1989 Ankara University Faculty of Medicine, ANKARA
1991 İzmir Atatürk Training and Research Hospital General Surgery Specialization Training, İZMİR
1989 - 1990 Atlı Village Health Center, Olur, ERZURUM
1990 - 1991 Olur District, Head of Olur District Health Group, ERZURUM
1991 - 1995 İzmir Atatürk Training and Research Hospital, İZMİR
1995 - 1997 Balikesir Military Hospital, BALIKESIR
1997 (March) İzmir Atatürk Training and Research Hospital, İZMİR
2008 National Cancer Institute Short-Term Research fellow Magee-Womens Hospital of The University of Pittsburgh Medical Center, Pittsburgh, USA
2008 - 2011 İzmir Atatürk Training and Research Hospital, İZMİR
2011 Private Tınaztepe Hospital, Chief Physician, IZMIR
2012 Surgical Oncology Specialist
List of Courses, Conferences, Scientific Publications, Papers and Posters
COEXISTENCE OF PANCREATIC NEUROENDOCRINE TUMOR AND PSEUDOTUMOR: TWO RARE LESIONS
By
Ozenbas, C (Ozenbas, Cemre) [1] ; Karaarslan, S (Karaarslan, Serap) [2] ; Gur, AS (Gur, Akif Serhat) [3]
(provided by Clarivate)
Source
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
Volume
33
Issue
3
Page
749-752
DOI
10.1177/10668969241272054
Published
MAY 2025
Early Access
SEP 2024
Indexed
2024-09-21
Document Type
Article
Abstract
Neuroendocrine tumors and pseudotumors of the pancreas are 2 separate rare lesions. Neuroendocrine tumors originate from neuroendocrine cells, but many different factors have been suggested for the origin of pseudotumors. As the first reports of these 2 distinct entities found in a single patient have been published, our aim is to present the imaging and pathological characteristics of these entities.
Keywords
Author Keywords
pancreaticpseudotumorp-NETneuroendocrine tumor
POLYPROPYLENE SUTURE GUIDED MICRODOCHECTOMY FOR PATHOLOGIC NIPPLE DISCHARGE
By
Gür, EÖ (Gur, Emine Ozlem) [1] ; Karaisli, S (Karaisli, Serkan) [1] ; Gür, AS (Gur, Akif Serhat) [2] ; Haciyanli, M (Haciyanli, Mehmet) [1]
(provided by Clarivate)
Source
Volume
35
Issue
4
Page
352-353
DOI
10.4274/balkanmedj.2017.1319
Published
JUL 2018
Indexed
2018-07-01
Document Type
Letter
Keywords
Keywords Plus
PREDICTING LIKELIHOOD OF HAVING FOUR OR MORE POSITIVE NODES IN PATIENT WITH SENTINEL LYMPH NODE-POSITIVE BREAST CANCER: A NOMOGRAM VALIDATION STUDY
By
Unal, B (Unal, Bulent) [1] ; Gur, AS (Gur, Akif Serhat) [1] ; Beriwal, S (Beriwal, Sushil) [2] ; Tang, G (Tang, Gong) [3] ; Johnson, R (Johnson, Ronald) [1] ; Ahrendt, G (Ahrendt, Gretchen) [1] ; Bonaventura, M (Bonaventura, Marguerite) [1] ; Soran, A (Soran, Atilla) [1]
(provided by Clarivate)
Source
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume
75
Issue
4
Page
1035-1040
DOI
10.1016/j.ijrobp.2008.12.028
Published
NOV 15 2009
Indexed
2009-11-15
Document Type
Article
Abstract
Purpose: Katz suggested a nomogram for predicting having four or more positive nodes in sentinel lymph node (SLN)-positive breast cancer patients. The findings from this formula might influence adjuvant radiotherapy decisions. Our goal was to validate the accuracy of the Katz nomogram.
Methods and Materials: We reviewed the records of 309 patients with breast cancer who had undergone completion axillary lymph node dissection. The factors associated with the likelihood of having four or more positive axillary nodes were evaluated in patients with one to three positive SLNs. The nomogram developed by Katz was applied to our data set. The area under the curve of the corresponding receiver operating characteristics curve was calculated for the nomogram.
