Reviewing the reliability of revised Melbourne Cerebral Palsy Hip Classification System across different medical specialties
By
Gok, M (Gok, Mustafa) [1] , [2] , [3] ; Oner, R (Oner, Ridvan) [4] ; Ozgezmez, FT (Ozgezmez, Ferit Tufan) [4] ; Aydin, E (Aydin, Elif) [5] ; Tosun, AF (Tosun, Ayse Fahriye) [6] ; Cullu, E (Cullu, Emre) [4]
(provided by Clarivate)
Source
JOINT DISEASES AND RELATED SURGERY
Volume
36
Issue
1
Page
148-154
DOI
10.52312/jdrs.2025.2023
Published
2025
Early Access
DEC 2024
Indexed
2024-12-18
Document Type
Review
Abstract
Objectives: The aim of this study was to measure the reliability of the expanded and revised Melbourne Cerebral Palsy Hip Classification System (r-MCPHCS) across different medical specialties. Patients and methods: Anteroposterior pelvic radiographs of a total of 44 patients (20 males, 24 females; median 16.7 years; range, 12 to 32 years) with cerebral palsy (CP) were analyzed between January 2005 and December 2020. Four medical specialists (an orthopedic surgeon, a pediatric neurologist, a radiologist, and a physical medicine and rehabilitation specialist) were included in the study. The time gap between the first and the second assessment was at least three months. The intra- and inter-observer intraclass correlation coefficient (IntraOb. and InterOb. ICCs) were calculated. An ICC of >0.8 was considered excellent fit. Results: The median IntraOb. ICC was found to be 0.93 (range, 0.89 to 0.97), the median InterOb. ICC was found to be 0.88 for the first assessment (A) and 0.93 for the second assessment (B). Both results were interpreted as excellent in terms of compatibility. Conclusion: Our study results suggest that r-MCPHCS is a well-designed, reliable and reproducible scale that is easy to use among different medical specialists.
Keywords
Author Keywords
Cerebral palsyhipreliabilityrevised Melbourne Cerebral Palsy Hip Classification System
Keywords Plus
CHILDRENDISPLACEMENTDISLOCATIONRECONSTRUCTIONINTRAOBSERVERSURVEILLANCEPREVENTIONSURGERY
Climate Change and Neurological Disorders in Children
By
Ayanoglu, M (Ayanoglu, Muge) [1] ; Tosun, AF (Tosun, Ayse Fahriye) [1]
Edited by
Aksu, H (Aksu, H)
Source
CLIMATE CHANGE: CHILD AND ADOLESCENT HEALTH AND MENTAL HEALTH
Page
25-29
Published
2023
Indexed
2023-01-01
Document Type
Article; Book Chapter
Abstract
The review article discusses the impact of climate change on pediatric patients with neurological disorders. Climate change, characterized by global warming caused by increasing gases such as CO2, CH4 and N2O, changes in precipitation patterns, and extreme weather events, is caused by increasing greenhouse gas concentrations. These changes are linked to a rise in infectious diseases with neurological disorders. Environmental neurotoxins, exacerbated by climate change, could accelerate neurodegenerative disorders. Malnutrition arising from disrupted agriculture threatens neurodevelopmental health. Elevated environmental temperatures increase the risk of metabolic and neurological abnormalities. The vulnerability of individuals with pre-existing neurological conditions, such as epilepsy and disabilities, has been discussed in details. The need for preventative actions, education, public awareness, and legal frameworks to mitigate climate change's adverse impact on neurological health has been emphasized.
Keywords
Author Keywords
Climate changeglobal warmingnervous system diseaseschild
Keywords Plus
TARC and Septin 7 can be better monitoring biomarkers than CX3CL1, sICAM5, and IRF5 in children with seizure-free epilepsy with monotherapy and drug-resistant epilepsy
By
Ayanoglu, M (Ayanoglu, Muge) [1] ; Çevik, Ö (Cevik, Ozge) [2] ; Erdogan, Ö (Erdogan, Omer) [2] ; Tosun, AF (Tosun, Ayse Fahriye) [1]
(provided by Clarivate)
Source
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume
134
Issue
3
Page
243-252
DOI
10.1080/00207454.2022.2100773
Published
MAR 3 2024
Early Access
JUL 2022
Indexed
2022-08-19
Document Type
Article
Abstract
Aim: To evaluate i) the relationship between epilepsy and inflammation by analyzing the levels of thymus activation-regulated chemokine (TARC), and interferon regulatory factor 5 (IRF5) in healthy controls, patients with epilepsy on monotherapy and polytherapy, ii) the levels of sICAM5, chemokine (c-x3-c motif) ligand 1 (CX3CL1), and septin 7 (SEPT7) which are important in both inflammation and synaptic formation. Methods: Patients who were seizure-free with monotherapy (epilepsy group-1), patients with drug-resistant epilepsy (epilepsy group-2), and healthy controls were included. Demographical data, disease durations, and medications were noted. Measurements were made by commercial ELISA kits. Results: The numbers of epilepsy group-1, epilepsy group-2, and healthy controls were 23, 20, and 21, respectively. TARC levels were significantly lower in healthy controls than in both epilepsy groups. Higher TARC levels than 0.58 pg/ml indicated epilepsy with a sensitivity of 81.8% and specificity of 84.0%. SEPT7 levels were significantly higher in epilepsy group-1 than in those epilepsy group-2. A negative correlation was found between SEPT7 levels and disease duration as is the case for the correlation between SEPT7 and average seizure duration. A positive correlation was found between IRF5 and CX3CL1 levels, SEPT7 and IRF5 levels, and IRF5 and sICAM5 levels. Conclusions: We suggest that TARC is a promising biomarker, even in a heterogeneous epilepsy group not only for drug-resistance epilepsy but also for seizure-free epilepsy with monotherapy. Additionally, drug resistance, longer disease, and longer seizure durations are related to lower levels of SEPT7, which has an essential role in immunological functions and dendritic morphology.
