome
Coexistence of disseminated granuloma annulare and asymptomatic multiple myeloma
By
Aktan, S (Aktan, Sebnem) [1] ; Akarsu, S (Akarsu, Sevgi) [1] ; Avci, CC (Avci, Ceylan Canbaz) [1] ; Lebe, B (Lebe, Banu) [2] ; Katgi, A (Katgi, Abdullah) [3] ; Özsan, GH (Ozsan, Guner Hayri) [3]
(provided by Clarivate)
Source
TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
Volume
47
Issue
3
Page
176-179
DOI
10.4274/turkderm.86094
Published
SEP 2013
Indexed
2013-09-01
Document Type
Article
Abstract
Granuloma annulare (GA), which is characterized by necrobiotic dermal papules, is a benign inflammatory dermatosis of unknown cause. Several morphologic forms of GA, including localized, disseminated, linear, nodular, perforating, subcutaneous, pustular, and arcuate dermal erythema have been reported in the literature. Disseminated GA, a rarely seen form, has been reported to be in association with some hematopoietic and solid malignancies, however, it has been suggested that the exact causative relationship between malignancy and GA is unclear. We present here a 66-year-old female patient with disseminated GA associated with asymptomatic multiple myeloma.
Keywords
Author Keywords
Granuloma annulare malignancy multiple myeloma
Prognostic significance of immunohistochemical classification of diffuse large B-cell lymphoma
By
Alacacioglu, I (Alacacioglu, Inci) [1] ; Ozcan, MA (Ozcan, Mehmet Ali) [1] ; Ozkal, S (Ozkal, Sermin) [2] ; Piskin, O (Piskin, Ozden) [1] ; Turgut, N (Turgut, Nurhilal) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Ozsan, GH (Ozsan, Guner Hayri) [1] ; Kargi, A (Kargi, Aydanur) [2] ; Undar, B (Undar, Bulent) [1]
(provided by Clarivate)
Source
Volume
14
Issue
2
Page
84-89
DOI
10.1179/102453309X385205
Published
APR 2009
Indexed
2009-04-01
Document Type
Article
Abstract
Aim: To evaluate the clinical significance of immunoperoxidase staining for CD10, bcl-6, mum-1 and bcl-2 to subdivide DLBCL into prognostic subgroups, we analysed 50 DLBCL cases using immunohistochemical methods.
Methods and results: Fifty DLBCL patients were evaluated retrospectively. The expression of CD10 was associated with better OS (p=0.04) whereas expression of mum-1 was associated with worse OS (p=0.009). There were no significance of OS in case of expression of bcl-6 (p=0.05) and bcl-2 (p=0.3). They were subclassified using CD10, mum-1, bcl-6 as germinal center B-cell like (GCB) lymphoma (30%) and non-GCB lymphoma (70%). The OS and EFS (event free survival) were longer in GCB group (p=0.002) and 5-year OS for GCB group was 92% compared with only 44% for the non-GCB group (p=0.02). The OS of the GCB group also was longer compared to that of the non-GCB group in low IPI subgroup (p=0.01).
Conclusion: The existance of survival differences between GCB a non-GCB group also in the patients with low IPI score, showed the importance of prognostic classification in the risk-adaptive treatment approaches. The classification as GCB and non-GCB based immunostains may enable to define more accurate prognostic groups in DLBCL.
Keywords
Lymphoma prognosis CD10 bcl-6 mum-1 bcl-2
Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias
By
Ozsan, GH (Ozsan, Guner Hayri) [2] ; Dispenzieri, A (Dispenzieri, Angela) [1]
(provided by Clarivate)
Source
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume
7
Issue
1
Page
65-73
DOI
10.1586/ECI.10.80
Published
JAN 2011
Indexed
2011-01-01
Document Type
Review
Abstract
After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.