Results: Of the 309 patients, 80 (25.9%) had four or more positive axillary lymph nodes. On multivariate analysis, the number of positive SLNs (p < .0001), overall metastasis size (p = .019), primary tumor size (p = .0001), and extracapsular extension (p = .01) were significant factors predicting for four or more positive nodes. For patients with <5% probability, 90.3% had fewer than four positive nodes and 9.7% had four or more positive nodes. The negative predictive value was 91.7%, and sensitivity was 80%. The nomogram was accurate and discriminating (area under the curve, .801).
Conclusion: The probability of four or more involved nodes is significantly greater in patients who have an increased number of positive SLNs, increased overall metastasis size, increased tumor size, and extracapsular extension. The Katz nomogram was validated in our patients. This nomogram will be helpful to clinicians making adjuvant treatment recommendations to their patients. (C) 2009 Elsevier Inc.
Keywords
Author Keywords
Breast CancerNomogramSentinel lymph nodeInvolved nodeRadiotherapy
Keywords Plus
CONSERVATIVE SURGERYAXILLARY NODESFAILUREIRRADIATIONINVOLVEMENTMETASTASISBIOPSYTHERAPYDISEASE
PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST: INTRADUCTAL APPEARANCE
By
Gur, AS (Gur, Akif Serhat) [1] ; Unal, B (Unal, Bulent) [1] ; Edington, H (Edington, Howard) [1] ; Kanbour-Shakir, A (Kanbour-Shakir, Amal) [2] ; Soran, A (Soran, Atilla) [1]
(provided by Clarivate)
Source
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Volume
35
Issue
4
Page
816-818
DOI
10.1111/j.1447-0756.2008.01009.x
Published
AUG 2009
Indexed
2009-08-01
Document Type
Article
Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferative lesion of breast stroma. The diagnosis of PASH can be made using imaging techniques such as ultrasound, magnetic resonance or mammography. Ductoscopy is a relatively new technique which is used for imaging the intraductal surface. We report a patient with PASH in whom ductoscopy was performed successfully.
Keywords
Author Keywords
Keywords Plus
CAN NOMOGRAMS PREDICT NON-SENTINEL LYMPH NODE METASTASIS AFTER NEOADJUVANT CHEMOTHERAPY IN SENTINEL LYMPH NODE-POSITIVE BREAST CANCER PATIENTS?
By
Unal, B (Unal, Bulent) [1] ; Gur, AS (Gur, Akif Serhat) [1] ; Ahrendt, G (Ahrendt, Gretchen) [1] ; Johnson, R (Johnson, Ronald) [1] ; Bonaventura, M (Bonaventura, Marguerite) [1] ; Soran, A (Soran, Atilla) [1]
(provided by Clarivate)
Source
Volume
9
Issue
2
Page
92-95
DOI
10.3816/CBC.2009.n.017
Published
MAY 2009
Indexed
2009-05-01
Document Type
Article
Abstract
Background: The predictive probability of breast cancer nomograms for non-sentinel node metastases (NSLNM) after neoadjuvant chemotherapy (NCT) in patients with a positive sentinel lymph node (SLN) biopsy is unknown. The aim of this study was to evaluate the accuracy of 3 different nomograms in patients receiving NCT Patients and Methods: Between 1999 and 2007, 54 patients presented with clinically NO disease received NCT Nomograms developed by Memorial Sloan-Kettering Cancer Center (MSKCC), Stanford University, and Tenon Hospital were used to calculate the probability of NSLNM by using tumor size at presentation and after NCT for the some patient. The discrimination of the nomograms was assessed by calculating the area under (AUC) the receiver operating characteristic curve, and it was accepted that AUC values 0.7-0.8 represent considerable discrimination Results: The median patient age was 50.9 years (range, 29-67 years). Twenty-two patients (38.8%) had positive NSLNM. The MSKCC and the Stanford nomograms yielded similar AUC regardless of whether initial or post-NCT tumor size was used to determine predicted probability of NSLNM (AUCs were < 0.70). AUC was 0.74 for the Tenon model using tumor size at presentation. After NCT, the AUCs were 0.64, 0.57, and 0.78 for the MSKCC, the Stanford, and the Tenon nomograms, respectively. Conclusion: Although the AUC of the Tenon model was acceptable for accuracy, we found a lower rate for predicting negative NSLNM in our group than in the Tenon Hospital report. All of the nomograms developed for use in the non-NCT population need to be used with caution in the NCT population
Keywords
Author Keywords
Lymphovascular invasionPathologic tumor sizeReceiver operating characteristic curve
Keywords Plus
BIOPSYCARCINOMAINVOLVEMENTDISSECTIONLIKELIHOODACCURATEDISEASEAXILLA
RISK FACTORS FOR BREAST CANCER-RELATED UPPER EXTREMITY LYMPHEDEMA: IS IMMEDIATE AUTOLOGOUS BREAST RECONSTRUCTION ONE OF THEM?