Keywords
Author Keywords
EpilepsyTARCsICAM5CX3CL1Septin 7
Keywords Plus
ACTIVATION-REGULATED CHEMOKINESYNAPTIC PLASTICITYHIPPOCAMPAL-NEURONSMESSENGER-RNASRAT-BRAINTELENCEPHALINRECEPTORICAM-5SERUMFRACTALKINE
Genetic Landscape of Congenital Myasthenic Syndromes From Turkey: Novel Mutations and Clinical Insights
By
Yis, U (Yis, Uluc) [1] ; Becker, K (Becker, Kerstin) [2] ; Kurul, SH (Kurul, Semra Hiz) [1] ; Uyanik, G (Uyanik, Goekhan) [3] , [4] ; Bayram, E (Bayram, Erhan) [1] ; Haliloglu, G (Haliloglu, Goknur) [5] ; Polat, AI (Polat, Ayse Ipek) [1] ; Ayanoglu, M (Ayanoglu, Muge) [1] ; Okur, D (Okur, Derya) [1] ; Tosun, AF (Tosun, Ayse Fahriye) [6] ;
(provided by Clarivate)
Source
Volume
32
Issue
8
Page
759-765
DOI
10.1177/0883073817705252
Published
JUL 2017
Indexed
2017-07-01
Document Type
Article
Abstract
Congenital myasthenic syndromes are clinically and genetically heterogeneous disorders of neuromuscular transmission. Most are treatable, but certain subtypes worsen with cholinesterase inhibitors. This underlines the importance of genetic diagnosis. Here, the authors report on cases with genetically proven congenital myasthenic syndromes from Turkey. The authors retrospectively reviewed their experience of all patients with congenital myasthenic syndromes, referred over a 5-year period (2011-2016) to the Child Neurology Department of Dokuz Eylul University, Izmir, Turkey. In addition, PubMed was searched for published cases of genetically proven congenital myasthenic syndromes originating from Turkey. In total, the authors identified 43 (8 new patients, 35 recently published patients) cases. Defects in the acetylcholine receptor (n = 15; 35%) were the most common type, followed by synaptic basal-lamina associated (n = 14; 33%) and presynaptic syndromes (n = 10; 23%). The authors had only 3 cases (7%) who had defects in endplate development. One patient had mutation GFPT1 gene (n = 1; 2%). Knowledge on congenital myasthenic syndromes and related genes in Turkey will lead to prompt diagnosis and treatment of these rare neuromuscular disorders.
Keywords
Author Keywords
congenital myasthenic syndromesgenetic diagnosisTurk
Keywords Plus
MISSENSE MUTATION COLQ MUTATIONS DIAGNOSIS SCOLIOSIS
Comorbid Obsessive Compulsive Disorder in a Child with Tuberous Sclerosis Complex
By
Ozgur, BG (Ozgur, Borte Gurbuz) [1] ; Aksu, H (Aksu, Hatice) [2] ; Tosun, AF (Tosun, Ayse Fahriye) [3]
(provided by Clarivate)
Source
PSYCHIATRY AND BEHAVIORAL SCIENCES
Volume
8
Issue
3
Page
142-144
DOI
10.5455/PBS.20180612101258
Published
2018
Indexed
2018-01-01
Document Type
Article
Abstract
Tuberous sclerosis complex (TSC) is a genetic disease that mostly affects the brain, skin, kidneys, eyes, heart and lungs. Various neuropsychiatric comorbidities such as mental retardation, mood disorders, anxiety disorders, disruptive/ aggressive behavior disorders, autism spectrum disorders have been reported. In this study, we report a 15-year old case of with an obsessive compulsive disorder and TSC who is the youngest case in the literature. His sexual and religious obsessions first started when he was 10 years old. In this paper, his medical and psychiatric history and treatment management are presented.