Keywords
Author Keywords
free light chain immunoglobulin multiple myeloma plasma cell disorders
Fatal Disseminated Mucormycosis In A Patient With Mantle Cell non-Hodgkin's Lymphoma: An Autopsy Case
By
Alacacioglu, I (Alacacioglu, Inci) [1] ; Kargi, A (Kargi, Aydanur) [2] ; Ozcan, MA (Ozcan, Mehmet Ali) ; Piskin, O (Piskin, Ozden) ; Solak, C (Solak, Cilem) ; Secil, M (Secil, Mustafa) [3] ; Unlu, M (Unlu, Mehtat) [2] ; Demirkan, F (Demirkan, Fatih) ; Ozsan, GH (Ozsan, Guner Hayri) ; Undar, B (Undar, Bulent)
(provided by Clarivate)
Source
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
Volume
13
Issue
3
Page
238-241
DOI
10.1590/S1413-86702009000300017
Published
JUN 2009
Indexed
2009-06-01
Document Type
Article
Abstract
A patient with mantle cell non-Hodgkin's lymphoma presented herself with fever, nausea, right upper quadrant pain on the 7th day of R-CHOP chemotherapy. After hospitalization with the suspicion of acute cholecystitis, she received antibiotherapy with G-CSF because of emerging neutropenia at the 10th day of chemotherapy. Abdominal computed tomography revealed small infarcts in the spleen and kidneys. The echymotic lesion which developed on her right lateral malleolus, became bullous in the following days and treated as ecthyma gangrenosum. Altough the patient was afebrile with a normal neutrophil count on the third day of antibiotherapy, she developed acute renal failure and deteriorated rapidly. The patient underwent hemodialysis but expired on the 10th day of hospitalization. Post mortem autopsy findings showed ischemic infarction and necrosis of parenchyma due to mycotic thrombosis of arteries and veins of many organs (heart, lung, diaphgram, kidneys, spleen, gut mucosa) as well as invasion of vessel walls and parenchyma by mucor. We reviewed mucormycosis in the light of this case.
Keywords
Author Keywords
Occurrence in a Case of Philadelphia Negative Acute Lymphoblastic Leukemia following Treatment for Ewing's Sarcoma
By
Katgi, A (Katgi, Abdullah) [1] ; Kahraman, S (Kahraman, Selda) [1] ; Ataca, P (Ataca, Pinar) [2] ; Piskin, Ö (Piskin, Ozden) [1] ; Özcan, MA (Ozcan, Mehmet Ali) [1] ; Özsan, GH (Ozsan, Guner Hayri) [1] ; Demirkan, F (Demirkan, Fatih) [1] ; Ündar, B (Undar, Bulent) [1]
(provided by Clarivate)
Source
Volume
25
Issue
2
Page
100-102
DOI
10.5472/MMJ.2012.02158.1
Published
2012
Indexed
2012-01-01
Document Type
Article
Abstract
Therapy-related leukemias are 10-20% of all acute leukemia cases. Therapy-related acute lymphoblastic leukemia (ALL) is less frequent than therapy-related acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). In this paper, we present a patient with Ewing's sarcoma (ES) in the soft tissue of his right breast cured by chemotherapy and radiotherapy. He developed Ph(-) ALL four years following the therapy.
Keywords
Author Keywords
Ph(-) ALL Secondary leukemia Ewing's sarcoma
Plasma thrombin activatable fibrinolysis inhibitor levels in Behcet's disease
By
Özcan, MA (Ozcan, Mehmet Ali) [1] ; Akar, S (Akar, Servet) [2] ; Alacacioglu, I (Alacacioglu, Inci) [1] ; Piskin, O (Piskin, Ozden) [1] ; Yüksel, F (Yuksel, Faize) [1] ; Gürler, O (Gurler, Oguz) [2] ; Akkoç, N (Akkoc, Nurullah) [2] ; Demirkan, F (Demirkan, Fatih) [1] ; Özsan, GH (Ozsan, Guner Hayri) [1] ; Özkan, S (Ozkan, Sebnem) [3] ;
(provided by Clarivate)
Source
TURKISH JOURNAL OF MEDICAL SCIENCES
Volume
37
Issue
5
Page
267-271
Published
OCT 2007
Indexed
2007-10-01
Document Type
Article
Abstract
Aim: The precise pathogenetic mechanisms causing thrombotic complications in Behcet's disease (BID) are still not known. To explain the pathogenesis with coagulation induction or a defective fibrinolysis superimposed on endothelial dysfunction, various hemostatic parameters were studied. Thrombin activatable fibrinolysis inhibitor (TAFI), downregulating plasmin generation and fibrinolysis, is a novel risk factor for thrombotic disorders. We studied plasma TAR levels in BD in comparison with healthy controls.
Materials and Methods: Twenty-three patients with BD (mean age: 38.3 +/- 10.83, M/F: 5/18) diagnosed according to the criteria of the International Study Group and 20 healthy volunteers (mean age: 38.05 +/- 6.29, M/F: 9/11) were enrolled in this study. Patients with liver or renal disease, diabetes mellitus, coronary artery disease, hemophilia, antiphospholipid antibody positivity or using oral contraceptive drugs were excluded from the study. Plasma TAFI levels were determined by using an ELISA test.
Results: The mean TAFI antigen levels were 8.40 +/- 1.81 mu g/ml in BID patients and 7.30 +/- 0.64 mu g/ml in healthy volunteers. A statistically significant difference was found between TAFI antigen levels of these two groups (P = 0.01).
Conclusions: TAR antigen levels were found to be increased in BID, regardless of thrombotic events. To clarify the exact role of TAFI in thrombotic complications of the disease, future studies including more patients with and without thrombosis are needed.
Keywords