By
Gur, A (Gur, Akif Serhat) [1] ; Unal, B (Unal, Bulent) [1] ; Ahrendt, G (Ahrendt, Gretchen) [1] ; Gimbel, M (Gimbel, Michael L.) [1] ; Kayiran, O (Kayiran, Oguz) [1] ; Johnson, R (Johnson, Ronald) [1] ; Bonaventura, M (Bonaventura, Marguerite) [1] ; Soran, A (Soran, Atilla) [1]
(provided by Clarivate)
Source
CENTRAL EUROPEAN JOURNAL OF MEDICINE
Volume
4
Issue
1
Page
65-70
DOI
10.2478/s11536-009-0010-0
Published
MAR 2009
Indexed
2009-03-01
Document Type
Article
Abstract
Breast cancer related upper extremity lymphedema (BCRL) reduces the quality of life of those who have had surgery for breast cancer. The aim of this study is to evaluate the risk factors for BCRL and determine whether immediate autologous tissue breast reconstruction is one of them. A case control study was conducted comparing patients with BCRL (n=97) to surgically treated breast cancer patients without BCRL (control, n=126). The groups were matched for age, type of breast surgery and radiation therapy. Postoperative upper extremity infection, body mass index (BMI), occupation (level of hand-use), and immediate autologous tissue breast reconstruction were investigated as a risk factor of BCRL. Mastectomy was performed on 47.6 % (n=60) and 37.2% (n=36) of patients in the control and the BCRL groups, respectively. Eight patients (13.3%) had immediate autologous tissue breast reconstruction in the control mastectomy group. Six of 36 BCRL patients (16.7%) underwent mastectomy with immediate autologous tissue breast reconstruction. There was no significant difference between groups with respect to incidence or method of immediate reconstruction (p=0.65). Patient occupation (level of hand use) was found to be positively correlated to development of BCRL (p=0.0001). Upper extremity infection rate was 22.7% in the BCRL group and 4.0% in the controls (p=0.0001). The mean BMI in the control and BCRL groups 26.8 kg/m(2) and 29.1kg/m(2), respectively (p=0.003). In conclusion, in this study characteristics positively associated with development of BCRL included occupation, infection, and increased BMI. Immediate reconstruction of the breast was not found as a risk factor for BCRL. However larger studies are needed, to further evaluate the effect of breast reconstruction on BCRL.