Keywords
Author Keywords
Obsessive-compulsive disorder tuberous sclerosis child
Cystic Encephalomalacia and Infantile Spasm as a Complication of Transient and Mild Hyperinsulinemic Hypoglycemia
By
Anik, A (Anik, Ahmet) [1] ; Anik, A (Anik, Ayse) [2] ; Ünüvar, T (Unuvar, Tolga) [1] ; Tosun, AF (Tosun, Ayse Fahriye) [3] ; Dursun, S (Dursun, Siar) [3] ; Akcan, AB (Akcan, Abdullah Baris) [2] ; Durum, Y (Durum, Yasemin) [4] ; Türkmen, MK (Turkmen, Munevver Kaynak) [2]
(provided by Clarivate)
Source
Volume
3
Issue
2
Page
129-132
DOI
10.4274/jpr.16878
Published
JUN 2016
Indexed
2016-06-01
Document Type
Article
Abstract
Although it is known that hypoglycemia could cause severe negative effects on brain development and also infantile spasm, it has not been reported that transient hyperinsulinemic hypoglycemia, which spontaneously improves over a short time, may cause infantile spasms. Infantile spasm is a disorder of early childhood typically seen in the first year of life, characterized by the occurence of sudden, brief, generally bilateral and symetric motor spasms of the muscles of the trunk, neck and limbs. Infantile spasms are classified as idiopathic or symptomatic. The most common form symptomatic infantile spasms is due to prenatal, perinatal or postnatal insults. A 3140 g, full-term baby was admitted with poor sucking and feeding difficulty on the postnatal second day. The patient was followed-up with the diagnosis of hyperinsulinemic hypoglycemia and intravenous glucose infusion (15 mg/kg/min) was administered, but due to the persistence of hypoglycemia, diazoxide treatment was initiated. Hypoglycemia was not observed under diazoxide treatment and the drug was gradually decreased; treatment was terminated on the 21st day. The patient was continuously normoglycemic during follow-up and admitted with flexor spasms on the 45th day. A modified hypsarrhythmia pattern was detected in the electroencephalography. On cranial magnetic resonance imaging, diffuse cystic encephalomalacia areas were observed in the temporoparietal white and gray matter. The convulsions were not completely controlled with adrenocorticotropic hormone and vigabatrin treatments. Topiramate and valproate were administered, by which convulsions were partially controlled.
Keywords
Author Keywords
Infantile spasm transient hypoglycemia hyperinsulinemia
Keywords Plus
NEONATAL HYPOGLYCEMIA IMAGING FINDINGS DAMAGE MRI
An Uncommon Cause of Duane Syndrome in a Child: Wildervanck Syndrome
By
Anik, A (Anik, Ahmet) [1] ; Dursun, S (Dursun, Siar) [2] ; Polat, A (Polat, Ahmet) [3] ; Anik, A (Anik, Ayse) [4] ; Ünüvar, T (Unuvar, Tolga) [1] ; Durum, Y (Durum, Yasemin) [5] ; Tosun, AF (Tosun, Ayse Fahriye) [2]
(provided by Clarivate)
Source
Volume
3
Issue
1
Page
53-55
DOI
10.4274/jpr.29200
Published
MAR 2016
Indexed
2016-03-01
Document Type
Article
Abstract
Duane syndrome is a congenital eye movement disorder characterized by limitation of abduction and/or adduction accompanied with lid fissure narrowing, and globe retraction in attempted adduction. Duane syndrome is mostly an isolated entity, but systemic anomalies have been reported in 6-10% of patients. Wildervanck syndrome (cervico-oculo-acoustic syndrome) is a very rare disease comprised of the triad of Klippel-Feil deformity (congenitally fused cervical vertebrae), Duane syndrome, and hearing loss. The disorder is limited, or almost completely limited, to females, raising the question of sex-linked dominance with lethality in the hemizygous male. Herein, we describe an adolescent girl who was admitted to our clinic for obesity and diagnosed with Wildervanck syndrome due to bilateral abducens paralysis (Duane syndrome), Klippel-Feil deformity and hearing loss.
Keywords
Author Keywords
Duane syndrome klippel-feil anomaly hearing loss wildervanck syndrome
A Case Presentation of Atypical X-linked Adrenoleukodystrophy: Initial Experience with ASL Technique
By
Durum, Y (Durum, Yasemin) [1] ; Dayanir, YÖ (Dayanir, Yelda Ozsunar) [1] ; Navaei, AH (Navaei, Amir Hossein) [1] ; Tosun, AF (Tosun, Ayse Fahriye) [2]
(provided by Clarivate)
Source
CURRENT MEDICAL IMAGING REVIEWS
Volume
14
Issue
1
Page
158-162
DOI
10.2174/1573405613666170504151024
Published
2018
Indexed
2018-03-06
Document Type
Article
Abstract
Background: A 7-year-old boy with an atypical form of X-linked adrenoleukodystrophy is reported, predominantly involving frontal, occipital and temporal lobes, corticospinal tracts and cerebellar lobes.
Methods: The disease has been well documented previously with Magnetic Resonance Imaging (MRI).
Discussion: However, there isn't enough data on Magnetic Resonance Perfusion Imaging (MRPI) and non-contrast Arterial Spin Labeling (ASL) technique in current literature.
Conclusion: We presented initial and follow up MRI and multiphase ASL perfusion MRI findings.
Keywords
Author Keywords
Atypical form adrenoleukodystrophy arterial spin labeling technique Magnetic Resonance Perfusion Imaging (MRPI)multiphase ASL perfusion