Keywords
Author Keywords
Breast CancerArm lymphedemaImmediate reconstructionOccupationBody mass indexInfection
Keywords Plus
ARM EDEMARADIOTHERAPYTHERAPYFLAPS
THE PREDICTIVE PROBABILITY OF TWO DIFFERENT BREAST CANCER NOMOGRAMS FOR NON SENTINEL AXILLARY LYMPH NODE METASTASIS IN POSITIVE SENTINEL LYMPH NODE BIOPSY
By
Gür, AS (Gur, Akif Serhat) [1] ; Ünal, B (Unal, Buelent) [1] ; Johnson, R (Johnson, Ronald) [1] ; Ahrendt, G (Ahrendt, Gretchen) [1] ; Bonaventura, M (Bonaventura, Marguerite) [1] ; Evrensel, T (Evrensel, Turkkan) [2] ; Soran, A (Soran, Atilla) [1]
(provided by Clarivate)
Source
JOURNAL OF BREAST HEALTH
Volume
4
Issue
3
Page
169-173
Published
JUL 2008
Indexed
2008-07-01
Document Type
Article
Abstract
INTRODUCTION: Non sentinel axillary lymph node metastasis (NSLNM) occurs in 35-50% of breast cancer (BC) patients having positive sentinel lymph nodes (SLN). A nomogram which includes 8 variables was developed at Memorial Sloan Kettering Cancer Center (MSKCC) in 2003 and it has been validated at sources outside that institution. The Stanford University group recently reported their nomogram which evaluated 3 variables. AIM: The aim of this study is to evaluate the predictability of two different scoring systems wherein 3 or 8 variables are used in the same patient groups.
MATERIALS and METHODS: We identified 201 patients who had a positive SLN biopsy and completion axillary lymph node dissection at Magee-Womens Hospital of UPMC over a 5 year period. The computerized BC nomograms developed by MSKCC and Stanford University were used to calculate the probability of non-sentinel lymph node metastases. Area Under (AUC) Receiver Operating Characteristics Curve (ROC) was calculated for each nomogram and the values more than 0.70 have been accepted that presents considerable discrimination.
RESULTS: Sixty-six of 201 patients (32.8%) had positive axillary NSLNM. The mean predicted probability of positive NSLNM was 25.4% (3-93), and 66.3% (7-100) for the MSKCC and Stanford nomograms, respectively. The AUC values were 0.73 and 0.67 for MSKCC and Stanford nomograms, respectively.
DISCUSSION and CONCLUSION: Nomograms for predicting the probability of NSLNM in BC patients have been in use for 5 years. It is clear there are discrepancies in the results of nomograms among the studies using the same scoring system. Notwithstanding the Stanford nomogram is easier to implement as it considers only 3 variables in our study, we found the MSKCC nomogram to be more predictive than the Stanford nomogram Nomograms developed at outside institutions should be used with caution when counseling patients regarding the risk of additional nodal disease.
Keywords
Author Keywords
breast cancersentinel lymph nodenomogram
Keywords Plus
LIKELIHOODINVOLVEMENTLIMITATIONSVALIDATIONCARCINOMADISEASE
AN UNUSUAL BREAST TUMOR: LEIOMYOSARCOMA REVIEW OF THE LITERATURE
By
Gür, AS (Gur, Akif Serhat) [1] ; Atahan, K (Atahan, Kemal) [1] ; Tarcan, E (Tarcan, Ercument) [1] ; Yigit, S (Yigit, Seyran) [2] ; Çökmez, A (Cokmez, Atilla) [1]
(provided by Clarivate)
Source
JOURNAL OF BREAST HEALTH
Volume
2
Issue
3
Page
141-144
Published
JUL 2006
Indexed
2006-07-01
Document Type
Article
Abstract
BACKGROUND: Primary leiomyosarcoma of the breast is a very rare type of breast tumors. Only 37 cases have been reported in the world literature. Case Presentation: Herein we report a 40-year old lady with breast sarcoma and analyze the previous cases aiming to determine the diagnostic and therapeutic options. She admitted to the clinic with a complaint of slowly growing mass. No specific imaging findings were present. The diagnosis was reached after the examination of pathological specimen using immunohistochemistry. Simple mastectomy was done since it is the best therapeutic option to prevent local recurrence and there is no need to do axillary lymphadenectomy since lymphatic metastasis is an exception in breast leiomyosarcomas.
CONCLUSION: A long disease-free survival interval is no guarantee of a cure since local or systemic recurrences may appear 15-20 years after the primary surgery.
International :
International Associtaion of Hepato Pancreato Biliary Surgery
European Society of Parenteral and Enteral Nutrition (ESPEN)
American Society of Breast Cancer
National
Turkish Surgery Association
Aegean Region Surgical Association
Izmir Breast Diseases Association